Article
Environmental Sciences
Chang-Fang Chiu, Shih-Jiuan Chiu, Li-Yuan Bai, Chia-Hsien Feng, Jing-Lan Hu, Wei-Yu Lin, Hao-Yu Huang, Jing-Ru Weng
Summary: The study showed that JBIR-100 could inhibit proliferation and induce apoptosis in breast cancer cells by modulating the Akt/NF-kappa B signaling pathway and Bcl-2 family members. Additionally, JBIR-100 also inhibited autophagy in MCF-7 cells.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Medicine, Research & Experimental
Hany H. Arab, Ahmed H. Eid, Azza A. K. El-Sheikh, El-Shaimaa A. Arafa, Ahmed M. Ashour
Summary: The study found that irbesartan can alleviate ethanol-induced gastric mucosal injury by suppressing inflammatory and apoptotic signals, while upregulating pro-autophagy events.
Article
Cell Biology
Flore Sneyers, Martijn Kerkhofs, Femke Speelman-Rooms, Kirsten Welkenhuyzen, Rita La Rovere, Ahmed Shemy, Arnout Voet, Guy Eelen, Mieke Dewerchin, Stephen W. G. Tait, Bart Ghesquiere, Martin D. Bootman, Geert Bultynck
Summary: Intracellular Ca2+ signals play a crucial role in various cellular processes. Research has shown that BAPTAi can induce apoptosis in cancer cells by inhibiting mTORC1 activity and impairing glycolysis, independent of Ca2+ signaling. Additionally, direct inhibition of PFKFB3 emerges as a potential therapeutic target in MCL-1-dependent cancers.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Bing X. Ross, Lin Jia, Dejuan Kong, Tiantian Wang, Heather M. Hager, Steven F. Abcouwer, David N. Zacks
Summary: After retinal detachment, the lack of HMGB1 accelerates photoreceptor cell death by reducing protective autophagy activation. The diminished autophagy levels in HMGB1 Delta rod retinas lead to increased apoptotic cell death in detached retinas.
Article
Biochemistry & Molecular Biology
Hyunwoo Chung, Hyunsung Nam, Thuy Nguyen-Phuong, Jiyun Jang, Sung Ji Hong, So Won Choi, Seung Bum Park, Chung-Gyu Park
Summary: The blockade of cytoplasmic HMGB1 (cHMGB1) decreases the viability of islet grafts, primary islets, and MIN6 cells under cellular stress, leading to reduced autophagic flux and increased apoptosis under lipotoxic stress. Furthermore, blocking cHMGB1 in HFD-fed mice has unfavorable outcomes on their glucose tolerance. This study suggests the role of cHMGB1 in the beta cell autophagy/apoptosis checkpoint and provides insights regarding HMGB1 and diabetes.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Yu Gan, Xiaoying Li, Shuangze Han, Li Zhou, Wei Li
Summary: This study confirmed the inhibitory effect of bergenin on colorectal cancer cells both in vivo and in vitro. Bergenin significantly reduced the viability and colony formation of CRC cells, and promoted apoptosis. Bergenin inhibited the Akt/GSK3 beta signaling and promoted the interaction between FBW7 and Mcl-1, resulting in the ubiquitination and degradation of Mcl-1. In vivo studies showed that bergenin reduced tumor size and weight without toxicity to vital organs in mice.
Article
Multidisciplinary Sciences
Tian-jiao Song, Xiao-hong Lin, Ping-ting Huang, Yu-qing Chen, Li-min Chen
Summary: Lung cancer is a malignant tumor with high morbidity and mortality rates worldwide. The current chemotherapy for lung cancer is ineffective due to drug resistance. Tripchlorolide (T4), a natural extract, has been found to have immunosuppressive and antitumor effects, making it a potential therapeutic agent for lung cancer. This study investigated the effect of T4 on reducing chemoresistance in lung cancer cells and explored the underlying mechanism. The results showed that T4 can increase the sensitivity of lung cancer cells to cisplatin, a chemotherapy drug, by reducing the expression of AEG-1 protein.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Agnieszka Gornowicz, Wojciech Szymanowski, Krzysztof Bielawski, Zbigniew Kaluza, Olga Michalak, Anna Bielawska
Summary: The study showed that the anti-MUC1 antibody in combination with OM-86II effectively reduced the viability of gastric cancer cells by promoting apoptosis and autophagy, while inhibiting proteins such as mTOR, sICAM1, and MMP-9.
Article
Oncology
Hiroyuki Araki, Hiroshi Tazawa, Nobuhiko Kanaya, Yoshinori Kajiwara, Motohiko Yamada, Masashi Hashimoto, Satoru Kikuchi, Shinji Kuroda, Ryuichi Yoshida, Yuzo Umeda, Yasuo Urata, Shunsuke Kagawa, Toshiyoshi Fujiwara
Summary: This study demonstrated the potential of p53-expressing telomerase-specific oncolytic adenovirus OBP-702 in the treatment of pancreatic ductal adeno-carcinoma (PDAC). OBP-702 enhances the efficacy of PD-1 blockade therapy by inducing immunogenic cell death (ICD) and anti-tumor immune responses.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Review
Oncology
Haolan Wang, Ming Guo, Hudie Wei, Yongheng Chen
Summary: MCL-1, an antiapoptotic protein, is frequently overexpressed in many tumor types and closely associated with tumorigenesis, poor prognosis, and drug resistance. Its central role in regulating the mitochondrial apoptotic pathway makes it an attractive target for cancer therapy. Progress has been made towards MCL-1 inhibitors and some have entered clinical trials.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xu Liu, Qiaoyu Zheng, Qiongfang Yu, Yan Hu, Yanmin Cheng, Zhaozhao Shao, Li Chen, Wenjie Ding, Dian Gao
Summary: The study demonstrates that Apatinib inhibits the proliferation of GC cells by promoting apoptosis and autophagy, altering cell cycle distribution, and inhibiting invasion and migration capacities of GC cells.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Pengzhan He, Yang He, Jingjing Ma, Yinghui Liu, Chuan Liu, Yu Baoping, Weiguo Dong
Summary: In this study, it was found that thymoquinone inhibited the proliferation of gastric cancer cells and induced concentration-dependent apoptosis and autophagy. These effects were mediated through the inhibition of the PI3K/Akt/mTOR pathway. The findings provide new insights into the specific mechanism of thymoquinone as an anti-gastric cancer drug.
PHYTOTHERAPY RESEARCH
(2023)
Article
Medicine, General & Internal
Changqing Ma, Chad E. Storer, Uma Chandran, William A. LaFramboise, Patricia Petrosko, Madison Frank, Douglas J. Hartman, Liron Pantanowitz, Talin Haritunians, Richard D. Head, Ta-Chiang Liu
Summary: Individuals with the ATG16L1 T300A genotype in gastric carcinoma show suppressed EGFR and PPAR pathways, increased tumor apoptosis, and improved overall survival. Genotyping gastric cancer patients may offer additional insights for clinical stratification.
Article
Chemistry, Multidisciplinary
Jianran Hu, Ping Li, Baozhong Shi, Jun Tie
Summary: Saikosaponin D (SSD) can enhance cisplatin sensitivity of gastric cancer cells by inducing apoptosis and autophagy, and inhibiting the IKK beta/NF-κB signaling pathway.
Article
Dermatology
Farzana Ahmed, Hsin-Yi Tseng, Antonio Ahn, Dilini Gunatilake, Sara Alavi, Michael Eccles, Helen Rizos, Stuart J. Gallagher, Jessamy C. Tiffen, Peter Hersey, Abdullah Al Emran
Summary: This study explores the resistance of melanoma to chemotherapy and suggests that melanoma with an inflammatory undifferentiated state may be susceptible to combination therapy. The study also investigates the variation in inflammasomes and death mechanisms in different melanoma, and raises the possibility of using the inflammatory state as biomarkers for inflammasome-targeted therapy.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Youming Zhu, Leu Jin, Ronghua Shi, Jinming Li, Yan Wang, Li Zhang, Chao-Zhao Liang, Vinod K. Narayana, David P. De Souza, Rick F. Thorne, Li Rong Zhang, Xu Dong Zhang, Mian Wu
Summary: This study reveals a novel long noncoding RNA (lncRNA) called gLINC that acts as a backbone for the formation of a metabolon involving glycolytic enzymes and lactate dehydrogenase A. The gLINC metabolon enhances glycolytic flux, ATP production, and cell survival under serine deprivation. Overexpression of gLINC in cancer cells promotes xenograft growth in mice on a serine-deprived diet, suggesting its role in cancer cell adaptation.
Article
Oncology
Sara Alavi, Abdullah Al Emran, Hsin-Yi Tseng, Jessamy C. Tiffen, Helen Marie McGuire, Peter Hersey
Summary: This study explores the role of nicotinamide in preventing and reversing T cell exhaustion, which has important implications for immunotherapy against cancers and viral infections. Nicotinamide supplementation was found to prevent the development of inhibitory receptors in T cells and promote the differentiation of T cells to effector states, suggesting a potential therapeutic strategy for enhancing immune responses.
Article
Biochemistry & Molecular Biology
Mark Marsland, Amiee Dowdell, Chen Chen Jiang, James S. Wilmott, Richard A. Scolyer, Xu Dong Zhang, Hubert Hondermarck, Sam Faulkner
Summary: There is increasing evidence suggesting the involvement of nerve growth factor (NGF) and its receptors in cancer growth. In this study, the expression of NGF, proNGF, TrkA, p75(NTR) and sortilin in melanoma was investigated. The results showed downregulation of NGF/ProNGF and TrkA in melanoma, indicating a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Environmental
Haoshi Gao, Stanislav Kan, Zhuyifan Ye, Yuchen Feng, Lei Jin, Xudong Zhang, Jiayin Deng, Ging Chan, Yuanjia Hu, Yongjun Wang, Dongsheng Cao, Yuanhui Ji, Mingtao Liang, Haifeng Li, Defang Ouyang
Summary: siRNA gene silencing therapy has great potential for treating diseases, but the formulation design of siRNA-LNP faces challenges. A novel integrated computer methodology based on machine learning and molecular dynamic simulation was successfully developed for siRNA-LNP formulation design.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Endocrinology & Metabolism
I-Cheng Lu, Hao Tan, Sheng-Hua Wu, Tzu-Yen Huang, Hsin-Yi Tseng, Jia-Joanna Wang, Gianlorenzo Dionigi, Young Jun Chai, Feng-Yu Chiang, Pi-Ying Chang, Che-Wei Wu
Summary: This study investigated the effect of neostigmine on the signal recovery of electromyography (EMG) following the administration of cisatracurium and rocuronium in a pig model. The results demonstrated that neostigmine accelerated the recovery of EMG signals and improved the amplitude recovery.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Leixi Cao, Ruijie Wang, Guangzhi Liu, Yuwei Zhang, Rick Francis Thorne, Xu Dong Zhang, Jinming Li, Yang Xia, Lili Guo, Fengmin Shao, Hao Gu, Mian Wu
Summary: This study reveals an interaction between LIF-Stat3 signaling and the glycolytic enzyme Pfkp in the differentiation of murine ESCs into specific cell lineages. The repression of Pfkp by Stat3 maintains pluripotency in ESCs, and lifting this repression results in differentiation towards the ectodermal lineage. Pfkp acts as a protein kinase to phosphorylate Lin41, stabilizing its expression and promoting the binding and degradation of mRNAs encoding ectodermal specification markers.
Article
Medicine, General & Internal
Chih-Yun Kuo, Hsin-Yi Tseng, Ivo Stachiv, Chon-Haw Tsai, Yi-Chun Lai, Tomas Nikolai
Summary: Neuropsychological tests are widely used for dementia assessment in clinical practice and are also important for differentiating between Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD), especially in the initial clinical presentations of behavioral variants of frontotemporal dementia (bvFTD) and primary progressive aphasia (PPA). However, the overlapping signs and cultural differences raise concerns about the validity and reliability of these tests. This case series combined NPTs with neuroimaging to examine their effectiveness in distinguishing between AD and FTLD, and the results showed that participants diagnosed with FTLD had lower scores in language and social cognition tests compared to AD participants, while PPA participants had lower scores in the Free and Cued Selective Reminding Test compared to bvFTD participants.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Analytical
Szu-Ying Li, Hsin-Yi Tseng, Bo-Wei Chen, Yu-Chun Lo, Huai-Hsuan Shao, Yen-Ting Wu, Ssu-Ju Li, Ching-Wen Chang, Ta-Chung Liu, Fu-Yu Hsieh, Yi Yang, Yan-Bo Lai, Po-Chun Chen, You-Yin Chen
Summary: Increasing requirements for neural implantation have led to advancements in semiconductor technologies, allowing for high-density electrode arrays to improve neural recordings. However, there are technological challenges, such as complex manufacturing processes and environmental concerns. A new eco-fabrication process for neural electrode arrays reduces carbon emissions and offers customization.
Article
Chemistry, Analytical
Yao-Wen Liang, Ming-Liang Lai, Feng-Mao Chiu, Hsin-Yi Tseng, Yu-Chun Lo, Ssu-Ju Li, Ching-Wen Chang, Po-Chuan Chen, You-Yin Chen
Summary: Fiber photometry can overcome methodological limitations and provide new insights into neural systems. It can accurately measure neural activity under deep brain stimulation without artifacts. This study demonstrated the use of a self-assembled optrode as a stimulator and biosensor to record both Ca2+ fluorescence and electrophysiological signals, revealing a correlation between local field potential and Ca2+ fluorescence signal in the evoked region.
Article
Engineering, Multidisciplinary
Na Zhang, Ling Qin, Ping Yu, Wei Gao, Yupeng Li
Summary: With the development of e-commerce and the increase in online shopping, users have higher demands on products. Enterprises need to design products that meet user demands accurately and quickly in order to improve user satisfaction and product competitiveness. This paper proposes a Grey-Markov model of user demands prediction based on online reviews, which predicts the monthly changing trend of user demands in advance. By using LDA topic model and sentiment analysis, user attention values and satisfaction values are obtained. The effectiveness of the proposed method is illustrated through examples of demand prediction and optimization design for smartphones and automobiles, providing a reference for manufacturing enterprises to optimize product design.
JOURNAL OF ENGINEERING DESIGN
(2023)
Article
Multidisciplinary Sciences
Hsin-Yi Tseng, Tzu-Yen Huang, Jia Joanna Wang, Yi-Chu Lin, I-Cheng Lu, Feng-Yu Chiang, Gianlorenzo Dionigi, Gregory W. Randolph, Che-Wei Wu
Summary: This article introduces experimental studies using a porcine model to investigate the safe activation and cooling parameters of surgical energy devices (SEDs) in thyroid and parathyroid surgery. The studies use electrophysiological and thermographic procedures to evaluate the safe activation distance and cooling time, ensuring the avoidance of recurrent laryngeal nerve injury.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Review
Medicine, Research & Experimental
Qingjuan Chen, Binhui Yang, Xiaochen Liu, Xu D. Zhang, Lirong Zhang, Tao Liu
Summary: CBP/p300, critical drivers of oncogenesis, promote tumorigenesis and have been shown to be over-expressed in cancer cells; their inhibitors and degraders are considered promising anticancer agents that reduce H3K27ac, regulate oncogene transcription, induce cancer cell death and activate immune response.
Article
Biochemistry & Molecular Biology
Dong Li, Li Na Hu, Si Min Zheng, Ting La, Li Yuan Wei, Xiao Jun Zhang, Zhen Hua Zhang, Jun Xing, Li Wang, Ruo Qi Li, Qin Zhu, Rick F. Thorne, Yu Chen Feng, Hubert Hondermarck, Xu Dong Zhang, Li Li, Jin Nan Gao
Summary: Active crosstalk between the nervous system and breast cancer cells has been experimentally demonstrated. Previous studies may have underestimated the importance of peripheral nerves in breast cancer development and progression. This study found that nerves are commonly present in breast cancers, predominantly of sympathetic origin, and high nerve density is associated with poor patient outcomes.
Correction
Cell Biology
Qi Luan, Lei Jin, Chen Chen Jiang, Kwang Hong Tay, Fritz Lai, Xiao Ying Liu, Yi Lun Liu, Su Tang Guo, Chun Ying Li, Xu Guang Yan, Hsin-Yi Tseng, Xu Dong Zhang
