Review
Pharmacology & Pharmacy
Jingqian Su, Lu Tang, Yingsheng Luo, Jingran Xu, Songying Ouyang
Summary: This article provides a comprehensive analysis of the structure and function of INSR and IRS proteins, as well as the drugs used for the treatment of diabetes. It serves as a valuable reference for the advancement of novel therapeutic agents for diabetes management.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Takayuki Matsumoto, Keisuke Takayanagi, Tomoki Katome, Mihoka Kojima, Kumiko Taguchi, Tsuneo Kobayashi
Summary: Enhanced contractile responses to UDP and UTP were observed in femoral arteries of SHR compared to WKY in both 12-month-old and 7-month-old rats under hypertension, while endothelium-denuded arteries showed increased contractions induced by UDP and UTP. Inhibition of cyclooxygenase decreased contractions induced by these nucleotides and eliminated differences in responses between SHR and WKY groups. This study highlights the importance of regulating extracellular uridine nucleotides-induced contractions in hypertension-associated peripheral arterial diseases.
Article
Biochemistry & Molecular Biology
Angela Dziedzic, Elzbieta Miller, Joanna Saluk-Bijak, Marta Niwald, Michal Bijak
Summary: Epidemiological studies confirm a high risk of ischemic events in secondary-progressive multiple sclerosis (SP MS) patients, which is directly associated with an increased level of pro-thrombotic activity of platelets. The study demonstrated enhanced platelet reactivity in response to adenosine diphosphate (ADP) in SP MS patients compared to controls, suggesting a potential molecular basis for the elevated risk of thromboembolism in MS. Identifying the molecular abnormalities of the platelet P2Y(12) receptor expression and functionality could contribute to the development of prevention and targeted treatment strategies for cardiovascular disorders in MS patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Juan Carlos Gil-Redondo, Jagoba Iturri, Felipe Ortega, Raquel Perez-Sen, Andreas Weber, Maria Teresa Miras-Portugal, Jose Luis Toca-Herrera, Esmerilda G. Delicado
Summary: Endothelial cells and astrocytes exhibit distinct mechanical responses upon stimulation of metabotropic P2Y nucleotide receptors, with the most significant effects observed after P2Y(2) receptor stimulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Usha Adiga, Nandit Banawalikar, Sriprajna Mayur, Radhika Bansal, Nafeesath Ameera, Sudhindra Rao
Summary: In patients with diabetes, leptin levels were lower, while women in the control group had significantly higher leptin levels compared to men. There were significant differences in serum insulin levels and insulin resistance among patients with different genotypes.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2021)
Article
Pharmacology & Pharmacy
Hongxing Wang, Hui Wu, Kehua Fang, Xiaotian Chang
Summary: The study showed significantly increased levels of uridine diphosphate (UDP) in the synovial fluid of rheumatoid arthritis (RA) patients, positively correlated with disease markers. UDP was found to promote RA pathogenesis by stimulating P2Y6 activity to increase IL-6 production.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Dominik Pesta, Tomas Jelenik, Oana-Patricia Zaharia, Pavel Bobrov, Sven Gorgens, Kalman Bodis, Yanislava Karusheva, Nina Krako Jakovljevic, Nebojsa M. Lalic, Daniel F. Markgraf, Volker Burkart, Karsten Mussig, Birgit Knebel, Jorg Kotzka, Jurgen Eckel, Klaus Strassburger, Julia Szendroedi, Michael Roden
Summary: The rs540467 SNP in the NDUFB6 gene is associated with adaptations to exercise training, with a notable impact on individuals with diabetes, particularly those with type 2 diabetes. Additionally, increasing physical activity levels may not always lead to improved insulin sensitivity in diabetes patients, where the polymorphism of the NDUFB6 gene could be a crucial factor.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Physiology
B. Ortega-Contreras, A. Armella, J. Appel, D. Mennickent, J. Araya, M. Gonzalez, E. Castro, A. M. Obregon, L. Lamperti, J. Gutierrez, E. Guzman-Gutierrez
Summary: Gestational Diabetes Mellitus (GDM) is a pathological condition in pregnant women that is associated with genetic predisposition. This review explores the potential effects of various polymorphisms in genes on the development of GDM.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Lok Mun Law, Norazrina Azmi, Ian Charles Paterson, Pei Yuen Ng
Summary: Chemotherapeutic agents like cisplatin often fail to treat advanced stage oral squamous cell carcinoma (OSCC) due to chemoresistance. This study focused on the role of purinergic receptors, specifically P2Y, in OSCC and explored the associated signaling pathways. The findings suggest that extracellular nucleotides have varied downstream effects in OSCC cells with different characteristics, indicating the potential for targeted therapy based on individual needs.
Article
Immunology
Yuyan Zhou, Lina Liu, Ruoxuan Xiang, Xiaoyang Bu, Guozheng Qin, Jiajia Dai, Zhigang Zhao, Xue Fang, Shuo Yang, Jun Han, Guodong Wang
Summary: In this study, it was found that Arctigenin (AR) extracted from Burdock has therapeutic effects on type 2 diabetes by reducing blood glucose and lipid levels, reversing tissue damage, and inhibiting inflammation. The mechanism of action seems to involve the inhibition of toll-like receptor 4 inflammatory signaling and reactivation of the IRS-2/GLUT4 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Qin Zhao, Ruoqian Xie, Yuxiao Zeng, Wanlu Li, Guolan Xiao, Yangyan Li, Gang Chen
Summary: The palladium-catalyzed oxidative C-H olefinations of uridine, deoxyuridine, uridine monophosphate and uridine analogues are reported. This protocol offers an efficient, atom-economic, and environmentally friendly approach for synthesizing biologically important C5-alkene modified uracil/uridine-containing derivatives and pharmaceutical candidates.
Article
Biochemistry & Molecular Biology
Laura Massarenti, Christina Aniol-Nielsen, Christian Enevold, Henrik Toft-Hansen, Claus Henrik Nielsen
Summary: Single nucleotide polymorphisms (SNPs) in insulin and insulin receptor genes may influence the interaction between the two molecules, and anti-insulin antibodies (IAs) may be associated with insulin treatment in patients with diabetes. This study found that two SNPs in the human insulin gene and two SNPs in the insulin receptor gene were associated with type 1 diabetes and glycaemic control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
F. Frost, M. J. Walshaw, D. Nazareth
Summary: Cystic fibrosis (CF) is a common life-threatening inherited condition in the Caucasian population, with pulmonary disease being the main contributor to morbidity. While life expectancy has improved, new challenges have arisen, with an increasing prevalence of CF-related diabetes being a significant issue.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2022)
Article
Medicine, Research & Experimental
Yao Liu, Ruifang Sun, XiaoPing Lin, Lanlan Wu, Hengying Chen, Siwen Shen, Yan Li, Yuanhuan Wei, Guifang Deng
Summary: Procyanidins (PA) improves insulin resistance via the NF-kappa B / NLRP3 pathway in gestational diabetes mellitus (GDM) and postpartum mice, partly through metabolites produced by gut microbiome.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Hematology
Guilherme Ruiz Leonardi, Caroline Honaiser Lescano, Jose Luiz Costa, Bruna Mazetto, Fernanda Andrade Orsi, Fabiola Zakia Monica
Summary: Platelet reactivity is significantly increased in patients with thrombotic antiphospholipid syndrome (t-PAPS), which may be related to the overexpression of P2Y(12) receptor and the lower levels of cAMP and cGMP.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Endocrinology & Metabolism
Stephan C. Collins, Hyun Woong Do, Benoit Hastoy, Alison Hugill, Julie Adam, Margarita V. Chibalina, Juris Galvanovskis, Mahdieh Godazgar, Sheena Lee, Michelle Goldsworthy, Albert Salehi, Andrei I. Tarasov, Anders H. Rosengren, Roger Cox, Patrik Rorsman
Article
Multidisciplinary Sciences
Ingmar Lundquist, Israa Mohammed Al-Amily, Sandra Meidute Abaraviciene, Albert Salehi
Review
Medicine, General & Internal
Linford Briant, Albert Salehi, Elisa Vergari, Quan Zhang, Patrik Rorsman
UPSALA JOURNAL OF MEDICAL SCIENCES
(2016)
Article
Biochemistry & Molecular Biology
Mengyin Cai, Pradeep Bompada, Albert Salehi, Juan R. Acosta, Rashmi B. Prasad, David Atac, Markku Laakso, Leif Groop, Yang De Marinis
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Patricio Atanes, Inmaculada Ruz-Maldonado, Ross Hawkes, Bo Liu, Min Zhao, Guo Cai Huang, Israa Mohammed Al-Amily, Albert Salehi, Stefan Amisten, Shanta J. Persaud
CELLULAR AND MOLECULAR LIFE SCIENCES
(2018)
Article
Endocrinology & Metabolism
Alexander Hamilton, Quan Zhang, Albert Salehi, Mara Willems, Jakob G. Knudsen, Anna K. Ringgaard, Caroline E. Chapman, Alejandro Gonzalez-Alvarez, Nicoletta C. Surdo, Manuela Zaccolo, Davide Basco, Paul R. V. Johnson, Reshma Ramracheya, Guy A. Rutter, Antony Galione, Patrik Rorsman, Andrei I. Tarasov
Article
Endocrinology & Metabolism
Stefan Amisten, Pontus Duner, Olof Asplund, Israa Mohammed Al-Amily, Leif Groop, Albert Salehi
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2018)
Article
Multidisciplinary Sciences
Davide Basco, Quan Zhang, Albert Salehi, Andrei Tarasov, Wanda Dolci, Pedro Herrera, Ioannis Spiliotis, Xavier Berney, David Tarussio, Patrik Rorsman, Bernard Thorens
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Stefan Amisten, Patricio Atanes, Ross Hawkes, Inmaculada Ruz-Maldonado, Bo Liu, Fariborz Parandeh, Min Zhao, Guo Cai Huang, Albert Salehi, Shanta J. Persaud
SCIENTIFIC REPORTS
(2017)
Article
Cell Biology
Enming Zhang, Israa Mohammed Al-Amily, Sarheed Mohammed, Cheng Luan, Olof Asplund, Meftun Ahmed, Yingying Ye, Danya Ben-Hail, Arvind Soni, Neelanjan Vishnu, Pradeep Bompada, Yang De Marinis, Leif Groop, Varda Shoshan-Barmatz, Erik Renstrom, Claes B. Wollheim, Albert Salehi
Article
Multidisciplinary Sciences
Elisa Vergari, Jakob G. Knudsen, Reshma Ramracheya, Albert Salehi, Quan Zhang, Julie Adam, Ingrid Wernstedt Asterholm, Anna Benrick, Linford J. B. Briant, Margarita V. Chibalina, Fiona M. Gribble, Alexander Hamilton, Benoit Hastoy, Frank Reimann, Nils J. G. Rorsman, Ioannis I. Spiliotis, Andrei Tarasov, Yanling Wu, Frances M. Ashcroft, Patrik Rorsman
NATURE COMMUNICATIONS
(2019)
Article
Physiology
Israa Mohammad Al-Amily, Pontus Duner, Leif Groop, Albert Salehi
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2019)
Article
Endocrinology & Metabolism
Jalal Taneera, Abdul Khader Mohammed, Sarah Dhaiban, Mawieh Hamad, Rashmi B. Prasad, Nabil Sulaiman, Albert Salehi
Article
Genetics & Heredity
Jalal Taneera, Sarah Dhaiban, Abdul Khader Mohammed, Debasmita Mukhopadhyay, Hayat Aljaibeji, Nabil Sulaiman, Joao Fadista, Albert Salehi
Article
Endocrinology & Metabolism
Stefan Amisten, Israa Mohammad Al-Amily, Arvind Soni, Ross Hawkes, Patricio Atanes, Shanta Jean Persaud, Patrik Rorsman, Albert Salehi
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)