Conformational dynamics of α-synuclein: insights from mass spectrometry

A Mass-Spectrometry-Based Framework To Define the Extent of Disorder in Proteins

(2014) Rebecca Beveridge et al.   ANALYTICAL CHEMISTRY

Probing Conformational Change of Intrinsically Disordered α-Synuclein to Helical Structures by Distinctive Regional Interactions with Lipid Membranes

(2014) Shin Jung C. Lee et al.   ANALYTICAL CHEMISTRY

Co-existence of Two Different α-Synuclein Oligomers with Different Core Structures Determined by Hydrogen/Deuterium Exchange Mass Spectrometry

(2014) Wojciech Paslawski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diverse Metastable Structures Formed by Small Oligomers of α-Synuclein Probed by Force Spectroscopy

(2014) Krishna Neupane et al.   PLoS One

Characterizing the Dynamics of α-Synuclein Oligomers Using Hydrogen/Deuterium Exchange Monitored by Mass Spectrometry

(2013) Simon Mysling et al.   BIOCHEMISTRY

α-Synuclein Misfolding Assessed with Single Molecule AFM Force Spectroscopy: Effect of Pathogenic Mutations

(2013) Alexey V. Krasnoslobodtsev et al.   BIOCHEMISTRY

Stepwise oligomerization of murine amylin and assembly of amyloid fibrils

(2013) Leonardo C. Palmieri et al.   BIOPHYSICAL CHEMISTRY

α-Synuclein: The Long Distance Runner

(2013) Sonia George et al.   BRAIN PATHOLOGY

α-Synuclein as an intrinsically disordered monomer - fact or artefact?

(2013) Eduardo Coelho-Cerqueira et al.   FEBS Journal

Ion Mobility Spectrometry–Mass Spectrometry Defines the Oligomeric Intermediates in Amylin Amyloid Formation and the Mode of Action of Inhibitors

(2013) Lydia M. Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Binding of Dopamine to Alpha-Synuclein is Mediated by Specific Conformational States

(2013) Eva Illes-Toth et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Insights into the role of the beta-2 microglobulin D-strand in amyloid propensity revealed by mass spectrometry

(2013) Aneika C. Leney et al.   Molecular BioSystems

Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization

(2013) Alireza Roostaee et al.   Molecular Neurodegeneration

Properties of native brain α-synuclein

(2013) Jacqueline Burré et al.   NATURE

Initiation of assembly of tau(273-284) and its ΔK280 mutant: an experimental and computational study

(2013) Luca Larini et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Insulin, islet amyloid polypeptide and C-peptide interactions evaluated by mass spectrometric analysis

(2013) Michael Landreh et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Familial Alzheimer’s Disease Mutations Differentially Alter Amyloid β-Protein Oligomerization

(2012) Megan Murray Gessel et al.   ACS Chemical Neuroscience

Mass spectrometry methods for intrinsically disordered proteins

(2012) Rebecca Beveridge et al.   ANALYST

Intrinsic disorder in proteins: a challenge for (un)structural biology met by ion mobility–mass spectrometry

(2012) Ewa Jurneczko et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Bacterial in-cell NMR of human α-synuclein: a disordered monomer by nature?: Figure 1

(2012) Andres Binolfi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Advances in ion mobility spectrometry–mass spectrometry reveal key insights into amyloid assembly

(2012) L.A. Woods et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

Biophysical properties and cellular toxicity of covalent crosslinked oligomers of α-synuclein formed by photoinduced side-chain tyrosyl radicals

(2012) Claudio D. Borsarelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Z-Phe-Ala-diazomethylketone (PADK) Disrupts and Remodels Early Oligomer States of the Alzheimer Disease Aβ42 Protein

(2012) Xueyun Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational Comparability of Factor IX–Fc Fusion Protein, Factor IX, and Purified Fc Fragment in the Absence and Presence of Calcium

(2012) Damian Houde et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Using Hydrogen/Deuterium Exchange Mass Spectrometry to Study Conformational Changes in Granulocyte Colony Stimulating Factor upon PEGylation

(2012) Hui Wei et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Targeting the Chameleon: a Focused Look at α-Synuclein and Its Roles in Neurodegeneration

(2012) Blanca A. Silva et al.   MOLECULAR NEUROBIOLOGY

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Phosphorylation of α-Synuclein at Y125 and S129 Alters Its Metal Binding Properties: Implications for Understanding the Role of α-Synuclein in the Pathogenesis of Parkinson’s Disease and Related Disorders

(2011) Yu Lu et al.   ACS Chemical Neuroscience

Aβ(39–42) Modulates Aβ Oligomerization but Not Fibril Formation

(2011) Megan Murray Gessel et al.   BIOCHEMISTRY

α-Synuclein misfolding and Parkinson's disease

(2011) Leonid Breydo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Structure and Dynamics of Oligomeric Intermediates in β2-Microglobulin Self-Assembly

(2011) David P. Smith et al.   BIOPHYSICAL JOURNAL

Autoproteolytic Fragments Are Intermediates in the Oligomerization/Aggregation of the Parkinson's Disease Protein Alpha-Synuclein as Revealed by Ion Mobility Mass Spectrometry

(2011) Camelia Vlad et al.   CHEMBIOCHEM

Aβ40 and Aβ42 Amyloid Fibrils Exhibit Distinct Molecular Recycling Properties

(2011) Laia Sánchez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Amyloid Formation Mechanism in Human IAPP: Dimers Have β-Strand Monomer−Monomer Interfaces

(2011) Nicholas F. Dupuis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand binding to distinct states diverts aggregation of an amyloid-forming protein

(2011) Lucy A Woods et al.   Nature Chemical Biology

Identification of Cross-Linked Peptides by High-Resolution Precursor Ion Scan

(2010) Amadeu H. Iglesias et al.   ANALYTICAL CHEMISTRY

Characterizing Early Aggregates Formed by an Amyloidogenic Peptide by Mass Spectrometry

(2010) Harriet L. Cole et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alteration of the α-Synuclein Folding Landscape by a Mutation Related to Parkinson’s Disease

(2010) Allan Chris M. Ferreon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Architecture of the RNA polymerase II–TFIIF complex revealed by cross-linking and mass spectrometry

(2010) Zhuo Angel Chen et al.   EMBO JOURNAL

A Combinatorial NMR and EPR Approach for Evaluating the Structural Ensemble of Partially Folded Proteins

(2010) Jampani Nageswara Rao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Native Electrospray and Electron-Capture Dissociation in FTICR Mass Spectrometry Provide Top-Down Sequencing of a Protein Component in an Intact Protein Assembly

(2010) Hao Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Elongated oligomers in  2-microglobulin amyloid assembly revealed by ion mobility spectrometry-mass spectrometry

(2010) D. P. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Compact conformations of α-synuclein induced by alcohols and copper

(2010) Antonino Natalello et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Molecular Mechanisms Underlying the Flavonoid-Induced Inhibition of α-Synuclein Fibrillation

(2009) Xiaoyun Meng et al.   BIOCHEMISTRY

Methionine oxidation stabilizes non-toxic oligomers of α-synuclein through strengthening the auto-inhibitory intra-molecular long-range interactions

(2009) Wenbo Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Binding of α-synuclein with Fe(III) and with Fe(II) and biological implications of the resultant complexes

(2009) Yong Peng et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Structural Reorganization of α-Synuclein at Low pH Observed by NMR and REMD Simulations

(2009) Kuen-Phon Wu et al.   JOURNAL OF MOLECULAR BIOLOGY

Binding of Cu(II) to Human α-Synucleins: Comparison of Wild Type and the Point Mutations Associated with the Familial Parkinson’s Disease

(2009) Lian Hong et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Amyloid β Protein: Aβ40 Inhibits Aβ42 Oligomerization

(2009) Megan M. Murray et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Human Islet Amyloid Polypeptide Monomers Form Ordered β-hairpins: A Possible Direct Amyloidogenic Precursor

(2009) Nicholas F. Dupuis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

(2009) Summer L. Bernstein et al.   Nature Chemistry

Experimental characterization of disordered and ordered aggregates populated during the process of amyloid fibril formation

(2009) N. Carulla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Charge neutralization and collapse of the C-terminal tail of alpha-synuclein at low pH

(2009) Sebastian McClendon et al.   PROTEIN SCIENCE

Development of an Ion Mobility Quadrupole Time of Flight Mass Spectrometer

(2008) Bryan J. McCullough et al.   ANALYTICAL CHEMISTRY

Ion mobility-mass spectrometry

(2008) Abu B. Kanu et al.   JOURNAL OF MASS SPECTROMETRY

Spermine Binding to Parkinson’s Protein α-Synuclein and Its Disease-Related A30P and A53T Mutants

(2008) Megan Grabenauer et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Site-Specific Interactions of Cu(II) with α and β-Synuclein: Bridging the Molecular Gap between Metal Binding and Aggregation

(2008) Andrés Binolfi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY