Article
Chemistry, Multidisciplinary
Jana Lieberz, Simone G. Shamay-Tsoory, Nira Saporta, Timo Esser, Ekaterina Kuskova, Birgit Stoffel-Wagner, Rene Hurlemann, Dirk Scheele
Summary: Loneliness is associated with decreased trust, larger social distances, and lower trustworthiness. Lonely individuals show reduced limbic and striatal activation, as well as weakened functional connectivity between the anterior insula and occipitoparietal regions during initial trust decisions.
Article
Behavioral Sciences
Liliana Amorim, Sandro Da Mesquita, Luis Jacinto, Magda J. Castelhano-Carlos, Nadine Correia Santos, Hugo Leite-Almeida, Nuno Sousa
Summary: This study examines the social interactions of a group of rats under different conditions of resource access. The results show that reductions in food availability lead to increased heterogeneity in behaviors such as sniffing, chasing, and fighting/struggling. Introducing the possibility of interaction with a female rat leads to a consistent increase in sniffing and fighting/struggling. These findings demonstrate how variations in access to reinforcers modulate social behavior in rats.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Psychology, Clinical
Alba Moreno-Gimenez, Laura Campos-Berga, Alicja Nowak, Rosa Sahuquillo-Leal, Ana D'Ocon, David Hervas, Pablo Navalon, Maximo Vento, Ana Garcia-Blanco
Summary: The study found that maternal age was negatively associated with children's personal-social skills and emotional regulation, indicating that older maternal age may be linked to poorer social interaction skills in children.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yanli Zhang, Yingting Pang, Weixi Feng, Yuxi Jin, Sijia Chen, Shixin Ding, Ze Wang, Ying Zou, Yun Li, Tianqi Wang, Peng Sun, Junying Gao, Yi Zhu, Xiaoyan Ke, Charles Marshall, Huang Huang, Chengyu Sheng, Ming Xiao
Summary: Research has found that patients with autism spectrum disorder (ASD) have higher levels of miR-124, which may be related to brain development and social isolation. Animal models indicate that the miR-124 signaling pathway is involved in regulating myelination in brain regions associated with early social experiences, and could be a potential therapeutic target for neuropsychiatric disorders related to social neglect or social isolation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Neurosciences
Neda Yazdanfar, Seyed Ali Mard, Javad Mahmoudi, Nima Bakhtiari, Alireza Sarkaki, Alireza Farnam
Summary: This study investigated the effects of maternal morphine exposure and post-weaning rearing conditions on memory, pain threshold, and ventral striatum dopaminergic activity in male offspring. The results showed that maternal MOR exposure and post-weaning social isolation could impair memory in offspring, while an enriched environment could reverse these adverse outcomes. Furthermore, environmental factors played a significant role in the behaviors and neurochemistry of the next generation, with enriched environment partially buffering the changes induced by maternal MOR exposure and social isolation.
Article
Management
Alain Cohn, Tobias Gesche, Michel Andre Marechal
Summary: Modern communication technologies enable efficient exchange of information, but the lack of personal interaction may lead individuals to exploit informational asymmetries and increase the risk of cheating. The experiments show that individuals are more likely to cheat when interacting with a machine, while they are more cautious and reluctant to report suspicious outcomes when interacting with a human, possibly due to social image concerns. Self-selection into communication channels can be used to screen for dishonest individuals, highlighting the key role of human presence in mitigating dishonest behavior.
MANAGEMENT SCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Atsushi Nakagomi, Taishi Tsuji, Masashige Saito, Kazushige Ide, Katsunori Kondo, Koichiro Shiba
Summary: This study examines the multidimensional impacts of social isolation on health and well-being. The results indicate that older adults who have high levels of social isolation have a higher risk of mortality compared to those with frequent social interactions.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Neurosciences
Ja Eun Choi, Bong-Kiun Kaang
Summary: Autism spectrum disorder (ASD) is a neuropsychiatric disorder with a gender-specific risk. Loneliness issue exists in patients with ASD, and emerging reports show gender distribution in symptoms. Acute social isolation increases the motivation to socially interact in a gender-dependent manner.
Article
Psychiatry
Sandra P. Zoubovsky, Michael T. Williams, Sarah Hoseus, Shivani Tumukuntala, Amy Riesenberg, Jay Schulkin, Charles V. Vorhees, Kenneth Campbell, Hee-Woong Lim, Louis J. Muglia
Summary: Prenatal stress in mice leads to anxiety-like behavior and increased activity of the HPA axis. Evidence of fetal amygdala programming precedes these abnormalities. In adult offspring, there are sex-specific amygdalar transcriptional changes and dysfunction in neurotransmitter systems. These abnormalities are primarily driven by in-utero stress exposure, but postnatal maternal care changes can reverse anxiety-related behaviors and partially rescue gene alterations associated with neurotransmission.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Neurosciences
Ling-Xiao Shen, Yu-Xiang Yang, Kevin Kuo, Hong-Qi Li, Shi-Dong Chen, Ke-Liang Chen, Qiang Dong, Lan Tan, Jin-Tai Yu
Summary: This study using Mendelian randomization method suggests a causal relationship between regular attendance at a gym or sports club and reduced risk of Alzheimer's disease, while Alzheimer's disease may reduce attendance at religious groups. Further research is needed to elucidate potential mechanisms.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Sade J. Abiodun, Joanna M. Salerno, Galen A. Mcallister, Gregory R. Samanez-Larkin, Kendra L. Seaman
Summary: This study investigated age-related differences in evoked responses to dynamic facial expressions. The results showed that older adults rated positive facial expressions (happy) more positively and negative facial expressions (angry and sad) more negatively than younger adults in terms of valence. However, there was no significant difference in arousal to negative expressions between older and younger adults. Overall, the findings suggest that older adults may be more sensitive to variations in dynamic facial expressions, particularly in terms of valence estimates.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Article
Psychology, Developmental
T. St John, A. Estes, K. K. Begay, J. Munson, M. A. Reiter, S. R. Dager, N. Kleinhans
Summary: Children with sensory abnormalities exhibit poorer social functioning compared to typically developing children, and have similar social functioning levels to those with autism spectrum disorder. Increased sensory abnormalities are associated with worse social functioning in all groups, highlighting the need for interventions to support social functioning in this population.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
Article
Geriatrics & Gerontology
Kaileigh A. Byrne, Reza Ghaiumy Anaraky
Summary: Social isolation is linked to poorer cognitive outcomes among older adults, but online social technology use may help alleviate this. This study found that greater use of social technology was associated with better cognitive functioning among socially isolated older adults, particularly among Black/African American individuals.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2022)
Article
Behavioral Sciences
Nicole C. Ferrara, Sydney Trask, Alexandra Ritger, Mallika Padival, J. Amiel Rosenkranz
Summary: Adolescence is a developmental period characterized by brain maturation and changes in social engagement. Changes in the social environment influence social behaviors. This study investigates how the social environment impacts age-specific social behaviors and explores changes in the amygdala.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Lierni Ugartemendia, Rafael Bravo, Martin Reuter, M. Yolanda Castano, Thomas Plieger, Vera Zamoscik, Peter Kirsch, Ana B. Rodriguez
Summary: This study aimed to improve age-related depression or social cognitive impairment through a tryptophan-enriched diet, showing a positive correlation in S'S' subjects. Factors such as age, genotype, and experimental conditions were important in influencing the outcomes of depression and social cognition.
CLINICAL NUTRITION
(2021)
Article
Food Science & Technology
Kenji Ishimoto, Yuta Nakamura, Shuichi Otani, Shohei Miki, Soya Maeda, Taiki Iwamoto, Yuma Konishi, Yukio Ago, Shinsaku Nakagawa
Summary: By examining the mixing ratio of BC and base materials in BC-SD, the dissolution ratio of BC in water can be improved, leading to increased absolute bioavailability. These findings are useful for reducing manufacturing costs and are important for future practical use.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2022)
Correction
Neurosciences
Tomoya Takemoto, Masayuki Baba, Kazumasa Yokoyama, Kohei Kitagawa, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Daisuke Mori, Norio Ozaki, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa
Article
Neurosciences
Tomoya Takemoto, Masayuki Baba, Kazumasa Yokoyama, Kohei Kitagawa, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Daisuke Mori, Norio Ozaki, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa
Summary: This study investigates the molecular mechanisms behind impaired social behavior in 3q29 microdeletion mice and demonstrates the significant role of oxytocin in restoring social behavior.
Article
Biochemistry & Molecular Biology
Yusuke Shintani, Atsuko Hayata-Takano, Yui Yamano, Mankato Ikuta, Rei Takeuchi, Kazuhiro Takuma, Takuya Okada, Naoki Toyooka, Ichiro Takasaki, Atsuro Miyata, Takashi Kurihara, Hitoshi Hashimoto
Summary: The study found that PAC1 antagonists PA-9 and PA-915 can alleviate anxiety-like behaviors induced by acute restraint stress in mice, and they have fast-acting anxiolytic properties, suggesting their potential as a novel treatment for anxiety.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Yuki Kambe, Thanh Trung Nguyen, Toshiharu Yasaka, Thu Thi Nguyen, Yoshimune Sameshima, Kohei Hashiguchi, Norihito Shintani, Hitoshi Hashimoto, Takashi Kurihara, Atsuro Miyata
Summary: This study found that pituitary adenylate cyclase-activating polypeptide (PACAP) is involved in the regulation of feeding by modulating the expression of galanin in the dorsomedial hypothalamus (DMH). Fasting increased galanin expression in the hypothalamus, but this increase was abolished in PACAP-knockout (KO) mice. Overexpression of PACAP in the ventromedial hypothalamus (VMH) increased galanin expression, while knockdown of PACAP in the VMH decreased galanin expression. Neural projections from PACAP-expressing cells in the VMH to the DMH were observed, and galanin expression in the DMH was weaker in PACAP-KO mice. Knockdown of galanin in the DMH resulted in reduced food intake during the dark cycle and after fasting, and increased food intake during the light cycle, similar to PACAP-KO mice.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Yukio Ago, Rei Yokoyama, Satoshi Asano, Hitoshi Hashimoto
Summary: The antidepressant effects of ketamine may be related to both the dopaminergic system and the serotonergic system, while the effects of (R)-ketamine may be independent of the monoaminergic system. Ketamine metabolites differ in their ability to regulate monoamine neurotransmitters, and some metabolites may share common serotonergic signaling mechanisms with ketamine.
Article
Multidisciplinary Sciences
Fumito Endo, Atsushi Kasai, Joselyn S. Soto, Xinzhu Yu, Zhe Qu, Hitoshi Hashimoto, Viviana Gradinaru, Riki Kawaguchi, Baljit S. Khakh
Summary: This study provides comprehensive molecular data on the diversity and mechanisms of astrocytes in the central nervous system, highlighting the role of certain genes in astrocyte morphology and their association with diseases such as Alzheimer's.
Article
Multidisciplinary Sciences
Takashi Nagashima, Suguru Tohyama, Kaori Mikami, Masashi Nagase, Mieko Morishima, Atsushi Kasai, Hitoshi Hashimoto, Ayako M. Watabe
Summary: This study reveals the pivotal role of the lateral parabrachial nucleus (lPB)-parasubthalamic nucleus (PSTN) pathway in fear-induced feeding suppression.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Masato Tanuma, Misaki Niu, Jin Ohkubo, Hiroki Ueno, Yuka Nakai, Yoshihisa Yokoyama, Kaoru Seiriki, Hitoshi Hashimoto, Atsushi Kasai
Summary: This study reveals the involvement of claustrum (CLA) neurons in stress response processing. It is found that the main inputs to CLA and basolateral amygdala (BLA) during stress come from specific brain regions. Furthermore, the study also identifies co-labeled double-projecting neurons in various brain regions, suggesting a stress response circuitry involving CLA and BLA.
Article
Cell Biology
Masafumi Noguchi, Susumu Kohno, Anna Pellattiero, Yukino Machida, Keitaro Shibata, Norihito Shintani, Takashi Kohno, Noriko Gotoh, Chiaki Takahashi, Atsushi Hirao, Luca Scorrano, Atsuko Kasahara
Summary: Drug resistance is a major challenge in chemotherapy and targeted cancer treatments. This study identifies the mitochondrial protein Opa1 as a participant in gefitinib resistance in lung adenocarcinoma cells. Inhibition of Opa1 restores mitochondrial morphology and sensitizes resistant cells to apoptosis induced by gefitinib. Combination treatment of gefitinib with a specific Opa1 inhibitor reduces tumor size in vivo and increases apoptosis. Targeting Opa1 could be a potential strategy to overcome gefitinib resistance.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Kotaro Sakamoto, Wararat Kittikulsuth, Eijiro Miyako, Akumwami Steeve, Rika Ishimura, Shinsaku Nakagawa, Yukio Ago, Akira Nishiyama
Summary: We have previously shown that KS-133 is a potent and specific antagonist of VIPR2. In this study, we aimed to investigate the effects of selective VIPR2 blockade by KS-133 on macrophage polarization and anti-tumor activity. Our results demonstrated that KS-133 upregulated genetic markers indicative of tumor-aggressive M1-type macrophages and downregulated those of tumor-supportive M2-type macrophages. Additionally, nanoformulation of KS-133 enhanced its pharmacological efficacy and improved the anti-tumor activity when combined with an immune checkpoint-inhibiting anti-PD-1 antibody.
Article
Biochemistry & Molecular Biology
Tamas Gaszner, Jozsef Farkas, Daniel Kun, Balazs Ujvari, Nora Furedi, Laszlo Akos Kovacs, Hitoshi Hashimoto, Dora Reglodi, Viktoria Kormos, Balazs Gaszner
Summary: Depression poses challenges to patients, the healthcare system, and the economy. This study used a mouse model to explore the "three-hit concept" of depression. The findings suggest that early life adversities and later life stress interact with the effect of fluoxetine therapy by modulating FOSB and H3K9ac in specific regions, supporting the reliability of the model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Shotaro Kawano, Masayuki Baba, Hotaka Fukushima, Daiki Miura, Hitoshi Hashimoto, Takanobu Nakazawa
Summary: This study analyzed the role of ANK2 in the developing mouse cerebral cortex and found that ANK2 regulates neural stem cell differentiation and neuronal migration. ANK2 haploinsufficiency may impair neural development and increase the risk of ASD in patients.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Misaki Niu, Atsushi Kasai, Masato Tanuma, Kaoru Seiriki, Hisato Igarashi, Takahiro Kuwaki, Kazuki Nagayasu, Keita Miyaji, Hiroki Ueno, Wataru Tanabe, Kei Seo, Rei Yokoyama, Jin Ohkubo, Yukio Ago, Misuzu Hayashida, Ken-Ichi Inoue, Masahiko Takada, Shun Yamaguchi, Takanobu Nakazawa, Shuji Kaneko, Hiroyuki Okuno, Akihiro Yamanaka, Hitoshi Hashimoto
Summary: This study reveals the crucial role of the claustrum in the regulation of stress-induced anxiety-related behaviors. Claustrum activation serves as a reliable marker of acute stress exposure, and its neuronal ensemble activation elicits anxiety-related behaviors while silencing attenuates such behaviors. The claustrum receives strong input from the basolateral amygdala, and selective optogenetic stimulation of the claustrum temporarily induces anxiety-related behaviors. Silencing of the claustrum ensemble increases resistance to chronic stress. The bidirectional control of stress-induced emotional responses by the claustrum suggests its potential as a target for prevention and treatment of stress-related disorders.
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)
