Article
Hematology
Nadya M. Morrow, Natasha A. Trzaskalski, Antonio A. Hanson, Evgenia Fadzeyeva, Dawn E. Telford, Sanjiv S. Chhoker, Brian G. Sutherland, Jane Y. Edwards, Murray W. Huff, Erin E. Mulvihill
Summary: Nobiletin improves insulin sensitivity and prevents atherosclerosis by normalizing intestinal lipogenesis and reducing triglyceride accumulation. It enhances triglyceride-rich lipoprotein clearance and attenuates postprandial lipemia. Nobiletin also increases GLP-1 levels and protects intestinal morphology, promoting vascular health.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven
Summary: By analyzing the co-expression of genes, we identified the small leucine-rich protein 1 (SMLR1) as a player in the VLDL biogenesis pathway. The loss of hepatic SMLR1 in mice leads to hepatic steatosis, reduced VLDL secretion, providing protection against hyperlipidemia and atherosclerosis.
Article
Pharmacology & Pharmacy
Marissa Lightbourne, Megan Startzell, Kimberley D. Bruce, Brianna Brite, Ranganath Muniyappa, Monica Skarulis, Robert Shamburek, Ahmed M. Gharib, Ronald Ouwerkerk, Mary Walter, Robert H. Eckel, Rebecca J. Brown
Summary: This study found that volanesorsen can decrease apoC-III and triglycerides in patients with partial lipodystrophy, improve insulin resistance and hepatic steatosis through an LPL-dependent mechanism.
JOURNAL OF CLINICAL LIPIDOLOGY
(2022)
Article
Nutrition & Dietetics
Soo Lim, Yoon Ji Kim, Ah Reum Khang, Robert H. Eckel
Summary: This study found that abdominal visceral obesity and low HDL-cholesterol concentrations were associated with increased postprandial triglycerides (TG) and apolipoprotein B (ApoB), and these elevated concentrations were linked with subclinical atherosclerosis.
CLINICAL NUTRITION
(2021)
Review
Cardiac & Cardiovascular Systems
Chris J. Packard, Angela Pirillo, Sotirios Tsimikas, Brian A. Ference, Alberico L. Catapano
Summary: Pharmacological approaches for reducing LDL cholesterol have been effective in reducing cardiovascular disease risk, but residual risk persists. Elevated triglycerides and triglyceride-rich lipoproteins are associated with increased cardiovascular risk, and apoC-III plays a key role in regulating their metabolism. New drugs targeting apoC-III can substantially reduce triglyceride levels.
CARDIOVASCULAR RESEARCH
(2023)
Article
Multidisciplinary Sciences
Juan Pang, Fitore Raka, Alya Abbas Heirali, Weijuan Shao, Dinghui Liu, Jianqiu Gu, Jia Nuo Feng, Chieko Mineo, Philip W. Shaul, Xiaoxian Qian, Bryan Coburn, Khosrow Adeli, Wenhua Ling, Tianru Jin
Summary: Resveratrol intervention improves lipid homeostasis by inhibiting the intestinal FXR/SR-B1 signaling pathway, which is linked to gut microbiota and bile acids.
NATURE COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Elizabeth M. Rhea, William A. Banks
Summary: The interactions between lipids, lipoproteins, and apolipoproteins with the blood-brain barrier (BBB) are diverse and important for both health and disease.
PHARMACEUTICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Joungyoun Kim, Sang-Jun Shin, Ye-Seul Kim, Hee-Taik Kang
Summary: The study investigated the relationship between TG/HDL-C ratio and diabetes incidence in Korean adults. Results showed that higher TG/HDL-C ratio was significantly associated with an increased risk of new-onset diabetes in both men and women.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Waqas A. Malick, Ori Waksman, Ron Do, Wolfgang Koenig, Aruna D. Pradhan, Erik S. G. Stroes, Robert S. Rosenson
Summary: Triglyceride-rich lipoproteins (TRLs) are associated with residual risk in atherosclerotic cardiovascular disease patients, but previous clinical trials on TG-lowering therapies have shown limited efficacy. However, with the introduction of new RNA-silencing therapies, there is renewed interest in reducing TRLs for reducing major adverse cardiovascular events. Understanding the pathophysiology of TRLs, the pharmacological effects of TRL-lowering therapies, and optimal trial design are crucial for achieving significant outcomes. (J Am Coll Cardiol 2023;81:1646-1658) (c) 2023 by the American College of Cardiology Foundation.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Late Tokgozoglu, Peter Libby
Summary: Lipid risk factors for cardiovascular disease depend on both lifestyle and additional measures for optimum control. Recent genetic findings have identified novel targets for lipid-lowering therapy, providing new avenues for management. New treatments targeting triglyceride-rich lipoproteins and lipoprotein(a) have emerged and shown improved efficacy and tolerability. Gene-editing approaches are also being explored in lipid management.
EUROPEAN HEART JOURNAL
(2022)
Article
Geriatrics & Gerontology
Ben Kirk, Kate Mooney, Sara Vogrin, Matthew Jackson, Gustavo Duque, Omid Khaiyat, Farzad Amirabdollahian
Summary: The study investigated the effects of 16 weeks of leucine-enriched whey protein supplementation and resistance-based exercise on cardiometabolic health markers in older adults. The results showed that supplementing protein could improve LDL cholesterol levels, lower insulin and HOMA-IR levels, and be beneficial to the health of older adults.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Cardiac & Cardiovascular Systems
Gabriel E. Shaya, Thorsten M. Leucker, Steven R. Jones, Seth S. Martin, Peter P. Toth
Summary: Coronary heart disease is the leading cause of disability and death worldwide, with significant residual risk despite advances in understanding complex interactions among risk factors. Factors such as systemic inflammation, diabetes, high-density lipoprotein, plasma triglycerides, and others may contribute to this residual risk.
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Camilla Pramfalk, Osman Ahmed, Matteo Pedrelli, Mirko E. Minniti, Serge Luquet, Raphael Gp Denis, Maria Olin, Jennifer Hardfeldt, Lise-Lotte Vedin, Knut R. Steffensen, Mikael Ryden, Leanne Hodson, Mats Eriksson, Paolo Parini
Summary: This study reveals that depletion of the cholesterol ester synthesis enzyme Soat2 improves metabolic control in mice by partitioning lipids into secretory and oxidative pathways, reducing hepatic steatosis.
JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Ludovico Abenavoli, Tiziana Larussa, Alessandro Corea, Anna Caterina Procopio, Luigi Boccuto, Marcello Dallio, Alessandro Federico, Francesco Luzza
Summary: NAFLD, characterized by a wide spectrum of liver disorders, is considered a major public health issue globally. Polyphenols, known for their anti-inflammatory and antioxidant properties, are believed to have potential benefits in preventing and treating NAFLD, though limited human clinical trials are available.
Article
Oncology
Josep Guma, Jose Adria-Cebrian, Belen Ruiz-Aguado, Cinta Albacar, Josefa Girona, Ricardo Rodriguez-Calvo, Neus Martinez-Micaelo, Eric W. F. Lam, Luis Masana, Sandra Guaita-Esteruelas
Summary: The study identified a positive association between TG-enriched particles and certain branched amino acids with breast cancer, suggesting a distinct metabolic signature in BC patients that could aid in improved stratification and treatment. This is the first time advanced NMR profiling has been used to identify relevant lipid and amino acid metabolites in BC serum samples for early and reliable diagnosis and prognosis.