SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity

Variola Type IB DNA Topoisomerase: DNA Binding and Supercoil Unwinding Using Engineered DNA Minicircles

(2014) Breeana G. Anderson et al.   BIOCHEMISTRY

Enzyme Promiscuity: Engine of Evolutionary Innovation

(2014) Chetanya Pandya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric Regulation of the Human and Mouse Deoxyribonucleotide Triphosphohydrolase Sterile α-Motif/Histidine-Aspartate Domain-containing Protein 1 (SAMHD1)

(2014) Cristina Miazzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Molecule Inhibition of SAMHD1 dNTPase by Tetramer Destabilization

(2014) Kyle J. Seamon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction

(2014) Jeongmin Ryoo et al.   NATURE MEDICINE

Structural basis of cellular dNTP regulation by SAMHD1

(2014) X. Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state

(2014) E. C. Hansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Retroviral Restriction Ability of SAMHD1, but Not Its Deoxynucleotide Triphosphohydrolase Activity, Is Regulated by Phosphorylation

(2013) Tommy E. White et al.   Cell Host & Microbe

Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV Infection

(2013) Junpeng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclease Activity of the Human SAMHD1 Protein Implicated in the Aicardi-Goutières Syndrome and HIV-1 Restriction

(2013) Natalia Beloglazova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-stranded nucleic acids promote SAMHD1 complex formation

(2013) Victoria Tüngler et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Oligomerization transforms human APOBEC3G from an efficient enzyme to a slowly dissociating nucleic acid-binding protein

(2013) Kathy R. Chaurasiya et al.   Nature Chemistry

Mechanism of allosteric activation of SAMHD1 by dGTP

(2013) Xiaoyun Ji et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases

(2013) B. Worsdorfer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy

(2013) S. R. Morrone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase

(2013) Chunfeng Zhu et al.   Nature Communications

Modulation of LINE-1 and Alu/SVA Retrotransposition by Aicardi-Goutières Syndrome-Related SAMHD1

(2013) Ke Zhao et al.   Cell Reports

SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations

(2012) Adriana Goncalves et al.   HUMAN MUTATION

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

Biological Phosphoryl-Transfer Reactions: Understanding Mechanism and Catalysis

(2011) Jonathan K. Lassila et al.   Annual Review of Biochemistry

Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase

(2011) Rebecca D. Powell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

(2011) David C. Goldstone et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Atomic Force Microscopy Studies Provide Direct Evidence for Dimerization of the HIV Restriction Factor APOBEC3G

(2010) Luda S. Shlyakhtenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

(2009) Gillian I Rice et al.   NATURE GENETICS