Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1

The thioacetate-ω(γ-lactam carboxamide) HDAC inhibitor ST7612AA1 as HIV-1 latency reactivation agent

(2015) Roger Badia et al.   ANTIVIRAL RESEARCH

Cyclin D3-dependent control of the dNTP pool and HIV-1 replication in human macrophages

(2015) Alba Ruiz et al.   CELL CYCLE

CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain

(2015) Junpeng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity

(2015) Kyle J. Seamon et al.   NUCLEIC ACIDS RESEARCH

SAMHD1 specifically restricts retroviruses through its RNase activity

(2015) Jongsu Choi et al.   Retrovirology

SAMHD1: At the Crossroads of Cell Proliferation, Immune Responses, and Virus Restriction

(2015) Ester Ballana et al.   TRENDS IN MICROBIOLOGY

The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells

(2015) Masashi Shingai et al.   PLoS Pathogens

Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity

(2014) Eduardo Pauls et al.   AIDS

SAMHD1 Specifically Affects the Antiviral Potency of Thymidine Analog HIV Reverse Transcriptase Inhibitors

(2014) Ester Ballana et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mouse knockout models for HIV-1 restriction factors

(2014) Jan Rehwinkel   CELLULAR AND MOLECULAR LIFE SCIENCES

SAMHD1 expression in blood cells of HIV-1 elite suppressors and viraemic progressors

(2014) E. L. Buchanan et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Gene editing using a zinc-finger nuclease mimicking the CCR5Δ32 mutation induces resistance to CCR5-using HIV-1

(2014) Roger Badia et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Increased expression of SAMHD1 in a subset of HIV-1 elite controllers

(2014) E. Riveira-Munoz et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses

(2014) Makoto Yamamoto et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell Cycle Control and HIV-1 Susceptibility Are Linked by CDK6-Dependent CDK2 Phosphorylation of SAMHD1 in Myeloid and Lymphoid Cells

(2014) Eduardo Pauls et al.   JOURNAL OF IMMUNOLOGY

Identification of Cellular Proteins Interacting with the Retroviral Restriction Factor SAMHD1

(2014) C. St. Gelais et al.   JOURNAL OF VIROLOGY

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction

(2014) Jeongmin Ryoo et al.   NATURE MEDICINE

p21 regulates the HIV-1 restriction factor SAMHD1

(2014) E. Pauls et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage

(2013) R. Clifford et al.   BLOOD

SAMHD1-dependent retroviral control and escape in mice

(2013) Jan Rehwinkel et al.   EMBO JOURNAL

SAMHD1 Restricts Herpes Simplex Virus 1 in Macrophages by Limiting DNA Replication

(2013) Eui Tae Kim et al.   JOURNAL OF VIROLOGY

p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway

(2013) A. Allouch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells

(2013) E. Franzolin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of SAMHD1 by Cyclin A2/CDK1 Regulates Its Restriction Activity toward HIV-1

(2013) Alexandra Cribier et al.   Cell Reports

Host Factor SAMHD1 Restricts DNA Viruses in Non-Dividing Myeloid Cells

(2013) Joseph A. Hollenbaugh et al.   PLoS Pathogens

Nucleotide embargo by SAMHD1: A strategy to block retroviral infection

(2012) Eduardo Pauls et al.   ANTIVIRAL RESEARCH

Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma

(2012) J. P. Leonard et al.   BLOOD

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

Intracellular nucleotide levels and the control of retroviral infections

(2012) Sarah M. Amie et al.   VIROLOGY

B Family DNA Polymerases Asymmetrically Recognize Pyrimidines and Purines

(2011) Travis J. Lund et al.   BIOCHEMISTRY

A Review Comparing Deoxyribonucleoside Triphosphate (dNTP) Concentrations in the Mitochondrial and Cytoplasmic Compartments of Normal and Transformed Cells

(2011) Vishal V. Gandhi et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Tinkering with a viral ribonucleotide reductase

(2008) David Lembo et al.   TRENDS IN BIOCHEMICAL SCIENCES

Inhibition of HSV-1 replication and HSV DNA polymerase by the chloroxoquinolinic ribonucleoside 6-chloro-1,4-dihydro-4-oxo-1-(β-d-ribofuranosyl) quinoline-3-carboxylic acid and its aglycone

(2007) Thiago Moreno L. Souza et al.   ANTIVIRAL RESEARCH