Article
Immunology
Jung Yeon Heo, Yu Bin Seo, Eun Jin Kim, Jacob Lee, Young Rong Kim, Jin Gu Yoon, Ji Yun Noh, Hee Jin Cheong, Woo Joo Kim, Soo-Young Yoon, Ju-Yeon Choi, Young Jae Lee, Hye Won Lee, Sung Soon Kim, Byoungguk Kim, Joon Young Song
Summary: This study evaluated the association between reactogenicity and immunogenicity after vaccination with different COVID-19 vaccines. It found that systemic adverse events after the first dose of ChAdOx1 nCoV-19 may be related to proinflammatory cytokine responses, while fever after the second dose of BNT162b2 is positively correlated with vaccine-induced immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Victoria Furer, Tali Eviatar, Devy Zisman, Hagit Peleg, Yolanda Braun-Moscovici, Alexandra Balbir-Gurman, Daphna Paran, David Levartovsky, Michael Zisapel, Ofir Elalouf, Ilana Kaufman, Adi Broyde, Ari Polachek, Joy Feld, Amir Haddad, Tal Gazitt, Muna Elias, Nizar Higazi, Fadi Kharouf, Sara Pel, Sharon Nevo, Ori Elkayam
Summary: In patients with autoimmune inflammatory rheumatic diseases (AIIRD) treated with rituximab (RTX), the predictors of a positive immunogenic response to the BNT162b2 mRNA vaccine include the number of RTX courses, cumulative RTX dose, IgG level prior to last RTX course, and interval between RTX treatment and vaccination. ANCA-associated vasculitis and inflammatory myositis patients have a low likelihood of a seropositive immunogenic response.
Article
Medicine, General & Internal
Hiroyuki Naruse, Hiroyasu Ito, Hideo Izawa, Masayoshi Sarai, Junnichi Ishii, Eirin Sakaguchi, Reiko Murakami, Tatsuya Ando, Hidetsugu Fujigaki, Kuniaki Saito
Summary: It was found that patients with cardiovascular disease have a poorer humoral response to the BNT162b2 mRNA COVID-19 vaccine, requiring closer monitoring and earlier revaccination to ensure stronger immunity and protection.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Panagiotis T. Diamantopoulos, Christina-Nefeli Kontandreopoulou, Aikaterini Gkoufa, Elena Solomou, Amalia Anastasopoulou, Eleni Palli, Panagiotis Kouzis, Spyros Bouros, Mihalis Samarkos, Gkikas Magiorkinis, Helen Gogas
Summary: This study investigated the efficacy and safety of the BNT162b2 vaccine in melanoma patients undergoing immunotherapy. The results showed that the vaccine had a high seroconversion rate and did not cause significant adverse events. Additionally, there were no changes in the subpopulations of T cells or myeloid cells after vaccination.
Article
Immunology
Tzu-Chien Lin, Pei-An Fu, Ya-Ting Hsu, Tsai-Yun Chen
Summary: This is a case report of Vaccine-induced immune thrombotic thrombocytopenia (VITT) following BNT162b2 (Pfizer-BioNTech) vaccine. A healthy 28-year-old man developed hemoptysis, bilateral leg pain, and headaches three weeks after his third dose of the COVID-19 vaccine. Further investigations revealed pulmonary embolisms, cerebral sinus, and deep iliac venous thrombosis. The diagnosis of VITT was confirmed by positive PF4 antibody assay. The patient responded well to intravenous immunoglobulins (IVIGs) and his symptoms are now under control with anticoagulant therapy. This case suggests that VITT can occur with mRNA-based vaccines like BNT162b2, and not just with adenoviral vector vaccines.
Article
Medicine, Research & Experimental
Davide Firinu, Andrea Perra, Marcello Campagna, Roberto Littera, Giuseppe Fenu, Federico Meloni, Selene Cipri, Francesca Sedda, Maria Conti, Michela Miglianti, Giulia Costanzo, Marta Secci, Gianmario Usai, Mauro Giovanni Carta, Riccardo Cappai, Germano Orru, Stefano Del Giacco, Ferdinando Coghe, Luchino Chessa
Summary: The study found that patients with IMIDs have significantly reduced humoral immune response after receiving the BNT162b2 vaccine, especially those treated with anti-CD20 drugs. At T2, IMID patients had lower IgG levels compared to the HCW group, but there was no significant difference at T3. Age and the disease itself were correlated with immune response after vaccination, while treatment did not have a significant impact except for anti-CD20 drugs.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Yvette N. Lamb
Summary: BNT162b2, a lipid nanoparticle-formulated mRNA vaccine encoding the SARS-CoV-2 spike protein, has received emergency use authorization in multiple countries for individuals aged 16 and older to prevent COVID-19.
Article
Medicine, General & Internal
D. Mevorach, E. Anis, N. Cedar, M. Bromberg, E. J. Haas, E. Nadir, S. Olsha-Castell, D. Arad, T. Hasin, N. Levi, R. Asleh, O. Amir, K. Meir, D. Cohen, R. Dichtiar, D. Novick, Y. Hershkovitz, R. Dagan, I Leitersdorf, R. Ben-Ami, I Miskin, W. Saliba, K. Muhsen, Y. Levi, M. S. Green, L. Keinan-Boker, S. Alroy-Preis
Summary: The incidence of myocarditis increased after receiving the BNT162b2 vaccine in Israel, particularly after the second dose among young male recipients. The clinical presentation of myocarditis after vaccination was usually mild.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Immunology
Victoria G. Hall, Victor H. Ferreira, Heidi Wood, Matthew Ierullo, Beata Majchrzak-Kita, Kathy Manguiat, Alyssia Robinson, Vathany Kulasingam, Atul Humar, Deepali Kumar
Summary: Delayed dosing intervals can enhance immune response to COVID-19 vaccination, including virus neutralization against wild-type and variant viruses. This finding has significant implications for the global implementation of vaccines.
Article
Medicine, General & Internal
Vanessa Alexandra Buetler, Nada Agbariah, Deborah Pia Schild, Fabian D. Liechti, Anna Wieland, Nicola Andina, Felix Hammann, Johanna A. Kremer Hovinga
Summary: This article presents a case of iTTP following COVID-19 vaccination and reviews previously reported cases. The findings suggest a potential association between COVID-19 vaccination and iTTP.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
Victoria Furer, Tali Eviatar, Devy Zisman, Hagit Peleg, Daphna Paran, David Levartovsky, Michael Zisapel, Ofir Elalouf, Ilana Kaufman, Roni Meidan, Adi Broyde, Ari Polachek, Jonathan Wollman, Ira Litinsky, Katya Meridor, Hila Nochomovitz, Adi Silberman, Dana Rosenberg, Joy Feld, Amir Haddad, Tal Gazzit, Muna Elias, Nizar Higazi, Fadi Kharouf, Gabi Shefer, Orly Sharon, Sara Pel, Sharon Nevo, Ori Elkayam
Summary: Vaccination with mRNA BNT162b2 vaccine showed reduced immunogenicity in patients with AIIRD compared to the general population, with risk factors including older age and treatment with glucocorticoids, rituximab, mycophenolate mofetil (MMF), and abatacept. However, most patients maintained stable disease activity post-vaccination.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Letter
Medicine, General & Internal
Shmuel Benenson, Yonatan Oster, Matan J. Cohen, Ran Nir-Paz
Summary: A systematic vaccination program for healthcare workers at Hadassah Medical Center in Israel showed high effectiveness in preventing Covid-19 starting from the second week after the first dose of BNT162b2 vaccine.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Noa Dagan, Noam Barda, Tal Biron-Shental, Maya Makov-Assif, Calanit Key, Isaac S. Kohane, Miguel A. Hernan, Marc Lipsitch, Sonia Hernandez-Diaz, Ben Y. Reis, Ran D. Balicer
Summary: The BNT162b2 COVID-19 vaccine showed high effectiveness in pregnant women in an observational cohort study in Israel, similar to the effectiveness seen in the general population.
Article
Immunology
Ting-Yu Lin, Yun-Hsuan Yeh, Li-Wen Chen, Chao-Neng Cheng, Chen Chang, Jun-Neng Roan, Ching-Fen Shen
Summary: This article reports a rare but potentially fatal case of hemophagocytic lymphohistiocytosis in a 14-year-old adolescent after receiving the BNT162b2 mRNA COVID-19 vaccine. The case suggests that immune activation after COVID-19 vaccination may interfere with the adequate immune response to certain infectious pathogens, resulting in a hyperinflammatory syndrome.
Article
Cardiac & Cardiovascular Systems
Jan Havlin, Monika Svorcova, Eliska Dvorackova, Jan Lastovicka, Robert Lischke, Tomas Kalina, Petr Hubacek
Summary: Transplant recipients showed weaker antibody response to mRNA COVID-19 vaccine compared to natural infection, with only a subset of patients demonstrating SARS-CoV-2 specific T-cell response. Further research is needed to identify the optimal vaccine type and schedule for immunocompromised transplant patients.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Letter
Rheumatology
Melek Yalcin Mutlu, Jochen Wacker, Koray Tascilar, Jule Taubmann, Bernhard Manger, Gerhard Kronke, Georg Schett, David Simon
Article
Rheumatology
Koray Tascilar, Filippo Fagni, Arnd Kleyer, Sara Bayat, Robert Heidemann, Florian Steiger, Gerhard Kronke, Daniela Bohr, Andreas Ramming, Fabian Hartmann, Daniel Klett, Anna Federle, Adrian P. Regensburger, Alexandra L. Wagner, Ferdinand Knieling, Markus F. Neurath, Georg Schett, Maximilian Waldner, David Simon
Summary: MSOT can non-invasively measure metabolic differences between arthritis and enthesitis in vivo. Enthesitis-related sonographic changes are associated with increased total Hb, oxygen saturation, and collagen content, while arthritis-related clinical and sonographic findings are associated with increased Hb levels, reduced oxygen saturation, and reduced collagen content.
Article
Health Care Sciences & Services
Samrachana Adhikari, Andrea R. Titus, Aaron Baum, Priscilla Lopez, Rania Kanchi, Stephanie L. Orstad, Brian Elbel, David C. Lee, Lorna E. Thorpe, Mark D. Schwartz
Summary: This study examines the impact of the COVID-19 pandemic on healthcare utilization among patients with type 2 diabetes. It finds that there were significant reductions in HbA1c measurements and in-person outpatient visits in the initial 3 months after the pandemic onset, but telehealth visits doubled during the same period. There were disparities in telehealth utilization by geography and race/ethnicity.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christoph Treutlein, Joerg H. W. Distler, Koray Tascilar, Sara Chenguiti Fakhouri, Andrea-Hermina Gyoerfi, Armin Atzinger, Alexandru-Emil Matei, Clara Dees, Maike Buettner-Herold, Torsten Kuwert, Olaf Prante, Tobias Baeuerle, Michael Uder, Georg Schett, Christian Schmidkonz, Christina Bergmann
Summary: This study provides evidence that [Ga-68]Ga-FAPI-04 uptake can visualize fibroblast activation in SSc-related myocardial fibrosis, making it a potential diagnostic option for monitoring cardiac fibroblast activity in situ. This has important implications for prognostic prediction in SSc patients.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Acoustics
Lars-Philip Paulus, Alexandra L. Wagner, Adrian Buehler, Roman Raming, Jorg Juengert, David Simon, Koray Tascilar, Alexander Schnell, Josefine Guenther, Ulrich Rother, Werner Lang, Andre Hoerning, Georg Schett, Markus F. Neurath, Joachim Woelfle, Maximilian J. Waldner, Ferdinand Knieling, Adrian P. Regensburger
Summary: Multispectral optoacoustic tomography (MSOT) shows promise as a reliable and stable imaging technique for diagnosing inflammatory bowel diseases. This study demonstrates the high reliability and temporal stability of MSOT in imaging the human intestine during fasting and after food intake.
Article
Orthopedics
Kinjal Vasavada, Dhruv S. Shankar, Amanda Avila, Charles C. Lin, David Marulanda, Laith M. Jazrawi, Jonathan Samuels
Summary: The purpose of this study was to determine the rate and characteristics of postoperative flares in rheumatic disease patients undergoing arthroscopic surgery, and the role of perioperative immunosuppression (IS) management in preventing or provoking these exacerbations. The study found that patients who continued to take IS medication or stopped taking IS medication before surgery had similar risks of flare-ups after arthroscopy, while patients not taking any IS medication had a lower risk of flaring.
Editorial Material
Orthopedics
J. Samuels, M. Attur
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Multidisciplinary Sciences
Samrachana Adhikari, Shiying You, Alan Chen, Sabrina Cheng, Keng-Yen Huang
Summary: This study applies data-driven statistical and machine learning methods to study mental health trajectories among Asian American children. It identifies high-risk and low-risk groups and identifies key early predictors. The findings can inform decisions regarding the timing of early intervention and prioritization of intervention programs.
Article
Rheumatology
David Simon, Ioanna Minopoulou, Stephan Kemenes, Sara Bayat, Koray Tascilar, Melek Yalcin Mutlu, Larissa Valor-Mendez, Gerhard Kroenke, Axel J. Hueber, Georg Schett, Arnd Kleyer
Summary: Objective. This study aimed to evaluate the effect of Janus kinase inhibition (JAKi) through baricitinib (BARI) on bone properties and synovial inflammation in rheumatoid arthritis (RA) patients. Results showed that BARI therapy significantly improved disease activity, synovial inflammation, and bone mass of RA patients, with no new safety signals observed.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Immunology
Bingjie Zhang, Rabi Upadhyay, Yuhan Hao, Marie I. Samanovic, Ramin S. Herati, John D. Blair, Jordan Axelrad, Mark J. Mulligan, Dan R. Littman, Rahul Satija
Summary: This study analyzed the T cell response after BNT162b2 vaccination using multimodal sequencing technologies. The researchers identified CD8(+) T cell subpopulations and explored their transcriptome, chromatin landscape, and immunophenotype. They also found that the frequency and differentiation outcomes of these CD8(+) T cell subpopulations were predictive of clinical outcomes in COVID-19 patients.
Article
Medicine, General & Internal
David C. Lee, Stephanie L. Orstad, Rania Kanchi, Samrachana Adhikari, Pasquale E. Rummo, Andrea R. Titus, Jose O. Aleman, Brian Elbel, Lorna E. Thorpe, Mark D. Schwartz
Summary: This study aimed to evaluate the impact of demographic, social, and geographic factors on glycemic control in diabetes patients. The results showed that female patients and those with lower baseline glycemic levels were more likely to achieve within-range glycemic control during follow-up. Surprisingly, older patients and those with more comorbidities were also more likely to achieve within-range glycemic control. However, the associations between geographic factors and glycemic control varied across different community types.
Letter
Health Care Sciences & Services
Koray Tascilar
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Rheumatology
Vanessa Bartsch, Filippo Fagni, Manuel Krieter, Mohammed Ibrahim, Selahattin-Alp Temiz, Melek Yalcin-Mutlu, Georg Schett, David Simon, Axel J. Hueber
Article
Environmental Sciences
Tara P. McAlexander, Victoria Ryan, Jalal Uddin, Rania Kanchi, Lorna Thorpe, Brian S. Schwartz, April Carson, Deborah B. Rolka, Samrachana Adhikari, Jonathan Pollak, Priscilla Lopez, Megan Smith, Melissa Meeker, Leslie A. McClure
Summary: Exposure to PM2.5 and O3 showed varying associations with new onset T2D across three large study samples in the US. The results differed by community type, and none of the populations found strong and clear positive associations.
ENVIRONMENTAL RESEARCH
(2023)
