Tissue factor-thrombin signaling enhances the fibrotic activity of myofibroblasts in systemic sclerosis through up-regulation of endothelin receptor A

C5a and TNF-  Up-Regulate the Expression of Tissue Factor in Intra-Alveolar Neutrophils of Patients with the Acute Respiratory Distress Syndrome

(2014) K. Kambas et al.   JOURNAL OF IMMUNOLOGY

Antiinflammatory and antifibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of interstitial lung disease

(2011) Galina S. Bogatkevich et al.   ARTHRITIS AND RHEUMATISM

Endothelin-1 Signaling Promotes Fibrosis In Vitro in a Bronchopulmonary Dysplasia Model by Activating the Extrinsic Coagulation Cascade

(2011) K. Kambas et al.   JOURNAL OF IMMUNOLOGY

Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial

(2010) M. Matucci-Cerinic et al.   ANNALS OF THE RHEUMATIC DISEASES

CCN2 is required for bleomycin-induced skin fibrosis in mice

(2010) Shangxi Liu et al.   ARTHRITIS AND RHEUMATISM

Bosentan Improves Skin Perfusion of Hands in Patients with Systemic Sclerosis with Pulmonary Arterial Hypertension

(2010) E. ROSATO et al.   JOURNAL OF RHEUMATOLOGY

Effect of bosentan on skin fibrosis in patients with systemic sclerosis: a prospective, open-label, non-comparative trial

(2010) A. Kuhn et al.   RHEUMATOLOGY

Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts

(2009) Galina S. Bogatkevich et al.   ARTHRITIS AND RHEUMATISM

Capillary dimension measured by computer-based digitalized image correlated with plasma endothelin-1 levels in patients with systemic sclerosis

(2009) Hyun-Sook Kim et al.   CLINICAL RHEUMATOLOGY

Endothelin receptor selectivity: evidence fromin vitroand pre-clinical models of scleroderma

(2009) X. Shiwen et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Thrombin-Induced Connective Tissue Growth Factor Expression in Human Lung Fibroblasts Requires the ASK1/JNK/AP-1 Pathway

(2009) C.-C. Yu et al.   JOURNAL OF IMMUNOLOGY

Critical roles for thrombin in acute and chronic inflammation

(2009) D. CHEN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Long-term outcome of systemic sclerosis-associated pulmonary arterial hypertension treated with bosentan as first-line monotherapy followed or not by the addition of prostanoids or sildenafil

(2009) D. Launay et al.   RHEUMATOLOGY

Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease?

(2009) Andrew Leask et al.   Journal of Cell Communication and Signaling

Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis

(2008) Xu Shi-Wen et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Functions and mechanisms of action of CCN matricellular proteins

(2008) Chih-Chiun Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mechanisms of vascular damage in SSc--implications for vascular treatment strategies

(2008) S. Guiducci et al.   RHEUMATOLOGY

Endothelin--role in vascular disease

(2008) D. Abraham et al.   RHEUMATOLOGY

Tissue Factor and Protease-Activated Receptor Signaling in Cancer

(2008) Florence Schaffner et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

The CCN family of proteins: structure–function relationships

(2008) Kenneth P. Holbourn et al.   TRENDS IN BIOCHEMICAL SCIENCES