Hypoxia Potentiates Palmitate-induced Pro-inflammatory Activation of Primary Human Macrophages

Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

(2014) Yun Sok Lee et al.   CELL

Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

(2014) Shinya U. Amano et al.   Cell Metabolism

Macrophage HIF-2  Ameliorates Adipose Tissue Inflammation and Insulin Resistance in Obesity

(2014) S. S. Choe et al.   DIABETES

Macrophages, Immunity, and Metabolic Disease

(2014) Joanne C. McNelis et al.   IMMUNITY

N-Acetylcysteine Attenuates Ischemia-Reperfusion-Induced Apoptosis and Autophagy in Mouse Liver via Regulation of the ROS/JNK/Bcl-2 Pathway

(2014) Chengfen Wang et al.   PLoS One

Dual-Specificity Phosphatases as Molecular Targets for Inhibition in Human Disease

(2013) Pablo Ríos et al.   ANTIOXIDANTS & REDOX SIGNALING

Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice

(2013) S. Fujisaka et al.   DIABETOLOGIA

Local proliferation of macrophages in adipose tissue during obesity-induced inflammation

(2013) Julia Haase et al.   DIABETOLOGIA

Immune Regulation in Obesity-Associated Adipose Inflammation

(2013) J. M. Han et al.   JOURNAL OF IMMUNOLOGY

Inflammasome-Mediated Secretion of IL-1  in Human Monocytes through TLR2 Activation; Modulation by Dietary Fatty Acids

(2013) R. G. Snodgrass et al.   JOURNAL OF IMMUNOLOGY

IL-4 reduces the proangiogenic capacity of macrophages by down-regulating HIF-1  translation

(2013) N. Dehne et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Hypoxia and Adipose Tissue Function and Dysfunction in Obesity

(2013) Paul Trayhurn   PHYSIOLOGICAL REVIEWS

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

(2012) Shurong Huang et al.   JOURNAL OF LIPID RESEARCH

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Adipose Tissue Vascularization: Its Role in Chronic Inflammation

(2011) Jianping Ye   Current Diabetes Reports

Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states

(2011) David L Morris et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Hypoxia-induced inflammatory cytokine secretion in human adipose tissue stromovascular cells

(2011) R. W. O’Rourke et al.   DIABETOLOGIA

Signaling by the Phosphatase MKP-1 in Dendritic Cells Imprints Distinct Effector and Regulatory T Cell Fates

(2011) Gonghua Huang et al.   IMMUNITY

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

The adipocyte as an endocrine organ in the regulation of metabolic homeostasis

(2011) H. James Harwood   NEUROPHARMACOLOGY

Acute Oxidative Stress Can Reverse Insulin Resistance by Inactivation of Cytoplasmic JNK

(2010) Alina Berdichevsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unsaturated FAs prevent palmitate-induced LOX-1 induction via inhibition of ER stress in macrophages

(2010) Junichi Ishiyama et al.   JOURNAL OF LIPID RESEARCH

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia

(2009) H.-Y. Fang et al.   BLOOD

HIF-1 in the inflammatory microenvironment

(2009) Nathalie Dehne et al.   EXPERIMENTAL CELL RESEARCH

Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages

(2008) Liliana Håversen et al.   ATHEROSCLEROSIS

Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells

(2008) David W. Chan et al.   CARCINOGENESIS

Reduced Adipose Tissue Oxygenation in Human Obesity: Evidence for Rarefaction, Macrophage Chemotaxis, and Inflammation Without an Angiogenic Response

(2008) M. Pasarica et al.   DIABETES

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE