Article
Medicine, Research & Experimental
Zheng Wang, Michelle F. Waldman, Tara J. Basavanhally, Aviva R. Jacobs, Gonzalo Lopez, Regis Y. Perichon, Johnny J. Ma, Elyse M. Mackenzie, James B. Healy, Yixin Wang, Sarah A. Hersey
Summary: This study investigated gene expression and viral infection in ME/CFS patients, identifying specific immune function genes that are upregulated in patients with severe symptoms. These gene targets could potentially serve as biomarkers for differentiation of ME/CFS patient subsets based on disease severity.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Kristen M. Marks, Minhee Kang, Triin Umbleja, Anchalee Avihingsanon, Patcharaphan Sugandhavesa, Andrea L. Cox, Karen Vigil, Hugo Perazzo, Jennifer C. Price, Leolin Katsidzira, Christina Vernon, Beverly Alston-Smith, Kenneth E. Sherman
Summary: In this international study, the HepB-CpG vaccine was effective in generating protective hepatitis B virus antibodies in people with HIV who had not been previously vaccinated. There were no unexpected safety concerns observed.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Per-Ole Carstens, Luisa M. Muellar, Arne Wrede, Sabrina Zechel, Martin M. Wachowski, Almuth Brandis, Sabine Krause, Stephan Zierz, Jens Schmidt
Summary: This study identified higher expression of BAFF, APRIL, and CXCL-13 in IBM and PM patients compared to controls, suggesting an involvement of B cell-related mechanisms in the pathophysiology of IBM and PM. Additionally, muscle fibers may play a role in the recruitment of B cells and sustaining inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Hsun Chang, Chien-Feng Kuo, Teng-Shun Yu, Liang-Yin Ke, Chung-Lieh Hung, Shin-Yi Tsai
Summary: This study found that infection with common pathogens, including bacteria and viruses, is associated with an increased risk of developing Chronic Fatigue Syndrome (CFS), based on an analysis of data from Taiwan's National Health Insurance Research Database.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Medicine, General & Internal
Rinaldo Pellicano, Arianna Ferro, Francesca Cicerchia, Simone Mattivi, Sharmila Fagoonee, Marilena Durazzo
Summary: Autoimmune hepatitis (AIH) is a chronic immune-inflammatory disease of the liver that is generally considered rare. It has a wide range of clinical manifestations from mild symptoms to severe hepatitis. Chronic liver damage leads to inflammation and oxidative stress, resulting in fibrosis and even cirrhosis. Liver biopsy is the gold standard for diagnosing fibrosis, but there are also serum biomarkers, scoring systems, and radiological methods available for diagnosis and staging. The goal of AIH treatment is to suppress fibrotic and inflammatory activities in the liver to prevent disease progression and achieve complete remission. Classic steroidal anti-inflammatory drugs and immunosuppressants are commonly used, but there are also new alternative drugs being researched.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Rasmine Birn-Rydder, Morten D. Jensen, Peter Jepsen, Lisbet Gronbaek
Summary: The presence of extrahepatic autoimmune diseases increases mortality in AIH patients, with patients having multiple extrahepatic autoimmune diseases having a higher mortality than those with just one.
LIVER INTERNATIONAL
(2022)
Article
Rheumatology
Zhenyu Zhong, Weiting Liao, Lingyu Dai, Xiaojie Feng, Guannan Su, Yu Gao, Qiuying Wu, Peizeng Yang
Summary: Patients with a time-weighted average prednisone dose greater than 20 mg/day may be classified as high risk for HBV reactivation or hepatitis flare, and prophylactic anti-HBV therapy may be needed for these high-risk patients.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Isabel Garrido, Susana Lopes, Manuel Sobrinho Simoes, Rodrigo Liberal, Joanne Lopes, Fatima Carneiro, Guilherme Macedo
Summary: The case of acute severe autoimmune hepatitis following COVID-19 vaccination highlights the importance of closely monitoring adverse reactions during the vaccination process to ensure safety. Healthcare providers must remain vigilant during mass COVID-19 vaccination to detect and manage potential complications promptly.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Immunology
Huajun Zhao, Yating Yu, Yucan Wang, Lianhui Zhao, Ailu Yang, Yifei Hu, Zhaoyi Pan, Zixuan Wang, Jiarui Yang, Qiuju Han, Zhigang Tian, Jian Zhang
Summary: The important role of cholesterol levels in DC dysfunction during CHB and the strategy of increasing cholesterol accumulation on DCs to enhance therapeutic vaccine efficacy against HBV have been demonstrated.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Immunology
Sheikh Mohammad Fazle Akbar, Mamun Al Mahtab, Julio Cesar Aguilar, Osamu Yoshida, Sakirul Khan, Eduardo Penton, Guillen Nieto Gerardo, Yoichi Hiasa
Summary: The objective of this study was to assess the safety and efficacy of a therapeutic vaccine (NASVAC) in patients with chronic hepatitis B (CHB) three years after the end of treatment (EOT). The results of the follow-up showed that NASVAC is a safe and effective treatment for CHB.
Article
Medicine, General & Internal
Doaa Mohammed Youssef, Amal S. S. El-Shal, Rabab M. M. Elbehidy, Mohamed Adel Fouda, Sally M. M. Shalaby, Lamiaa Lotfy El Hawy, Abdelrahman Fathi Elsadek, Mayy Abd Alfattah Neemat-Allah, Seham M. M. Ramadan, Amal Gohary, Faika Arab, Mona Alsharkawy, Sabry Abdel Rahman Tolba, Mohamed Mohamed Abdelsalam, Ezzat Kamel Amin, Mona Hamed Gehad
Summary: This study aimed to investigate the immune response to hepatitis B vaccine in children on hemodialysis and analyze the interfering factors. Results showed that 70% of the children had poor immune response to the vaccine, with only 30% showing a high-level response. Factors such as sex, dialysis duration, and HCV infection were significantly related to the poor response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Peter C. Grayson, Cristina Ponte, Ravi Suppiah, Joanna C. Robson, Katherine Bates Gribbons, Andrew Judge, Anthea Craven, Sara Khalid, Andrew Hutchings, Debashish Danda, Raashid A. Luqmani, Richard A. Watts, Peter A. Merkel
Summary: This study developed and validated new classification criteria for Takayasu arteritis through expert panel review and data analysis. The model showed a high level of accuracy and sensitivity when tested in the validation data set.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Margherita Bellucci, Francesco Germano, Stefano Grisanti, Chiara Castellano, Francesco Tazza, Emanuela Maria Mobilia, Davide Visigalli, Giovanni Novi, Federico Massa, Silvia Rossi, Paolo Durando, Corrado Cabona, Angelo Schenone, Diego Franciotta, Luana Benedetti
Summary: This article reports a case in which a patient developed GBS symptoms after COVID-19 infection, recovered after treatment, but experienced a recurrence of GBS after receiving the COVID-19 vaccine. Based on this case and previous observations, there may be a possible causal link between SARS-CoV-2 and GBS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Joshua Y. Kwon, Nader D. Daoud, Jana G. Hashash, Michael F. Picco, Francis A. Farraye
Summary: Heplisav-B, a 2-dose vaccine, is an effective vaccine for HBV in patients with IBD, with an overall efficacy of 78.3%. Patients on an immunomodulator and/or 2 or more immunosuppressants had decreased response rate to vaccination.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Craig Lammert, Sai N. Chalasani, Elizabeth J. Atkinson, Bryan M. McCauley, Konstantinos N. Lazaridis
Summary: The onset of autoimmune hepatitis (AIH) may result from the interaction of environmental triggers within a genetic background, with risk factors associated with AIH including urinary tract infections, oral contraceptive use, and immunization history.
LIVER INTERNATIONAL
(2021)