Article
Medicine, General & Internal
Athimalaipet Ramanan, Pierre Quartier, Nami Okamoto, Ivan Foeldvari, Alberto Spindler, Sarka Fingerhutova, Jordi Anton, Zhongkai Wang, Gabriella Meszaros, Joana Araujo, Ran Liao, Stuart Keller
Summary: Baricitinib demonstrated good efficacy and acceptable safety in the treatment of polyarticular juvenile idiopathic arthritis, extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis, and juvenile psoriatic arthritis.
Article
Rheumatology
Umang Bhardwaj, Narendra K. Bagri, Rakesh Lodha, Sushil K. Kabra, Thirumurthy Velpandian, Ravindra M. Pandey
Summary: This study aimed to evaluate the efficacy and safety of pulse dexamethasone therapy in children with treatment-naive non-systemic JIA. The results showed that the addition of pulse dexamethasone to standard treatment may not have any advantage in improving ACR-Pedi 70 scores at medium-term follow-up.
Article
Medicine, General & Internal
Nicolino Ruperto, Hermine Brunner, Olga Synoverska, Tracy Ting, Carlos Abud Mendoza, Alberto Spindler, Yulia Vyzhga, Katherine Marzan, Lyudmila Grebenkina, Irit Tirosh, Lisa Imundo, Rita Jerath, Daniel J. Kingsbury, Betul Sozeri, Sheetal S. Vora, Sampath Prahalad, Elena Zholobova, Yonatan Butbul Aviel, Vyacheslav Chasnyk, Melissa Lerman, Kabita Nanda, Heinrike Schmeling, Heather Tory, Yosef Uziel, Diego O. Viola, Holly B. Posner, Keith S. Kanik, Ann Wouters, Cheng Chang, Richard Zhang, Irina Lazariciu, Ming-Ann Hsu, Ricardo M. Suehiro, Alberto Martini, Daniel J. Lovell
Summary: The trial showed that tofacitinib is an effective treatment for patients with polyarticular course JIA. New oral therapies are particularly relevant for children and adolescents, who might prefer to avoid injections.
Article
Allergy
Melody C. Carter, Irina Maric, Erica H. Brittain, Yun Bai, Keith Lumbard, Hyejeong Bolan, Daly Cantave, Linda M. Scott, Dean D. Metcalfe
Summary: The study aimed to determine the efficacy of omalizumab in managing patients with frequent episodes of IA, showing a trend of efficacy in the treatment group but no statistically significant differences. Overall, omalizumab was safely administered to a difficult-to-treat patient population with IA.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kai Huang, Ying Ding, Linling Que, Nannan Chu, Yunfei Shi, Zhenzhong Qian, Wei Qin, Yuanxin Chen, Xianghong Gu, Jiakun Wang, Zhiwei Zhang, Jianguo Xu, Qing He
Summary: This study aimed to investigate the safety, tolerability, and pharmacokinetics of WXFL10203614 in healthy Chinese subjects. A total of 592 subjects were enrolled, and results showed good safety and tolerability of WXFL10203614 in all dose levels, with dose-related changes in pharmacokinetic parameters. The findings support further clinical development of WXFL10203614 in patients with rheumatoid arthritis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Michelle Petri, Ian N. Bruce, Thomas Doerner, Yoshiya Tanaka, Eric F. Morand, Kenneth C. Kalunian, Mario H. Cardiel, Maria E. Silk, Christina L. Dickson, Gabriella Meszaros, Lu Zhang, Bochao Jia, Youna Zhao, Conor J. McVeigh, Marta Mosca
Summary: Baricitinib, an oral inhibitor of Janus kinase 1 and 2, was evaluated as a treatment for patients with systemic lupus erythematosus (SLE) in a 52-week phase 3 study. The study found that baricitinib did not significantly improve SLE disease activity compared with placebo, and there were no new safety concerns.
Article
Pharmacology & Pharmacy
Rocco Mollace, Micaela Gliozzi, Roberta Macri, Annamaria Tavernese, Vincenzo Musolino, Cristina Carresi, Jessica Maiuolo, Carolina Muscoli, Carlo Tomino, Giuseppe Maria Rosano, Massimo Fini, Maurizio Volterrani, Bruno Silvestrini, Vincenzo Mollace
Summary: This study investigated the safety profile of a new sublingual aspirin formulation in healthy volunteers. The results showed that this formulation had a better safety profile compared to standard aspirin, especially in reducing gastric mucosal lesions.
Article
Immunology
Jeremy T. Campillo, Paul Bikita, Marlhand Hemilembolo, Frederic Louya, Francois Missamou, Sebastien D. S. Pion, Michel Boussinesq, CedricB Chesnais
Summary: In a trial conducted in the Republic of the Congo, researchers assessed the safety and efficacy of levamisole for individuals with high microfilarial densities of Loa loa. The results showed that a single dose of 2.5mg/kg levamisole temporarily reduced the microfilarial densities, indicating its potential as a pretreatment to prevent adverse events after ivermectin treatment. However, further testing with higher doses or longer regimens is needed.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Anesthesiology
Jonathan Vela, Lene Dreyer, Kristian Kjaer Petersen, Lars Arendt-Nielsen, Kirsten Skjaerbaek Duch, Salome Kristensen
Summary: This study aimed to investigate the use of CBD as an adjuvant analgesic therapy in patients with hand osteoarthritis or psoriatic arthritis. The results showed no significant effects of CBD on pain intensity, sleep quality, depression, anxiety, or pain catastrophizing scores compared to placebo.
Article
Pediatrics
Tingyan He, Yu Xia, Ying Luo, Jun Yang
Summary: This study aimed to evaluate the efficacy and potential adverse effects of JAKi in patients with systemic juvenile idiopathic arthritis (SJIA). The results showed that JAKi may be an alternative or adjuvant agent for patients with persistently active disease, glucocorticoid-related adverse reactions, or SJIA-MAS.
FRONTIERS IN PEDIATRICS
(2023)
Article
Cell Biology
Justine Maller, Terry Morgan, Mayu Morita, Frank McCarthy, Yunshin Jung, Katrin J. Svensson, Joshua E. Elias, Claudia Macaubas, Elizabeth Mellins
Summary: The study suggests that intercellular communication mediated by extracellular vesicles plays an important role in the pathogenesis of systemic juvenile idiopathic arthritis. The number and cellular sources of extracellular vesicles differ between the active and inactive states of the disease and healthy controls.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Review
Rheumatology
Claas H. Hinze, Dirk Foell, Christoph Kessel
Summary: Systemic juvenile idiopathic arthritis (sJIA) is a disease characterized by severe systemic inflammation and arthritis. It poses challenges to rheumatologists treating pediatric and adult patients worldwide. Although treatment plans exist for classic sJIA, there is still a lack of clear treatment approaches for early sJIA without arthritis and complicated sJIA.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Review
Immunology
Bert Malengier-Devlies, Mieke Metzemaekers, Carine Wouters, Paul Proost, Patrick Matthys
Summary: Neutrophils play a crucial role in the innate immune system, using both oxidative and non-oxidative defense mechanisms to eradicate pathogens, and also act as decision shaping cells guiding other leukocytes for immune responses. The development and release of neutrophils are tightly regulated under both homeostatic and emergency conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Sarfaraz A. Hasni, Sarthak Gupta, Michael Davis, Elaine Poncio, Yenealem Temesgen-Oyelakin, Philip M. Carlucci, Xinghao Wang, Mohammad Naqi, Martin P. Playford, Rishi R. Goel, Xiaobai Li, Ann J. Biehl, Isabel Ochoa-Navas, Zerai Manna, Yinghui Shi, Donald Thomas, Jinguo Chen, Angelique Biancotto, Richard Apps, Foo Cheung, Yuri Kotliarov, Ashley L. Babyak, Huizhi Zhou, Rongye Shi, Katie Stagliano, Wanxia Li Tsai, Laura Vian, Nathalia Gazaniga, Valentina Giudice, Shajia Lu, Stephen R. Brooks, Meggan MacKay, Peter Gregersen, Nehal N. Mehta, Alan T. Remaley, Betty Diamond, John J. O'Shea, Massimo Gadina, Mariana J. Kaplan
Summary: Increased risk of premature cardiovascular disease in systemic lupus erythematosus (SLE) is mitigated by the Janus kinase inhibitor tofacitinib, demonstrated in a Phase 1 double-blind randomized trial in SLE patients where tofacitinib showed safety and improvements in cardiometabolic and immunologic parameters.
NATURE COMMUNICATIONS
(2021)
Review
Medicine, General & Internal
William G. Ambler, Kabita Nanda, Karen Brandt Onel, Susan Shenoi
Summary: This review focuses on the treatment options and potential future therapeutics for systemic juvenile idiopathic arthritis (SJIA). Recent advancements in targeted therapies have improved patient outcomes, but there are still subsets of patients with refractory disease and severe complications.
ANNALS OF MEDICINE
(2022)
Article
Rheumatology
Rina Mina, Khalid Abulaban, Marisa S. Klein-Gitelman, Barbara A. Eberhard, Stacy P. Ardoin, Nora Singer, Karen Onel, Lori Tucker, Kathleen O'neil, Tracey Wright, Elizabeth Brooks, Kelly Rouster-Stevens, Lawrence Jung, Lisa Imundo, Brad Rovin, David Witte, Jun Ying, Hermine I. Brunner
ARTHRITIS CARE & RESEARCH
(2016)
Article
Cell & Tissue Engineering
Gali Shalev-Malul, David C. Soler, Anthony E. Ting, Nicholas A. Lehman, Emma Barnboym, Thomas S. McCormick, Donald D. Anthony, Hillard M. Lazarus, Arnold I. Caplan, Maya Breitman, Nora G. Singer
STEM CELLS TRANSLATIONAL MEDICINE
(2016)
Article
Rheumatology
Rina Mina, Marisa S. Klein-Gitelman, Shannen Nelson, B. Anne Eberhard, Gloria Higgins, Nora G. Singer, Karen Onel, Lori Tucker, Kathleen M. O'Neil, Marilynn Punaro, Deborah M. Levy, Kathleen Haines, Alberto Martini, Nicolino Ruperto, Daniel Lovell, Hermine I. Brunner
ANNALS OF THE RHEUMATIC DISEASES
(2014)
Review
Rheumatology
Daniel E. Furst, Edward Clark Keystone, Alexander K. So, Juergen Braun, Ferry C. Breedveld, Gerd R. Burmester, Fabrizio De Benedetti, Thomas Doerner, Paul Emery, Roy Fleischmann, Allan Gibofsky, J. R. Kalden, Arthur Kavanaugh, Bruce Kirkham, Philip Mease, A. Rubbert-Roth, Joachim Sieper, Nora G. Singer, Josef S. Smolen, Piet L. C. M. Van Riel, Michael H. Weisman, Kevin L. Winthrop
ANNALS OF THE RHEUMATIC DISEASES
(2013)
Article
Rheumatology
Stacy P. Ardoin, Laura Eve Schanberg, Christy I. Sandborg, Huiman X. Barnhart, Greg W. Evans, Eric Yow, Kelly L. Mieszkalski, Norman T. Ilowite, Anne Eberhard, Lisa F. Imundo, Yuki Kimura, Deborah Levy, Emily von Scheven, Earl Silverman, Suzanne L. Bowyer, L. Punaro, Nora G. Singer, David D. Sherry, Deborah K. McCurdy, Marissa Klein-Gitelman, Carol Wallace, Richard M. Silver, Linda Wagner-Weiner, Gloria C. Higgins, Hermine I. Brunner, Lawrence Jung, Jennifer B. Soep, Ann M. Reed, Susan D. Thompson
ANNALS OF THE RHEUMATIC DISEASES
(2014)
Article
Rheumatology
L. E. Schanberg, C. Sandborg, H. X. Barnhart, S. P. Ardoin, E. Yow, G. W. Evans, K. L. Mieszkalski, N. T. Ilowite, A. Eberhard, L. F. Imundo, Y. Kimura, E. von Scheven, E. Silverman, S. L. Bowyer, M. Punaro, N. G. Singer, D. D. Sherry, D. McCurdy, M. Klein-Gitelman, C. Wallace, R. Silver, L. Wagner-Weiner, G. C. Higgins, H. I. Brunner, L. Jung, J. B. Soep, A. M. Reed, J. Provenzale, S. D. Thompson
ARTHRITIS AND RHEUMATISM
(2012)
Article
Spectroscopy
Shan Yang, Bolan Li, Mikhail N. Slipchenko, Anna Akkus, Nora G. Singer, Yener N. Yeni, Ozan Akkus
JOURNAL OF RAMAN SPECTROSCOPY
(2013)
Article
Rheumatology
R. Mina, M. S. Klein-Gitelman, S. Nelson, B. A. Eberhard, G. Higgins, N. G. Singer, K. Onel, L. Tucker, K. M. O'Neil, M. Punaro, D. M. Levy, K. Haines, J. Ying, H. I. Brunner
Article
Medicine, General & Internal
Qing Zhou, Dan Yang, Amanda K. Ombrello, Andrey V. Zavialov, Camilo Toro, Anton V. Zavialov, Deborah L. Stone, Jae Jin Chae, Sergio D. Rosenzweig, Kevin Bishop, Karyl S. Barron, Hye Sun Kuehn, Patrycja Hoffmann, Alejandra Negro, Wanxia L. Tsai, Edward W. Cowen, Wuhong Pei, Joshua D. Milner, Christopher Silvin, Theo Heller, David T. Chin, Nicholas J. Patronas, John S. Barber, Chyi-Chia R. Lee, Geryl M. Wood, Alexander Ling, Susan J. Kelly, David E. Kleiner, James C. Mullikin, Nancy J. Ganson, Heidi H. Kong, Sophie Hambleton, Fabio Candotti, Martha M. Quezado, Katherine R. Calvo, Hawwa Alao, Beverly K. Barham, Anne Jones, James F. Meschia, Bradford B. Worrall, Scott E. Kasner, Stephen S. Rich, Raphaela Goldbach-Mansky, Mario Abinun, Elizabeth Chalom, Alisa C. Gotte, Marilynn Punaro, Virginia Pascual, James W. Verbsky, Troy R. Torgerson, Nora G. Singer, Timothy R. Gershon, Seza Ozen, Omer Karadag, Thomas A. Fleisher, Elaine F. Remmers, Shawn M. Burgess, Susan L. Moir, Massimo Gadina, Raman Sood, Michael S. Hershfield, Manfred Boehm, Daniel L. Kastner, Ivona Aksentijevich
NEW ENGLAND JOURNAL OF MEDICINE
(2014)
Review
Rheumatology
Uzma A. Syeda, Nora G. Singer, Marina Magrey
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2013)
Article
Rheumatology
Rina Mina, Marisa S. Klein-Gitelman, Angelo Ravelli, Michael W. Beresford, Tadej Avcin, Graciela Espada, B. Anne Eberhard, Laura E. Schanberg, Kathleen M. O'Neil, Clovis A. Silva, Gloria C. Higgins, Karen Onel, Nora G. Singer, Emily von Scheven, Lisa F. Imundo, Shannen Nelson, Edward H. Giannini, Hermine I. Brunner
ARTHRITIS CARE & RESEARCH
(2012)
Article
Rheumatology
Rina Mina, Emily von Scheven, Stacy P. Ardoin, B. Anne Eberhard, Marilynn Punaro, Norman Ilowite, Joyce Hsu, Marisa Klein-Gitelman, L. Nandini Moorthy, Eyal Muscal, Suhas M. Radhakrishna, Linda Wagner-Weiner, Matthew Adams, Peter Blier, Lenore Buckley, Elizabeth Chalom, Gaelle Chedeville, Andrew Eichenfield, Natalya Fish, Michael Henrickson, Aimee O. Hersh, Roger Hollister, Olcay Jones, Lawrence Jung, Deborah Levy, Jorge Lopez-Benitez, Deborah McCurdy, Paivi M. Miettunen, Ana I. Quintero-Del Rio, Deborah Rothman, Ornella Rullo, Natasha Ruth, Laura E. Schanberg, Earl Silverman, Nora G. Singer, Jennifer Soep, Reema Syed, Larry B. Vogler, Ali Yalcindag, Cagri Yildirim-Toruner, Carol A. Wallace, Hermine I. Brunner
ARTHRITIS CARE & RESEARCH
(2012)
Article
Rheumatology
Reut Gurion, Nora G. Singer
CURRENT RHEUMATOLOGY REPORTS
(2013)
Article
Rheumatology
Angela Byun Robinson, Vin Tangpricha, Eric Yow, Reut Gurion, Laura E. Schanberg, Grace A. McComsey
LUPUS SCIENCE & MEDICINE
(2014)