Article
Multidisciplinary Sciences
Richard Ainsworth, Deepa Hammaker, Gyrid Nygaard, Cecilia Ansalone, Camilla Machado, Kai Zhang, Lina Zheng, Lucy Carrillo, Andre Wildberg, Amanda Kuhs, Mattias N. D. Svensson, David L. Boyle, Gary S. Firestein, Wei Wang
Summary: This study characterizes clusters of RA cell lines with distinctive TF biology by integrating transcriptomic and epigenomic data and validates the predicted differences.
NATURE COMMUNICATIONS
(2022)
Article
Rheumatology
Onosi Sylvia Ifesemen, Daniel Frederick McWilliams, Sam Norton, Patrick D. W. Kiely, Adam Young, David Andrew Walsh
Summary: The study aims to describe the prevalence, risk factors, and longitudinal course of fatigue in early rheumatoid arthritis (RA) patients. The findings suggest that fatigue is common and persistent in early RA, and diverse characteristics indicative of central mechanisms are associated with persistent fatigue.
Article
Rheumatology
Nicki Verweij, Gerben Zwezerijnen, Marieke ter Wee, Jerney de Jongh, Maqsood Yaqub, Dirkjan van Schaardenburg, Adriaan Lammertsma, Alexandre Voskuyl, Willem Lems, Maarten Boers, Conny van der Laken
Summary: This study aimed to investigate the application of macrophage positron emission tomography (PET) in patients with early rheumatoid arthritis (RA). The results showed that macrophage PET assessment after 2 weeks of COBRA light treatment correlated with clinical response after 3 months of treatment.
Article
Pharmacology & Pharmacy
Xiao Wang, Xiaoping Huang, Pingzhang Gao, Yanxuan Ren, Xiaokun Li, Yong Diao
Summary: In this study, the protective role of kallistatin against rheumatoid arthritis (RA) was analyzed, and it was found that kallistatin can mitigate chondrocyte apoptosis mediated by IL-1 beta and inhibit the synthesis of ECM-degrading enzymes. It also suppressed IL-1 beta-mediated inflammation through the NF-kappa B pathway. In animal models, kallistatin administration significantly reduced the severity of RA.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Chang Shu, Jun Chen, Meiyan Lv, Yiyuan Xi, Jujia Zheng, Xiangwei Xu
Summary: Plumbagin may attenuate RA-induced damage to cells and joints by down-regulating the levels of inflammatory cytokines and MMPs through inhibiting the activation of the NF-kappa B pathway.
Review
Cell Biology
Maryam Hemmatzadeh, Elham Ahangar Parvin, Hamed Mohammadi, Gholamreza Azizi, Navid Shomali, Farhad Jadidi-Niaragh
Summary: Rheumatoid arthritis is an autoimmune chronic disorder characterized by immune cell involvement, genetic predisposition, and inflammatory responses. The pathogenesis of RA is mainly regulated through autoimmune irregularity of T and B cells, with immune checkpoint molecules playing a crucial role in modulating immune responses.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Rheumatology
Roswitha Dietzel, Sabine Wiegmann, Diana Borucki, Christian Detzer, Kim Nikola Zeiner, Desiree Schaumburg, Bjoern Buehring, Frank Buttgereit, Gabriele Armbrecht
Summary: In patients with rheumatoid arthritis (RA), chronic inflammation can lead to muscle depletion. The study found that sarcopenia is more common in RA patients and is associated with factors such as body weight, BMI, inflammation markers, and disease duration.
Article
Immunology
W. Watson Buchanan, Colin A. Kean, Walter F. Kean, K. D. Rainsford
Summary: It is difficult to determine the exact origin of Rheumatoid Arthritis, but there were clear descriptions in the 17th century. Augustin Jacob Landre-Beauvais is credited with the first clear description of the disease in his thesis. Sir Alfred Baring Garrod gave the disease its current name in 1859, which was later adapted by the Ministry of Health in Britain in 1922. Some forms of Juvenile Arthritis are related to adult Rheumatoid Arthritis, and if left untreated, it can lead to severe joint damage and systemic complications. The discovery of anti TNF-alpha agents in the 1990s and subsequent biologic agents have greatly improved the clinical outcome of Rheumatoid Arthritis.
INFLAMMOPHARMACOLOGY
(2023)
Article
Orthopedics
Haiyan You, Mengwei Cheng, Cui Ma, Wenjuan Zheng, Yu Jiang, Di Chen, Yu Tang
Summary: This study explored differences in B lymphocyte subsets and cytokines in RA patients, finding that the percentage of plasmablasts was significantly higher in active RA patients. Plasmablast percentage was correlated with C reaction protein and could serve as an early diagnostic marker for RA. ROC curve analysis showed good specificity and sensitivity for diagnosing RA using the percentage of plasmablasts.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Rheumatology
Faye A. H. Cooles, Jessica Tarn, Dennis W. Lendrem, Najib Naamane, Chung M. A. Lin, Ben Millar, Nicola J. Maney, Amy E. Anderson, Nishanthi Thalayasingam, Julie Diboll, Vincent Bondet, Darragh Duffy, Michael R. Barnes, Graham R. Smith, Sandra Ng, David Watson, Rafael Henkin, Andrew P. Cope, Louise N. Reynard, Arthur G. Pratt, John D. Isaacs
Summary: The interferon gene signature (IGS) in early, treatment naive rheumatoid arthritis (eRA) patients can negatively affect initial treatment response by causing sustained, epigenetically mediated increases in lymphocyte activation and proliferation. This highlights the importance of the IGS as a prognostic biomarker and suggests the rationale for targeting IFN-alpha in selected eRA patients.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Engineering, Biomedical
Xingliang Liu, Shi Chen, Lixin Liu, Yongming Chen
Summary: By adjusting the core-shell structure of nanoparticles, this study selectively scavenged cfDNA in the joint cavity of patients with rheumatoid arthritis, resulting in superior therapeutic effects.
ACTA BIOMATERIALIA
(2023)
Article
Immunology
Jingjing Qi, Jiaqing Liu, Xiangge Zhao, Huina Huang, Yawei Tang, Xia Li
Summary: Our study found that IL-27 can promote B cell dysfunction in rheumatoid arthritis by activating the mTOR signaling pathway. The study aimed to explore the effects of IL-27 on B cell metabolism and clarify the mechanisms by which IL-27 enhances glycolysis to induce B cell hyperactivation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Kathrin Koedderitzsch, Ekaterina Zezina, Lingzi Li, Matthias Herrmann, Nadine Biesemann
Summary: The study revealed a direct role of TNF in the glycolytic reprogramming of FLS, confirming the potency of immunometabolism in RA. TNF stimulation was shown to enhance glycolysis, reduce GLUT1 and GAPDH levels, which may be linked to treatment response in patients.
SCIENTIFIC REPORTS
(2021)
Article
Rheumatology
Fan Cao, Da-Peng Li, Guo-Cui Wu, Yi-Sheng He, Yu-Chen Liu, Jing-Jing Hou, Qin-Yu Ni, Li-Ming Tao, Zheng-Xuan Jiang, Hai-Feng Pan
Summary: This study provides an overview and analysis of the temporal trends in the prevalence of musculoskeletal disorders in women of childbearing age at global, regional, and national levels over the past 30 years. The results indicate a favorable overall trend in the prevalence of these disorders globally, but there are still 138 countries experiencing unfavorable rising trends. This raises concerns about the timely achievement of the Sustainable Development Goals.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Tamas Nemeth, Gyorgy Nagy, Thomas Pap
Summary: Fibroblast-like synoviocytes (FLS) are crucial cellular components in the synovial membrane of joints, contributing to normal joint function. However, under inflammatory conditions like rheumatoid arthritis (RA), FLS can become overactive and promote inflammation. Therefore, understanding the role of FLS in RA is essential for disease treatment.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Rheumatology
Daichi Hayashi, Frank W. Roemer, Felix Eckstein, Jonathan Samuels, Ali Guermazi
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
(2020)
Review
Orthopedics
J. Samuels, M. H. Pillinger, D. Jevsevar, D. Felson, L. S. Simon
Summary: Intra-articular injections of glucocorticoids have been shown to be effective and relatively safe in patients with knee osteoarthritis, with few contraindications and rare injection-associated complications when delivered with proper technique. However, there are still important unanswered questions regarding the long-term effects and predictive factors of response to intra-articular glucocorticoids in knee osteoarthritis patients, highlighting the need for further research in this area.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Biochemical Research Methods
Hongwei Zhang, Eugene Ciccimaro, Jacob Zalaznick, Bogdan G. Sleczka, Laurence Menard, Timothy Olah, Petia Shipkova
Letter
Orthopedics
B. Plotz, M. Pillinger, J. Samuels
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Orthopedics
Yunyun Luo, Jonathan Samuels, Svetlana Krasnokutsky, Inger Byrjalsen, Virginia B. Kraus, Yi He, Morten A. Karsdal, Steven B. Abramson, Mukundan Attur, Anne C. Bay-Jensen
Summary: This study examined the association of cartilage formation level with OA severity and radiographic OA progression using the blood-based marker PRO-C2. Results showed that subjects with low levels of PRO-C2 had greater risk of joint space narrowing progression, indicating PRO-C2 may be an objective indicator of a low cartilage repair endotype with radiographic progression.
JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY
(2021)
Article
Rheumatology
Wenyu Fu, Aubryanna Hettinghouse, Yujianan Chen, Wenhuo Hu, Xiang Ding, Meng Chen, Yuanjing Ding, Jyoti Mundra, Wenhao Song, Ronghan Liu, Young-Su Yi, Mukundan Attur, Jonathan Samuels, Eric Strauss, Philipp Leucht, Ran Schwarzkopf, Chuan-Ju Liu
Summary: This study identifies 14-3-3ε as an inducible component of the TNFR2 receptor complex in chondrocytes in response to PGRN, presenting a previously unrecognized TNFR2 pathway in the pathogenesis of osteoarthritis.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Rebecca H. Haberman, Ramin Sedaghat Herati, David Simon, Marie Samanovic, Rebecca B. Blank, Michael Tuen, Sergei B. Koralov, Raja Atreya, Koray Tascilar, Joseph R. Allen, Rochelle Castillo, Amber R. Cornelius, Paula Rackoff, Gary Solomon, Samrachana Adhikari, Natalie Azar, Pamela Rosenthal, Peter Izmirly, Jonathan Samuels, Brian Golden, Soumya Reddy, Markus Neurath, Steven B. Abramson, Georg Schett, Mark J. Mulligan, Jose U. Scher
Summary: The study found that patients with immune-mediated inflammatory diseases (IMIDs) on methotrexate treatment showed impaired humoral and cellular immune response to COVID-19 mRNA vaccines, while healthy subjects and IMID patients on biologic treatments demonstrated strong antibody responses. These results suggest that different strategies may need to be explored to enhance immunization efficacy for IMID patients on methotrexate treatment.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Immunology
Gwenny M. Verstappen, Lu Gao, Sarah Pringle, Erlin A. Haacke, Bert van der Vegt, Silvia C. Liefers, Vishal Patel, Yanhua Hu, Sumanta Mukherjee, Julie Carman, Laurence C. Menard, Frederik K. L. Spijkervet, Arjan Vissink, Hendrika Bootsma, Frans G. M. Kroese
Summary: This study aimed to evaluate the immunopathway activation in paired parotid and labial gland tissue from pSS and non-SS sicca patients with different biopsy results. The results showed that biopsy-positive pSS patients could be distinguished from non-SS sicca patients based on salivary gland gene expression, while biopsy-negative pSS patients had indistinguishable gene expression patterns from non-SS sicca patients. Different patterns of immunopathway activation in salivary glands of pSS patients argue for personalized treatment approaches.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Yu Feng, Liguo Liu, Jing Li, Jia Huang, Jenny H. Xie, Laurence Menard, Yanfen Shi, Xiaohong Zhao, Shan Xie, Wenjuan Zang, Haidong Tan, Zhiying Yang, Ling Ni
Summary: This study reveals the presence of NR4A2 B cells in the tumor microenvironment of hepatocellular carcinoma (HCC), which may play a negative role in antitumor immunity and are significantly correlated with PD-L1 expression. Therefore, B cells may serve as a promising immunotherapeutic target for HCC treatment.
Article
Orthopedics
Kinjal Vasavada, Dhruv S. Shankar, Amanda Avila, Charles C. Lin, David Marulanda, Laith M. Jazrawi, Jonathan Samuels
Summary: The purpose of this study was to determine the rate and characteristics of postoperative flares in rheumatic disease patients undergoing arthroscopic surgery, and the role of perioperative immunosuppression (IS) management in preventing or provoking these exacerbations. The study found that patients who continued to take IS medication or stopped taking IS medication before surgery had similar risks of flare-ups after arthroscopy, while patients not taking any IS medication had a lower risk of flaring.
Editorial Material
Orthopedics
J. Samuels, M. Attur
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Medicine, Research & Experimental
Jeff W. Chen, Jean-Nicolas Schickel, Nikolaos Tsakiris, Joel Sng, Florent Arbogast, Delphine Bouis, Daniele Parisi, Ruchi Gera, Joshua M. Boeckers, Fabien R. Delmotte, Margaret Veselits, Catharina Schuetz, Eva-Maria Jacobsen, Carsten Posovszky, Ansgar S. Schulz, Klaus Schwarz, Marcus R. Clark, Laurence Menard, Eric Meffre
Summary: Using humanized mouse models, it was observed that there is a strong skewing of the expressed immunoglobulin repertoire upon transit into the peripheral naive B cell pool. Positive selection of expanded naive B cells is beneficial, while negative selection of autoreactive B cells requires the involvement of regulatory T cells.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Orthopedics
Kinjal Vasavada, Laith M. Jazrawi, Jonathan Samuels
Summary: With the rise of arthroscopic surgeries in patients with rheumatic diseases, physicians are managing immunosuppressive medications to minimize infection risk and optimize disease control. There is a lack of randomized controlled trial data specifically for arthroscopic surgeries, leading to uncertainties in perioperative management of immunosuppressants in this patient population.
CURRENT REVIEWS IN MUSCULOSKELETAL MEDICINE
(2021)
Article
Rheumatology
Mukundan Attur, Xin Duan, Lei Cai, Tianzhen Han, Weili Zhang, Eric D. Tycksen, Jonathan Samuels, Robert H. Brophy, Steven B. Abramson, Muhammad Farooq Rai
Summary: Postn deficiency was found to significantly reduce cartilage degeneration and synovitis in both post-traumatic and age-related models of OA in mice, as well as result in lower trabecular bone parameters. Additionally, RNA-seq analysis revealed differences in gene expression related to cell adhesion, differentiation, cell cycle, and DNA repair between Postn(-/-) and wild-type mice, suggesting a potential mechanistic role of Postn in OA.
ARTHRITIS RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Jeff W. Chen, Tyler A. Rice, Jason M. Bannock, Agata A. Bielecka, Juliet D. Strauss, Jason R. Catanzaro, Haowei Wang, Laurence C. Menard, Jennifer H. Anolik, Noah W. Palm, Eric Meffre