Article
Rheumatology
Jelena Vojinovic, Ivan Foeldvari, Joke Dehoorne, Violeta Panaviene, Gordana Susic, Gerd Horneff, Valda Stanevicha, Katarzyna Kobusinska, Zbigniew Zuber, Bogna Dobrzyniecka, Jonathan Akikusa, Tadej Avcin, Cecilia Borlenghi, Edmund Arthur, Svitlana Y. Tatulych, Chuanbo Zang, Vassilis Tsekouras, Bonnie Vlahos, Alberto Martini, Nicolino Ruperto
Summary: CLIPPER2 is an 8-year study on the safety and efficacy of etanercept in patients with juvenile idiopathic arthritis (JIA). The study found that etanercept treatment was well tolerated and effective in these patients.
Article
Rheumatology
Joeri W. van Straalen, Roline M. Krol, Gabriella Giancane, Violeta Panaviene, Laura Marinela Ailioaie, Pavla Dolezalova, Marco Cattalini, Gordana Susic, Flavio R. Sztajnbok, Despoina Maritsi, Tamas Constantin, Sujata Sawhney, Marite Rygg, Sheila Knupp Oliveira, Ellen Berit Nordal, Claudia Saad-Magalhaes, Nadina Rubio-Perez, Marija Jelusic, Sytze de Roock, Nico M. Wulffraat, Nicolino Ruperto, Joost F. Swart
Summary: IBD development in JIA is associated with enthesitis-related arthritis and a family history of autoimmune disease. An increased incidence of IBD was observed with etanercept therapy regardless of concomitant methotrexate use.
Article
Rheumatology
Gabriella Giancane, Riccardo Papa, Sebastiaan Vastert, Francesca Bagnasco, Joost F. Swart, Pierre Quartier, Jordi Anton, Sylvia Kamphuis, Helga Sanner, Mia Glerup, Fabrizio De Benedetti, Elena Tsitsami, Agustin Remesal, Estefania Moreno, Jaime De Inocencio, Charlotte Myrup, Chiara Pallotti, Isabelle Kone-Paut, Karin Franck-Larsson, Hakan Malmstrom, Susanna Cederholm, Angela Pistorio, Nico Wulffraat, Nicolino Ruperto
Summary: This study evaluated the long-term safety profile of anakinra in patients with sJIA. The results showed an overall decreasing incidence of adverse events over time.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Naveen Ravichandran, Shivika Guleria, Namita Mohindra, Amita Aggarwal
Summary: This study assessed the long-term functional outcomes in ERA patients from China and found that delay in diagnosis was the sole predictor of poor functional outcome.
Article
Pediatrics
Xuefeng Xu, Xiaohui Liu, Wenjie Zheng, Jihong Xiao, Xiaozhong Li, Ling Wu, Lixia Zou, Qian Ouyang, Yaoyao Shangguan, Kezhao Lin, Xiaomei Dai, Yuanling Chen, Yiping Xu, Jianqiang Wu, Meiping Lu
Summary: This study suggests that the combination of rhTNFR-Fc and MTX significantly improves symptoms and disease activity in children with JIA.
FRONTIERS IN PEDIATRICS
(2022)
Article
Immunology
Mohamad Hamad Saied, Joeri W. van Straalen, Sytze de Roock, Gerrie C. J. de Joode-Smink, Joost F. Swart, Nico M. Wulffraat, Marc H. A. Jansen
Summary: This retrospective study investigated short and long-term disease activity and vaccine-related adverse events in JIA patients treated with immunosuppressive and immunomodulatory therapies who received the MMR booster vaccine. The study found that MMR booster vaccination was safe and did not worsen disease activity during long-term follow-up in a large cohort of JIA patients.
Article
Biochemistry & Molecular Biology
Franck Zekre, Rolando Cimaz, Mireille Paul, Teresa Giani, Louis Waeckel, Anne-Emmanuelle Berger, Jean-Louis Stephan, Myriam Normand, Stephane Paul, Hubert Marotte
Summary: This study found that children with oligoarticular and ERA subsets in juvenile idiopathic arthritis (JIA) had higher IgG titers against P. gingivalis and P. intermedia, indicating the involvement of oral dysbiosis in the occurrence of JIA in these subgroups.
Article
Biochemistry & Molecular Biology
Magdalena Wojdas, Klaudia Dabkowska, Kornelia Kuznik-Trocha, Grzegorz Wisowski, Iwona Lachor-Motyka, Katarzyna Komosinska-Vassev, Krystyna Olczyk, Katarzyna Winsz-Szczotka
Summary: This study assessed the effects of ETA therapy on ECM metabolism in JIA patients. The results showed that GAGs and TAS concentrations were significantly lower in patients with aggressive JIA, while MMP-1 and MMP-3 levels were significantly higher. Anti-cytokine therapy did not normalize any of the assessed parameters.
Article
Medicine, General & Internal
Athimalaipet Ramanan, Pierre Quartier, Nami Okamoto, Ivan Foeldvari, Alberto Spindler, Sarka Fingerhutova, Jordi Anton, Zhongkai Wang, Gabriella Meszaros, Joana Araujo, Ran Liao, Stuart Keller
Summary: Baricitinib demonstrated good efficacy and acceptable safety in the treatment of polyarticular juvenile idiopathic arthritis, extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis, and juvenile psoriatic arthritis.
Article
Rheumatology
Johannes C. Nossent, Erin Kelty, Helen Keen, David Preen, Charles Inderjeeth
Summary: Systemic juvenile idiopathic arthritis (S-JIA) is a rare, potentially life-threatening autoinflammatory condition in children. A study investigated the epidemiological characteristics and long-term outcomes of S-JIA in the Australasian region. The annual incidence of S-JIA was 0.61/100,000, with a stable prevalence rate of 7.15/100,000. Disease flares occurred in 24% of patients during a median follow-up of 8 years, with higher rates in boys than girls. No deaths were reported, but there were substantial rates of readmission and emergency department visits for other illnesses.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Monika Ostrowska, Emil Michalski, Piotr Gietka, Malgorzata Manczak, Magdalena Posadzy, Iwona Sudol-Szopinska
Summary: This study compared MRI findings between patients clinically suspected of Juvenile Idiopathic Arthritis (JIA) and patients with ankle arthralgia of unknown cause. The results showed that inflammatory features were observed on MRI, with tenosynovitis being significantly more common in JIA patients. However, the MRI summarized score did not effectively differentiate between JIA and non-JIA patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Erick M. Marigi, Dustin Lee, Ian Marigi, Jean-David Werthel, Jonathan D. Barlow, John W. Sperling, Joaquin Sanchez-Sotelo, Bradley S. Schoch
Summary: The study demonstrates that primary shoulder arthroplasty is an effective surgical option for pain reduction and ROM improvement in JIA patients, with TSA showing better pain relief and patient-reported outcomes in the long term compared to HA.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2021)
Article
Medicine, General & Internal
Doaa W. Nada, Abdelkawy Moghazy, Abdallah El-Sayed Allam, Alessia Alunno, Amira M. Ibrahim
Summary: This study found that patients with sJIA showed favorable disease outcomes with TCZ treatment for 1 year, especially if the drugs were administered earlier in the disease course and in younger patients with a more pronounced inflammatory status. Younger age, shorter disease duration, lower disease activity, higher serum ferritin, and systemic manifestations were associated with more favorable treatment response.
FRONTIERS IN MEDICINE
(2021)
Review
Biology
Lucia M. Sur, Remus Gaga, Emanuela Duca, Genet Sur, Iulia Lupan, Daniel Sur, Gabriel Samasca, Cecilia Lazea, Calin Lazar
Summary: Juvenile idiopathic arthritis poses a significant challenge for pediatricians in terms of diagnosis and classification. Current criteria are rigid and may not fully accommodate the diversity within JIA subtypes. Future classifications based on pathophysiological and genetic criteria may be necessary.
Article
Immunology
Mohamad Hamad Saied, Joeri W. van Straalen, Sytze de Roock, Gerrie C. J. de Joode-Smink, Frans M. Verduyn Lunel, Joost F. Swart, Nico M. Wulffraat, Marc H. A. Jansen
Summary: Although the MMR booster vaccine provides long-term immunoprotection in the majority of JIA patients, those who are receiving immunomodulatory therapies may have lower levels of protective antibodies. Therefore, it is recommended to regularly measure antibody levels and consider additional boosters based on the results.
Article
Rheumatology
Rina Mina, Khalid Abulaban, Marisa S. Klein-Gitelman, Barbara A. Eberhard, Stacy P. Ardoin, Nora Singer, Karen Onel, Lori Tucker, Kathleen O'neil, Tracey Wright, Elizabeth Brooks, Kelly Rouster-Stevens, Lawrence Jung, Lisa Imundo, Brad Rovin, David Witte, Jun Ying, Hermine I. Brunner
ARTHRITIS CARE & RESEARCH
(2016)
Article
Cell & Tissue Engineering
Gali Shalev-Malul, David C. Soler, Anthony E. Ting, Nicholas A. Lehman, Emma Barnboym, Thomas S. McCormick, Donald D. Anthony, Hillard M. Lazarus, Arnold I. Caplan, Maya Breitman, Nora G. Singer
STEM CELLS TRANSLATIONAL MEDICINE
(2016)
Article
Rheumatology
Rina Mina, Marisa S. Klein-Gitelman, Shannen Nelson, B. Anne Eberhard, Gloria Higgins, Nora G. Singer, Karen Onel, Lori Tucker, Kathleen M. O'Neil, Marilynn Punaro, Deborah M. Levy, Kathleen Haines, Alberto Martini, Nicolino Ruperto, Daniel Lovell, Hermine I. Brunner
ANNALS OF THE RHEUMATIC DISEASES
(2014)
Review
Rheumatology
Daniel E. Furst, Edward Clark Keystone, Alexander K. So, Juergen Braun, Ferry C. Breedveld, Gerd R. Burmester, Fabrizio De Benedetti, Thomas Doerner, Paul Emery, Roy Fleischmann, Allan Gibofsky, J. R. Kalden, Arthur Kavanaugh, Bruce Kirkham, Philip Mease, A. Rubbert-Roth, Joachim Sieper, Nora G. Singer, Josef S. Smolen, Piet L. C. M. Van Riel, Michael H. Weisman, Kevin L. Winthrop
ANNALS OF THE RHEUMATIC DISEASES
(2013)
Article
Rheumatology
Stacy P. Ardoin, Laura Eve Schanberg, Christy I. Sandborg, Huiman X. Barnhart, Greg W. Evans, Eric Yow, Kelly L. Mieszkalski, Norman T. Ilowite, Anne Eberhard, Lisa F. Imundo, Yuki Kimura, Deborah Levy, Emily von Scheven, Earl Silverman, Suzanne L. Bowyer, L. Punaro, Nora G. Singer, David D. Sherry, Deborah K. McCurdy, Marissa Klein-Gitelman, Carol Wallace, Richard M. Silver, Linda Wagner-Weiner, Gloria C. Higgins, Hermine I. Brunner, Lawrence Jung, Jennifer B. Soep, Ann M. Reed, Susan D. Thompson
ANNALS OF THE RHEUMATIC DISEASES
(2014)
Article
Spectroscopy
Shan Yang, Bolan Li, Mikhail N. Slipchenko, Anna Akkus, Nora G. Singer, Yener N. Yeni, Ozan Akkus
JOURNAL OF RAMAN SPECTROSCOPY
(2013)
Article
Rheumatology
R. Mina, M. S. Klein-Gitelman, S. Nelson, B. A. Eberhard, G. Higgins, N. G. Singer, K. Onel, L. Tucker, K. M. O'Neil, M. Punaro, D. M. Levy, K. Haines, J. Ying, H. I. Brunner
Article
Medicine, General & Internal
Qing Zhou, Dan Yang, Amanda K. Ombrello, Andrey V. Zavialov, Camilo Toro, Anton V. Zavialov, Deborah L. Stone, Jae Jin Chae, Sergio D. Rosenzweig, Kevin Bishop, Karyl S. Barron, Hye Sun Kuehn, Patrycja Hoffmann, Alejandra Negro, Wanxia L. Tsai, Edward W. Cowen, Wuhong Pei, Joshua D. Milner, Christopher Silvin, Theo Heller, David T. Chin, Nicholas J. Patronas, John S. Barber, Chyi-Chia R. Lee, Geryl M. Wood, Alexander Ling, Susan J. Kelly, David E. Kleiner, James C. Mullikin, Nancy J. Ganson, Heidi H. Kong, Sophie Hambleton, Fabio Candotti, Martha M. Quezado, Katherine R. Calvo, Hawwa Alao, Beverly K. Barham, Anne Jones, James F. Meschia, Bradford B. Worrall, Scott E. Kasner, Stephen S. Rich, Raphaela Goldbach-Mansky, Mario Abinun, Elizabeth Chalom, Alisa C. Gotte, Marilynn Punaro, Virginia Pascual, James W. Verbsky, Troy R. Torgerson, Nora G. Singer, Timothy R. Gershon, Seza Ozen, Omer Karadag, Thomas A. Fleisher, Elaine F. Remmers, Shawn M. Burgess, Susan L. Moir, Massimo Gadina, Raman Sood, Michael S. Hershfield, Manfred Boehm, Daniel L. Kastner, Ivona Aksentijevich
NEW ENGLAND JOURNAL OF MEDICINE
(2014)
Review
Rheumatology
Uzma A. Syeda, Nora G. Singer, Marina Magrey
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2013)
Article
Rheumatology
Rina Mina, Marisa S. Klein-Gitelman, Angelo Ravelli, Michael W. Beresford, Tadej Avcin, Graciela Espada, B. Anne Eberhard, Laura E. Schanberg, Kathleen M. O'Neil, Clovis A. Silva, Gloria C. Higgins, Karen Onel, Nora G. Singer, Emily von Scheven, Lisa F. Imundo, Shannen Nelson, Edward H. Giannini, Hermine I. Brunner
ARTHRITIS CARE & RESEARCH
(2012)
Article
Rheumatology
Rina Mina, Emily von Scheven, Stacy P. Ardoin, B. Anne Eberhard, Marilynn Punaro, Norman Ilowite, Joyce Hsu, Marisa Klein-Gitelman, L. Nandini Moorthy, Eyal Muscal, Suhas M. Radhakrishna, Linda Wagner-Weiner, Matthew Adams, Peter Blier, Lenore Buckley, Elizabeth Chalom, Gaelle Chedeville, Andrew Eichenfield, Natalya Fish, Michael Henrickson, Aimee O. Hersh, Roger Hollister, Olcay Jones, Lawrence Jung, Deborah Levy, Jorge Lopez-Benitez, Deborah McCurdy, Paivi M. Miettunen, Ana I. Quintero-Del Rio, Deborah Rothman, Ornella Rullo, Natasha Ruth, Laura E. Schanberg, Earl Silverman, Nora G. Singer, Jennifer Soep, Reema Syed, Larry B. Vogler, Ali Yalcindag, Cagri Yildirim-Toruner, Carol A. Wallace, Hermine I. Brunner
ARTHRITIS CARE & RESEARCH
(2012)
Article
Rheumatology
Ellen M. Ginzler, Stephen Wax, Anand Rajeswaran, Samuel Copt, Jan Hillson, Eleanor Ramos, Nora G. Singer
ARTHRITIS RESEARCH & THERAPY
(2012)
Article
Rheumatology
Reut Gurion, Nora G. Singer
CURRENT RHEUMATOLOGY REPORTS
(2013)
Article
Rheumatology
Norman T. Ilowite, Kristi Prather, Yuliya Lokhnygina, Laura E. Schanberg, Melissa Elder, Diana Milojevic, James W. Verbsky, Steven J. Spalding, Yukiko Kimura, Lisa F. Imundo, Marilynn G. Punaro, David D. Sherry, Stacey E. Tarvin, Lawrence S. Zemel, James D. Birmingham, Beth S. Gottlieb, Michael L. Miller, Kathleen O'Neil, Natasha M. Ruth, Carol A. Wallace, Nora G. Singer, Christy I. Sandborg
ARTHRITIS & RHEUMATOLOGY
(2014)
Article
Rheumatology
Angela Byun Robinson, Vin Tangpricha, Eric Yow, Reut Gurion, Laura E. Schanberg, Grace A. McComsey
LUPUS SCIENCE & MEDICINE
(2014)