Metabolic reprogramming and inflammation act in concert to control vascular remodeling in hypoxic pulmonary hypertension

The role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes

(2015) Steven C. Pugliese et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by lipopolysaccharide in colorectal cancer

(2015) Peng Yang et al.   CELLULAR SIGNALLING

Inflammatory and Immune Responses in the Arterial Media

(2015) G. Tellides et al.   CIRCULATION RESEARCH

Macrophages and cancer: from mechanisms to therapeutic implications

(2015) Renato Ostuni et al.   TRENDS IN IMMUNOLOGY

Targeting T cell metabolism for therapy

(2015) David O'Sullivan et al.   TRENDS IN IMMUNOLOGY

Pyruvate kinase M2 facilitates colon cancer cell migration via the modulation of STAT3 signalling

(2014) Peng Yang et al.   CELLULAR SIGNALLING

The Metabolic Theory of Pulmonary Arterial Hypertension

(2014) Roxane Paulin et al.   CIRCULATION RESEARCH

Characterization of a Resident Population of Adventitial Macrophage Progenitor Cells in Postnatal Vasculature

(2014) Peter J. Psaltis et al.   CIRCULATION RESEARCH

Mitochondria: Roles in pulmonary hypertension

(2014) Véronique Freund-Michel et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Fibroblast heterogeneity in the cancer wound

(2014) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adventitial Fibroblasts Induce a Distinct Proinflammatory/Profibrotic Macrophage Phenotype in Pulmonary Hypertension

(2014) Karim C. El Kasmi et al.   JOURNAL OF IMMUNOLOGY

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

(2014) Stanley Ching-Cheng Huang et al.   NATURE IMMUNOLOGY

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth

(2014) Ubaldo E. Martinez-Outschoorn et al.   SEMINARS IN CANCER BIOLOGY

Metabolism and Bioenergetics in the Right Ventricle and Pulmonary Vasculature in Pulmonary Hypertension

(2014) Stephen L. Archer et al.   Pulmonary Circulation

Aortic Remodeling After Transverse Aortic Constriction in Mice Is Attenuated With AT 1 Receptor Blockade

(2013) Shao-Qing Kuang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Warburg effect then and now: From cancer to inflammatory diseases

(2013) Eva M. Palsson-McDermott et al.   BIOESSAYS

Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner

(2013) T. A. Mace et al.   CANCER RESEARCH

Sevoflurane Preconditioning Attenuates Myocardial Ischemia/Reperfusion Injury via Caveolin-3-Dependent Cyclooxygenase-2 Inhibition

(2013) J. Zhao et al.   CIRCULATION

Uncoupling Protein 2 Deficiency Mimics the Effects of Hypoxia and Endoplasmic Reticulum Stress on Mitochondria and Triggers Pseudohypoxic Pulmonary Vascular Remodeling and Pulmonary Hypertension

(2013) Peter Dromparis et al.   CIRCULATION RESEARCH

MicroRNA-124 Controls the Proliferative, Migratory, and Inflammatory Phenotype of Pulmonary Vascular Fibroblasts

(2013) Daren Wang et al.   CIRCULATION RESEARCH

Clinical Profile and Underdiagnosis of Pulmonary Hypertension in US Veteran Patients

(2013) Bradley A. Maron et al.   Circulation-Heart Failure

Proteome Profiling of Cancer-Associated Fibroblasts Identifies Novel Proinflammatory Signatures and Prognostic Markers for Colorectal Cancer

(2013) S. Torres et al.   CLINICAL CANCER RESEARCH

Metabolic dysfunction in pulmonary hypertension: the expanding relevance of the Warburg effect

(2013) Katherine A. Cottrill et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Targeting lactate metabolism for cancer therapeutics

(2013) Joanne R. Doherty et al.   JOURNAL OF CLINICAL INVESTIGATION

Pulmonary Hypertension in Chronic Lung Diseases

(2013) Werner Seeger et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Relevant Issues in the Pathology and Pathobiology of Pulmonary Hypertension

(2013) Rubin M. Tuder et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Updated Clinical Classification of Pulmonary Hypertension

(2013) Gerald Simonneau et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Metabolic Alterations in Lung Cancer–Associated Fibroblasts Correlated with Increased Glycolytic Metabolism of the Tumor

(2013) Virendra K. Chaudhri et al.   MOLECULAR CANCER RESEARCH

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1

(2013) P Wang et al.   ONCOGENE

Role of Arginase 1 from Myeloid Cells in Th2-Dominated Lung Inflammation

(2013) Luke Barron et al.   PLoS One

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Osteopontin is an endogenous modulator of the constitutively activated phenotype of pulmonary adventitial fibroblasts in hypoxic pulmonary hypertension

(2012) Adil Anwar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lung18F-Fluorodeoxyglucose Positron Emission Tomography for Diagnosis and Monitoring of Pulmonary Arterial Hypertension

(2012) Glenn Marsboom et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Immune and Inflammatory Cell Involvement in the Pathology of Idiopathic Pulmonary Arterial Hypertension

(2012) Rajkumar Savai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Host Responses in Tissue Repair and Fibrosis

(2012) Jeremy S. Duffield et al.   Annual Review of Pathology-Mechanisms of Disease

The Adventitia: Essential Regulator of Vascular Wall Structure and Function

(2012) Kurt R. Stenmark et al.   Annual Review of Physiology

Mitochondria in Vascular Health and Disease

(2012) Peter Dromparis et al.   Annual Review of Physiology

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells

(2012) B. Everts et al.   BLOOD

Hypoxia induces unique proliferative response in adventitial fibroblasts by activating PDGFβ receptor-JNK1 signalling

(2012) Evgeniy Panzhinskiy et al.   CARDIOVASCULAR RESEARCH

Sustained Generation of Nitric Oxide and Control of Mycobacterial Infection Requires Argininosuccinate Synthase 1

(2012) Joseph E. Qualls et al.   Cell Host & Microbe

Histone Deacetylation Inhibition in Pulmonary Hypertension

(2012) Lan Zhao et al.   CIRCULATION

Selective Class I Histone Deacetylase Inhibition Suppresses Hypoxia-Induced Cardiopulmonary Remodeling Through an Antiproliferative Mechanism

(2012) Maria A. Cavasin et al.   CIRCULATION RESEARCH

Into the matrix

(2012) Pitchumani Sivakumar et al.   CURRENT OPINION IN PULMONARY MEDICINE

Pulmonary arterial lesions in explanted lungs after transplantation correlate with severity of pulmonary hypertension in chronic obstructive pulmonary disease

(2012) Jørn Carlsen et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

From sentinel cells to inflammatory culprits: cancer-associated fibroblasts in tumour-related inflammation

(2012) Charlotte Servais et al.   JOURNAL OF PATHOLOGY

The role of cardiac fibroblasts in the transition from inflammation to fibrosis following myocardial infarction

(2012) Frans A. van Nieuwenhoven et al.   VASCULAR PHARMACOLOGY

The role of the myofibroblast in tumor stroma remodeling

(2012) Marcela Otranto et al.   Cell Adhesion & Migration

Targeting the Adventitial Microenvironment in Pulmonary Hypertension: A Potential Approach to Therapy that Considers Epigenetic Change

(2012) Kurt R. Stenmark et al.   Pulmonary Circulation

Targeting Energetic Metabolism

(2011) Rubin M. Tuder et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Alternative Macrophage Activation and Metabolism

(2011) Justin I. Odegaard et al.   Annual Review of Pathology-Mechanisms of Disease

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

Emergence of Fibroblasts with a Proinflammatory Epigenetically Altered Phenotype in Severe Hypoxic Pulmonary Hypertension

(2011) M. Li et al.   JOURNAL OF IMMUNOLOGY

Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth

(2011) Lei Lv et al.   MOLECULAR CELL

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Inflammatory Alterations of the Extracellular Matrix in the Tumor Microenvironment

(2011) Junko Iijima et al.   Cancers

Hypoxia Inducible-Factor1α Regulates the Metabolic Shift of Pulmonary Hypertensive Endothelial Cells

(2010) Iwona Fijalkowska et al.   AMERICAN JOURNAL OF PATHOLOGY

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Characterization of Phosphoglycerate Kinase-1 Expression of Stromal Cells Derived from Tumor Microenvironment in Prostate Cancer Progression

(2010) J. Wang et al.   CANCER RESEARCH

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Activation of fibroblasts in cancer stroma

(2010) Kati Räsänen et al.   EXPERIMENTAL CELL RESEARCH

Metabolism strikes back: metabolic flux regulates cell signaling

(2010) C. M. Metallo et al.   GENES & DEVELOPMENT

CXCR3-dependent accumulation and activation of perivascular macrophages is necessary for homeostatic arterial remodeling to hemodynamic stresses

(2010) Jing Zhou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure

(2010) Lin Piao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Categorization and impact of pulmonary hypertension in patients with advanced COPD

(2010) Michael J. Cuttica et al.   RESPIRATORY MEDICINE

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Fatty Acid Oxidation and Malonyl-CoA Decarboxylase in the Vascular Remodeling of Pulmonary Hypertension

(2010) G. Sutendra et al.   Science Translational Medicine

Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment

(2009) Danielle L. Burke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure

(2009) Kurt R. Stenmark et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma

(2009) Mayuko Furuta et al.   CARCINOGENESIS

Inflammation, Growth Factors, and Pulmonary Vascular Remodeling

(2009) Paul M. Hassoun et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth

(2009) M. Augsten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

(2009) John T. Pesce et al.   PLoS Pathogens

Hypoxia exposure induces the emergence of fibroblasts lacking replication repressor signals of PKC  in the pulmonary artery adventitia

(2008) M. Das et al.   CARDIOVASCULAR RESEARCH

Liver Myofibroblasts Regulate Infiltration and Positioning of Lymphocytes in Human Liver

(2008) Andrew P. Holt et al.   GASTROENTEROLOGY

MyD88-dependent, superoxide-initiated inflammation is necessary for flow-mediated inward remodeling of conduit arteries

(2008) Paul C.Y. Tang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Fibroblasts as novel therapeutic targets in chronic inflammation

(2007) S J Flavell et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY