Article
Chemistry, Multidisciplinary
Ruoqiong Cao, Afsal Kolloli, Ranjeet Kumar, James Owens, Kayvan Sasaninia, Charles Vaughn, Mohkam Singh, Edward Truong, Nala Kachour, Abrianna Beever, Wael Khamas, Selvakumar Subbian, Vishwanath Venketaraman
Summary: In an in vivo mouse model of active M. tb infection, diethyl maleate (DEM)-induced glutathione (GSH) deficiency led to increased oxidative stress, impaired granuloma response, and increased M. tb survival. These findings provide insights into how GSH deficiency can interfere with the control of M. tb infection.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Analytical
Shuai Huang, Haiyang Wang, Xinxin Liu, Lanxiang Liu, Dan Liu, Xiaozhe Zhang, Lihua Zhang, Peng Xie, Yukui Zhang
Summary: This study presents a mass spectrometry imaging (MSI) approach for mapping thiol compounds on brain tissue sections. The developed method allows for selective and rapid detection of glutathione (GSH) synthesis and metabolic pathway related metabolites. The method also enables quantitative detection of exogenous N-acetylcysteine tissue sections, with a detection limit of 0.05 ng. The capabilities of the method are demonstrated through mapping thiol compounds on brain tissue from a chronic social defeat stress (CSDS) depression model mice.
ANALYTICA CHIMICA ACTA
(2023)
Article
Multidisciplinary Sciences
K. G. Aghila Rani, Nelson C. Soares, Betul Rahman, Hamza M. Al-Hroub, Mohammad H. Semreen, Sausan Al Kawas
Summary: The study investigates the biochemical and pathophysiological changes caused by medwakh smoking and examines the salivary metabolomics profile of medwakh smokers. Analysis of saliva samples reveals 37 uniquely and differentially abundant metabolites and 20 differentially altered metabolic pathways in medwakh smokers. The study highlights the association of altered redox homeostasis, metabolic pathways, antioxidant system, and CRP levels with the distinctive saliva metabolomics profile in medwakh smokers. Further research is needed to explore the diagnostic utility of these altered metabolites in larger cohorts.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Nassima Bekaddour, Nikaia Smith, Benoit Beitz, Alba Llibre, Tom Dott, Anne Baudry, Anne-Sophie Korganow, Sebastien Nisole, Richard Mouy, Sylvain Breton, Brigitte Bader-Meunier, Darragh Duffy, Benjamin Terrier, Benoit Schneider, Pierre Quartier, Mathieu P. Rodero, Jean-Philippe Herbeuval
Summary: This study investigated the effects of targeting the CXCR4 receptor as an alternative strategy for treating rheumatoid arthritis (RA). The results showed that CXCR4 targeting with CB effectively inhibited the production of key inflammatory cytokines by monocytes and led to a reduction in disease progression in a mouse model of collagen-induce arthritis. These findings suggest that targeting CXCR4 with CB could be a promising therapeutic option for chronic and viral-induced inflammatory diseases, including RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Food Science & Technology
Filio Petsini, Agathi Ntzouvani, Maria Detopoulou, Vasiliki D. Papakonstantinou, Nick Kalogeropoulos, Elizabeth Fragopoulou, Tzortzis Nomikos, Meropi D. Kontogianni, Smaragdi Antonopoulou
Summary: Eating farmed fish fed with an olive-pomace enriched diet affects PAF metabolism and markers of inflammation and oxidative stress, but has similar effects to conventionally fed farmed fish.
Article
Medicine, Research & Experimental
Acharya Balkrishna, Vivek Gohel, Nishit Pathak, Rani Singh, Meenu Tomer, Malini Rawat, Rishabh Dev, Anurag Varshney
Summary: Atherosclerosis is a major pathological process of cardiovascular diseases, which can begin early in life and remain silent before symptoms manifest. The formation of foamy macrophages due to dysregulated lipid metabolism is important in atherosclerotic plaque development. Current pharmacotherapy for atherosclerosis is limited, but "Lipidom" has shown potential with its antioxidant, lipid-lowering, and anti-inflammatory properties. This study aimed to characterize the pharmacological effects of "Lipidom" using experimental models.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Francesco Galli, Giada Marcantonini, Daniela Giustarini, Maria Cristina Albertini, Anna Migni, Linda Zatini, Antimo Gioiello, Ranieri Rossi, Desiree Bartolini
Summary: SARS-CoV-2 infection causes severe respiratory distress syndrome and inflammatory complications, with increased severity in older patients and those with comorbidities. The virus may take advantage of age-related abnormalities in cellular redox balance. Changes in cellular metabolism and Cys/GSH fluxes, as well as ER stress pathway activation, are associated with the pro-oxidant effects of SARS-CoV-2 infection. Antiviral drugs and cytoprotective agents like N-acetyl cysteine may help limit the cytopathic effects of the virus and restore tissue homeostasis post-infection.
Article
Food Science & Technology
Ganwarige Sumali N. Fernando, Natalia N. N. Sergeeva, Nikolaos Vagkidis, Victor Chechik, Lisa J. J. Marshall, Christine Boesch
Summary: This study compares the effects of four main betalains and finds that all of them have anti-inflammatory properties, but only betacyanins have radical scavenging capacities, indicating potential different responses under oxidative stress conditions.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Chemistry, Medicinal
Ruixia Lan, Qingqing Chang, Linlin Wei, Zhihui Zhao
Summary: The results indicated that COS could maintain intestinal integrity under oxidative stress by modulating the intestinal oxidative status and release of inflammatory cytokines.
Article
Nutrition & Dietetics
Agnieszka Zembron-Lacny, Edyta Wawrzyniak-Gramacka, Anna Ksiazek, Aleksandra Zagrodna, Wieslaw Kopec, Malgorzata Slowinska-Lisowska
Summary: Intense physical exercise leads to increased production of reactive oxygen and nitrogen species. This study examined the effects of dipeptide intake combined with exercise on the oxi-antioxidant response. The results showed that dipeptide intake led to a significant increase in the NO/H2O2 ratio after exercise, indicating enhanced antioxidant status. Additionally, dipeptides were found to reduce C-reactive protein levels, suggesting their anti-inflammatory properties. These findings suggest that dipeptides have potential in reducing oxidative stress and inflammation in physically active individuals.
Article
Biotechnology & Applied Microbiology
H. S. Rohith, Prakash Motiram Halami
Summary: The study evaluates the effects of a combination of Bacillus licheniformis and Bifidobacterium breve on the gene expression and immune response of HT-29 cells. The combination of these probiotic bacteria showed anti-inflammatory activity and improved the gastrointestinal environment, making it a promising treatment for intestinal disorders.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Review
Environmental Sciences
Marco Panizzolo, Vitor Hugo Martins, Federica Ghelli, Giulia Squillacioti, Valeria Bellisario, Giacomo Garzaro, Davide Bosio, Nicoletta Colombi, Roberto Bono, Enrico Bergamaschi
Summary: The increased awareness of health effects from micro- and nanoplastics pollution has led to a significant amount of studies. International efforts are being made to understand the hazard of these pollutants. However, there is a limited number of studies directly measuring human exposure to micro- and nanoplastics and its impact on health. This review provides an overview of the current research on biomarkers of oxidative stress, inflammation, and genotoxicity related to exposure, using various models. Both in vitro and in vivo models suggest that increased oxidative stress and inflammation are the main mechanisms leading to adverse effects.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cell Biology
Alireza Bastin, Asie Sadeghi, Mohammad Hadi Nematollahi, Moslem Abolhassani, Abbas Mohammadi, Hamed Akbari
Summary: Malvidin inhibits inflammation and oxidative stress in LPS-induced THP-1 cells, significantly affecting cytokine secretion, reducing oxidative stress levels, and increasing antioxidant activity.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Redouane Rebai, Luc Jasmin, Abdennacer Boudah
Summary: The study showed that treatment with the antidepressant agomelatine reversed the inflammatory and oxidative stress effects caused by a high fat diet in obese rats, leading to improved anxiety and depressive behaviors. Agomelatine decreased levels of proinflammatory cytokines and oxidative stress markers, restored BDNF levels, and increased antioxidant enzyme activity in the brain.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Yasmin Bangash, Ammara Saleem, Muhammad Furqan Akhtar, Fareeha Anwar, Bushra Akhtar, Ali Sharif, Muhammad Imran Khan, Aslam Khan
Summary: This study found that PTN can alleviate the symptoms of atopic dermatitis by reducing inflammation, oxidative damage, and inflammatory cytokine expression in the skin of diseased animals. Therefore, PTN may be an effective drug for treating atopic dermatitis and other inflammatory skin disorders.
INFLAMMOPHARMACOLOGY
(2023)
Article
Biology
Olga Papagianni, Thomas Loukas, Athanasios Magkoutis, Maria Kagoudi, Dimitrios Skalkos, Dimitrios Kafetzopoulos, Charalampia Dimou, Haralabos C. Karantonis, Antonios E. Koutelidakis
Summary: Mediterranean functional foods and their by-products may have beneficial effects on hyperlipidemia, hyperglycemia, and oxidative stress modulation, contributing to the prevention of chronic diseases. This study investigated the postprandial responses of metabolic biomarkers in healthy volunteers after consuming an innovative mayonnaise-based appetizer enhanced with olive paste. The results showed that consumption of the enhanced appetizer led to decreased total serum cholesterol and glucose levels, as well as an increase in plasma total antioxidant activity.
Article
Green & Sustainable Science & Technology
Afroditi Michalaki, Elpida Niki Iliopoulou, Angeliki Douvika, Constantina Nasopoulou, Dimitris Skalkos, Haralabos Christos Karantonis
Summary: This research examines the skin bioactivities of two grape skin extracts from Samos white and red grapes. The extracts showed high levels of total phenolics, antiradical activity, resistance to plasma oxidation, and antithrombotic activity. Different phenolic compounds were identified in each extract. This research adds value to these grape by-products and offers potential benefits to the food industry and public health.
Article
Chemistry, Multidisciplinary
Afroditi Michalaki, Haralabos C. C. Karantonis, Anastasia S. S. Kritikou, Nikolaos S. S. Thomaidis, Marilena E. E. Dasenaki
Summary: This study aimed to establish an extraction method for the most abundant phenolic compounds in Petroselinum crispum leaves. The extraction conditions were optimized using response surface methodology and ultrasound-assisted extraction. The phenolic compounds in the extracts were accurately quantified using HPLC-PDA, and their identification was performed using UPLC-Q-TOF MS. The extracts obtained under the optimal conditions contained a sufficient amount of phenolic compounds for use in the production of functional foods.
APPLIED SCIENCES-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Smaragdi Antonopoulou, Constantinos A. Demopoulos
Summary: Atherosclerosis is a progressive vascular disease caused by inflammation and oxidation. The Mediterranean diet, especially olive oil, has been recognized as a healthy dietary pattern. This review focuses on the effects of olive oil microconstituents in atherosclerosis, particularly their inhibitory activity against Platelet-Activating Factor (PAF) actions. The anti-atherogenic effect of olive oil is attributed to the synergistic action of its microconstituents, including polar lipids, polyphenols, and alpha-tocopherol. Daily moderate intake of olive oil in a balanced diet is significant for healthy adults.
Article
Pharmacology & Pharmacy
Paraskevi Detopoulou, Sophia Letsiou, Tzortzis Nomikos, Alexandros Karagiannis, Spiros A. Pergantis, Christos Pitsavos, Demosthenes B. Panagiotakos, Smaragdi Antonopoulou
Summary: This study investigated the relationship between selenium distribution in plasma and cardiovascular disease. The results showed an inconclusive relationship between selenium and cardiovascular disease, especially in terms of different selenospecies. Total selenium in selenoproteins was positively associated with a 10-year relative risk of cardiovascular disease. Individuals with high selenium but low glutathione peroxidase 3 had a higher cardiovascular risk.
CURRENT VASCULAR PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Paraskevi Detopoulou, Evangelia Damigou, Smaragdi Antonopoulou, Elizabeth Fragopoulou, Christina Chysohoou, Christos Pitsavos, Demosthenes Panagiotakos
Summary: This study assessed the relationship between Food Compass Score (FCS) and inflammatory and lipid markers in cardiovascular disease-free volunteers. The results showed that FCS was inversely correlated with CRP, Amyloid A, and homocysteine. This suggests that a diet high in FCS may have a protective effect against inflammation.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Evangelia Damigou, Paraskevi Detopoulou, Smaragdi Antonopoulou, Christina Chrysohoou, Fotios Barkas, Elpiniki Vlachopoulou, Christina Vafia, Costas Tsioufis, Evangelos Liberopoulos, Petros P. Sfikakis, Christos Pitsavos, Demosthenes Panagiotakos
Summary: Food Compass Score (FCS), a useful tool for assessing overall diet quality, was shown to be useful in identifying potential cardiovascular disease candidates in a long-term period, even in populations with good background dietary habits, such as those following a Mediterranean diet.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2023)
Article
Chemistry, Medicinal
Ioannis Panagiotakopoulos, Haralabos C. Karantonis, Ioannis Geraris Kartelias, Constantina Nasopoulou
Summary: The study explored the use of vegetable oils as environmentally friendly extraction solvents to recover astaxanthin from shrimp by-products. Utilizing olive oil as the extracting medium with specific extraction conditions resulted in efficient extraction of astaxanthin, and the encapsulation efficiency with coacervates showed potential for application in food industries.
Article
Chemistry, Multidisciplinary
Olga Papagianni, Chrysoula Kaloteraki, Aikaterini Kandyliari, Panagiota Potsaki, Panorea Bousdouni, Kalliopi Almpounioti, Camille Ouzaid, Anna-Kyriaki Mavrou, Vasiliki Panteli, Thomas Loukas, Athanasios Magkoutis, Dimitrios Skalkos, Haralabos C. C. Karantonis, Antonios E. E. Koutelidakis
Summary: Olive oil, the main source of polyphenols in the Mediterranean diet, has been found to reduce cardiometabolic risk factors. However, the consumption of refined olive oil has led to a decrease in polyphenol intake. This study investigated the effects of enhancing refined olive oil with orange peel extract on postprandial lipemia, glycemia, and oxidative stress in individuals at risk of cardiometabolic problems. The results showed a significant reduction in LDL-cholesterol after consuming the functional olive oil, indicating its potential to modulate cardiometabolic risk factors.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Panagiotis Achilladelis, Andreas Stergios Petsas, Haralabos Christos Karantonis
Summary: This study assessed the impact of fortifying tahini with red grape pomace extract and aquafaba on bioactivity. In vitro experiments showed that fortified tahini had increased polyphenolic content, total flavonoid content, antioxidant capacity, and antiplatelet activity compared to plain tahini. The results suggest that fortifying tahini with these bioactive compounds can reduce waste and improve its nutritional value, potentially contributing to the prevention of chronic diseases.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Chrysoula Kaloteraki, Panoraia Bousdouni, Kalliopi Almpounioti, Camille Ouzaid, Olga Papagianni, Fotini Sfikti, Elina Dimitsa, Dimitra Tsami, Anastasia Grammatiki Sarivasilleiou, Haralabos C. Karantonis, Dimitrios Skalkos, Aikaterini Kandyliari, Antonios E. Koutelidakis
Summary: Nowadays, there is a growing demand for healthy and sustainable food products, leading to the exploration of innovative food technologies such as fortification with bioactive compounds sourced from herbs or by-products. This study focused on fortifying refined olive oils with natural bioactive compounds and by-products through different methods. The results showed that the temperature, sample concentration, and maceration time were crucial factors in the fortification process. In vitro digestion process demonstrated the bioavailability of the fortified olive oils, with certain compounds showing higher antioxidant and phenolic predicted bioavailability indices compared to the control oil. This study highlights the potential of fortifying refined olive oils with natural herbs or by-products to enhance their nutritional value.
APPLIED SCIENCES-BASEL
(2023)
Article
Food Science & Technology
Ioannis Geraris Kartelias, Haralabos Christos Karantonis, Efstathios Giaouris, Ioannis Panagiotakopoulos, Constantina Nasopoulou
Summary: This study successfully converted Olympus Mountain tea sweetened with honey into a novel beverage with enhanced functional properties through kombucha fermentation. The fermentation process increased the content of vitamins and antioxidant activity, and exhibited inhibitory effects on various enzymes.
Article
Nutrition & Dietetics
Paraskevi Detopoulou, Elizabeth Fragopoulou, Tzortzis Nomikos, Smaragdi Antonopoulou
Summary: The study found that there is an association between PA and PAF levels as well as Lp-PLA(2) activity, and this association is influenced by gender, indicating the involvement of PAF in cell membrane impairment. Additionally, PA is positively correlated with DAC, suggesting a protective effect of antioxidants on cellular health.
FRONTIERS IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
Smaragdi Antonopoulou, Maria Detopoulou, Elizabeth Fragopoulou, Tzortzis Nomikos, Nastasia Mikellidi, Mary Yannakoulia, Adamantini Kyriacou, Evdokia Mitsou, Demosthenes Panagiotakos, Costas Anastasiou
Summary: This study investigated the effects of OOPLE-enriched low-fat yogurt on metabolic profile, platelet aggregation, and inflammation markers in healthy individuals. The enriched yogurt intake resulted in reduced IL-10 levels and platelet sensitivity against PAF, with no impact on energy intake, body weight, glucose, and lipid metabolism. Lower IL-6 levels were observed after 4 weeks of enriched yogurt intake compared to plain yogurt.
HUMAN NUTRITION & METABOLISM
(2022)
