Systems biology of lupus: Mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance, and selecting targets for treatment

PP2A Dephosphorylates Elf-1 and Determines the Expression of CD3  and FcR  in Human Systemic Lupus Erythematosus T Cells

(2014) Y.-T. Juang et al.   JOURNAL OF IMMUNOLOGY

CD28 Costimulation Is Essential for Human T Regulatory Expansion and Function

(2014) T. N. Golovina et al.   JOURNAL OF IMMUNOLOGY

Activated Renal Macrophages Are Markers of Disease Onset and Disease Remission in Lupus Nephritis

(2014) L. Schiffer et al.   JOURNAL OF IMMUNOLOGY

Differential Expression and Molecular Associations of Syk in Systemic Lupus Erythematosus T Cells

(2014) S. Krishnan et al.   JOURNAL OF IMMUNOLOGY

Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys

(2014) J. C. Crispin et al.   JOURNAL OF IMMUNOLOGY

Methylation Status of CpG Islands Flanking a cAMP Response Element Motif on the Protein Phosphatase 2Ac  Promoter Determines CREB Binding and Activity

(2014) K. Sunahori et al.   JOURNAL OF IMMUNOLOGY

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

Accelerated Pathological and Clinical Nephritis in Systemic Lupus Erythematosus-Prone New Zealand Mixed 2328 Mice Doubly Deficient in TNF Receptor 1 and TNF Receptor 2 via a Th17-Associated Pathway

(2009) N. Jacob et al.   JOURNAL OF IMMUNOLOGY

PTPN22 Deficiency Cooperates with the CD45 E613R Allele to Break Tolerance on a Non-Autoimmune Background

(2009) J. Zikherman et al.   JOURNAL OF IMMUNOLOGY

Activation of Mammalian Target of Rapamycin Controls the Loss of TCR  in Lupus T Cells through HRES-1/Rab4-Regulated Lysosomal Degradation

(2009) D. R. Fernandez et al.   JOURNAL OF IMMUNOLOGY

Autophagy Is Essential for Mitochondrial Clearance in Mature T Lymphocytes

(2009) H. H. Pua et al.   JOURNAL OF IMMUNOLOGY

Rituximab and mycophenolate mofetil for relapsing proliferative lupus nephritis: a long-term prospective study

(2009) John N. Boletis et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Tuberous Sclerosis Complex Regulates Trafficking of Glucose Transporters and Glucose Uptake

(2008) Xiuyun Jiang et al.   AMERICAN JOURNAL OF PATHOLOGY

Variability in the biological response to anti-CD20 B cell depletion in systemic lupus erythaematosus

(2008) D Albert et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-DNA Ig peptides promote Treg cell activity in systemic lupus erythematosus patients

(2008) Bevra H. Hahn et al.   ARTHRITIS AND RHEUMATISM

Haplotypes of the HRES-1 endogenous retrovirus are associated with development and disease manifestations of systemic lupus erythematosus

(2008) Rudolf Pullmann et al.   ARTHRITIS AND RHEUMATISM

An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus

(2008) Frances Rena Bahjat et al.   ARTHRITIS AND RHEUMATISM

Metabolic control of T cell activation and death in SLE

(2008) David Fernandez et al.   AUTOIMMUNITY REVIEWS

Rho GTPase-mediated pathways in mature CD4+ T cells

(2008) Alessandra B. Pernis   AUTOIMMUNITY REVIEWS

Altered B-cell signaling in lupus

(2008) Kui Liu et al.   AUTOIMMUNITY REVIEWS

Altered B cell receptor signaling in human systemic lupus erythematosus

(2008) Scott A. Jenks et al.   AUTOIMMUNITY REVIEWS

Oxidative stress, DNA methylation and carcinogenesis

(2008) Rodrigo Franco et al.   CANCER LETTERS

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE

(2008) Matilda W. Nicholas et al.   CLINICAL IMMUNOLOGY

A Modular Analysis Framework for Blood Genomics Studies: Application to Systemic Lupus Erythematosus

(2008) Damien Chaussabel et al.   IMMUNITY

The Lupus-Related Lmb3 Locus Contains a Disease-Suppressing Coronin-1A Gene Mutation

(2008) M. Katarina Haraldsson et al.   IMMUNITY

Critical roles of the PI3K/Akt signaling pathway in T cell development

(2008) Marisa M. Juntilla et al.   IMMUNOLOGY LETTERS

B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency

(2008) Vikas A. Gupta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells

(2008) Sokol Haxhinasto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE

(2008) Vilma Urbonaviciute et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutations inSTAT3andIL12RB1impair the development of human IL-17–producing T cells

(2008) Ludovic de Beaucoudrey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1

(2008) Y. Gwack et al.   MOLECULAR AND CELLULAR BIOLOGY

B-Cell Depletion for Autoimmune Thrombocytopenia and Autoimmune Hemolytic Anemia in Pediatric Systemic Lupus Erythematosus

(2008) S. Kumar et al.   PEDIATRICS

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosus

(2008) Richard Furie et al.   ARTHRITIS RESEARCH & THERAPY