Article
Neurosciences
Marcus M. Weera, Rosetta S. Shackett, Hannah M. Kramer, Jason W. Middleton, Nicholas W. Gilpin
Summary: The study demonstrates the crucial role of CeA projections to the lateral hypothalamus in avoidance behavior of male rats exposed to stress-related stimuli, suggesting potential implications for substance abuse and traumatic stress disorders. Moreover, the avoidance behavior is found to be associated with intrinsic properties of LH-projecting CeA cells.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Kyuhyun Choi, Jee Hyun Yi, Changwoo Lee, Kyungjoon Park, Shin Jung Kang, Ki Soon Shin
Summary: This study reveals the significant role of presynaptic HCN channels in high-frequency stimulation-induced presynaptic long-term potentiation and modulation of synaptic transmission. It is important for further understanding the neural mechanisms underlying fear memory.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biology
Marcus M. Weera, Abigail E. Agoglia, Eliza Douglass, Zhiying Jiang, Shivakumar Rajamanickam, Rosetta S. Shackett, Melissa A. Herman, Nicholas J. Justice, Nicholas W. Gilpin
Summary: We have successfully generated and validated a transgenic CRF1-Cre-(td)Tomato rat model, which can be used to study the role of CRF1 receptor-expressing neurons in hormone-mediated behaviors. We found that the expression pattern of this rat model is similar to the known expression pattern of CRF1 cells, and it can be investigated using modern genetic techniques.
Article
Pharmacology & Pharmacy
Yadira Ibarguen-Vargas, Samuel Leman, Rupert Palme, Catherine Belzung, Alexandre Surget
Summary: Despite showing promise initially, CRF-R1 antagonists have not been effective in clinical trials for anxiety or depression. These drugs may be more beneficial in single stressful situations or for individuals with chronic stress conditions. Although they can improve negative feedback in chronically stressed individuals, long-term use of CRF-R1 antagonists may lead to overactivation of the HPA axis, raising concerns about potential physiological outcomes under ongoing chronic stress.
Article
Neurosciences
Valentina Licheri, Giuseppe Talani, Giovanni Biggio, Enrico Sanna
Summary: It is well known that ethanol affects neuronal function through its interaction with membrane proteins and intracellular pathways. This study investigated the effect of ethanol on HCN channels in CA3 pyramidal neurons and found that ethanol modulates HCN-mediated Ih in a concentration-dependent and bi-directional manner. This modulation was mimicked by forskolin and antagonized by drugs that interfere with the AC/cAMP/PKA pathway and selective HCN inhibitor ZD7288.
Article
Neurosciences
Alek H. Metwalli, Alessandra Pross, Ester Desfilis, Antonio Abellan, Loreta Medina
Summary: Understanding the neural mechanisms that regulate the stress response is critical for improving animal welfare. Corticotropin-releasing factor (CRF) plays a crucial role in this regulation, and its receptors and binding protein also contribute. In this study, the mRNA expression of CRF, CRF receptors 1 and 2, and CRF binding protein in chicken telencephalon during embryonic and early posthatching development was examined. The results showed that CRF and its receptors were expressed early in pallial areas regulating sensory processing and cognition, while the expression in subpallial areas regulating stress response occurred later. This study provides insights into the negative effects of noise and light on prehatching chicken embryos and highlights the maturation of stress regulation with age.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Julia N. C. Toews, Tristan J. Philippe, Lesley A. Hill, Matthew Dordevic, Allende Miguelez-Crespo, Natalie Z. M. Homer, Mark Nixon, Geoffrey L. Hammond, Victor Viau
Summary: This study disrupted the SerpinA6 gene expression in rats using CRISPR/cas9 and found that the absence of CBG led to a decrease in total plasma corticosterone levels, with the sex differences in adrenal morphology and gene expression being eliminated.
Article
Neurosciences
Mariacristina Mazzitelli, Vadim Yakhnitsa, Benjamin Neugebauer, Volker Neugebauer
Summary: This study demonstrates the critical involvement of CeA-CRF neurons in pain-related behaviors and the beneficial effects of inhibiting these neurons in neuropathic pain.
Review
Behavioral Sciences
Taylor A. McCorkle, Jessica R. Barson, Ramesh Raghupathi
Summary: Mild traumatic brain injury can result in chronic affective disorders such as depression and anxiety, but there are currently no effective drug therapies available. Preclinical studies have identified underlying mechanisms and sex differences, suggesting a novel approach is needed for research on drug therapy. Investigating treatments for deficits in affective behaviors as one entity may advance mild TBI drug therapy.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Biology
Tyler R. Rivet, Christine Lalonde, T. C. Tai
Summary: The present study investigates how chronic exposure to the synthetic glucocorticoid dexamethasone during late gestation alters the expression of genes related to behavior in brain areas relevant to the regulation and function of the hypothalamic-pituitary-adrenal axis. The results suggest that prenatal exposure to elevated levels of glucocorticoids plays a role in the dysregulation of the hypothalamic-pituitary-adrenal axis and potentially learning and memory by altering the expression of specific genes within the amygdala and PVN.
Article
Biochemistry & Molecular Biology
Roberto Rodriguez-Ortiz, Ataulfo Matinez-Torres
Summary: Epilepsy is a chronic neurological disorder affecting 50 million people worldwide, with zebrafish used to model the disease. Mutations in the activated HCN channel were generated and phenotypic characteristics related to epilepsy were observed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Paulo Pinares-Garcia, James Spyrou, Chaseley E. McKenzie, Ian C. Forster, Ming S. Soh, Erlina Mohamed Syazwan, Mohammed Atif, Christopher A. Reid
Summary: In this study, the effects of Org 34167 on HCN channels were analyzed in human embryonic kidney cells and mouse neurons. The results showed that Org 34167 is a broad-spectrum inhibitor of HCN channels, slowing activation and causing a hyperpolarising shift in voltage-dependence of activation. It also reduced I (h)-mediated sag in mouse neurons. Additionally, Org 34167 exhibited anti-depressive activity in mice, but higher doses resulted in adverse effects.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiaolu Lei, Junwei Zeng, Yan Yan, Xiaohong Liu
Summary: This study aimed to investigate the modulation of HCN channel activity on the expression and function of P2X2 and P2X3 receptors. The results showed that intrathecal administration of HCN channel blocker ZD7288 significantly reduced mechanical hyperalgesia and the increased expression of P2X2 and P2X3 receptors in rats with chronic constriction injury of sciatic nerve. Furthermore, it was found that the opening of HCN channels could enhance the expression and function of P2X2 and P2X3 receptors via the cAMP-PKA signaling pathway. These findings provide important insights into the mechanism of nerve injury-induced pain hypersensitivity.
NEUROCHEMICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Evgenia Sitnikova, Elizaveta Rutskova, Kirill Smirnov
Summary: Spike-wave discharges are caused by thalamocortical network disorder in idiopathic generalized epilepsy. Currently available anti-epileptic drugs have significant side effects due to low selectivity to molecular targets. Activation of alpha2B adrenergic receptors (ARs) in the thalamus shows potential as a specific molecular target for absence epilepsy. HCN and calcium channels are proposed as relevant cellular targets of alpha2 ARs in spike-wave activity generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Viren H. Makhijani, Janay P. Franklin, Kalynn Van Voorhies, Brayden Fortino, Joyce Besheer
Summary: The studies showed that exposure of male rats to TMT can lead to escalations in sweetened alcohol self-administration and reduction in BLA response to alcohol, and the frequency of exposure may influence the outcomes.
PSYCHOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Justin M. Dragna, Alexandra M. Gade, Lee Tran, Vince M. Lynch, Eric V. Anslyn
Article
Psychiatry
A. C. Johnson, L. Tran, B. Greenwood-Van Meerveld
TRANSLATIONAL PSYCHIATRY
(2015)
Article
Endocrinology & Metabolism
Sarah Everman, Christian Meyer, Lee Tran, Nyssa Hoffman, Chad C. Carroll, William L. Dedmon, Christos S. Katsanos
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2016)
Article
Behavioral Sciences
Lee Tran, N. Bradley Keele
BEHAVIOURAL BRAIN RESEARCH
(2016)
Meeting Abstract
Sport Sciences
Christos S. Katsanos, Sarah Everman, Lee Tran, Nyssa Hoffman, William L. Dedmon, Chad C. Carroll
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2016)
Article
Multidisciplinary Sciences
Lee Tran, Paul D. Hanavan, Latoya E. Campbell, Elena De Filippis, Douglas F. Lake, Dawn K. Coletta, Lori R. Roust, Lawrence J. Mandarino, Chad C. Carroll, Christos S. Katsanos
Article
Endocrinology & Metabolism
Lee Tran, Katon A. Kras, Nyssa Hoffman, Jayachandran Ravichandran, Jared M. Dickinson, Andrew D'Lugos, Chad C. Carroll, Shivam H. Patel, Lawrence J. Mandarino, Lori Roust, Christos S. Katsanos
Article
Physiology
Lee Tran, Paul R. Langlais, Nyssa Hoffman, Lori Roust, Christos S. Katsanos
EXPERIMENTAL PHYSIOLOGY
(2019)
Article
Physiology
Nathan Serrano, Lee Tran, Nyssa Hoffman, Lori Roust, Elena A. De Filippis, Chad C. Carroll, Shivam H. Patel, Katon A. Kras, Matthew Buras, Christos S. Katsanos
Summary: During acute aerobic exercise and recovery, mitochondrial and mixed-muscle protein synthesis in the muscle of humans does not increase regardless of obesity status.
FRONTIERS IN PHYSIOLOGY
(2021)
Meeting Abstract
Endocrinology & Metabolism
Lee Tran, Paul Langlais, Elena A. De Filippis, Tonya R. Benjamin, Lori R. Roust, Chad C. Carroll, Lawrence J. Mandarino, Christos Katsanos
Meeting Abstract
Biochemistry & Molecular Biology
Lee Tran, Latoya Campbell, Dawn Coletta, Lawrence Mandarino, Christos Katsanos
Meeting Abstract
Biochemistry & Molecular Biology
Katon Kras, Wayne Willis, Lee Tran, Elena De Filippis, Lori Roust, Christos Katsanos
Meeting Abstract
Biochemistry & Molecular Biology
Lee Tran, Elena De Filippis, Douglas Lake, Lawrence Mandarino, Christos Katsanos
Meeting Abstract
Endocrinology & Metabolism
Christos S. Katsanos, Lee Tran, Lawrence J. Mandarino, Eleanna De Filippis, John M. Miles, Lori Roust
Article
Physiology
Lee Tran, Haley Masters, Lori R. Roust, Christos S. Katsanos
PHYSIOLOGICAL REPORTS
(2015)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)
