Article
Biochemistry & Molecular Biology
Yuxia Li, Qun Zhao, Yuan Cao, Jigang Si, Jing Li, Kai Cao, Xiaoming Pang
Summary: The research found that probucol reduces homocysteine-induced CRP expression, inhibits oxidative stress in the inflammatory process, and thereby decreases CRP levels in both the vessel wall and circulation.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Geriatrics & Gerontology
Betty Manrique-Espinoza, Rosa Palazuelos-Gonzalez, Victoria Pando-Robles, Oscar Rosas-Carrasco, Aaron Salinas-Rodriguez
Summary: This study analyzed the association between tumor necrosis factor-alpha (TNF-alpha), Interleukin-10 (IL-10), C-reactive protein (CRP) and physical performance in a sample of older adults in rural Mexico. The results showed a significant association between higher CRP levels and low physical performance, while IL-10 and TNF-alpha did not show a significant association.
Article
Nutrition & Dietetics
Nicola Veronese, Damiano Pizzol, Lee Smith, Ligia J. Dominguez, Mario Barbagallo
Summary: Magnesium supplementation may significantly reduce human inflammatory markers, particularly serum CRP and NO levels.
Review
Food Science & Technology
Shanshan Hou, Zezhong Tian, Dan Zhao, Ying Liang, Suming Dai, Qiuhua Ji, Zhiying Fan, Zhihao Liu, Meitong Liu, Yan Yang
Summary: This meta-analysis examines the efficacy and optimal dose of CoQ10 supplementation on inflammatory indicators. The results show that CoQ10 can significantly reduce the levels of circulating CRP, IL-6, and TNF-a, and increase the concentration of circulating CoQ10. Daily supplementation of 300-400 mg CoQ10 is recommended for superior inhibition of inflammatory factors.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Mitra Hariri, Bahareh Amirkalali, Hamid Reza Baradaran, Ali Gholami
Summary: This study conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effect of parenteral selenium on inflammatory markers. The results revealed that parenteral selenium supplementation significantly reduced serum IL-6 levels but did not have a significant effect on CRP levels.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Oncology
Tim Schauer, Anne-Sophie Mazzoni, Anna Henriksson, Ingrid Demmelmaier, Sveinung Berntsen, Truls Raastad, Karin Nordin, Bente K. Pedersen, Jesper F. Christensen
Summary: The study compared the effects of high-intensity and low-to-moderate intensity exercise on inflammatory markers in cancer patients. Results showed significant increases of IL6, IL8, IL10, and TNFA post-treatment regardless of exercise intensity, with no difference for CRP or IL1B. In breast cancer patients, high-intensity exercise resulted in a lesser increase of CRP and TNFA.
ENDOCRINE-RELATED CANCER
(2021)
Article
Nutrition & Dietetics
Genevieve Milesi, Anna Rangan, Sara Grafenauer
Summary: Whole grain foods may have anti-inflammatory effects and can significantly reduce inflammatory markers, especially in overweight/obese individuals and those with pre-existing conditions.
Review
Oncology
Daniel C. McFarland, Meredith Doherty, Thomas M. Atkinson, Robin O'Hanlon, William Breitbart, Christian J. Nelson, Andrew H. Miller
Summary: This study conducted a systematic review and meta-analysis to examine the relationship between inflammation and depression in cancer patients. The findings suggest that peripheral inflammatory markers, such as IL-6, TNF, and CRP, are associated with depressive symptoms in various cancer settings. These results have implications for the identification and management of depression in cancer patients.
Article
Integrative & Complementary Medicine
Bethany Forseth, Michele Polfuss, Michael Brondino, Michael W. Lawlor, Margaret J. Beatka, Mariah J. Prom, Janis Eells, Jeri-Ann Lyons
Summary: Yoga participants had significantly lower scores in perceived stress and depression compared to non-yoga participants, but no significant differences in inflammatory markers were observed. Further research is needed.
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2021)
Article
Biotechnology & Applied Microbiology
Mahmood Rasool, Arif Malik, Sulayman Waquar, Qura Tul Ain, Rabia Rasool, Muhammad Asif, Nisreen Anfinan, Absarul Haque, Hina Alam, Sagheer Ahmed, Mohammad Hamid Hamdard
Summary: The study revealed significant increases in inflammatory and stress-related markers in patients with colon cancer, along with lower levels of antioxidants. This suggests that oxidative stress and lipid peroxidation play a crucial role in the development of colon cancer by influencing various signaling cascades and DNA modifications.
Review
Psychology, Multidisciplinary
Ya-Hai Wang, Jingwang Tan, Huan-Huan Zhou, Meng Cao, Yu Zou
Summary: This meta-analysis investigated the effects of long-term exercise training on inflammatory biomarkers in healthy subjects. The results showed that long-term exercise training led to a significant decrease in levels of interleukin-6, C-reactive protein, and tumor necrosis factor alpha. Subgroup analysis revealed that longer duration and moderate intensity exercise had greater anti-inflammatory effects. Meta-regression analysis found that the reduction in C-reactive protein levels was weakened with increasing exercise intensity.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Multidisciplinary Sciences
Chiara Griseta, Petronilla Battista, Fabio Castellana, Isabella Colonna, Sabrina Sciarra, Roberta Zupo, Ilaria Bortone, Luisa Lampignano, Sarah Tirelli, Giuseppe Berardino, Anita Mollica, Madia Lozupone, Francesco Panza, Pietro Fiore, Brigida Minafra, Rodolfo Sardone
Summary: Growing evidence shows the impact of inflammation on brain aging and neurodegeneration. This study examines the connection between global cognitive function and executive function, and the inflammatory markers IL-6, CRP, and TNF-alpha. The study, which involved a population-based sample of older adults in Southern Italy, measured blood levels of IL-6, CRP, and TNF-alpha, as well as administered two neuropsychological tests. The results indicate that higher levels of IL-6 were associated with cognitive impairment in this population.
Article
Food Science & Technology
Li-Juan Tan, Su Bin Hwang, Sangah Shin
Summary: This study conducted a 5-year observation on 17,310 individuals aged 40 and above in South Korea, and found a positive association between ultra-processed food (UPF) consumption and the risk of dyslipidemia and obesity. However, consuming highly processed foods (less processed and healthier foods) was associated with a lower risk of dyslipidemia and obesity.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jiong Yu, Xiaowei Shi, Jing Ma, Ronggao Chen, Siyi Dong, Sen Lu, Jian Wu, Cuilin Yan, Shusen Zheng, Lanjuan Li, Xiao Xu, Hongcui Cao
Summary: The study showed that baseline C-reactive protein (CRP) is independently associated with clinically significant bacterial infections 30 days post-liver transplantation (LT). The combination of CRP and organ failure number can effectively predict the risk of bacterial infection post-LT.
Article
Nutrition & Dietetics
Federica Sabia, Alessandra Borgo, Alessandra Lugo, Paola Suatoni, Daniele Morelli, Silvano Gallus, Anna Villarini, Ugo Pastorino
Summary: The aim of this study was to assess the relationship between adherence to a healthy diet, such as the Mediterranean diet, and C-reactive protein (CRP) levels in heavy smokers. The study found that simplified questionnaire scores were inversely associated with CRP levels, suggesting that targeted nutritional intervention could reduce CRP levels.
Article
Biochemistry & Molecular Biology
E. Fragopoulou, P. Detopoulou, E. Alepoudea, T. Nomikos, N. Kalogeropoulos, S. Antonopoulou
Summary: The study found that SFA were related to increased PAF biosynthesis and decreased Lp-PLA2 only in women, while MUFA were inversely associated with PAF biosynthesis and positively with Lp-PLA2. The pattern of high MUFA and low n6 was associated with reduced PAF biosynthesis and/or increased catabolism, suggesting that fatty acids play a role in amplifying or reducing inflammation.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2021)
Article
Nutrition & Dietetics
Agathi Ntzouvani, Smaragdi Antonopoulou, Elizabeth Fragopoulou, Meropi D. Kontogianni, Tzortzis Nomikos, Anastasia Mikellidi, Marianna Xanthopoulou, Nick Kalogeropoulos, Demosthenes Panagiotakos
Summary: This study found that consumption of enriched farmed gilthead sea bream did not have a greater effect on coagulation markers in adults compared to conventionally fed fish.
Review
Biochemistry & Molecular Biology
Spyridon Methenitis, Ioanna Stergiou, Smaragdi Antonopoulou, Tzortzis Nomikos
Summary: Subclinical, low-grade inflammation is a key factor in many chronic diseases, and understanding the anti-inflammatory properties of diet is challenging. Exercise-induced muscle damage may serve as a useful model for evaluating the effects of diet on inflammation in humans.
Review
Nutrition & Dietetics
Paraskevi Detopoulou, Constantinos A. Demopoulos, Smaragdi Antonopoulou
Summary: This review discusses the pathophysiology of COVID-19 and potential anti-viral micronutrients and phytochemicals, highlighting the importance of a healthy diet such as the Mediterranean diet in preventing the disease. The role of platelet activating factor (PAF) in COVID-19 pathogenesis is also emphasized, suggesting that a diet containing PAF inhibitors may target both inflammation and thrombosis to prevent the deleterious effects of COVID-19. Further experimental confirmation is needed to validate the PAF-COVID-19 hypothesis.
Article
Pharmacology & Pharmacy
Paraskevi Detopoulou, Tzortzis Nomikos, Elizabeth Fragopoulou, Smaragdi Antonopoulou
Summary: This study investigated the relationship between PAF metabolism and liver diseases, particularly non-alcoholic fatty liver disease. The findings indicated that bound-PAF and Lp-PLA(2) activity predicted serum GGT activity, while Lp-PLA(2) was also related to the fatty liver index (FLI). These results shed light on the metabolic pathways linking Lp-PLA(2) to other atherosclerosis and/or oxidative markers and emphasize the important role of PAF.
CURRENT VASCULAR PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Smaragdi Antonopoulou, Filio Petsini, Maria Detopoulou, Theoharis C. Theoharides, Constantinos A. Demopoulos
Summary: This study found that mRNA vaccination for COVID-19 affects human platelet aggregation response and the Spike protein modulates PAF production and activity. This finding may provide new directions for treating patients infected with SARS-CoV-2.
Article
Food Science & Technology
Filio Petsini, Agathi Ntzouvani, Maria Detopoulou, Vasiliki D. Papakonstantinou, Nick Kalogeropoulos, Elizabeth Fragopoulou, Tzortzis Nomikos, Meropi D. Kontogianni, Smaragdi Antonopoulou
Summary: Eating farmed fish fed with an olive-pomace enriched diet affects PAF metabolism and markers of inflammation and oxidative stress, but has similar effects to conventionally fed farmed fish.
Editorial Material
Biochemistry & Molecular Biology
Theoharis C. Theoharides, Smaragdi Antonopoulou, Constantinos A. Demopoulos
Review
Biochemistry & Molecular Biology
Smaragdi Antonopoulou, Constantinos A. Demopoulos
Summary: Atherosclerosis is a progressive vascular disease caused by inflammation and oxidation. The Mediterranean diet, especially olive oil, has been recognized as a healthy dietary pattern. This review focuses on the effects of olive oil microconstituents in atherosclerosis, particularly their inhibitory activity against Platelet-Activating Factor (PAF) actions. The anti-atherogenic effect of olive oil is attributed to the synergistic action of its microconstituents, including polar lipids, polyphenols, and alpha-tocopherol. Daily moderate intake of olive oil in a balanced diet is significant for healthy adults.
Article
Pharmacology & Pharmacy
Paraskevi Detopoulou, Sophia Letsiou, Tzortzis Nomikos, Alexandros Karagiannis, Spiros A. Pergantis, Christos Pitsavos, Demosthenes B. Panagiotakos, Smaragdi Antonopoulou
Summary: This study investigated the relationship between selenium distribution in plasma and cardiovascular disease. The results showed an inconclusive relationship between selenium and cardiovascular disease, especially in terms of different selenospecies. Total selenium in selenoproteins was positively associated with a 10-year relative risk of cardiovascular disease. Individuals with high selenium but low glutathione peroxidase 3 had a higher cardiovascular risk.
CURRENT VASCULAR PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Evangelia Damigou, Paraskevi Detopoulou, Smaragdi Antonopoulou, Christina Chrysohoou, Fotios Barkas, Elpiniki Vlachopoulou, Christina Vafia, Costas Tsioufis, Evangelos Liberopoulos, Petros P. Sfikakis, Christos Pitsavos, Demosthenes Panagiotakos
Summary: Food Compass Score (FCS), a useful tool for assessing overall diet quality, was shown to be useful in identifying potential cardiovascular disease candidates in a long-term period, even in populations with good background dietary habits, such as those following a Mediterranean diet.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2023)
Article
Nutrition & Dietetics
Paraskevi Detopoulou, Elizabeth Fragopoulou, Tzortzis Nomikos, Smaragdi Antonopoulou
Summary: The study found that there is an association between PA and PAF levels as well as Lp-PLA(2) activity, and this association is influenced by gender, indicating the involvement of PAF in cell membrane impairment. Additionally, PA is positively correlated with DAC, suggesting a protective effect of antioxidants on cellular health.
FRONTIERS IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
Smaragdi Antonopoulou, Maria Detopoulou, Elizabeth Fragopoulou, Tzortzis Nomikos, Nastasia Mikellidi, Mary Yannakoulia, Adamantini Kyriacou, Evdokia Mitsou, Demosthenes Panagiotakos, Costas Anastasiou
Summary: This study investigated the effects of OOPLE-enriched low-fat yogurt on metabolic profile, platelet aggregation, and inflammation markers in healthy individuals. The enriched yogurt intake resulted in reduced IL-10 levels and platelet sensitivity against PAF, with no impact on energy intake, body weight, glucose, and lipid metabolism. Lower IL-6 levels were observed after 4 weeks of enriched yogurt intake compared to plain yogurt.
HUMAN NUTRITION & METABOLISM
(2022)
Article
Nutrition & Dietetics
M. Kouvari, C. Boutari, C. Chrysohoou, E. Fragkopoulou, S. Antonopoulou, D. Tousoulis, C. Pitsavos, D. B. Panagiotakos, C. S. Mantzoros
Summary: The study reveals an inverse association between Mediterranean diet and NAFLD. Mediterranean diet offers protection against diabetes and CVD among subjects with NAFLD.
CLINICAL NUTRITION
(2021)
