Article
Biochemistry & Molecular Biology
Ziyan Lin, Ai Chen, Hongwang Cui, Ruihua Shang, Tian Su, Xiaoyan Li, Kekun Wang, Jing Yang, Keli Gao, Jie Lv, Jie Shen, Shanzhi Wang, Yonghui Qi, Minghao Guo, Yongjun Zhu
Summary: This study identified the occurrence of renal tubular epithelial cell necroptosis in CKD patients, especially in stages 2 and 3a CKD. Renal tubular epithelial cell necroptosis mediates renal tubulointerstitial fibrosis in patients with chronic kidney disease, which is related to the TGF-beta 1/Smad3 signaling pathway.
Article
Cell Biology
Jonatan Barrera-Chimal, Nathalie Henley, Michael Philip Grant, Schrodinger Cenatus, Pedro Geraldes, Vincent Pichette, Casimiro Gerarduzzi
Summary: This study evaluated the effects of chronic oral tungsten exposure on renal inflammation in mice. It was found that tungsten exposure led to lysosome accumulation in renal tubular epithelial cells, interstitial infiltration of immune cells, and increased levels of proinflammatory cytokines. Tungsten also reduced cell viability and increased reactive oxygen species generation. Overall, prolonged tungsten exposure resulted in oxidative injury and chronic renal inflammation.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lini Jin, Binfeng Yu, Guangjun Liu, Wanyun Nie, Junni Wang, Jianghua Chen, Liang Xiao, Hongguang Xia, Fei Han, Yi Yang
Summary: Activation of mitophagy improves mitochondrial health, reduces TGF-beta 1/Smad signaling, alleviates TEC injuries, and decreases inflammatory infiltration in the kidneys.
Article
Biochemistry & Molecular Biology
Minjung Son, Ga Young Kim, Yejin Yang, Sugyeong Ha, Jeongwon Kim, Doyeon Kim, Hae Young Chung, Hyung Ryong Moon, Ki Wung Chung
Summary: The PPAR pan agonist MHY2013 effectively prevents renal fibrosis in both in vitro and in vivo models, suggesting its therapeutic potential against chronic kidney diseases. MHY2013 inhibits fibroblast activation and reduces inflammation through PPAR gamma and beta activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Lin Ye, Xueting Hu, Xiang Hu, Sihui Yin, Jianqiang Chen, Hanghui He, Shanshan Hong, Bin Yang, Krishna K. Singh, Jianpeng Feng, Yi Wang, Wu Luo, Guang Liang
Summary: Obesity is a major risk factor for chronic kidney disease, but the curcumin derivative C66 has been found to attenuate obesity-induced renal injury by inhibiting chronic inflammation and apoptosis through targeting NF-κB and JNK pathways, suggesting its potential in preventing obesity-associated renal diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Sean E. DeWolf, Sashi G. Kasimsetty, Alana A. Hawkes, Lisa M. Stocks, Sunil M. Kurian, Dianne B. McKay
Summary: This study demonstrates for the first time that endogenous DAMPs released from injured RTECs directly activate PRR signaling in healthy RTECs. These findings provide new insights for the treatment of renal IRI.
Article
Surgery
Katharina Schuette-Nuetgen, Maria Edeling, Dominik Kentrup, Barbara Heitplatz, Veerle Van Marck, Alexander Zarbock, Melanie Meersch-Dini, Hermann Pavenstaedt, Stefan Reuter
Summary: IL24 plays an important role in renal ischemia-reperfusion injury by inducing apoptosis and endoplasmic reticulum stress in renal tubular epithelial cells. It can serve as a biomarker and a potential therapeutic target in patients with ischemia-induced acute kidney injury.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Review
Physiology
Peipei Wang, Jing Ouyang, Zhanjun Jia, Aihua Zhang, Yunwen Yang
Summary: The prevalence of renal diseases is increasing globally, yet the pathogenesis and effective treatments are still unclear. DNA damage and the related DNA damage response have been identified as common factors in acute kidney injury (AKI) and chronic kidney disease (CKD). Reactive oxygen species induced DNA damage is a common type involved in the development of these conditions. Recent developments in the field of DNA damage have provided insights into the role of DNA damage and DNA damage response in renal tubular epithelial cell injury. Focusing on DNA damage and DNA damage response may offer valuable diagnostic biomarkers and treatment strategies for renal diseases.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shuguang Yuan, Youliang Wang, Zheng Li, Xiaojun Chen, Panai Song, Anqun Chen, Zhong Qu, Si Wen, Hong Liu, Xuejing Zhu
Summary: The study revealed that TLR4 may exacerbate tubular injury and fibrosis in T2DKD through the GSDMD-mediated pyroptosis pathway. Activation of GSDMD can inhibit apoptosis and activate pyroptosis, which may involve a potential switch mechanism between TLR4-mediated pyroptosis and apoptosis.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Cell Biology
Ying Yang, Chensheng Li, Xia Gu, Junhui Zhen, Suwei Zhu, Tingting Lv, Qiang Wan, Yi Liu
Summary: The study demonstrated that ING2 plays a crucial role in modulating mitochondrial respiration of TECs by regulating mtDNA transcription and the abundance of respiratory chain components. ING2 also showed to be involved in the ubiquitination of mitochondrial transcription factor MRPL12, affecting TEC mitochondrial function. Additionally, ING2-mediated modulation on mtDNA transcription and mitochondrial respiration were found to be associated with TEC injuries induced by serum deprivation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Ying Yang, Chensheng Li, Xia Gu, Junhui Zhen, Suwei Zhu, Tingting Lv, Qiang Wan, Yi Liu
Summary: ING2 plays a crucial role in regulating mitochondrial respiration in tubular epithelial cells, potentially maintaining mitochondrial homeostasis by modulating mtDNA transcription and respiratory chain components. Additionally, ING2 regulates the ubiquitination of a mitochondrial transcription factor MRPL12, and has a protective effect on tubular epithelial cells against acute ischemic injury.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xingzhao Ji, Xiaoli Yang, Xia Gu, Lingju Chu, Shengnan Sun, Jian Sun, Peng Song, Qian Mu, Ying Wang, Xiaoming Sun, Dun Su, Tong Su, Shaoshuai Hou, Yao Lu, Chen Ma, Mingqiang Liu, Tianyi Zhang, Weiying Zhang, Yi Liu, Qiang Wan
Summary: Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and mortality in diabetic patients. This study reveals that mitochondrial ribosomal protein L12 (MRPL12) plays a crucial role in DKD by affecting mitochondrial function. Cullin3 (CUL3), an E3 ubiquitin ligase, has been identified to mediate the ubiquitination of MRPL12, leading to mitochondrial biosynthesis dysfunction. The findings suggest a potential therapeutic strategy for DKD by targeting the CUL3-MRPL12 pathway.
Article
Cardiac & Cardiovascular Systems
Ashish Verma, Anand Vaidya, Sonu Subudhi, Sushrut S. Waikar
Summary: The study found that higher serum aldosterone levels are independently associated with an increased risk for kidney disease progression in individuals with chronic kidney disease, regardless of concomitant diabetes. This suggests a potential role for mineralocorticoid receptor antagonists in delaying CKD progression even in those without diabetes.
EUROPEAN HEART JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Yao Zhang, Jianjian Zhang, Dengyuan Feng, Hai Zhou, Zeping Gui, Ming Zheng, Zhou Hang, Zijie Wang, Zengjun Wang, Min Gu, Ruoyun Tan
Summary: This study revealed that ferroptosis of renal tubular epithelial cells (RTECs) may contribute to renal tubular injury in chronic renal allograft dysfunction (CAD). TNF-alpha induced ferroptosis by inhibiting GPX4 transcription through upregulating IRF1 in RTECs. Ferroptotic RTECs might secrete profibrotic factors to activate neighboring fibroblasts or induce EMT in adjacent RTECs.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Christiana Magkrioti, Georgia Antonopoulou, Dionysios Fanidis, Vaia Pliaka, Theodore Sakellaropoulos, Leonidas G. Alexopoulos, Christoph Ullmer, Vassilis Aidinis
Summary: This study investigated the response of human proximal tubular epithelial cells to LPA and other pathological stimuli, identifying signaling pathways and inflammatory factors that may play a role in the pathogenesis of CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Yen-Wen Liu, Chi-Ting Su, Eing-Ju Song, Wei-Chuan Tsai, Yi-Heng Li, Liang-Miin Tsai, Jyh-Hong Chen, Junne-Ming Sung
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2015)
Article
Engineering, Environmental
Ya-Yun Cheng, Neng-Chyan Huang, Yu-Tzu Chang, Junne-Ming Sung, Kun-Hung Shen, Chang-Chih Tsai, How-Ran Guo
JOURNAL OF HAZARDOUS MATERIALS
(2017)
Article
Multidisciplinary Sciences
Ching-Hua Yeh, Liang-Po Hsieh, Ming-Chung Lin, Tsui-Shan Wei, Hui-Ching Lin, Chia-Cheng Chang, Chung-Hsi Hsing
Article
Urology & Nephrology
Hsi-Hao Wang, Shih-Yuan Hung, Junne-Ming Sung, Kuan-Yu Hung, Jung-Der Wang
AMERICAN JOURNAL OF KIDNEY DISEASES
(2014)
Article
Pathology
Cherng-Shyang Chang, Pei-Jane Tsai, Junne-Ming Sung, Ju-Yi Chen, Li-Chun Ho, Kumar Pandya, Nobuyo Maeda, Yau-Sheng Tsai
AMERICAN JOURNAL OF PATHOLOGY
(2014)
Article
Hematology
Li-Chun Ho, Junne-Ming Sung, Yau-Sheng Tsai, Hsi-Hao Wang, Yi-Che Li, Yi-Ting Chen, Min-Yu Chang, Shih-Yuan Hung
BLOOD PURIFICATION
(2014)
Article
Endocrinology & Metabolism
Yu-Tzu Chang, Jia-Ling Wu, Chih-Cheng Hsu, Jung-Der Wang, Junne-Ming Sung
Article
Microbiology
Yu-Tzu Chang, Hsuan-Chen Wang, Ming-Cheng Wang, An-Bang Wu, Junne-Ming Sung, H. Sunny Sun, Ih-Jen Su, Wei-Chih Kan, Chih-Chiang Chien, Jyh-Chang Hwang, Hsien-Yi Wang, Chin-Chung Tseng, Chi-Jung Wu
JOURNAL OF CLINICAL MICROBIOLOGY
(2014)
Article
Immunology
Yao-Ming Chen, Yuan-Pin Hung, Chien-Fang Huang, Nan-Yao Lee, Chiung-Yu Chen, Junne-Ming Sung, Chia-Ming Chang, Po-Lin Chen, Ching-Chi Lee, Yi-Hui Wu, Hsiao-Ju Lin, Wen-Chien Ko
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2014)
Letter
Medicine, General & Internal
Chun-Mei Lin, Ming-Chin Yang, Shang-Jyh Hwang, Junne-Ming Sung
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2014)
Editorial Material
Urology & Nephrology
Ke-En Chen, Chao-Chun Yang, Julia Yu-Yun Lee, Junne-Ming Sung
KIDNEY INTERNATIONAL
(2014)
Article
Biotechnology & Applied Microbiology
Junne-Ming Sung, Chi-Ting Su, Yu-Tzu Chang, Yu-Ru Su, Wei-Chuan Tsai, Saprina P. H. Wang, Chun-Shin Yang, Liang-Miin Tsai, Jyh-Hong Chen, Yen-Wen Liu
BIOMED RESEARCH INTERNATIONAL
(2014)
Article
Immunology
Ting-Jing Shen, Chia-Ling Chen, Ming-Kai Jhan, Po-Chun Tseng, Rahmat Dani Satria, Chung-Hsi Hsing, Chiou-Feng Lin
Summary: Propofol, a short-acting intravenous sedative agent, has shown potential antiviral effects against Dengue virus infection by inhibiting viral release and protein expression, as well as reducing inflammation in cell models.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Immunology
Rahmat Dani Satria, Tzu-Wen Huang, Ming-Kai Jhan, Ting-Jing Shen, Po-Chun Tseng, Yun-Ting Wang, Zhen-Yu Yang, Chung-Hsi Hsing, Chiou-Feng Lin
Summary: This study investigated the potential induction and mechanism of cytopathic effects of DENV on peripheral blood cells ex vivo. Results showed significant changes in cell morphology and immune cell counts, indicating potential hematological damage caused by DENV-induced TNF-alpha.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Editorial Material
Urology & Nephrology
Zheng-Zhe Wu, Chih-Hen Yu, Junne-Ming Sung
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)