Review
Pharmacology & Pharmacy
Gabriel Hoi-Huen Chan, Enoch Chan, Carsten Tsun-Ka Kwok, George Pak-Heng Leung, Simon Ming-Yuen Lee, Sai-Wang Seto
Summary: Ageing is a risk factor for degenerative diseases, including cardiovascular diseases. The tumor suppressor gene p53 may play a regulatory role in vascular remodeling, atherosclerosis, and pulmonary hypertension. Further studies are needed to fully understand the effects of p53 in cardiovascular function and its therapeutic potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Mandy O. J. Grootaert, Martin R. Bennett
Summary: Vascular smooth muscle cells play a key role in atherosclerosis by forming a protective fibrous cap and exhibiting various phenotypes that can affect plaque formation and stability. They are a larger proportion of atherosclerotic plaques than previously thought and their plasticity is regulated by various mechanisms.
CARDIOVASCULAR RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Xiaoyan Shi, Hongfei Wu, Yarong Liu, Hanwen Huang, Ling Liu, Yulong Yang, Tingting Jiang, Min Zhou, Min Dai
Summary: The study found that during the progression of atherosclerosis, stimulation by gut microbial LPS leads to high expression of OPN in circulating monocytes, promoting abnormal proliferation of VSMCs in the aorta. Pae can improve atherosclerosis by inhibiting the accumulation of gut microbial LPS and activation of monocytes/macrophages.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ruyi Zhang, Fan Bu, Yubing Wang, Mei Huang, Xiaomin Lin, Changmeng Wu, Juanjiang Chen, Yiyi Huang, Haifang Wang, Shu Ye, Xiumei Hu, Qian Wang, Lei Zheng
Summary: The study found that long noncoding RNA RP4-639F20.1 is downregulated in atherosclerosis. RP4-639F20.1 interacts with THRAP3 and downregulates c-FOS expression, thereby inhibiting the proliferation and migration of vascular smooth muscle cells. In vivo experiments also revealed that RP4-639F20.1 can deter the development of atherosclerosis. Therefore, RP4-639F20.1 and c-FOS could serve as potential therapeutic targets for atherosclerosis-related diseases.
Article
Biochemistry & Molecular Biology
Hui-Hsuan Lin, Ming-Chang Hsieh, Chi-Ping Wang, Pei-Rong Yu, Ming-Shih Lee, Jing-Hsien Chen
Summary: In this study, GTIN was found to inhibit VSMCs proliferation and migration, reduce ROS generation, and potentially play a role in controlling atherosclerosis and other cardiovascular diseases.
Review
Chemistry, Medicinal
Diem Thi Ngoc Huynh, Kyung-Sun Heo
Summary: Mitochondrial dynamics and mitophagy play crucial roles in regulating VSMC proliferation and migration through different mechanisms, with dynamin-related protein-1 and mitofusion-2 being key molecules in this process.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
YongPeng Fang, JinShuang Li, XuDong Niu, NingShun Ma, Jia Zhao
Summary: This study found that hypomethylation of the promoter of Rnase6 led to upregulated Rnase6 expression in AS patients, affecting cell proliferation, migration, ROS content, and inflammatory factor secretion, and activating the PI3K/Akt signaling pathway.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fabienne Burger, Daniela Baptista, Aline Roth, Rafaela Fernandes da Silva, Fabrizio Montecucco, Francois Mach, Karim J. Brandt, Kapka Miteva
Summary: The study demonstrated that oxLDL-activated monocytes can directly affect VSMCs in a co-culture system, leading to reduced expression of certain markers and upregulation of others, as well as activation of caspase 1, secretion of IL-1 beta, and pyroptosis in VSMCs. The activation of VSMC NLRP3 inflammasome by monocytes may play a detrimental role in atherosclerotic plaque stability in human atherosclerosis, as evidenced by findings in both mice and human atherosclerotic plaques.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Changpo Lin, Lirong Xu, Xiao Tang, Xiaobo Li, Chao Lu, Qianyun Cheng, Junhao Jiang, Yang Shen, Dong Yan, Ruizhe Qian, Weiguo Fu, Daqiao Guo
Summary: Disruption of Bmal1 in VSMCs worsens atherosclerosis by promoting VSMC migration and monocyte transmigration and impairing antioxidant function. Therefore, Bmal1 may be a potential therapeutic target and biomarker of atherosclerosis in the future.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Joseph M. Miano, Edward A. Fisher, Mark W. Majesky
Summary: Studying the phenotypic modulation of vascular smooth muscle cells is crucial for understanding the pathogenesis of atherosclerosis and developing new therapies. Recent technological and conceptual advances shed light on the multifunctionality and plasticity of VSMCs.
Article
Physiology
Eun Yeong Jeon, Seung Eun Baek, Ji On Kim, Jong Min Choi, Eun Jeong Jang, Chi Dae Kim
Summary: The study reveals that HMGB1 significantly increases migration of vascular smooth muscle cells (VSMCs) and the induction of OPN expression by HMGB1 plays a crucial role in VSMC migration. This suggests that the AP-1-OPN signaling axis in VSMCs could be a potential therapeutic target for vascular remodeling in injured vasculatures.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Cell Biology
Genmao Cao, Xuezhen Xuan, Jie Hu, Ruijing Zhang, Haijiang Jin, Honglin Dong
Summary: Vascular smooth muscle cells (VSMCs) are highly plastic and can switch into synthetic VSMCs to repair vascular injury. Multiple phenotypes of VSMCs have been discovered in vascular aging, atherosclerosis, and aortic aneurysm. The transformation of VSMCs is regulated by various factors such as transcription factors, growth factors, and non-coding RNAs.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Engineering, Biomedical
Deborah D. Chin, Christopher Poon, Jonathan Wang, Johan Joo, Victor Ong, Zhangjingyi Jiang, Kayley Cheng, Anastasia Plotkin, Gregory A. Magee, Eun Ji Chung
Summary: The delivery of miR-145 micelles to VSMCs shows promise in mitigating atherosclerosis progression by altering cell phenotypes and reducing plaque growth. In mouse experiments, miR-145 micelles significantly inhibited the advancement of atherosclerosis.
Review
Biochemistry & Molecular Biology
Yu Jiang, Hai-Yan Qian
Summary: Atherosclerosis (AS) is the accumulation of lipids and inflammatory debris in the arterial wall, leading to gradual occlusion of the arterial lumen. Despite therapeutic advances, AS remains the most common cause of cardiovascular diseases and the main mechanism of death and disability worldwide. Vascular smooth muscle cells (VSMCs) play a crucial role in AS, with remarkable plasticity and involvement in various processes such as phenotypic transformation, proliferation, migration, calcification, and apoptosis. Transcription factors and complex interactions of conserved cis-regulatory elements are key in the transcriptional regulation of VSMC genes, and manipulating transcription factors can regulate the development of atherosclerotic lesions.
MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Megumi Miyabe, Nobuhisa Nakamura, Tomokazu Saiki, Satoru Miyabe, Mizuho Ito, Sachiko Sasajima, Tomomi Minato, Tatsuaki Matsubara, Keiko Naruse
Summary: Atherosclerosis is a leading cause of death globally, and there is a correlation between periodontal disease and atherosclerosis. This study used Porphyromonas gingivalis-derived LPS (Pg-LPS) to investigate the proliferation and migration of human aortic smooth muscle cells (HASMCs). The results suggest that Pg-LPS promotes atherosclerosis through the activation of the TLR4-MAPK signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Trang Thi Doan Luong, Rashad Tuffaha, Mirjam Schuchardt, Barbara Moser, Nadeshda Schelski, Beate Boehme, Can Gollmann-Tepekoylu, Clara Schramm, Johannes Holfeld, Burkert Pieske, Erich Gulbins, Markus Toelle, Markus van der Giet, Florian Lang, Kai-Uwe Eckardt, Jakob Voelkl, Ioana Alesutan
Summary: The study found that acid sphingomyelinase (ASM)/ceramide is a critical regulator in promoting vascular smooth muscle cell (VSMC) calcification, partly through SGK1-dependent signaling. Inhibiting ASM may help reduce the progression of vascular calcification during chronic kidney disease (CKD).
Article
Anesthesiology
Isabell A. Just, Farnoush Alborzi, Maren Godde, Sascha Ott, Alexander Meyer, Julia Stein, Stefan Mazgareanu, Markus van der Giet, Kai M. Schmidt-Ott, Volkmar Falk, Felix Schoenrath
Summary: This study aimed to investigate the risk factors and typical clinical course of cardiac surgery-associated acute kidney injury (CS-AKI) and derive strategies for perioperative clinical routines. The results showed that close monitoring of renal function for at least 72 hours after cardiac surgery is crucial, especially in patients with preexisting chronic kidney disease (CKD) and signs of CS-AKI. Renal protective strategies should be initiated early to prevent the onset of AKI.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Article
Public, Environmental & Occupational Health
K. Fehrenbacher, C. Apel, D. Bertsch, M. S. van der Giet, S. van der Giet, M. Grass, C. Gschwandtl, N. Heussen, N. Hundt, C. Kuehn, A. Morrison, M. Mueller-Ost, M. Mueller-Tarpet, S. Porath, J. Risse, S. Schmitz, V Schoeffl, L. Timmermann, K. Wernitz, T. Kuepper
Summary: White noise exposure at high altitude poses a higher risk for noise-induced hearing loss, despite acclimatization increasing arterial oxygen saturation, it does not offer sufficient protection for the inner ear. Therefore, protective devices are recommended at altitudes above 1500 meters when noise levels exceed 75 dB, and should be used definitively above 80 dB to consider individual reactions to hypobaric hypoxia at high altitude.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2021)
Article
Medicine, General & Internal
Bertram Pitt, Gerasimos Filippatos, Rajiv Agarwal, Stefan D. Anker, George L. Bakris, Peter Rossing, Amer Joseph, Peter Kolkhof, Christina Nowack, Patrick Schloemer, Luis M. Ruilope
Summary: Finerenone therapy improved cardiovascular outcomes in patients with type 2 diabetes and stage 2 to 4 CKD with moderately elevated albuminuria or stage 1 or 2 CKD with severely elevated albuminuria, compared to placebo. The risk of the primary outcome event was significantly lower in the finerenone group, primarily driven by a reduction in hospitalization for heart failure.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Physiology
Alexander Reshetnik, Jonida Gjolli, Markus van der Giet, Friederike Compton
Summary: Invasive thermodilution techniques are still the gold standard for cardiac output measurement, but there is a growing need for non-invasive techniques to simplify the process. A novel oscillometry-based CO estimation method was evaluated and found to have some level of agreement with transpulmonary thermodilution in certain circumstances.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biology
Jaqueline Herrmann, Manasa Reddy Gummi, Mengdi Xia, Markus van der Giet, Markus Toelle, Mirjam Schuchardt
Summary: Arterial vessel diseases, particularly vascular calcification, are major contributors to cardiovascular morbidity and mortality. With various pathophysiological pathways involved, numerous rodent models and detection methods have been established for basic research. The aim is to provide an overview of available rodent models and quantification methods, emphasizing adherence to the 3R principles of replacement, reduction, and refinement.
Article
Multidisciplinary Sciences
Max Taubert, Elke Schaeffner, Peter Martus, Markus van der Giet, Uwe Fuhr, Amina Loesment, Natalie Ebert
Summary: In this study, the impact of a Bayesian estimation procedure on iohexol clearance estimates was evaluated, and an optimal sampling strategy was identified based on data in individuals aged 70+. A simplified three-compartment model was found to be optimal for estimating iohexol clearance in elderly patients with reduced GFR.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Jaqueline Herrmann, Mengdi Xia, Manasa Reddy Gummi, Anna Greco, Annika Schacke, Markus van der Giet, Markus Toelle, Mirjam Schuchardt
Summary: Vessel wall calcification is a structural pathology of aged vessels associated with high cardiovascular mortality in elderly patients. Chronic inflammation and oxidative stress in aging lead to activation of PRRs in vascular cells, contributing to VSMC calcification. Inhibition of PRR activation may be a potential target for reducing vascular calcification and subsequent cardiovascular mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Peripheral Vascular Disease
Thomas Weber, Jaques Amar, Tine de Backer, Thilo Burkard, Marcus van der Giet, Philippe Gosse, Andrzej Januszewicz, Thomas Kahan, Giuseppe Mancia, Christopher C. Mayer, Maria Lorenza Muiesan, George S. Stergiou, Konstantinos Tsioufis, Bernard Vaisse, Reinhold Kreutz
Summary: The Covid-19 pandemic led to a significant decrease in non-Covid-19 related hypertension care procedures. The first wave and lockdown period saw the largest reduction in diagnostic and therapeutic procedures related to hypertension. The long-term consequences on blood pressure control and cardiovascular events need further investigation.
Article
Medicine, Research & Experimental
Rebecca Ingenhoff, Juliet Nandawula, Trishul Siddharthan, Isaac Ssekitoleko, Richard Munana, Benjamin E. Bodnar, Ivan Weswa, Bruce J. Kirenga, Gerald Mutungi, Markus van der Giet, Robert Kalyesubula, Felix Knauf
Summary: This study aims to evaluate the effectiveness of a community health worker (CHW)-led intervention in blood pressure control among hypertensive patients in low-income and middle-income countries (LMICs). The intervention includes monthly household visits by trained CHWs for monitoring, assessment, and counseling. The results of this study will provide important information for hypertension management in LMIC settings.
Article
Genetics & Heredity
Markus Toelle, Cornelia Henkel, Jaqueline Herrmann, Christoph Daniel, Milen Babic, Mengdi Xia, Anna M. Schulz, Kerstin Amann, Markus van der Giet, Mirjam Schuchardt
Summary: This study evaluated an adenine-based uremic mouse model to study medial vessel calcification and senescence-associated secretory phenotype (SASP) changes, providing a basis for understanding molecular pathogenesis and potential therapeutic interventions.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Biochemistry & Molecular Biology
Anna Greco, Jaqueline Herrmann, Milen Babic, Manasa Reddy Gummi, Markus van der Giet, Markus Toelle, Mirjam Schuchardt
Summary: This study aims to establish a rapid and efficient working protocol for specific detection of hydroxyapatite (HAP) in cells and tissue, using a fluorescence dye, OsteoSense (TM). This method combines high specificity and improved sensitivity, making it valuable for researching the pathogenesis of vascular calcification and testing therapeutic inhibitors.
Article
Biochemistry & Molecular Biology
Jinwen Zhou, Manasa Reddy Gummi, Anna Greco, Milen Babic, Jaqueline Herrmann, Farid I. Kandil, Markus van der Giet, Markus Toelle, Mirjam Schuchardt
Summary: Medial vascular calcification (MAC) involves HAP deposition in the medial layer of the vessel wall, leading to vessel disruption and stiffness. Due to the lack of direct therapeutic interventions, understanding MAC pathogenesis is crucial. Although various methods exist to study the pathophysiological processes in the vessel wall, a method for assessing the physiological properties is currently unavailable. This study aims to address this gap by validating a method for measuring the biomechanical properties of the arterial wall during vascular calcification using small-vessel-myography.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
