Article
Oncology
Swapna Asuthkar, Sujatha Venkataraman, Janardhan Avilala, Katherine Shishido, Rajeev Vibhakar, Bethany Veo, Ian J. Purvis, Maheedhara R. Guda, Kiran K. Velpula
Summary: Medulloblastoma (MB) is the most common malignant pediatric brain tumor, and the standard of care for MB patients includes maximum safe resection, postoperative craniospinal irradiation, and chemotherapy. Recent research has identified SMYD3 as a crucial epigenetic regulator, which activates the transcription of cyclin D3 and drives the growth of Group 3 Myc+ MB cells.
Article
Pharmacology & Pharmacy
Ying Hou, Rong Liu, Mengwei Xia, Chong Sun, Bingling Zhong, Jie Yu, Nana Ai, Jin-Jian Lu, Wei Ge, Bo Liu, Xiuping Chen
Summary: NAN triggers G1 phase cell cycle arrest and caspase-independent apoptosis in CRC cells through downregulation of cyclin D1 and inhibition of eEF1A-targeted translation.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cell Biology
Natheer Al-Rawi, Muwaffaq Al Ani, Asif Quadri, Zaid Hamdoon, Aktham Awwad, Sausan Al Kawas, Ahmed Al Nuaimi
Summary: The study revealed that the expression of E-cadherin and beta-catenin in oral squamous cell carcinoma is associated with the severity of the tumor and prognosis.
HISTOLOGY AND HISTOPATHOLOGY
(2021)
Editorial Material
Cell Biology
Emiliano Maiani, Giacomo Milletti, Francesco Cecconi
Summary: AMBRA1 is a key scaffold protein that regulates early autophagosome formation, cell growth, and G1/S phase transition, and its deficiency is associated with neurodevelopmental defects and cancer. By controlling the expression of D-type cyclins, AMBRA1 plays a crucial role in maintaining genome integrity during DNA replication and represents a novel mechanism of cell cycle regulation interconnected with genomic stability in development and cancer.
Article
Pharmacology & Pharmacy
Hai-Zhou Wu, Lan-Ya Li, Shi-Long Jiang, Yi-Zhi Li, Xiao-Mei Shi, Xin-Yuan Sun, Zhuo Li, Yan Cheng
Summary: This study found that overexpression of RSK2 in melanoma leads to resistance to vemurafenib therapy and is associated with poor overall survival in melanoma patients. In addition, the inhibition of RSK2 can suppress melanoma cell proliferation and enhance sensitivity to vemurafenib.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Dongli Guo, Jing Jin, Jianghui Liu, Xiaoping Dong, Daojuan Li, Yutong He
Summary: Silencing miR-29b in ESCC cells can increase BTG2 expression and decrease intracellular cyclin D1 levels, leading to cell cycle arrest and accumulation in the G0/G1 phase, which reduces sensitivity to radiotherapy.
STRAHLENTHERAPIE UND ONKOLOGIE
(2021)
Review
Genetics & Heredity
Mostafa Saleban, Erica L. Harris, James A. Poulter
Summary: D-type cyclins encode G1/S cell cycle checkpoint proteins, which are crucial for determining cell cycle exit and progression. Proper control of cell cycle exit is essential during embryonic development, and defects in the regulation of intracellular D-type cyclins can lead to abnormal initiation of stem cell differentiation in various organ systems. Additionally, abnormal stabilization of D-type cyclins is observed in diseases characterized by excessive cell proliferation, such as cancer and overgrowth disorders. In this review, we will summarize and compare the roles of each D-type cyclin in development and provide examples of how their dysregulation can contribute to disease.
Article
Chemistry, Multidisciplinary
Tianci Han, Liang Zhang, Wei Tong, Jian Zhao, Wei Wang
Summary: This study explores the interaction between cyclin D1 and calycosin and provides insights into their binding properties and potential structural changes. The results indicate that hydrogen bonding and van der Waals forces are involved in the binding of calycosin with cyclin D1, leading to structural alterations in cyclin D1. Additionally, calycosin inhibits lung cancer cell proliferation by arresting the cell cycle at the G1 phase.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Review
Oncology
Wei Cai, Lin-Zhen Shu, Ding-Jie Liu, Lv Zhou, Meng-Meng Wang, Huan Deng
Summary: Cyclin D1 acts as a sensor for mitogenic signals by binding to CDK4/6 and plays a crucial role in integrating external mitogenic inputs and cell cycle progression. It interacts with transcription factors and regulates important cellular processes such as differentiation, proliferation, apoptosis, and DNA repair. Dysregulation of cyclin D1 contributes to the development of papillary thyroid carcinoma (PTC). Understanding the mechanisms behind cyclin D1 overexpression and its role in PTC tumorigenesis can lead to the identification of effective therapeutic strategies and the development of targeted treatment options.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Francesca Giordano, Maria D'Amico, Francesca Ida Montalto, Rocco Malivindi, Adele Chimento, Francesca Luisa Conforti, Vincenzo Pezzi, Maria Luisa Panno, Sebastiano Ando, Francesca De Amicis
Summary: Glioblastoma multiforme (GBM) is an aggressive cancer type with poor outcomes, and enrichment of GBM stem cells (GSCs) is believed to be the cause of its recurrence and chemoresistance. In this study, low-dose treatment of γ-secretase inhibitor RO4929097 (GSI) and resveratrol (RSV) reversed the mesenchymal phenotype of GBM cells to an epithelial-like phenotype, affecting invasion and stemness. The mechanism involves cyclin D1, cyclin-dependent kinase (CDK4), and paxillin (Pxn) phosphorylation, leading to reduced Pxn interaction with vinculin (Vcl) and altered cell migration. The study suggests that targeting Cdk4 with Notch inhibitors and RSV could be a potential therapeutic strategy for aggressive brain tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Shau-Hsuan Li, Limei Qian, Yen-Hao Chen, Hung- Lu, Hsin-Ting Tsai, Haiwen Lyu, Runxiang Yang, Chang-Han Chen
Summary: MYO1B expression is increased in ESCC and correlated with tumor stage, TNM stage, and poor outcomes. Depletion of MYO1B impairs oncogenesis and enhances chemosensitivity in ESCC. SNAI2 is a downstream effector of MYO1B, and suppression of MYO1B downregulates SNAI2 expression and inhibits the SNAI2/cyclin D1 pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Immunology
Lei Yang, You-Ling Shi, Yan Ma, Wei-Wei Ren, Guang-Ming Pang, Jiao Liu
Summary: The study revealed that the upregulation of KLF16 expression in OSCC cells, interfering with KLF16 resulted in cell cycle arrest, inhibited cell growth, and promoted cell apoptosis.
Article
Biotechnology & Applied Microbiology
Xin Chen, Chang Liu, Meng Zhang, Yumei Zhang
Summary: Maduramicin inhibits cell growth and proliferation, alters the cell cycle, decreases Cyclin D1 expression, and suppresses AKT-Cyclin D1 signaling, leading to myocardial cell toxicity.
Article
Biochemistry & Molecular Biology
Chenxia Ren, Cuiling Wu, Changqing Yang, Changhong Lian
Summary: Vitamin C exerts an antiproliferative effect on gastric carcinoma cells by regulating the cell cycle and autophagy through downregulation of Cyclin D1.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Satoshi Miyashita, Tomoo Owa, Yusuke Seto, Mariko Yamashita, Shogo Aida, Masaki Sone, Kentaro Ichijo, Tomoki Nishioka, Kozo Kaibuchi, Yoshiya Kawaguchi, Shinichiro Taya, Mikio Hoshino
Summary: The study reveals that cyclin D1 (CCND1) directly regulates both proliferative and immature states of cerebellar granule cell progenitors (GCPs) by controlling the phosphorylation state of ATOH1 protein and cell cycle progression. Additionally, PROX1 downregulates Ccnd1 expression by histone deacetylation in GCPs, leading to cell cycle exit and differentiation. WNT signaling upregulates PROX1 expression in GCPs, suggesting a cooperative signaling cascade involving WNT-PROX1-CCND1-ATOH1 in controlling the states of GCPs.
Article
Oncology
Yen-Sung Huang, Shin-Huei Fu, Kuo-Cheng Lu, Jin-Shuen Chen, Hsin-Yi Hsieh, Huey-Kang Sytwu, Chia-Chao Wu
Article
Biochemistry & Molecular Biology
Ling-Yueh Hu, Che-Chang Chang, Yen-Sung Huang, Wen-Cheng Ghou, Ying-Mei Lin, Chun-Chen Ho, Wei-Ting Chen, Hsiu-Ming Shih, Chia-Ni Hsiung, Pei-Ei Wu, Chen-Yang Shen
HUMAN MOLECULAR GENETICS
(2018)
Article
Endocrinology & Metabolism
Yen-Sung Huang, Kuo-Cheng Lu, Tai-Kuang Chao, Jin-Shuen Chen, Ann Chen, Cheng-Yi Guo, Hsin-Yi Hsieh, Hsiu-Ming Shih, Huey-Kang Sytwu, Chia-Chao Wu
JOURNAL OF PINEAL RESEARCH
(2018)
Article
Multidisciplinary Sciences
Che-Chang Chang, Yen-Sung Huang, Ying-Mei Lin, Chia-Ju Lin, Jen-Chong Jeng, Shin-Mei Liu, Tsai-Ling Ho, Ruei-Ting Chang, Chun A. Changou, Chun-Chen Ho, Hsiu-Ming Shih
SCIENTIFIC REPORTS
(2018)
Article
Otorhinolaryngology
Cheng-Yu Yang, Chih-Kung Lin, Cheng-Chih Hsieh, Chang-Huei Tsao, Chun-Shu Lin, Bo Peng, Yen-Tzu Chen, Chun-Chieh Ting, Wei-Chin Chang, Gu-Jiun Lin, Huey-Kang Sytwu, Yuan-Wu Chen
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Review
Biochemistry & Molecular Biology
Shyi-Jou Chen, Gu-Jiun Lin, Jing-Wun Chen, Kai-Chen Wang, Chiung-Hsi Tien, Chih-Fen Hu, Chia-Ning Chang, Wan-Fu Hsu, Hueng-Chuen Fan, Huey-Kang Sytwu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Food Science & Technology
Shing-Hwa Huang, Ching-Len Liao, Shyi-Jou Chen, Li-Ge Shi, Li Lin, Yuan-Wu Chen, Chia-Pi Cheng, Huey-Kang Sytwu, Shih-Ta Shang, Gu-Jiun Lin
JOURNAL OF FUNCTIONAL FOODS
(2019)
Article
Pharmacology & Pharmacy
Gu-Jiun Lin, Chih-Hsiung Wu, Chiao-Chi Yu, Jeng-Rong Lin, Xiao-Dong Liu, Yuan-Wu Chen, Hao-Ming Chang, Zhi-Jie Hong, Chia-Pi Cheng, Huey-Kang Sytwu, Shing-Hwa Huang
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2019)
Article
Cell Biology
Yi-Hsuan Lin, Yi-Hsun Wang, Yi-Jen Peng, Feng-Cheng Liu, Gu-Jiun Lin, Shing-Hwa Huang, Huey-Kang Sytwu, Chia-Pi Cheng
Article
Cell Biology
Yen-Sung Huang, Kuo-Cheng Lu, Hsu-Wen Chao, Ann Chen, Tai-Kuang Chao, Cheng-Yi Guo, Hsin-Yi Hsieh, Hsiu-Ming Shih, Huey-Kang Sytwu, Chia-Chao Wu
Summary: The downregulation of melatonin receptor 1A (MTNR1A) is linked to various diseases, including membranous nephropathy. Research has shown that hnRNPL plays a role in upregulating MTNR1A expression post-transcriptionally, potentially serving as a therapeutic target for renal diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Environmental Sciences
Ching-Huang Lai, Chia-Chi Chou, Hsiao-Chi Chuang, Gu-Jiun Lin, Chih-Hong Pan, Wei-Liang Chen
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2020)
Article
Multidisciplinary Sciences
Heng Lin, Yen-Sung Huang, Jean-Michel Fustin, Masao Doi, Huatao Chen, Hui-Huang Lai, Shu-Hui Lin, Yen-Lurk Lee, Pei-Chih King, Hsien-San Hou, Hao-Wen Chen, Pei-Yun Young, Hsu-Wen Chao
Summary: This study demonstrates that the accumulation of hyperpolyploid hepatocytes around the centrilobular region of the liver may indicate the origin of preneoplastic formation. Upregulation of Aurkb plays a critical role in promoting hyperpolyploidization, leading to the development of HCC cells.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Jeng-Rong Lin, Shing-Hwa Huang, Chih-Hsiung Wu, Yuan-Wu Chen, Zhi-Jie Hong, Chia-Pi Cheng, Huey-Kang Sytwu, Gu-Jiun Lin
Summary: Type 1 diabetes mellitus is a T cell-mediated autoimmune disease, and regulatory T cells play a critical role in maintaining immune system homeostasis and preventing autoimmunity.
Article
Biochemistry & Molecular Biology
Shing-Hwa Huang, Shun-Li Kuo, Shyi-Jou Chen, Jeng-Rong Lin, Yuan-Wu Chen, Zhi-Jie Hong, Huey-Kang Sytwu, Gu-Jiun Lin
Summary: The study found that alpha-lipoic acid (ALA) has immunomodulatory effects and may have therapeutic potential in the treatment of type 1 diabetes. ALA treatment was shown to suppress autoimmune response and promote the differentiation of regulatory T cells (Tregs), improving the outcomes of islet transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yen-Sung Huang, Chang-Chieh Wu, Che-Chang Chang, Shiu-Feng Huang, Hong-Yi Kuo, Hsiu-Ming Shih
Summary: Upregulation of Daxx is associated with colorectal cancer, and it can promote CRC cell growth by activating PIK3CA.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)