Article
Multidisciplinary Sciences
S. Macherey, M. M. Meertens, C. Adler, S. Braumann, S. Heyne, T. Tichelbaecker, F. S. Niessen, H. Christ, I Ahrens, F. M. Baer, F. Eberhardt, M. Horlitz, A. Meissner, J. M. Sinning, S. Baldus, S. Lee
Summary: The study analyzed the impact of respiratory infectious diseases on STEMI, showing that these diseases did not lead to treatment delays or an increase in mortality rates.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Chang-Hung Tsai, Pei-Tseng Kung, Shun-Mu Wang, Tung-Han Tsai, Wen-Chen Tsai
Summary: This study aimed to evaluate the effect of the 24-hour PCI service model on the survival rate of STEMI patients. The results showed that STEMI patients sent to hospitals with 24-hour PCI services had a significantly lower risk of death after an emergency department visit. However, the model did not reduce the risk of emergency department revisits and readmission.
SCIENTIFIC REPORTS
(2023)
Article
Health Care Sciences & Services
Zorica Savovic, Bozidar Pindovic, Maja Nikolic, Ivan Simic, Goran Davidovic, Vladimir Ignjatovic, Jelena Vuckovic, Nenad Zornic, Tamara Nikolic Turnic, Vladimir Zivkovic, Ivan Srejovic, Sergej Bolevich, Vladimir Jakovljevic, Violeta Iric Cupic
Summary: The aim of the study was to investigate the role of oxidative stress in the early evaluation of STEMI and NSTEMI patients and its impact on the development of myocardial infarction. Blood samples were collected from the patients to measure oxidative stress biomarkers and antioxidant enzyme activity.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Giuseppe De Luca, Magdy Algowhary, Berat Uguz, Dinaldo C. Oliveira, Vladimir Ganyukov, Zan Zimbakov, Miha Cercek, Lisette Okkels Jensen, Poay Huan Loh, Lucian Calmac, Gerard Roura Ferrer, Alexandre Quadros, Marek Milewski, Fortunato Scotto D'Uccio, Clemens von Birgelen, Francesco Versaci, Jurrien Ten Berg, Gianni Casella, Aaron Wong Sung Lung, Petr Kala, Jose Luis Diez Gil, Xavier Carrillo, Maurits Dirksen, Victor M. Becerra-Munoz, Michael Kang-Yin Lee, Dafsah Arifa Juzar, Rodrigo de Moura Joaquim, Roberto Paladino, Davor Milicic, Periklis Davlouros, Nikola Bakraceski, Filippo Zilio, Luca Donazzan, Adriaan Kraaijeveld, Gennaro Galasso, Lux Arpad, Marinucci Lucia, Guiducci Vincenzo, Maurizio Menichelli, Alessandra Scoccia, Aylin Hatice Yamac, Kadir Ugur Mert, Xacobe Flores Rios, Tomas Kovarnik, Michal Kidawa, Jose Moreu, Flavien Vincent, Enrico Fabris, Inigo Lozano Martinez-Luengas, Marco Boccalatte, Francisco Bosa Ojeda, Carlos Arellano-Serrano, Gianluca Caiazzo, Giuseppe Cirrincione, Hsien-Li Kao, Juan Sanchis Fores, Luigi Vignali, Helder Pereira, Stephane Manzo, Santiago Ordonez, Alev Arat Ozkan, Bruno Scheller, Heidi Lehtola, Rui Teles, Christos Mantis, Ylitalo Antti, Joao Antonio Brum Silveira, Rodrigo Zoni, Ivan Bessonov, Stefano Savonitto, George Kochiadakis, Dimitrios Alexopulos, Carlos E. Uribe, John Kanakakis, Benjamin Faurie, Gabriele Gabrielli, Alejandro Gutierrez Barrios, Juan Pablo Bachini, Alex Rocha, Frankie Chor-Cheung Tam, Alfredo Rodriguez, Antonia Anna Lukito, Veauthyelau Saint-Joy, Gustavo Pessah, Andrea Tuccillo, Giuliana Cortese, Guido Parodi, Mohamed Abed Bouraghda, Elvin Kedhi, Pablo Lamelas, Harry Suryapranata, Matteo Nardin, Monica Verdoia
Summary: The study aims to explore the relationship between smokers and mortality rate among primary PCI patients during the COVID-19 era. The results show that active smokers have better epicardial recanalization and lower in-hospital and 30-day mortality compared to non-smokers and previous smokers.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Chenxi Song, Shuai Liu, Dong Yin, Yang Wang, Yanyan Zhao, Weixian Yang, Shubin Qiao, Kefei Dou, Bo Xu
Summary: The COVID-19 pandemic has led to a significant decrease in emergent reperfusion therapy for STEMI patients, as well as a trend towards higher in-hospital adverse events risk.
CURRENT PROBLEMS IN CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Giuseppe De Luca, Niels Debel, Miha Cercek, Lisette Okkels Jensen, Marija Vavlukis, Lucian Calmac, Tom Johnson, Gerard Rourai Ferrer, Vladimir Ganyukov, Wojtek Wojakowski, Tim Kinnaird, Clemens von Birgelen, Yves Cottin, Alexander IJsselmuiden, Bernardo Tuccillo, Francesco Versaci, Kees-Jan Royaards, Jurrien ten Berg, Mika Laine, Maurits Dirksen, Massimo Siviglia, Gianni Casella, Petr Kala, Jose Luis Diez Gil, Adrian Banning, Victor Becerra, Ciro De Simone, Andrea Santucci, Xavier Carrillo, Alessandra Scoccia, Giovanni Amoroso, Arnoud Wj van't Hof, Tomas Kovarnik, Grigorios Tsigkas, Julinda Mehilli, Gabriele Gabrielli, Xacobe Flores Rios, Nikola Bakraceski, Sebastien Levesque, Giuseppe Cirrincione, Vincenzo Guiducci, Michal Kidawa, Leonardo Spedicato, Lucia Marinucci, Peter Ludman, Filippo Zilio, Gennaro Galasso, Enrico Fabris, Maurizio Menichelli, Arturo Garcia-Touchard, Stephane Manzo, Gianluca Caiazzo, Jose Moreu, Juan Sanchis Fores, Luca Donazzan, Luigi Vignali, Rui Teles, Edouard Benit, Pierfrancesco Agostoni, Francisco Bosa Ojeda, Heidi Lehtola, Santiago Camacho-Freiere, Adriaan Kraaijeveld, Ylitalo Antti, Marco Boccalatte, Pierre Deharo, Inigo Lozano Martinez-Luengas, Bruno Scheller, Efthymia Varytimiadi, Raul Moreno, Giuseppe Uccello, Benjamin Faurie, Alejandro Gutierrez Barrios, Marek Milewski, Ewout Bruwiere, Pieter Smits, Bor Wilbert, Fortunato Scotto Di Uccio, Guido Parodi, Elvin Kedhi, Monica Verdoia
Summary: The study reveals that among STEMI patients undergoing PPCI, those who are SARS-CoV-2 positive have a higher mortality rate, higher incidence of in-stent thrombosis, and are more likely to have culprit lesions in the right coronary artery compared to SARS-CoV-2 negative patients.
Article
Biology
Mohammad Ali Sheikh Beig Goharrizi, Saeed Ghodsi, Majid Mokhtari, Sayyed Sajjad Moravveji
Summary: This study identified the STEMI-related non-invasive markers and found that ARGL, CLEC4E, and EIF3D genes showed significant differential expression in Iranian patients. The ROC curve for CLEC4E gene had an AUC of 0.786 in predicting STEMI. Additionally, a prognostic model was developed to stratify the risk of heart failure progression, and SI00AI2 was a common biomarker between STEMI and NSTEMI patients.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Medicine, General & Internal
Oreste Lanza, Nicola Cosentino, Claudia Lucci, Marta Resta, Mara Rubino, Valentina Milazzo, Monica De Metrio, Filippo Trombara, Jeness Campodonico, Jose Pablo Werba, Alice Bonomi, Giancarlo Marenzi
Summary: Prior statin therapy is associated with a better in-hospital clinical outcome in patients with STEMI undergoing primary PCI.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Elena de Dios, Cesar Rios-Navarro, Nerea Perez-Sole, Jose Gavara, Victor Marcos-Garces, Maria J. Forteza, Ricardo Oltra, Jose M. Vila, Francisco J. Chorro, Vicente Bodi
Summary: Lymphopenia after ST-segment elevation myocardial infarction (STEMI) is associated with adverse cardiac consequences and poor prognosis. Increased expression of regulatory T cell and immune checkpoint genes CD25, CD69, PD-1, and CTLA-4 following STEMI correlates with better short- and long-term cardiac structure and function, with CD25 potentially predicting the extent of infarction size after one week.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Caren Sourij, Faisal Aziz, Sarah Krappinger, Andreas Praschk, Thomas Metzner, Harald Kojzar, Andreas Zirlik, Tatjana Stojakovic, Dieter Paetzold, Dirk von Lewinski, Robert Zweiker, Hubert Scharnagl, Harald Sourij
Summary: This study investigated changes in Lp(a) levels after an acute myocardial infarction. The results showed that Lp(a) levels were the lowest during the acute myocardial infarction and started to increase significantly immediately thereafter, with the highest levels at the post-discharge follow-up.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Haixia Qin, Siyuan Li, Zhenbing Liu
Summary: The study revealed that Shexiang Baoxin Pill (SBP) has a protective effect on myocardial ischemia/reperfusion injury in patients with STEMI, improving cardiac function and decreasing myocardial infarction area.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Julia Stehli
Summary: This editorial discusses the role of gender in pre-hospital delay in patients with ST-elevation myocardial infarction.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Giuseppe De Luca, Magdy Algowhary, Berat Uguz, Dinaldo C. Oliveira, Vladimir Ganyukov, Oliver Busljetik, Miha Cercek, Lisette Okkels Jensen, Poay Huan Loh, Lucian Calmac, Gerard Roura i Ferrer, Alexandre Quadros, Marek Milewski, Fortunato Scotto D'Uccio, Clemens von Birgelen, Francesco Versaci, Jurrien Ten Berg, Gianni Casella, Aaron Wong Sung Lung, Petr Kala, Jose Luis Diez Gil, Xavier Carrillo, Maurits Dirksen, Victor Becerra Munoz, Michael Kang-yin Lee, Dafsah Arifa Juzar, Rodrigo de Joaquim Joaquim, Roberto Paladino, Davor Milicic, Periklis Davlouros, Nikola Bakraceski, Filippo Zilio, Luca Donazzan, Adriaan Kraaijeveld, Gennaro Galasso, Lux Arpad, Lucia Marinucci, Vincenzo Guiducci, Maurizio Menichelli, Alessandra Scoccia, Aylin Hatice Yamac, Kadir Ugur Mert, Xacobe Flores Rios, Tomas Kovarnik, Michal Kidawa, Jose Moreu, Vincent Flavien, Enrico Fabris, Inigo Lozano Martinez-Luengas, Marco Boccalatte, Francisco Bosa Ojeda, Carlos Arellano-Serrano, Gianluca Caiazzo, Giuseppe Cirrincione, Hsien-Li Kao, Juan Sanchis Fores, Luigi Vignali, Helder Pereira, Stephane Manzo-Silberman, Santiago Ordonez, Alev Arat Ozkan, Bruno Scheller, Heidi Lehitola, Rui Teles, Christos Mantis, Ylitalo Antti, Joao Antonio Brum Silveira, Cesar Rodrigo Zoni, Ivan Bessonov, Giuseppe Uccello, George Kochiadakis, Dimitrios Alexopulos, Carlos E. Uribe, John Kanakakis, Benjamin Faurie, Gabriele Gabrielli, Alejandro Gutierrez Barrios, Juan Pablo Bachini, Alex Rocha, Frankie C. C. Tam, Alfredo Rodriguez, Antonia Anna Lukito, Veauthyelau Saint-Joy, Gustavo Pessah, Andrea Tuccillo, Alfonso Ielasi, Giuliana Cortese, Guido Parodi, Mohammed Abed Burgadha, Elvin Kedhi, Pablo Lamelas, Harry Suryapranata, Matteo Nardin, Monica Verdoia
Summary: The COVID-19 pandemic significantly impacted the management of patients with ST-segment elevation myocardial infarction (STEMI), leading to a decrease in PCI procedures, slower treatment for elderly patients, and an increase in in-hospital and 30-day mortality during the pandemic.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Robert A. Kloner, Jeffrey L. Creech, Gregg W. Stone, William W. O'Neill, Daniel Burkhoff, J. Richard Spears
Summary: Despite the reduction in door-to-balloon times, the rates of death and heart failure in patients with ST-segment elevation myocardial infarction have plateaued, indicating a need to further reduce MI size. Localized delivery of supersaturated oxygen therapy has shown promise in reducing infarct size and improving cardiac function, making it a potential adjunctive therapy for myocardial salvage.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2021)
Article
Biology
Roxana Hodas, Imre Benedek, Nora Rat, Istvan Kovacs, Monica Chitu, Theodora Benedek
Summary: The COVID-19 pandemic had a major impact on cardiovascular emergencies, decreasing non-AMI hospitalizations and increasing the percentage of AMI cases. It also led to a reduction in late STEMI cases in the STEMI group.
Article
Medical Laboratory Technology
Moritz Biener, Evangelos Giannitsis, Thomas Thum, Christian Bar, Kiril M. Stoyanov, Christian Salbach, David De Gonzalo-Calvo, Norbert Frey, Matthias Mueller-Hennessen
Summary: The study found that miR-21-5p and miR-122-5p can predict the survival rate of patients with cardiovascular diseases in the emergency department, but do not add prognostic information to hs-cTnT.
CLINICAL BIOCHEMISTRY
(2022)
Article
Medical Laboratory Technology
Vitali Koch, Christian Booz, Leon D. Gruenewald, Moritz H. Albrecht, Tatjana Gruber-Rouh, Katrin Eichler, Ibrahim Yel, Scherwin Mahmoudi, Jan-Erik Scholtz, Simon S. Martin, Christiana Graf, Thomas J. Vogl, Christophe Weber, Stefan E. Hardt, Norbert Frey, Evangelos Giannitsis
Summary: The study assessed the performance of D-dimer testing for ACS diagnosis and prediction of MI outcomes. The results showed that D-dimer concentrations were significantly different in patients with different levels of hs-cTnT. Higher D-dimer levels were associated with an increased risk of recurrent MI and all-cause mortality. D-dimer was an independent predictor of all-cause mortality and subsequent MI events. However, D-dimer did not significantly improve diagnostic performance unless values exceeded the 95th percentile.
CLINICAL BIOCHEMISTRY
(2022)
Article
Cardiac & Cardiovascular Systems
Ali Amr, Marc Hinderer, Lena Griebel, Dominic Deuber, Christoph Egger, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Daniel Huhn, Jan Haas, Karen Frese, Marc Schweig, Ninja Marnau, Annika Kraemer, Claudia Durand, Florian Battke, Hans-Ulrich Prokosch, Michael Backes, Andreas Keller, Dominique Schroeder, Hugo A. Katus, Norbert Frey, Benjamin Meder
Summary: The PROMISE concept aims to democratize genetic data through transparent, secure, and patient-centric data management. In a pilot study, patients showed increased importance on genetic data safety and reported changes in attitude towards data handling after using the PROMISE app.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Moritz Biener, Evangelos Giannitsis, Katharina Hogrefe, Matthias Mueller-Hennessen, Hanna Froehlich, Hugo A. Katus, Norbert Frey, Lutz Frankenstein, Tobias Taeger
Summary: For stable outpatients, MID calculated from changes in hs-cTnT measured 365 +/- 120 days apart can help predict an uneventful clinical course.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Evangelos Giannitsis, Norbert Frey
EUROPEAN HEART JOURNAL
(2022)
Correction
Cardiac & Cardiovascular Systems
Thomas M. Helms, Christian A. Perings, Philipp Sommer, Friedrich Koehler, Norbert Frey, Stephan von Haehling, Christiane Tiefenbacher, Karin Rybak, Stefan Sack, Martin Stockburger
Article
Cardiac & Cardiovascular Systems
Thomas M. Helms, Christian A. Perings, Philipp Sommer, Friedrich Koehler, Norbert Frey, Stephan von Haehling, Christiane Tiefenbacher, Karin Rybak, Stefan Sack, Martin Stockburger
Summary: Telemedical services, particularly in cardiological telemedicine centers, have the potential to address the increasing burden of cardiovascular diseases such as chronic heart failure. By implementing a systematic quality management system, TMCs can ensure structured telemonitoring and treatment interventions lead to improved patient care while meeting legal and normative requirements.
Article
Cardiac & Cardiovascular Systems
Daniel Finke, Markus B. Heckmann, Susanna Wilhelm, Lukas Entenmann, Hauke Hund, Nina Bougatf, Hugo A. Katus, Norbert Frey, Lorenz H. Lehmann
Summary: The study reveals that cancer patients with reduced left ventricular function or elevated cardiac biomarkers have higher all-cause mortality. NT-proBNP is found to be significantly higher in cancer patients and predicts ACM more accurately compared to hs-cTnT. Risk factors for atherosclerosis, such as diabetes and age (>65 years), were significant predictors for increased ACM in cancer patients.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Hatim Seoudy, Jasmin Shamekhi, Lisa Voigtlaender, Sebastian Ludwig, Johanne Frank, Tim Kujat, Peter Bramlage, Baravan Al-Kassou, Atsushi Sugiura, Ashraf Yusuf Rangrez, Niklas Schofer, Thomas Puehler, Georg Lutter, Moritz Seiffert, Georg Nickenig, Lenard Conradi, Norbert Frey, Dirk Westermann, Jan -Malte Sinning, Derk Frank
Summary: This study evaluated the risk stratification ability of serum C-reactive protein to albumin ratio (CAR) in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR), and the results showed that CAR was associated with increased all-cause mortality.
MAYO CLINIC PROCEEDINGS
(2022)
Article
Medicine, General & Internal
Samira Soltani, Michael Boehm, Norbert Frey, Matthias Eden, Amr Abdin, Johann Bauersachs
Summary: The 2021 guidelines of the European Society of Cardiology emphasize the early implementation of four drug classes to reduce mortality for patients with heart failure with reduced ejection fraction (HFrEF), including ACEi or ARNI, BB, MRA, and SGLT2i. This article aims to provide a practical compendium to support physicians in providing safe and efficacious treatment for HFrEF patients.
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
(2022)
Article
Pharmacology & Pharmacy
Vitali Koch, Leon D. Gruenewald, Tatjana Gruber-Rouh, Simon Martin, Katrin Eichler, Christian Booz, Ibrahim Yel, Thomas J. Vogl, Kristina Buchner, Marco Hagenmueller, Winfried Maerz, Norbert Frey, Stefan E. Hardt, Johannes H. Riffel
Summary: This study found that HA treatment can improve cardiac function, reduce collagen accumulation, and produce positive molecular and tissue effects in the process of cardiac remodeling in rats. Combining HA with standard heart failure medication can further enhance the treatment effects.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Elham Kayvanpour, Michael Wisdom, Maximilian K. Lackner, Farbod Sedaghat-Hamedani, Jes-Niels Boeckel, Marion Muller, Rose Eghbalian, Jan Dudek, Shirin Doroudgar, Christoph Maack, Norbert Frey, Benjamin Meder
Summary: Through experiments on zebrafish embryos and HEK293A cells, it was found that VARS2 depletion may lead to heart failure, CNS dysfunction, and skeletal muscle damage. VARS2-depleted cells showed reduced enzymatic activity, rearrangement of ETC complexes, activation of the ISR, and disruptions in mitochondrial FAO.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fabrice F. Darche, Nina D. Ullrich, Ziqiang Huang, Michael Koenen, Rasmus Rivinius, Norbert Frey, Patrick A. Schweizer
Summary: “Novel protocols for the differentiation of hiPSC into cardiac pacemaker cells were established, with protocol E being the most efficient among them. The protocols were characterized by their ability to upregulate cardiac pacemaker-specific genes and induce excellent rate responsiveness to stimulation.”
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Amr Abdin, Johann Bauersachs, Samira Soltani, Matthias Eden, Norbert Frey, Michael Boehm
Summary: Heart failure remains a global healthcare challenge despite significant developments in pharmacotherapies. There are concerns regarding low medication dosages and incomplete drug classes in real-world settings, and current guidelines lack detailed recommendations. A practical approach algorithm is proposed to assist physicians in treating HF patients.
Article
Pharmacology & Pharmacy
Panagiotis Xynogalos, Ann-Kathrin Rahm, Sebastian Fried, Safak Chasan, Daniel Scherer, Claudia Seyler, Hugo A. Katus, Norbert Frey, Edgar Zitron
Summary: This study analyzed the effect of the antiarrhythmic drug verapamil on the inwardly rectifying potassium current of cardiomyocytes. The results showed that verapamil inhibited the Kir2.1, Kir2.2, and Kir2.3 channels, with the inhibition of Kir2.3 being a previously unknown finding. Further experiments revealed that the inhibition of Kir2.3 by verapamil was dependent on specific binding sites and interference with PIP2 activation. This finding provides a potential target for the development of selective antiarrhythmic drugs targeting Kir2.3 channels.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)