Article
Biochemistry & Molecular Biology
Atif Zafar, Hang Pong Ng, Rachel Diamond-Zaluski, Gun-Dong Kim, Ernest Ricky Chan, Sally L. Dunwoodie, Jonathan D. Smith, Ganapati H. Mahabeleshwar
Summary: The transcriptionally dynamic macrophages play key roles in the development of inflammatory vascular diseases. In this study, the CITED2 was identified as a cell-intrinsic negative regulator of inflammation in macrophages. The deficiency of CITED2 elevates pro-inflammatory gene expression and contributes to the development of atherosclerotic plaques.
Review
Biochemistry & Molecular Biology
Tatsuo Kawai, Katherine J. Elliott, Rosario Scalia, Satoru Eguchi
Summary: ADAMs play a key role in cell signaling by shedding cytokines and growth factors, leading to cell proliferation and inflammation. Among them, ADAM17 is the most extensively studied member and may have significant implications in cardiovascular diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yiwen Zha, Yongqi Yang, Yue Zhou, Bingqian Ye, Hongliang Li, Jingyan Liang
Summary: In this study, the active ingredient Evodiamine in Evodia rutaecarpa was found to regulate the proliferation, migration, inflammatory response, and oxidative stress in vascular smooth muscle cells by inhibiting the activation of the PI3K/Akt axis. This leads to a significant reduction in atherosclerotic plaque formation and suggests a potential future role for Evodiamine as an anti-atherosclerotic agent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Shushu Song, Yinghong Shi, Weicheng Wu, Hao Wu, Lei Chang, Peike Peng, Lei Zhang, Jia Fan, Jianxin Gu, Yuanyuan Ruan
Summary: Dysfunction of ER proteins is closely related to HCC development. RTN3 is expressed in normal hepatocytes but downregulated in HCC, predicting poor outcomes in patients with certain gene mutations or infections. RTN3 functions as a suppressor of HCC by activating the Chk2/p53 pathway, but its effects are abrogated in HBV-positive cells.
Article
Cardiac & Cardiovascular Systems
Francesca Vacante, Julie Rodor, Mukesh K. Lalwani, Amira D. Mahmoud, Matthew Bennett, Azzurra L. De Pace, Eileen Miller, Kim Van Kuijk, Jenny de Bruijn, Marion Gijbels, Thomas C. Williams, Michael B. Clark, Jessica P. Scanlon, Amanda C. Doran, Rusty Montgomery, David E. Newby, Mauro Giacca, Donal O'Carroll, Patrick W. F. Hadoke, Laura Denby, Judith C. Sluimer, Andrew H. Baker
Summary: The loss of CARMN lncRNA is identified as a critical early event that primes vSMCs toward a proatherogenic phenotype in vitro and accelerates the development of atherosclerosis in vivo. Knockout of CARMN impairs the expression of miR-143 and miR-145 under homeostatic conditions, leading to increased volume, size, proinflammatory cell content, and altered plaque composition during atherosclerosis induction in mice.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Daniel Tortolani, Camilla Di Meo, Sara Standoli, Francesca Ciaramellano, Salam Kadhim, Eric Hsu, Cinzia Rapino, Mauro Maccarrone
Summary: Rare cannabis-derived phytocannabinoids (pCBs) have therapeutic potential in skin disorders and their anti-inflammatory effects were investigated in this study. The experiment involved using lipopolysaccharide (LPS) to induce inflammation in human keratinocytes (HaCaT cells) and measuring the levels of pro-inflammatory interleukins. The results showed that pCBs significantly reduced the release of pro-inflammatory interleukins and modulated MAPK signaling, suggesting their potential as a treatment for inflammation-related skin pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Weifeng Li, Jinjin Yu, Xin Xiao, Wenqi Li, Lulu Zang, Tengfei Han, Dezhu Zhang, Xiaofeng Niu
Summary: The study found that ECG can inhibit VSMCs proliferation and migration, reduce cholesterol levels and oxidative stress by regulating inflammation, cell cycle, and gene expression pathways, suggesting potential clinical applications in preventing atherosclerosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Yusuke Kametani, Shota Tanaka, Yuriko Wada, Shota Suzuki, Ayaka Umeda, Kosuke Nishinaka, Yoshiaki Okada, Makiko Maeda, Shigeru Miyagawa, Yoshiki Sawa, Masanori Obana, Yasushi Fujio
Summary: Mammalian cardiomyocytes largely cease to proliferate immediately after birth, limiting the regenerative activity of the heart. Inhibition of GSK-3 promotes cardiomyocyte proliferation, and YAP is endogenously activated. This study addresses the importance of YAP activity in GSK-3 inhibitor-induced cardiomyocyte proliferation.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Medical Laboratory Technology
Chen Yang, Xuan Xiao, Liang Huang, Fan Zhou, Lin-hui Chen, Yu-Yan Zhao, Shun-Lin Qu, Chi Zhang
Summary: KLF4 plays a crucial role in atherosclerosis, regulating foam cell formation, vascular smooth muscle cells phenotypic transformation, and other important processes.
CLINICA CHIMICA ACTA
(2021)
Article
Cardiac & Cardiovascular Systems
Qiang Zhang, Xiao-Hui Wen, Shi-Lin Tang, Zhen-Wang Zhao, Chao-Ke Tang
Summary: Atherosclerosis is a lipid-driven chronic inflammatory disease and the major pathophysiological basis of various cardiovascular diseases. Gelsolin, a member of the Gelsolin family, plays a crucial role in regulating the cytoskeleton and participating in biological functions such as cell movement, metabolism, apoptosis, and phagocytosis. Increasing evidence suggests that Gelsolin is closely related to atherosclerosis, involving lipid metabolism, inflammation, cell proliferation, migration, and thrombosis. This article reviews the role of Gelsolin in atherosclerosis from the perspectives of inflammation, apoptosis, angiogenesis, and thrombosis.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Review
Cell Biology
Thomas N. Wight, Anthony J. Day, Inkyung Kang, Ingrid A. Harten, Gernot Kaber, David C. Briggs, Kathleen R. Braun, Joan M. Lemire, Michael G. Kinsella, Aleksander Hinek, Mervyn J. Merrilees
Summary: V3 is an understudied isoform of the versican family, lacking glycosaminoglycan chains. Despite limited research, studies have shown expression of V3 during development and disease, with significant phenotypic effects observed in experimental models. However, there are currently no antibodies available to distinguish V3 from other isoforms.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Tanyaporn Pattarabanjird, Melissa Marshall, Aditi Upadhye, Prasad Srikakulapu, James C. Garmey, Antony Haider, Angela M. Taylor, Esther Lutgens, Coleen A. McNamara
Summary: This study reveals a novel role for P62 in driving BAFF-induced B1b cell proliferation and IgM(OSE) production to attenuate diet-induced atherosclerosis. Results also identify a direct role for Id3 in antagonizing E2A from activating the p62 promoter. Moreover, analysis of putative human B1 cells also implicates these pathways in coronary artery disease subjects, suggesting P62 as a new immunomodulatory target for treating atherosclerosis.
CIRCULATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Aziz M. Rangwala, Victoria R. Mingione, George Georghiou, Markus A. Seeliger
Summary: Phosphorylation plays a vital role in regulating biological processes, and protein kinases have been extensively studied for their involvement in human health and disease. Some kinases possess additional catalytic functions in addition to phosphotransferase activity, while others have lost their catalytic activity completely. In this study, we analyzed the UniProtKB database for bifunctional protein kinases and focused on those crucial for bacterial and human cellular homeostasis. These kinases have diverse functional roles in environmental sensing, metabolic regulation, immune-host defense, and cell cycle control. This article explores their dual catalytic activities and their contributions to disease pathogenesis.
Review
Biochemistry & Molecular Biology
Subroto Chatterjee, Amrita Balram, Wendy Li
Summary: Lactosylceramide plays a crucial role in glycosphingolipid biosynthesis and lipid raft function, transducing external stimuli into cellular phenotypes. Its synthesis and activation by various stimuli leads to oxidative stress and inflammation, contributing to diseases like atherosclerosis and cancer through diverse signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Saleh A. Almatroodi, Ahmad Almatroudi, Amjad Ali Khan, Arshad Husain Rahmani
Summary: Cancer is a leading cause of death worldwide, and natural compounds like formononetin have been shown to inhibit cancer growth through their antioxidant and anti-inflammatory effects. Formononetin, a type of isoflavone, regulates inflammation, angiogenesis, cell cycle, and apoptosis, and has been proven effective against various cancer types. This review emphasizes the role of formononetin in different cancers and its influence on cell signaling pathways. Further clinical trials are needed to explore its potential in cancer prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Alejandra Barroso-Hernandez, Abril Ramirez-Higuera, Carolina Pena-Montes, Sergio Alberto Cortes-Ramirez, Mauricio Rodriguez-Dorantes, Oscar Lopez-Franco, Rosa Maria Oliart-Ros
Summary: This study investigated the effects of an omega-3 PUFA rich algal oil on locomotive alterations induced by haloperidol and D-2 receptor protein and gene expression in Wistar rats. The results confirmed the beneficial effects of omega-3 PUFA in reducing locomotive alterations and stimulating D-2 receptor presence, indicating their positive role in brain health.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Oncology
Cristina Diaz del Arco, Lourdes Estrada Munoz, Rodrigo Barderas Manchado, Alberto Pelaez Garcia, Luis Ortega Medina, Elena Molina Roldan, Guillermo Solis Fernandez, Soledad Garcia Gomez de las Heras, Ma Jesus Fernandez Acenero
PATHOLOGY & ONCOLOGY RESEARCH
(2020)
Article
Oncology
Cristina Diaz del Arco, Lourdes Estrada Munoz, Andres Sanchez Pernaute, Luis Ortega Medina, Soledad Garcia Gomez de las Heras, Ricardo Garcia Martinez, Maria Jesus Fernandez Acenero
Summary: This study compared the prognostic value of 3 different LN classifications for patients with resected GC, showing that LNR-based classification stratified patients better for prognosis assessment. Further studies are needed to evaluate the impact of the number of LN examined, cutoff values, and anatomic extent of LN disease in GC.
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2021)
Article
Pathology
Cristina Diaz del Arco, Lourdes Estrada Munoz, Luis Ortega Medina, Angela Chavez, Irene Ruiz Adelantado, Soledad Garcia Gomez de las Heras, M. Jesus Fernandez Acenero
ANNALS OF DIAGNOSTIC PATHOLOGY
(2020)
Article
Pathology
Cristina Diaz del Arco, Lourdes Estrada Munoz, Andres Sanchez Pernaute, Luis Ortega Medina, Soledad Garcia Gomez de las Heras, Ricardo Garcia Martinez, Ma. Jesus Fernandez Acenero
Summary: Analyzing the tumor-LNR classification can successfully predict the prognosis of resected gastric cancer patients. The T-LNR classification is significantly associated with tumor characteristics, patient progression, and death, demonstrating good stratification and discrimination capabilities.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2021)
Article
Oncology
David S. Moura, Maria Pena-Chilet, Juan Antonio Cordero Varela, Ramiro Alvarez-Alegret, Carolina Agra-Pujol, Francisco Izquierdo, Rafael Ramos, Luis Ortega-Medina, Francisco Martin-Davila, Carolina Castilla-Ramirez, Carmen Nieves Hernandez-Leon, Cleofe Romagosa, Maria Angeles Vaz Salgado, Javier Lavernia, Silvia Bague, Empar Mayodormo-Aranda, Luis Vicioso, Jose Emilio Hernandez Barcelo, Jordi Rubio-Casadevall, Ana de Juan, Maria Concepcion Fiano-Valverde, Nadia Hindi, Maria Lopez-Alvarez, Serena Lacerenza, Joaquin Dopazo, Antonio Gutierrez, Rosa Alvarez, Claudia Valverde, Javier Martinez-Trufero, Javier Martin-Broto
Summary: This study identified a six-gene predictive signature of trabectedin efficacy in advanced soft-tissue sarcomas. By evaluating 118 genes involved in DNA damage repair, potential biomarkers of trabectedin sensitivity or resistance were defined. Targeting some genes of this signature may enhance trabectedin efficacy in treatment.
MOLECULAR ONCOLOGY
(2021)
Article
Pathology
M. J. Fernandez-Acenero, R. Barderas, A. Pelaez Garcia, J. Martinez-Useros, L. Diez-Valladares, Perez-Aguirre, L. Ortega Medina, S. de la Serna Esteban, S. Garcia-Botella, C. Diaz del Arco, C. Galindo
Summary: Results from the study on pancreatic carcinoma revealed that cytoplasmic expression of AIP in both epithelial and stromal cells is associated with poor prognosis, while nuclear translocation of AIP seems to improve prognosis.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2021)
Article
Pathology
Cristina Diaz del Arco, Lourdes Estrada Munoz, Andres Sanchez Pernaute, Luis Ortega Medina, Soledad Garcia Gomez de las Heras, Ricardo Garcia Martinez, Ma. Jesus Fernandez Acenero
Summary: The retrospective study conducted in a Western tertiary center showed that various LNR classifications are significantly associated with clinicopathological features and independently prognostic. Different LNR classifications can better stratify patients into distinct prognostic categories, helping to predict patients' overall survival and disease-free survival.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2021)
Article
Oncology
Cristina Diaz del Arco, Luis Ortega Medina, Lourdes Estrada Munoz, Elena Molina Roldan, M. Angeles Ceron Nieto, Soledad Garcia Gomez de las Heras, M. Jesus Fernandez Acenero
Summary: Borrmann classification is commonly used for advanced gastric cancer diagnosis. The classification shows distinct clinicopathological and biological entities in patients, but does not have a direct association with prognosis. Further research is needed to verify its role in patient stratification.
Article
Oncology
Antonio Gomez, Miguel L. Pato, Luis Bujanda, Nuria Sala, Osmel Companioni, Angel Cosme, Martina Tufano, David J. Hanly, Nadia Garcia, Jose Miguel Sanz-Anquela, Javier P. Gisbert, Consuelo Lopez, Jose Ignacio Elizalde, Miriam Cuatrecasas, Victoria Andreu, Maria Jose Paules, Maria Dolores Martin-Arranz, Luis Ortega, Elvira Poves, Jesus Barrio, Maria Angeles Torres, Guillermo Munoz, Angel Ferrandez, Maria Jose Ramirez-Lazaro, Sergio Lario, Carlos A. Gonzalez, Manel Esteller, Maria Berdasco
Summary: Intestinal metaplasia is associated with an increased risk of gastric cancer, and finding molecular biomarkers can aid in guiding prevention programs. Helicobacter pylori infection influences DNA methylation, requiring early adoption of prevention strategies. Research suggests that intestinal metaplasia partially resembles the methylation patterns of intestinal gastric cancer.
Editorial Material
Cardiac & Cardiovascular Systems
Carla Jimenez Martinez, Roberto Del Castillo-Medina, Pablo Robles Velasco, Elena Batlle Lopez, Ana Vegas Serrano, Maria Anguita Gamez, Paula Campelos Fernandez, Melchor Saiz-Pardo Sanz, Luis Ortega Medina, Javier Botas Rodriguez
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Review
Cell Biology
Cristina Diaz del Arco, Luis Ortega Medina, Lourdes Estrada Munoz, Soledad Garcia Gomez Heras, Ma Jesus Fernandez Acenero
Summary: Gastric cancer remains a major global health issue, with poor prognosis and challenging patient categorization.
HISTOLOGY AND HISTOPATHOLOGY
(2021)
Article
Oncology
Gloria Marquina, Silvia Sanchez-Ramon, Ana Sarnago, Luis Ortega, Ana Bustos, Florentino Hernando, Juan Luis Cebrian, Antonio Casado
Summary: This case report describes an extremely rare occurrence where bilateral lung metastases spontaneously disappeared after surgical resection of the primary sarcoma, without additional systemic therapy. The patient underwent surgery and adjuvant external beam radiotherapy, with no evidence of disease recurrence during a 35-month follow-up period. Additional studies were conducted to gain insights into the potential causes of this rare phenomenon.
CASE REPORTS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Cristina Diaz del Arco, Lourdes Estrada Munoz, Elena Molina Roldan, Luis Ortega Medina, Soledad Garcia Gomez de las Heras, Angela Chavez, Ma Jesus Fernandez Acenero
Summary: In Western GC patients, Lauren subtype, pT stage, and lymph node ratio are significantly associated with tumor recurrence and patient survival. The developed prognostic models show good prognostic performance and have the potential to aid in personalized patient management.
SAUDI JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Emergency Medicine
F. Javier Martin-Sanchez, Juan Gonzalez del Castillo, Adrian Valls Carbo, Amanda Lopez Picado, Carmen Martinez-Valero, Juande D. Miranda, Ana Chacon, Pedro Lopez-Ayala, David Chaparro, Gabriel Cozar Lopez, Maria del Mar Suarez-Cadenas, Pablo Jerez Fernandez, Enrique del Toro, Eduardo Cardassay, Beatriz Angos, Cristina Diaz del Arco, Esther Rodriguez Adrada, Maria Teresa Montalvo Moraleda, Carolina Espejo Paeres, Carlos Elvira, Miguel Angel Garcia Brinon, Jose Ma Leal Pozuelo, Luis Ortega, Cristina Fernandez Perez, Juan Jorge Gonzalez Armengol