Article
Clinical Neurology
Eli R. Lebowitz, Carla E. Marin, Meital Orbach, Natalina Salmaso, Flora M. Vaccarino, Wendy K. Silverman
Summary: This study examines the intergenerational pathway linking fibroblast growth factor 2 (FGF2) levels in mothers to FGF2 levels in children, and to the children's anxiety and depressive symptoms. The results show a significant positive correlation between FGF2 levels in mothers and children, and a significant negative correlation between children's FGF2 levels and their anxiety and depression symptoms. Structural equation modeling reveals that increases in maternal FGF2 levels are associated with increases in child FGF2 levels, which in turn are associated with decreases in child anxiety and depression symptoms, controlling for maternal anxiety and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Editorial Material
Cell Biology
Haodong Wang, Min Zhang, Liang Ge
Summary: It has been found that cholesterol promotes the secretion of FGF2 through an unconventional secretory pathway, enhancing the binding of PI(4,5)P-2 to FGF2 and altering the membrane properties to increase the translocation of FGF2.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Chao Chen, Zhenxing Zhang, Caiyun Liu, Bin Wang, Ping Liu, Shu Fang, Fan Yang, Yongping You, Xinjian Li
Summary: Excessive consumption of fructose contributes to cancer development. This study reveals that glucose deprivation induces fructolysis in glioblastoma cells, which is mediated by ATF4. Inhibition of ATF4-dependent fructolysis significantly suppresses growth and colony formation of glioblastoma cells in vitro and in vivo.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Esther Paulo, Yun Zhang, Ruchi Masand, Tony L. Huynh, Youngho Seo, Danielle L. Swaney, Margaret Soucheray, Erica Stevenson, David Jimenez-Morales, Nevan J. Krogan, Biao Wang
Summary: The study reveals that the deficiency of Leucine-rich pentatricopeptide repeat containing-protein in brown adipocytes affects mitochondrial-fueled thermogenesis, and activation of transcription factor 4 can improve cold tolerance in mice, not only in wild-type but also in Ucp1 knockout mice. Additionally, ATF4 activation in brown adipocytes can improve systemic metabolism.
Review
Medicine, Research & Experimental
Yaosheng Xiao, Xunlu Xie, Zhixi Chen, Guoqiang Yin, Weihao Kong, Jianguo Zhou
Summary: ATF4 plays a crucial role in maintaining bone homeostasis and inhibiting the development of osteoporosis. It promotes bone formation and inhibits bone resorption.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Svenja Zielke, Simon Kardo, Laura Zein, Muriel Mari, Adriana Covarrubias-Pinto, Maximilian N. Kinzler, Nina Meyer, Alexandra Stolz, Simone Fulda, Fulvio Reggiori, Donat Koegel, Sjoerd van Wijk
Summary: Selective degradation of the endoplasmic reticulum (ER) through reticulophagy is involved in cellular energy restoration and ER homeostasis. The compound loperamide triggers ATF4 upregulation and ER stress, leading to autophagy and autophagic cell death in glioblastoma cells. This process is mediated by the reticulophagy receptors RETREG1 and TEX264.
Article
Genetics & Heredity
Tiit Ord, Daima Ord, Priit Adler, Tonis Oerd
Summary: This study demonstrates the regulatory effects of GWAS genetic variants on gene expression by altering ATF4-mediated transcriptional activation. By cataloguing ATF4 binding sites in the human genome and identifying overlaps with trait-associated genetic variants, the study reveals the allelic transcriptional activity of these SNPs and confirms their regulatory effects in additional cellular models. The use of CRISPR-Cas9 technology further confirms the impact of specific genetic variants on target gene expression.
Article
Multidisciplinary Sciences
Davy Vanhoutte, Tobias G. Schips, Alexander Vo, Kelly M. Grimes, Tanya A. Baldwin, Matthew J. Brody, Federica Accornero, Michelle A. Sargent, Jeffery D. Molkentin
Summary: The Thbs family of proteins, particularly Thbs1, plays a critical role in regulating adult cardiomyocyte size in the stressed heart through activation of PERK-eIF2 alpha -ATF4-induced autophagy.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Magdalena M. Szewczyk, Genna M. Luciani, Victoria Vu, Alex Murison, David Dilworth, Samir H. Barghout, Mathieu Lupien, Cheryl H. Arrowsmith, Mark D. Minden, Dalia Barsyte-Lovejoy
Summary: This study identifies the important role of the PRMT5-ATF4 axis in AML, showing that PRMT5 inhibition leads to abnormal transcription and splicing of the ATF4 gene, resulting in nuclear retention of ATF4 mRNA and decreased cytoplasmic ATF4 transcript levels, leading to decreased ATF4 protein levels and downregulation of ATF4 target gene expression, increased oxidative stress, growth arrest, and cellular senescence. Leukemia cells with EVI1 oncogene overexpression demonstrate dependence on PRMT5 function and regulation of oxidative stress response.
Editorial Material
Biochemistry & Molecular Biology
Durga Mahor, Rishikesh Pandey, Vinay Bulusu
Summary: The study reveals that cellular metabolic adaptations following inhibition of the tricarboxylic acid cycle involve the convergent activation of the integrated stress response through ATF4-mediated rewiring of amino acid and redox metabolic pathways.
TRENDS IN BIOCHEMICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Carly Boye, Kyle Christensen, Kamal Asadipour, Scott DeClemente, Michael Francis, Anna Bulysheva
Summary: This study optimized gene electrotransfer and bioprinting techniques to accelerate tendon healing, showing that the combination of collagen scaffolds and angiogenic GET therapy can improve angiogenesis and biocompatibility of implants, potentially enhancing graft biocompatibility in tendon repair.
BIOELECTROCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Hui Jiang, Cong Wang, An Zhang, Yufeng Li, Jianping Li, Zhan Li, Xin Yang, Yinglong Hou
Summary: The cardiotoxicity of Sorafenib is associated with the ferroptosis of cardiomyocytes. Activation of endoplasmic reticulum stress and the unfolded protein response might be attributed to lipid reactive oxygen species-mediated perturbation of the endoplasmic reticulum. ATF4 promotes cardiomyocyte survival by up-regulation of SLC7A11 and suppression of ferroptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Shuting Han, Liyuan Zhu, Yiran Zhu, Yuan Meng, Jiaqiu Li, Ping Song, Neelum Aziz Yousafzai, Lifeng Feng, Miaoqin Chen, Yanmei Wang, Hongchuan Jin, Xian Wang
Summary: Inhibition of glutaminolysis activates the ATF4 pathway to induce pro-survival autophagy in cancer cells, while also upregulating ATF4 expression by abrogating m(6)A modification and YTHDF2-mediated RNA decay. Targeting ATF4-induced autophagy could enhance the efficacy of glutaminolysis-targeting therapies for cancer treatment.
Article
Cell Biology
Abigail S. Krall, Peter J. Mullen, Felicia Surjono, Milica Momcilovic, Ernst W. Schmid, Christopher J. Halbrook, Apisadaporn Thambundit, Steven D. Mittelman, Costas A. Lyssiotis, David B. Shackelford, Simon R. Knott, Heather R. Christofk
Summary: Mitochondrial respiration is essential for cell proliferation by generating biosynthetic precursors like aspartate. Inhibition of electron transport chain can deplete aspartate and impair ATF4 and mTORC1 activities. Adding exogenous asparagine can restore these activities and promote cell proliferation in the context of ETC inhibition.
Article
Biochemistry & Molecular Biology
Chan Yoon Park, Seul Ki Lee, Jimin Kim, Donguk Kim, Han Choe, Ji-Hoon Jeong, Kyung-Chul Choi, Hye Soon Park, Sung Nim Han, Yeon Jin Jang
Summary: Non-alcoholic fatty liver disease (NAFLD) is often related to obesity, insulin resistance, and endoplasmic reticulum (ER) stress. Elevated levels of hepatokine leukocyte cell-derived chemotaxin-2 (LECT2) have been found in NAFLD patients, and the activation of ER stress/UPR signaling seems to induce LECT2 expression, with ATF4 potentially mediating the transcriptional upregulation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)