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Multidisciplinary Sciences
Rui Zhou, Guodong Wang, Qi Li, Fanxi Meng, Can Liu, Rui Gan, Dapeng Ju, Meimei Liao, Junjie Xu, Di Sang, Xue Gao, Shuang Zhou, Kejia Wu, Quanzhi Sun, Ying Guo, Chongyang Wu, Zhiyu Chen, Lin Chen, Bihan Shi, Haiyan Wang, Xia Wang, Huaiye Li, Tao Cai, Bin Li, Fengchao Wang, Hiromasa Funato, Masashi Yanagisawa, Eric Erquan Zhang, Qinghua Liu
Summary: This study characterizes a major signaling pathway for the transcriptional regulation of sleep in mice, involving the LKB1-SIK3 pathway and phosphorylation of HDAC4/HDAC5. The findings provide insights into the molecular mechanisms that regulate sleep quantity and offer new potential targets for the treatment of sleep disorders.
Review
Biochemistry & Molecular Biology
Nazmus Salehin, Hilary Knowles, V. Pragathi Masamsetti, Patrick P. L. Tam
Summary: This review focuses on the current understanding of the interplay between signaling input and downstream transcriptional activity in the differentiation of germ layer tissue and cell lineages during gastrulation. It highlights the conservation and divergence of cellular and molecular mechanisms in the development of germ layers, with a particular emphasis on human embryo.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2022)
Review
Cell Biology
Kamalakshi Deka, Yinghui Li
Summary: The NF-kappa B signaling pathway plays a major role in inflammation and innate immunity, and is also crucial for cancer initiation and progression. It consists of canonical and non-canonical pathways, with the canonical pathway being prevalent in various human malignancies and inflammation-related diseases. The non-canonical pathway is also increasingly recognized in disease pathogenesis.
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Gastroenterology & Hepatology
Jianlong Ma, Zhuolin Yang, Zhuofu Huang, Linke Li, Jingliang Huang, Jingying Chen, Rui Ni, Lingfei Luo, Jianbo He
Summary: In end-stage liver diseases, the dysfunctionality of hepatocytes and the scarcity of donor organs make liver transplantation the only curative therapeutic solution. Promoting the transdifferentiation of biliary epithelial cells (BECs) offers a promising treatment, yet the factors governing BEC-derived liver regeneration remain unknown. This study used zebrafish to identify a liver regeneration defect mutant (lrd) and found that the loss of rngtt led to defects in BEC dedifferentiation, progenitor cell activation, and cell proliferation during liver regeneration initiation. The findings suggest that Rngtt is a new factor that initiates BEC-derived liver regeneration.
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Biology
Katarzyna Szymanska, Karsten Boldt, Clare Logan, Matthew Adams, Philip A. Robinson, Marius Ueffing, Elton Zeqiraj, Gabrielle Wheway, Colin A. Johnson
Summary: This study provides mechanistic insight into ciliary ubiquitin processing and uncovers UBE2E1 and RNF34 as novel interactants of MKS1. UBE2E1 mediates both regulatory and degradative ubiquitination of MKS1, and phosphorylated beta-catenin processing occurs at the ciliary base.
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Endocrinology & Metabolism
Aysha B. Khalid, Jacquelyn Pence, Sarocha Suthon, Jianjian Lin, Gustavo A. Miranda-Carboni, Susan A. Krum
Summary: GATA4 is a transcription factor that plays a role in osteoblast differentiation, with its knockout in mice resulting in decreased trabecular bone properties and reduced MSCs, along with decreased expression of WNT signalosome components.
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Multidisciplinary Sciences
Nitish Gulve, Chenhe Su, Zhong Deng, Samantha S. Soldan, Olga Vladimirova, Jayamanna Wickramasinghe, Hongwu Zheng, Andrew V. Kossenkov, Paul. M. Lieberman
Summary: The tumor suppressor proteins DAXX and ATRX play a critical role in regulating p53 chromatin accessibility and DNA damage response in cancers with alternative lengthening of telomeres (ALT). Disruption of this pathway is essential for the survival of ALT cells.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Jiajia Wang, Xichen Wan, Qihua Le
Summary: SOX9, a member of the SRY-related HMG-box transcription factors, plays a critical role in fetal development and stem cell homeostasis. The interactions between SOX9 and the canonical Wnt signalling pathway are involved in various physiological and pathological processes of stem cells, including organ development, stem cell proliferation, differentiation, and tumorigenesis. This review summarizes the molecular mechanism of cross-interactions between SOX9 and the canonical Wnt signalling pathway, outlines its regulatory effects on homeostasis in different types of stem cells, and explores its potential in translational stem cell therapy.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
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Multidisciplinary Sciences
Yinhua Jin, Teni Anbarchian, Peng Wu, Abby Sarkar, Matt Fish, Weng Chuan Peng, Roel Nusse
Summary: Cell proliferation is tightly regulated by various factors, including transcriptional repressors E2F7 and E2F8. In this study, it was discovered that Wnt/β-catenin signaling maintains active cell division in the liver through the transcription factor Tbx3. Tbx3 directly represses the transcription of E2f7 and E2f8, thereby promoting mitosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cell Biology
Fabio Arturo Iannotti, Rosa Maria Vitale
Summary: PPARs are a family of nuclear receptors that regulate the expression of target genes involved in metabolism, immune reaction, cell differentiation, and other cellular changes. They are activated by various lipid molecules, including cannabinoids, and interact with the endocannabinoid system to modulate physiological and pathophysiological functions.
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Cell & Tissue Engineering
Ramakanth Satthenapalli, Scott Lee, Jayanthi Bellae Papannarao, Timothy A. Hore, Akash Chakraborty, Peter P. Jones, Regis R. Lamberts, Rajesh Katare
Summary: This study successfully differentiated pluripotent stem cells into ventricular-specific cardiomyocytes by regulating Wnt and retinoic acid signaling pathways.
STEM CELL RESEARCH & THERAPY
(2022)
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Biochemistry & Molecular Biology
Yen-Sung Huang, Chang-Chieh Wu, Che-Chang Chang, Shiu-Feng Huang, Hong-Yi Kuo, Hsiu-Ming Shih
Summary: Upregulation of Daxx is associated with colorectal cancer, and it can promote CRC cell growth by activating PIK3CA.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Dermatology
Yinglu Guan, Youn Joo Yang, Priyadharsini Nagarajan, Yejing Ge
Summary: Epithelial stem cells play crucial roles in maintaining skin homeostasis, wound repair, and cancer, with their function tightly controlled by various transcriptional and signaling mechanisms. After injury, stem cells exhibit lineage plasticity and adjust their differentiation fate according to damage signals.
EXPERIMENTAL DERMATOLOGY
(2021)
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Cell Biology
Jasmin Moneer, Stefan Siebert, Stefan Krebs, Jack Cazet, Andrea Prexl, Qin Pan, Celina Juliano, Angelika Boettger
Summary: Through RNA-seq and single-cell sequencing data, the study identified the regulatory mechanisms of Notch signaling in head patterning and interstitial cell differentiation in Hydra.
JOURNAL OF CELL SCIENCE
(2021)
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Cell Biology
Ruiyao Xu, Xianxian Wang, Sadia Safi, Nico Braunegger, Agnes Hipgrave Ederveen, Michelle Rottmann, Joachim Wittbrodt, Manfred Wuhrer, Janine Wesslowski, Gary Davidson
Summary: Reception of Wnt signals is mediated by Frizzled receptors and a co-receptor LRP6 or LRP5. Precise control of receptor activation is crucial to regulate Wnt/beta-catenin signaling for proper cellular function. A glycosyltransferase B3GnT2-like has been identified to modify LRP6 and enhance Wnt/beta-catenin signaling. This study highlights the importance of LRP6 as a regulatory hub in Wnt signaling and provides insight into the selective targeting of a signaling pathway component by a specific glycosyltransferase.
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Dentistry, Oral Surgery & Medicine
Gu-Jiun Lin, Yen-Sung Huang, Chih-Kung Lin, Shing-Hwa Huang, Hsiu-Ming Shih, Huey-Kang Sytwu, Yuan-Wu Chen
CLINICAL ORAL INVESTIGATIONS
(2016)
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Multidisciplinary Sciences
Chia-Chao Wu, Yen-Sung Huang, Jin-Shuen Chen, Ching-Feng Huang, Sui-Lung Su, Kuo-Cheng Lu, Yuh-Feng Lin, Pauling Chu, Shih-Hua Lin, Huey-Kang Sytwu
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Oncology
Yen-Sung Huang, Che-Chang Chang, Szu-Shuo Lee, Yuh-Shan Jou, Hsiu-Ming Shih
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Oncology
Yen-Sung Huang, Shin-Huei Fu, Kuo-Cheng Lu, Jin-Shuen Chen, Hsin-Yi Hsieh, Huey-Kang Sytwu, Chia-Chao Wu
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Biochemistry & Molecular Biology
Ling-Yueh Hu, Che-Chang Chang, Yen-Sung Huang, Wen-Cheng Ghou, Ying-Mei Lin, Chun-Chen Ho, Wei-Ting Chen, Hsiu-Ming Shih, Chia-Ni Hsiung, Pei-Ei Wu, Chen-Yang Shen
HUMAN MOLECULAR GENETICS
(2018)
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Endocrinology & Metabolism
Yen-Sung Huang, Kuo-Cheng Lu, Tai-Kuang Chao, Jin-Shuen Chen, Ann Chen, Cheng-Yi Guo, Hsin-Yi Hsieh, Hsiu-Ming Shih, Huey-Kang Sytwu, Chia-Chao Wu
JOURNAL OF PINEAL RESEARCH
(2018)
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Multidisciplinary Sciences
Che-Chang Chang, Yen-Sung Huang, Ying-Mei Lin, Chia-Ju Lin, Jen-Chong Jeng, Shin-Mei Liu, Tsai-Ling Ho, Ruei-Ting Chang, Chun A. Changou, Chun-Chen Ho, Hsiu-Ming Shih
SCIENTIFIC REPORTS
(2018)
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Biochemistry & Molecular Biology
Yen-Sung Huang, Hsin-Yi Hsieh, Hsiu-Ming Shih, Huey-Kang Sytwu, Chia-Chao Wu
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2014)
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Oncology
Jeng-Long Hsieh, Che-Hsin Lee, Min-Li Teo, Yih-Jyh Lin, Yen-Sung Huang, Chao-Liang Wu, Ai-Li Shiau
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Cell Biology
Yen-Sung Huang, Che-Chang Chang, Tien-Chi Huang, Yung-Lin Hsieh, Hsiu-Ming Shih
Article
Cell Biology
Hong-Yi Kuo, Yen-Sung Huang, Chin-Hsiu Tseng, Yi-Chen Chen, Yu-Wei Chang, Hsiu-Ming Shih, Cheng-Wen Wu
Article
Biochemistry & Molecular Biology
Che-Chang Chang, Mandar T. Naik, Yen-Sung Huang, Jen-Chong Jeng, Pei-Hsin Liao, Hong-Yi Kuo, Chun-Chen Ho, Yung-Lin Hsieh, Chiou-Hong Lin, Nai-Jia Huang, Nandita M. Naik, Camy C-H. Kung, Shu-Yu Lin, Ruey-Hwa Chen, Kun-Sang Chang, Tai-Huang Huang, Hsiu-Ming Shih
Article
Cell Biology
Yen-Sung Huang, Kuo-Cheng Lu, Hsu-Wen Chao, Ann Chen, Tai-Kuang Chao, Cheng-Yi Guo, Hsin-Yi Hsieh, Hsiu-Ming Shih, Huey-Kang Sytwu, Chia-Chao Wu
Summary: The downregulation of melatonin receptor 1A (MTNR1A) is linked to various diseases, including membranous nephropathy. Research has shown that hnRNPL plays a role in upregulating MTNR1A expression post-transcriptionally, potentially serving as a therapeutic target for renal diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Heng Lin, Yen-Sung Huang, Jean-Michel Fustin, Masao Doi, Huatao Chen, Hui-Huang Lai, Shu-Hui Lin, Yen-Lurk Lee, Pei-Chih King, Hsien-San Hou, Hao-Wen Chen, Pei-Yun Young, Hsu-Wen Chao
Summary: This study demonstrates that the accumulation of hyperpolyploid hepatocytes around the centrilobular region of the liver may indicate the origin of preneoplastic formation. Upregulation of Aurkb plays a critical role in promoting hyperpolyploidization, leading to the development of HCC cells.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Yen-Sung Huang, Chang-Chieh Wu, Che-Chang Chang, Shiu-Feng Huang, Hong-Yi Kuo, Hsiu-Ming Shih
Summary: Upregulation of Daxx is associated with colorectal cancer, and it can promote CRC cell growth by activating PIK3CA.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
