Ligand binding to distinct states diverts aggregation of an amyloid-forming protein

Mutations That Replace Aromatic Side Chains Promote Aggregation of the Alzheimer’s Aβ Peptide

(2011) Anne H. Armstrong et al.   BIOCHEMISTRY

Amyloid fibril protein nomenclature: 2010 recommendations from the nomenclature committee of the International Society of Amyloidosis

(2010) Jean D. Sipe et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

A Combined High-Resolution Mass Spectrometric and in silico Approach for the Characterisation of Small Ligands of β2-Microglobulin

(2010) Luca Regazzoni et al.   ChemMedChem

Stacked Sets of Parallel, In-register β-Strands of β2-Microglobulin in Amyloid Fibrils Revealed by Site-directed Spin Labeling and Chemical Labeling

(2010) Carol L. Ladner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aromatic Small Molecules Remodel Toxic Soluble Oligomers of Amyloid β through Three Independent Pathways

(2010) Ali Reza A. Ladiwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol Selectively Remodels Soluble Oligomers and Fibrils of Amyloid Aβ into Off-pathway Conformers

(2010) Ali Reza A. Ladiwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Magic Angle Spinning NMR Analysis of β2-Microglobulin Amyloid Fibrils in Two Distinct Morphologies

(2010) Galia T. Debelouchina et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mass spectrometry and the amyloid problem—How far can we go in the gas phase?

(2010) Alison E. Ashcroft   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Elongated oligomers in  2-microglobulin amyloid assembly revealed by ion mobility spectrometry-mass spectrometry

(2010) D. P. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the Mechanism of Nonspecific Inhibitors of Protein Aggregation: Dissecting the Interactions of α-Synuclein with Congo Red and Lacmoid

(2009) Christofer Lendel et al.   BIOCHEMISTRY

Deciphering Drift Time Measurements from Travelling Wave Ion Mobility Spectrometry-Mass Spectrometry Studies

(2009) David P. Smith et al.   EUROPEAN JOURNAL OF MASS SPECTROMETRY

Fibril Fragmentation Enhances Amyloid Cytotoxicity

(2009) Wei-Feng Xue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Competition between Intramolecular and Intermolecular Interactions in an Amyloid-Forming Protein

(2009) Katy E. Routledge et al.   JOURNAL OF MOLECULAR BIOLOGY

Human Islet Amyloid Polypeptide Monomers Form Ordered β-hairpins: A Possible Direct Amyloidogenic Precursor

(2009) Nicholas F. Dupuis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oligomers of the Prion Protein Fragment 106−126 Are Likely Assembled from β-Hairpins in Solution, and Methionine Oxidation Inhibits Assembly without Altering the Peptide’s Monomeric Conformation

(2009) Megan Grabenauer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

(2009) Summer L. Bernstein et al.   Nature Chemistry

Rifampicin Does Not Prevent Amyloid Fibril Formation by Human Islet Amyloid Polypeptide but Does Inhibit Fibril Thioflavin-T Interactions: Implications for Mechanistic Studies of β-Cell Death†

(2008) Fanling Meng et al.   BIOCHEMISTRY

Sulfonated molecules that bind a partially structured species of β2-microglobulin also influence refolding and fibrillogenesis

(2008) Chiara Carazzone et al.   ELECTROPHORESIS

Annular Protofibrils Are a Structurally and Functionally Distinct Type of Amyloid Oligomer

(2008) Rakez Kayed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibril Growth Kinetics Reveal a Region of β2-microglobulin Important for Nucleation and Elongation of Aggregation

(2008) Geoffrey W. Platt et al.   JOURNAL OF MOLECULAR BIOLOGY

Small-molecule aggregates inhibit amyloid polymerization

(2008) Brian Y Feng et al.   Nature Chemical Biology

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly

(2008) Wei-Feng Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Amyloid Fibrillization of Hen Egg-White Lysozymes by Rifampicin and p-Benzoquinone

(2007) Valerie H. Lieu et al.   BIOTECHNOLOGY PROGRESS