Article
Immunology
Matthias Girndt, Patricia Houser, Roberto Manllo-Karim, John E. Ervin, Chaim Charytan, Stephen Chow, Margarita Symonian-Silver, Lawrence Lehrner, Douglas Linfert, Douglas Shemin, Ann Michelsen, Fang Xie, Robert S. Janssen
Summary: This study evaluated the long-term immunogenicity and safety of HepB-CpG and HepB-Eng vaccines in patients with chronic kidney disease. The results showed that HepB-CpG induced a more persistent immune response and the safety profiles of both vaccines were similar.
Article
Transplantation
Harold J. Manley, Gideon Aweh, Jill Frament, Vladimir Ladik, Eduardo K. Lacson
Summary: This study compared the seroprotection rates of HepB and HepB-CpG vaccines in dialysis patients. The results showed that the seroprotection rate of HepB vaccine was significantly higher than that of HepB-CpG vaccine in initial vaccination. However, in repeat and booster vaccinations, the two vaccines had similar seroprotection rates. Patients who received multiple doses of HepB-CpG had higher seroprotection rates. The optimal dosing of HepB-CpG requires further study.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Biotechnology & Applied Microbiology
Matthias Girndt, Manfred Plueer, Frank Dellanna, Ann K. Michelsen, Joachim Beige, Kai Toussaint, Hubert J. Wehweck, Michael Koch, Syrus Hafezi Rachti, Justus Faust, Hans-Peter Bosselmann, Oliver Witzke, Robert S. Janssen
Summary: This study compared the immunogenicity and safety of different hepatitis B vaccines in patients receiving chronic hemodialysis. The study found that HepB-CpG induced higher levels of seroprotection and had a similar safety profile compared to other vaccines.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Immunology
Brenna Reilly-Evans, Beatrix Dudzik, David J. Costlow, Carlos Hartmann, Ann M. Khalsa, Christelle Kassis, Monika T. Zmarlicka
Summary: This study aims to evaluate and compare the seroprotection incidence of HepB-alum vs HepB-CpG in people with HIV (PWH). The results show that HepB-CpG has a significantly higher seroprotection rate compared to HepB-alum in PWH.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Immunology
Ahmed M. Awad, Adu Ntoso, Jeffrey J. Connaire, German T. Hernandez, Kiranjit Dhillon, Lisa Rich, Heather Henderson, Robert Lynn, Randall N. Hyer, Fang Xie, Kimberly Erby, Robert S. Janssen
Summary: The study demonstrated that HepB-CpG administered to patients receiving hemodialysis induced very high anti-HBs concentrations and seroprotection in a high proportion of recipients, with good tolerability.
Article
Immunology
Rebecca Khaimova, Briann Fischetti, Rebecca Cope, Leonard Berkowitz, Anjali Bakshi
Summary: This study evaluated the seroconversion rate following Heplisav-B (R) administration in PLWH with previous HBV vaccination failure. Results showed that Heplisav-B (R) was highly effective in achieving immunity to HBV in PLWH who failed non-adjuvanted recombinant vaccines.
Article
Gastroenterology & Hepatology
Joshua Y. Kwon, Nader D. Daoud, Jana G. Hashash, Michael F. Picco, Francis A. Farraye
Summary: Heplisav-B, a 2-dose vaccine, is an effective vaccine for HBV in patients with IBD, with an overall efficacy of 78.3%. Patients on an immunomodulator and/or 2 or more immunosuppressants had decreased response rate to vaccination.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Immunology
Guan-Huei Lee, Seng-Gee Lim
Summary: HEPLISAV-B, a hepatitis B vaccine with rHBsAg mixed with CpG motifs, has shown superior seroprotection rate and safety profile compared to existing vaccines, especially in populations with traditionally poor vaccine response.
EXPERT REVIEW OF VACCINES
(2021)
Review
Pharmacology & Pharmacy
Caroline R. Champion
Summary: The HepB-CpG vaccine induces higher and faster immune responses in adults, especially in those who may not respond well to traditional vaccines. However, studies have shown potential adverse effects such as acute myocardial infarction, herpes zoster, and death associated with HepB-CpG. Long-term safety and immune memory persistence of HepB-CpG still need further investigation.
ANNALS OF PHARMACOTHERAPY
(2021)
Article
Immunology
Bradley Ackerson, Lina S. Sy, Jeff Slezak, Lei Qian, Kristi Reynolds, Runxin Huang, Zendi Solano, William Towner, Sijia Qiu, Sarah R. Simmons, Steven J. Jacobsen, Katia J. Bruxvoort
Summary: This study compared the incidence of immune-mediated diseases, herpes zoster, and anaphylaxis between recipients of HepB-CpG and HepB-alum vaccines. The results showed that there were similar rates of most immune-mediated diseases and herpes zoster between the two groups, except for a slightly higher rate of rheumatoid arthritis. The incidence of anaphylaxis was very low. Therefore, HepB-CpG vaccine does not have significant safety concerns compared to HepB-alum vaccine.
Article
Immunology
Samuel R. Schnittman, Roland Zepf, Jennifer Cocohoba, David Sears
Summary: This retrospective study evaluated the seroprotection rates of Heplisav-B in people with HIV, showing favorable results compared to prior HBV vaccines. Further research on the effectiveness of repeat vaccination or higher dosing in nonresponders is needed.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2021)
Article
Biotechnology & Applied Microbiology
Anitta Ahonen, Ying Zhang, Tomas Marcek, Jessie Lumley, David R. Johnson, Dalya Guris, Marissa B. Wilck
Summary: Vaccination against hepatitis B provides long-term protection despite reductions in antibody levels. The study confirms the persistence of immune memory and long-term protection against HepB infection with the DTaP5-IPV-HepB-Hib vaccine.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Immunology
Robert Perrillo, Luis Felipe Garrido, Tsung-Wei Ma, Robert Rahimi, Barbara Lilly
Summary: An FDA approved immune adjuvanted HBV vaccine was tested in immunosuppressed individuals, and 70% of participants developed seroprotective anti-HBs by week 24.
Article
Gastroenterology & Hepatology
Waseem Amjad, Joseph Alukal, Talan Zhang, Anurag Maheshwari, Paul J. Thuluvath
Summary: The two-dose recombinant hepatitis B vaccine (Heplisav-B) was found to have better seroconversion rates than the three-dose vaccine (Engerix-B) in patients with chronic liver disease. Factors such as cirrhosis, COPD, and renal failure were associated with a lower likelihood of achieving immunogenicity. Patients who received Heplisav-B had a significantly higher likelihood of achieving immunity compared to those who received Engerix-B.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Immunology
Tatyana Kushner, Vivian Huang, Robert Janssen
Summary: This study evaluated the use of the HepB-CpG vaccine during pregnancy and its impact on pregnant women. The results showed that the HepB-CpG vaccine remained immunogenic after pregnancy and had similar pregnancy outcomes compared to women who received the HepB-alum vaccine before pregnancy.
Article
Immunology
Carolyn Yanavich, Hugo Perazzo, Fan Li, Nicole Tobin, David Lee, Sara Zabih, Michelle Morata, Cristiane Almeida, Valdilea G. Veloso, Beatriz Grinsztejn, Grace M. Aldrovandi
Summary: The relationship between the microbiome and liver disease in HIV-infection was examined by analyzing the rectal microbiome. The study found distinct microbial profiles in HIV mono-infected individuals with steatosis or fibrosis, some of which are similar to those associated with non-alcoholic fatty liver disease in HIV-negative populations. Further studies are needed to understand the role of the gut microbiota in the pathogenesis of liver disease in HIV-infected persons.
Review
Public, Environmental & Occupational Health
Rodolfo Castro, Marcelo Ribeiro-Alves, Catia Oliveira, Carmen Phang Romero, Hugo Perazzo, Mario Simjanoski, Flavio Kapciznki, Vicent Balanza-Martinez, Raquel B. De Boni
Summary: This study aimed to describe the most frequent lifestyle domains addressed by Digital Health Interventions (DHIs), the most frequent outcomes used to measure lifestyle changes, and the most frequent delivery methods for DHIs. The findings revealed that the most frequently evaluated domains were diet/nutrition and physical activity, and the most frequent delivery methods were smartphone apps and websites.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Gastroenterology & Hepatology
Flavia Fernandes, Juliana Piedade, Gabriela Freitas, Philippe Area, Ricardo Santos, Beatriz Grinsztejn, Valdilea Veloso, Gustavo Pereira, Hugo Perazzo
Summary: This study evaluated the agreement and accuracy of point shear-wave elastography (p-SWE) and 2D shear-wave elastography (2D-SWE) for liver fibrosis staging. The results showed satisfactory correlation between p-SWE and 2D-SWE with transient elastography (TE). p-SWE seemed to be more accurate than 2D-SWE in identifying patients with more advanced fibrosis.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Nathalia Beatriz Ramos de Sa, Milena Neira-Goulart, Marcelo Ribeiro-Alves, Hugo Perazzo, Kim Mattos Geraldo, Maria Pia Diniz Ribeiro, Sandra Wagner Cardoso, Beatriz Grinsztejn, Valdilea G. Veloso, Artur Capao, Marilda Mendonca Siqueira, Ohanna Cavalcanti de Lima Bezerra, Cristiana Couto Garcia, Larissa Rodrigues Gomes, Andressa da Silva Cazote, Dalziza Victalina de Almeida, Carmem Beatriz Wagner Giacoia-Gripp, Fernanda Heloise Cortes, Mariza Goncalves Morgado
Summary: This study investigated the impact of inflammasome genetic variants on the severity of COVID-19, revealing that certain genotypes in the NLRP3 and CARD8 genes are associated with protection against severe COVID-19 outcomes.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Infectious Diseases
Rodolfo Castro, Marcelo Ribeiro-Alves, Valdilea G. Veloso, Hugo Perazzo
Summary: The study aimed to describe the burden of hospitalizations due to hepatitis of unknown etiology in children/adolescents in Brazilian public hospitals. Significant differences in the incidence rates of hospitalizations for hepatitis of unknown etiology were found across different age groups, with some patients requiring liver transplantation and experiencing mortality during hospitalization.
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
(2022)
Letter
Gastroenterology & Hepatology
Hugo Perazzo, Mayara Secco Torres Silva, Carolina Coutinho, Eduardo Mesquita Peixoto, Simone da Costa Cruz Silva, Sandra W. W. Cardoso, Estevao Portela Nunes, Valdilea G. G. Veloso, Beatriz Grinsztejn, INI Fiocruz Monkeypox Study Grp
JOURNAL OF VIRAL HEPATITIS
(2023)
Article
Gastroenterology & Hepatology
Elio C. Castro Filho, Flavia F. Fernandes, Cristiane Villela-Nogueira, Eduardo Madeira, Fernando Barros, Rodrigo Luz, Gustavo Henrique Pereira, Hugo Perazzo
Summary: Liver stiffness measurement by transient elastography can accurately predict high-risk varices, and when combined with platelet count, can effectively rule out high-risk varices in patients with compensated advanced chronic liver disease. This method offers a high accuracy rate and low rate of missed diagnosis compared to gastrointestinal endoscopy.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Mariana Coelho, Flavia Fernandes, Sandra W. Cardoso, Juliana Piedade, Marcos Vinicius Torres da Silva, Ricardo Santos, Valdilea G. Veloso, Beatriz Grinsztejn, Gustavo Henrique Pereira, Hugo Perazzo
Summary: This study evaluated the accuracy and agreement between two-dimensional shear-wave elastography (2D-SWE) LOGIQ-S8 and transient elastography in Rio de Janeiro, Brazil. The results showed that 2D-SWE had good agreement with transient elastography and excellent accuracy in identifying individuals at high risk for compensated-advanced chronic liver disease (c-ACLD).
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Genetics & Heredity
Milena Neira-Goulart, Nathalia Beatriz Ramos de Sa, Marcelo Ribeiro-Alves, Hugo Perazzo, Kim Mattos Geraldo, Maria Pia Diniz Ribeiro, Sandra Wagner Cardoso, Beatriz Grinsztejn, Valdilea G. Veloso, Larissa Rodrigues Gomes, Andressa da Silva Cazote, Dalziza Victalina de Almeida, Carmem Beatriz Wagner Giacoia-Gripp, Fernanda Heloise Cortes, Mariza Goncalves Morgado
Summary: This study explores the impact of genetic variations in inflammasome genes on the clinical course of COVID-19. The findings suggest that certain genetic variations may influence the progression to critical outcomes, such as mechanical ventilation support or death, in individuals with COVID-19.
Review
Gastroenterology & Hepatology
Hugo Perazzo, Rodolfo Castro, Cristiane Villela-Nogueira, Marcos Torres, Samara Luiza Silva, Sandra W. Cardoso, Beatriz Grinsztejn, Valdilea G. Veloso
Summary: Data on the acceptability and usability of hepatitis C virus self-testing using oral fluid tests are scarce. However, this study found that HCVST with oral fluid tests was feasible and well-accepted. The correct sample collection rate and the proportion of people who performed HCVST without assistance were relatively high, indicating that oral fluid HCVST could be considered for HCV testing in key populations.
JOURNAL OF VIRAL HEPATITIS
(2023)
Article
Public, Environmental & Occupational Health
Hugo Perazzo, Juliana L. Goncalves, Sandra W. Cardoso, Beatriz Grinsztejn, Valdilea G. Veloso, Paula M. Luz
Summary: Daily adherence to antiretroviral therapy (ART) is crucial for improving the length and quality of life for people living with HIV (PLHIV). This study in Rio de Janeiro explored how socioeconomic status, alcohol misuse, and food insecurity impact ART adherence. The results showed that lower socioeconomic status and higher food insecurity were associated with poorer adherence, while alcohol misuse had a direct negative effect. Providing socioeconomic support and addressing alcohol-related issues can enhance HIV care.
Article
Gastroenterology & Hepatology
Juliana Piedade, Livia Guimaraes, Joana Duarte, Lorena Gouveia, Tamar Garfinkel, Zulane Veiga, Camila Alcantara, Hugo Perazzo, Flavia Fernandes, Gustavo Pereira
Summary: This study found that minimal hepatic encephalopathy (MHE) still exists in patients with cirrhosis after achieving a sustained virological response (SVR) to direct-acting agents (DAA) treatment for hepatitis C virus (HCV). SVR does not completely resolve MHE, and older age, hypertension, and hypoalbuminemia after SVR are independent predictors of MHE after SVR.
CLINICAL AND EXPERIMENTAL HEPATOLOGY
(2022)
Article
Health Care Sciences & Services
Lara E. Coelho, Paula M. Luz, Debora C. Pires, Emilia M. Jalil, Hugo Perazzo, Thiago S. Torres, Sandra W. Cardoso, Eduardo M. Peixoto, Sandro Nazer, Eduardo Massad, Mariangela F. Silveira, Fernando C. Barros, Ana T. R. Vasconcelos, Carlos A. M. Costa, Rodrigo T. Amancio, Daniel A. M. Villela, Tiago Pereira, Guilherme T. Goedert, Cleber V. B. D. Santos, Nadia C. P. Rodrigues, Beatriz Grinsztejn, Valdilea G. Veloso, Claudio J. Struchiner
Summary: A seroprevalence study conducted in a favela complex in Rio de Janeiro, Brazil revealed a higher than expected prevalence of anti-SARS-CoV-2 antibodies. The prevalence varied across different favelas, with young adults, those living in larger households, and individuals with poor adherence to social distancing and use of public transportation having the highest odds of having anti-S IgG antibodies.
LANCET REGIONAL HEALTH-AMERICAS
(2022)
Article
Health Care Sciences & Services
Hugo Perazzo, Sandra W. Cardoso, Maria Pia D. Ribeiro, Rodrigo Moreira, Lara E. Coelho, Emilia M. Jalil, Andre Miguel Japiassu, Elias Pimentel Gouvea, Estevao Portela Nunes, Hugo Boechat Andrade, Luciano Barros Gouvea, Marcel Treptow Ferreira, Pedro Mendes de Azambuja Rodrigues, Ronaldo Moreira, Kim Geraldo, Lucilene Freitas, Vinicius V. Pacheco, Esau Custodio Joao, Trevon Fuller, Veronica Diniz Rocha, Ceuci de Lima Xavier Nunes, Tamara Newman Lobato Souza, Ana Luiza Castro Conde Toscano, Alexandre Vargas Schwarzbold, Helena Carolina Noal, Gustavo de Araujo Pinto, Paula Macedo de Oliveira Lemos, Carla Santos, Fernanda Carvalho de Queiroz Mello, Valdilea G. Veloso, Beatriz Grinsztejn
Summary: This study evaluated the in-hospital mortality and incidence of rehospitalization or death after hospital discharge in a Brazilian multicenter cohort of COVID-19 patients. The study found high in-hospital mortality rates due to COVID-19 and elderly patients remained at high risk of rehospitalization and death after hospital discharge.
LANCET REGIONAL HEALTH-AMERICAS
(2022)
