Article
Virology
Wang Xu, Yuhang Wang, Letian Li, Xiaoyun Qu, Quan Liu, Tiyuan Li, Shipin Wu, Ming Liao, Ningyi Jin, Shouwen Du, Chang Li
Summary: This study reveals a direct interaction between IFITM3 and influenza HA protein via the transmembrane domain, shedding light on the biological significance of IFITM3 in restricting influenza virus infection or HA-mediated antagonism or escape.
Article
Biochemistry & Molecular Biology
Lisa M. Petti, Benjamin N. Koleske, Daniel DiMaio
Summary: Most eukaryotic transmembrane and secreted proteins contain N-terminal signal peptides that facilitate membrane insertion and subsequent degradation. A small hydrophobic protein can act as a signal peptide while retaining transforming activity, interacting with target protein transmembrane domains. This finding suggests that naturally occurring signal peptides may have additional biological activities.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kinjal Shah, Amr Al-Haidari, Jianmin Sun, Julhash U. Kazi
Summary: Interaction of T cell receptor with MHC-antigenic peptide complex leads to activation of T cell signaling pathways that mediate gene expression. Adaptor proteins act as scaffolds in integrating these pathways to connect different signaling cascades, facilitating full T cell activation.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Immunology
Natacha Zanin, Christine Viaris de Lesegno, Christophe Lamaze, Cedric M. Blouin
Summary: The internalized IFNAR complex plays a crucial role in regulating signal transduction triggered by IFN binding to IFNAR, determining the fate of IFNAR subunits and controlling IFN-induced signal transduction through finely tuned interactions. Investigating the complexity of IFN receptor intracellular routes is necessary to reveal new insights into the role of IFNAR membrane dynamics in type I IFNs signaling selectivity and biological activity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alexey S. Kazakov, Alexander D. Sofin, Nadezhda V. Avkhacheva, Evgenia I. Deryusheva, Victoria A. Rastrygina, Maria E. Permyakova, Vladimir N. Uversky, Eugene A. Permyakov, Sergei E. Permyakov
Summary: Interferon-beta (IFN-beta) activity is affected by interactions with S100 proteins, including S100A1, S100A4, S100A6, S100P, and S100B. This study demonstrates the interaction between IFN-beta and S100B, and shows that monomerization of S100B enhances its affinity to IFN-beta. The modulation of IFN-beta activity by S100B could be relevant to the progression of various oncological and neurological diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Jean-Philippe Defour, Emilie Leroy, Sharmila Dass, Thomas Balligand, Gabriel Levy, Ian C. Brett, Nicolas Papadopoulos, Celine Mouton, Lidvine Genet, Christian Pecquet, Judith Staerk, Steven O. Smith, Stefan N. Constantinescu, Lewis E. Kay
Summary: The study investigates the structural basis of activation for TpoR mutations S505N and W515K that induce myeloproliferative neoplasms. Ligand-independent activation of TpoR by TM asparagine (Asn) substitutions is shown to be proportional to the proximity of the Asn mutation to the intracellular membrane surface. The loss of helical structure in the juxtamembrane (JM) R/KWQFP motif and the effect of helical structure in the JM motif on receptor function are also investigated.
Review
Pharmacology & Pharmacy
Zhaotong Cong, Yi-Lynn Liang, Qingtong Zhou, Sanaz Darbalaei, Fenghui Zhao, Wenbo Feng, Lihua Zhao, H. Eric Xu, Dehua Yang, Ming-Wei Wang
Summary: Class B1 G protein-coupled receptors have important functions in human physiology and disease pathology. Recent advances in cryo-electron microscopy and X-ray crystallography have provided detailed insights into their three-dimensional structures, ligand recognition, and receptor activation. These findings offer new avenues for developing improved therapeutic agents.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yuri Park, Sang Jun Han
Summary: Endometriosis is an estrogen-dependent inflammatory disease that causes pelvic pain and infertility in women. Immune system defects may contribute to the progression of endometriosis. Elevated levels of interferon, a cytokine, play a crucial role in endometriosis progression, but also have a critical role in normal endometrial function, particularly in pregnancy initiation and maintenance.
Article
Chemistry, Analytical
Su-jin Hong, Eungyeong Park, Yoon-ha Jang, Ji-yeon Shim, Yeonju Park, Sila Jin, Shuang Guo, Yeon-ju Kim, Min-jeong Son, Lei Chen, Kwang-il Lim, Young Mee Jung
Summary: In this study, we utilized probe-free surface-enhanced Raman scattering (SERS) to identify multiple types of viruses by obtaining the spectral fingerprint of their surface proteins. Furthermore, the SERS-based method successfully distinguished influenza virus variants with surface protein mutations.
ANALYTICAL CHEMISTRY
(2022)
Review
Plant Sciences
Kumar Abhinandan, Subramanian Sankaranarayanan, Stuart Macgregor, Daphne R. Goring, Marcus A. Samuel
Summary: This paper reviews the mechanism of self-incompatibility in plants, with a focus on the early stages of pollen-pistil interactions in Brassicaceae, revealing several key signaling events and molecular components.
TRENDS IN PLANT SCIENCE
(2022)
Article
Cell Biology
Jerome Tubiana, Yufei Xiang, Li Fan, Haim J. Wolfson, Kong Chen, Dina Schneidman-Duhovny, Yi Shi
Summary: This study demonstrates that the extensively mutated receptor binding site of the SARS-CoV-2 Omicron variant reduces its antigenicity and explains the lower antibody titers associated with breakthrough infections. The research also suggests a potential trajectory of future viral evolution.
Article
Plant Sciences
Zhengjie Yuan, Yanfei Geng, Yuanxing Dai, Jing Li, Mingfang Lv, Qiansheng Liao, Li Xie, Heng-Mu Zhang
Summary: The P9-2 protein of Southern rice black-streaked dwarf virus (SRBSDV) has been found to induce cell death in both bacterial and plant cells. Its localization to the plasma membrane (PM) is essential for its cell death-inducing ability. The central transmembrane hydrophobic domain and specific amino acid residues play important roles in the induction of cell death by P9-2. This study also suggests that the nonstructural protein of fijiviruses may trigger cell death by targeting conserved cellular factors or via a highly conserved mechanism.
MOLECULAR PLANT PATHOLOGY
(2023)
Article
Multidisciplinary Sciences
Roarke A. Kamber, Yoko Nishiga, Bhek Morton, Allison M. Banuelos, Amira A. Barkal, Felipe Vences-Catalan, Mingxin Gu, Daniel Fernandez, Jose A. Seoane, David Yao, Katherine Liu, Sijie Lin, Kaitlyn Spees, Christina Curtis, Livnat Jerby-Arnon, Irving L. Weissman, Julien Sage, Michael C. Bassik
Summary: This study developed a platform for unbiased identification of factors that impede antibody-dependent cellular phagocytosis (ADCP) in cancer cells, revealing the important roles of the enzyme APMAP and the G-protein-coupled receptor GPR84 in this process. This helps to expand our knowledge of the mechanisms governing cancer resistance to macrophage phagocytosis.
Review
Biochemistry & Molecular Biology
Michael J. Morgan, You-Sun Kim
Summary: This article discusses the roles of RIPK3 in cell signaling and necroptosis, as well as the pathways that trigger RIPK3 activation and cell death. The significance of this research lies in revealing the association of necroptosis with inflammation and the immune system, and exploring the potential role of RIPK3 in diseases.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Qingshan Fu, James J. Chou
Summary: The study identified the structure of the TMD of the S protein of SARS-CoV-2, revealing it as a transmembrane alpha-helix trimer that spontaneously assembles in the membrane, with a strong hydrophobic core. The research also found that, despite being highly stable, single mutations can completely dissociate this trimer.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)