CuATSM improves motor function and extends survival but is not tolerated at a high dose in SOD1G93A mice with a C57BL/6 background

The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1G93A mice

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Genetics of amyotrophic lateral sclerosis: A review

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Mapping human microbiome drug metabolism by gut bacteria and their genes

(2019) Michael Zimmermann et al.   NATURE

Cu II (atsm) inhibits ferroptosis: implications for treatment of neurodegenerative disease

(2019) Authors Adam Southon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neuroprotective effect of CuATSM on neurotoxin-induced motor neuron loss in an ALS mouse model

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Oxidative Release of Copper from Pharmacologic Copper Bis(thiosemicarbazonato) Compounds

(2018) John J. Sirois et al.   INORGANIC CHEMISTRY

CuII(atsm) Attenuates Neuroinflammation

(2018) Xin Yi Choo et al.   Frontiers in Neuroscience

CuATSM Protects Against the In Vitro Cytotoxicity of Wild-Type-Like Copper–Zinc Superoxide Dismutase Mutants but not Mutants That Disrupt Metal Binding

(2018) Natalie E. Farrawell et al.   ACS Chemical Neuroscience

The Copper bis(thiosemicarbazone) Complex CuII(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu

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Introduction to supplement: the current status of treatment for ALS

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July 2017 ENCALS statement on edaravone

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CuII(atsm) improves the neurological phenotype and survival of SOD1G93A mice and selectively increases enzymatically active SOD1 in the spinal cord

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Investigation into the Oxidation of CuATSM as a Mechanism for Copper Release

(2016) Lillian Padgitt-Cobb   FREE RADICAL BIOLOGY AND MEDICINE

Endogenous Cu in the central nervous system fails to satiate the elevated requirement for Cu in a mutant SOD1 mouse model of ALS

(2016) J. B. Hilton et al.   Metallomics

Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SODG93A mice co-expressing the Copper-Chaperone-for-SOD

(2016) Jared R. Williams et al.   NEUROBIOLOGY OF DISEASE

A study of dose response and organ susceptibility of copper toxicity in a rat model

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A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

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Oral Treatment with CuII(atsm) Increases Mutant SOD1 In Vivo but Protects Motor Neurons and Improves the Phenotype of a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

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Biochemical, Histological, and Memory Impairment Effects of Chronic Copper Toxicity: A Model for Non-Wilsonian Brain Copper Toxicosis in Wistar Rat

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Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis

(2013) Erin J. McAllum et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Development of a Smartphone App for a Genetics Website: The Amyotrophic Lateral Sclerosis Online Genetics Database (ALSoD)

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Effect of genetic background on onset and disease progression in the SOD1-G93A model of amyotrophic lateral sclerosis

(2012) Renzo Mancuso et al.   Amyotrophic Lateral Sclerosis

The hypoxia imaging agent Cu II (atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease

(2012) Lin W. Hung et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Iron Accumulation in Deep Cortical Layers Accounts for MRI Signal Abnormalities in ALS: Correlating 7 Tesla MRI and Pathology

(2012) Justin Y. Kwan et al.   PLoS One

Effect of genetic background on phenotype variability in transgenic mouse models of amyotrophic lateral sclerosis: A window of opportunity in the search for genetic modifiers

(2011) Terry D. Heiman-Patterson et al.   Amyotrophic Lateral Sclerosis

Diacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (CuII(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model

(2011) Cynthia P. W. Soon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII

(2011) P. S. Donnelly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Some thoughts on the mechanism of cellular trapping of Cu(II)-ATSM

(2010) Jason L.J. Dearling et al.   NUCLEAR MEDICINE AND BIOLOGY

The gastrointestinal microbiota as a site for the biotransformation of drugs

(2008) Tiago Sousa et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

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