Article
Cardiac & Cardiovascular Systems
Selin Gencer, Yvonne Doering, Yvonne Jansen, Soyolmaa Bayasgalan, Yi Yan, Mariaelvy Bianchini, Ismail Cimen, Madeleine Mueller, Linsey J. F. Peters, Remco T. A. Megens, Philipp von Hundelshausen, Johan Duchene, Patricia Lemnitzer, Oliver Soehnlein, Christian Weber, Emiel P. C. van der Vorst
Summary: Arterial endothelial ACKR3 plays an important role in the development of atherosclerosis by mediating endothelium-immune cell adhesion, most likely through inflammatory MAPK and NF-kB pathways.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ghassan Bkaily, Danielle Jacques
Summary: The vascular endothelium is crucial in embryogenesis and aging, and it lines the blood vessels as a cell monolayer. It is recognized by the immune system as part of the body, so any abnormality in the endothelium exposes tissues to the immune system, leading to inflammation and vascular diseases like atherosclerosis. The endothelium's secretory role allows it to release vasoconstrictors, vasorelaxants, and cardio-modulatory factors that maintain proper circulatory system functioning. Adhesion molecules play a significant role in cardiovascular physiology and pathology by providing a seal for the monolayer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Atif Zafar, Hang Pong Ng, Rachel Diamond-Zaluski, Gun-Dong Kim, Ernest Ricky Chan, Sally L. Dunwoodie, Jonathan D. Smith, Ganapati H. Mahabeleshwar
Summary: The transcriptionally dynamic macrophages play key roles in the development of inflammatory vascular diseases. In this study, the CITED2 was identified as a cell-intrinsic negative regulator of inflammation in macrophages. The deficiency of CITED2 elevates pro-inflammatory gene expression and contributes to the development of atherosclerotic plaques.
Review
Biochemistry & Molecular Biology
Nadja Paeslack, Maximilian Mimmler, Stefanie Becker, Zhenling Gao, My Phung Khuu, Amrit Mann, Frano Malinarich, Tommy Regen, Christoph Reinhardt
Summary: Gut commensals play a significant role in the modulation of tryptophan metabolism, affecting innate immune cell functions and promoting the production of specific cells and cytokines. Microbiota-derived tryptophan metabolites also influence vascular endothelium and can impact the development of vascular inflammatory phenotypes.
Article
Microbiology
Osezua Oseghale, Stella Liong, Madison Coward-Smith, Eunice E. To, Jonathan R. Erlich, Raymond Luong, Felicia Liong, Mark Miles, Shaghayegh Norouzi, Cara Martin, Sharon O'Toole, Robert D. Brooks, Steven Bozinovski, Ross Vlahos, John J. O'Leary, Doug A. Brooks, Stavros Selemidis
Summary: Influenza A virus infection during pregnancy leads to dysfunction in aortic endothelial cells and vascular smooth muscle, with the perivascular adipose tissue (PVAT) playing a role in viral dissemination and inflammation. The PVAT exhibits increased levels of inflammatory cells and activated T cells along with increased neutrophils, pro-inflammatory cytokines, and oxidative stress markers.
Article
Biochemistry & Molecular Biology
Nathan J. Martin, Belal Chami, Abigail Vallejo, Albaraa A. Mojadadi, Paul K. Witting, Gulfam Ahmad
Summary: Intracellular redox imbalance in endothelial cells can lead to cardiovascular diseases, and 4-MetT can ameliorate endothelial dysfunction by inhibiting inflammation induced by SAA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Chao Ye, Fen Zheng, Nan Wu, Guo-qing Zhu, Xiu-zhen Li
Summary: Vascular remodeling plays a crucial role in the development of various vascular diseases and is closely associated with the release of extracellular vesicles (EVs). EVs impact vascular remodeling by affecting oxidative stress, inflammation, calcification, and lipid plaque formation. Therefore, EVs have the potential to be used as biomarkers for diagnosis and prognosis, as well as therapeutic targets for vascular remodeling and cardiovascular diseases.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Dentistry, Oral Surgery & Medicine
D. Wu, Y. Weng, Y. Feng, B. Liang, H. Wang, L. Li, Z. Wang
Summary: In periodontitis, Trem1 regulates polarization of M1 macrophages through the STAT3/HIF-1α signaling pathway. Studies suggest that targeting Trem1 could be a potential strategy for the treatment of periodontitis by modulating macrophage polarization.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Raffaele Maio, Maria Perticone, Edoardo Suraci, Angela Sciacqua, Giorgio Sesti, Francesco Perticone
Summary: Impaired endothelium-dependent vasodilation and high-sensitivity C-reactive protein (hs-CRP) predict the development of incident heart failure in hypertensive patients. Older age, female gender, higher baseline heart rate, glucose, insulin, creatinine, and hs-CRP mean values are associated with a higher risk of developing heart failure.
Article
Multidisciplinary Sciences
Daniella A. Lefteri, Steven R. Bryden, Marieke Pingen, Sandra Terry, Emily F. Beswick, Georgi Georgiev, Marleen Van der Laan, Valeria Mastrullo, Paola Campagnolo, Robert Waterhouse, Margus Varjak, Andres Merits, Rennos Fragkoudis, Stephen Griffin, Kave Shams, Emilie Pondeville, Clive S. McKimmie
Summary: Viruses transmitted by Aedes mosquitoes are a significant global cause of disease. The enhancement of virus infection by mosquito saliva is mediated by a gene product called sialokinin, which rapidly reduces endothelial barrier integrity. This mechanism is absent in Anopheles mosquitoes, explaining their incompetence in transmitting arthropod-borne viruses. Therapeutic strategies targeting sialokinin have potential in reducing disease severity following infection with Aedes-mosquito-borne viruses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Agnieszka Krupa, Weronika Gonciarz, Paulina Rusek-Wala, Tomasz Rechcinski, Adrian Gajewski, Zuzanna Samsel, Anna Dziuba, Agnieszka Smiech, Magdalena Chmiela
Summary: Chronic Helicobacter pylori infections and a high-fat diet may synergistically contribute to the development of proatherogenic conditions, as evidenced by the infiltration of inflammatory cells into the vascular endothelium and the decreased elasticity of arteries observed in animal models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Haoyang Zhou, Dafeng Yang, Henry S. Cheng, Michael G. McCoy, Daniel Perez-Cremades, Stefan Haemmig, Danny Wong, Lei Chen, Mark W. Feinberg
Summary: The study uncovers an important role of miR-181b in regulating vascular endothelial aging through the MAP3K3-MAPK signaling pathway, revealing potential therapeutic targets for anti-aging therapy in cardiovascular disease.
Article
Multidisciplinary Sciences
Max Lenz, Manuel Salzmann, Cosmin Ciotu, Christoph Kaun, Konstantin A. Krychtiuk, Andreja Rehberger Likozar, Miran Sebestjen, Laura Goederle, Sabine Rauscher, Zoriza Krivaja, Christoph J. Binder, Kurt Huber, Christian Hengstenberg, Bruno K. Podesser, Michael J. M. Fischer, Johann Wojta, Philipp J. Hohensinner, Walter S. Speidl
Summary: This study demonstrates the importance of Na+ influx modulation in cellular response to inflammation. Ranolazine, a known antianginal drug, reduces intracellular Na+ levels and shows anti-inflammatory effects in both human patients and a mouse atherosclerotic disease model.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Hematology
Yao Wei Lu, Nina Martino, Brennan D. Gerlach, John M. Lamar, Peter A. Vincent, Alejandro P. Adam, John J. Schwarz
Summary: MEF2 is a critical regulator of vascular homeostasis with downstream effects on gene expression programs involved in atherosclerosis development and the promotion of an anti-inflammatory and antithrombotic endothelium. Its deficiency leads to systemic inflammation, hemorrhage, thrombocytopenia, leukocytosis, and rapid lethality. MEF2 also plays a role in regulating multiple pathways, including the expression of Klf2 and Klf4 for anti-inflammatory and antithrombotic endothelium, as well as Notch family genes for atheroprotection.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Peripheral Vascular Disease
Vanessa Oliveira, Anne E. Kwitek, Curt D. Sigmund, Lisa L. Morselli, Justin L. Grobe
Summary: Obesity is the major obstacle to improving cardiovascular health, involving changes in energy balance control that may lead to hypertension. Drug development targeting metabolism often leads to hypertension, but new research suggests different subtypes of AGRP neurons may have varying effects on feeding, metabolism, or blood pressure control.
Editorial Material
Peripheral Vascular Disease
Ryohei Kuroda, Satoru Eguchi
AMERICAN JOURNAL OF HYPERTENSION
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Keisuke Okuno, Satoru Eguchi
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Stephanie M. Cicalese, Josiane Fernandes da Silva, Fernanda Priviero, R. Clinton Webb, Satoru Eguchi, Rita C. Tostes
Summary: Cells respond to stress by activating defense signaling pathways for survival or cell death. Arterial hypertension and aging share mechanisms that mediate chronic cell stress, potentially leading to unresolved pathologies.
CIRCULATION RESEARCH
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Stephanie Cicalese, Satoru Eguchi
CARDIOVASCULAR RESEARCH
(2022)
Editorial Material
Medicine, Research & Experimental
Keiichi Torimoto, Satoru Eguchi
Summary: The study highlights the role of sPRR as a ligand for AT1R, causing endothelial dysfunction and hypertension. The interaction between sPRR and AT1R contributes to obesity-induced cardiovascular diseases. The sPRR/AT1R complex may be a potential therapeutic target for endothelial dysfunction.
Article
Peripheral Vascular Disease
Masaaki Korai, James Purcell, Yoshinobu Kamio, Kazuha Mitsui, Hajime Furukawa, Kimihiko Yokosuka, Takeshi Miyamoto, Hitomi Sato, Hiroki Sato, Satoru Eguchi, Jinglu Ai, Michael T. Lawton, Tomoki Hashimoto
Summary: Neutrophil extracellular traps (NETs) play a crucial role in promoting the rupture of intracranial aneurysm. Pharmacological and genetic interventions targeting NETs can effectively reduce the rate of aneurysm rupture. Inhibition of NET formation may represent a potential therapeutic strategy for preventing aneurysmal rupture.
Article
Clinical Neurology
Kimihiko Yokosuka, Caleb Rutledge, Yoshinobu Kamio, Atsushi Kuwabara, Hiroki Sato, Redi Rahmani, James Purcell, Satoru Eguchi, Jacob F. Baranoski, Tigran Margaryan, Artak Tovmasyan, Jinglu Ai, Michael T. Lawton, Tomoki Hashimoto
Summary: The study shows that dietary daidzein and its metabolite, equol, protect against aneurysm formation in ovariectomized female mice by activating estrogen receptor-beta and suppressing inflammation. This suggests the potential therapeutic value of dietary daidzein and equol for preventing intracranial aneurysms and related subarachnoid hemorrhage.
Review
Medicine, Research & Experimental
Jeffrey Kingsley, Keiichi Torimoto, Tomoki Hashimoto, Satoru Eguchi
Summary: Sarcopenia is characterized by progressive loss of muscle mass and strength, leading to increased risks of falls, fractures, disability, and death. The causes are multifactorial, including genetics, aging, immobility, nutritional deficiencies, inflammation, stress, and endocrine factors. Prevention or reduction of sarcopenia requires exploring new treatment methods.
Review
Peripheral Vascular Disease
Tolga Kilic, Keisuke Okuno, Satoru Eguchi, Zamaneh Kassiri
Summary: This review discusses the role of ADAMs and ADAMTSs in abdominal and thoracic aortic aneurysm and their regulation of the function of different cell types.
Article
Biochemistry & Molecular Biology
Junchul Shin, Soon-Gook Hong, Soo Young Choi, Meghan E. Rath, Jason Saredy, Daniel G. Jovin, Jacqueline Sayoc, Hye-Sang Park, Satoru Eguchi, Victor Rizzo, Rosario Scalia, Hong Wang, Steven R. Houser, Joon-Young Park
Summary: Tumor suppressor p53 plays a pivotal role in regulating mitochondrial remodeling in endothelial cells. It controls the content, fusion/fission processes, and intracellular signaling molecules associated with mitophagy and apoptosis pathways. In addition, p53 is involved in the mechanism of flow-induced mitochondrial remodeling by binding to mitochondrial transcription factor A (TFAM) and improving mtDNA integrity.
Article
Peripheral Vascular Disease
Keisuke Okuno, Keiichi Torimoto, Stephanie M. Cicalese, Kyle Preston, Victor Rizzo, Tomoki Hashimoto, Thomas M. Coffman, Matthew A. Sparks, Satoru Eguchi
Summary: Smooth muscle AT(1A) receptors mediate Ang II-induced vascular remodeling in both hypertensive and non-hypertensive conditions, contributing to medial hypertrophy and perivascular fibrosis. These findings indicate an independent etiology of blood pressure elevation and hypertensive vascular remodeling in response to Ang II.
Article
Cardiac & Cardiovascular Systems
Stephanie Cicalese, Keiichi Torimoto, Keisuke Okuno, Katherine J. Elliott, Victor Rizzo, Tomoki Hashimoto, Satoru Eguchi
Summary: This study demonstrates that a chemical chaperone called 3HNA can prevent vascular remodeling and hypertension by preserving protein homeostasis. In a mouse model, treatment with 3HNA prevented AngII-induced hypertension and reduced vascular medial thickening and perivascular fibrosis. Additionally, 3HNA attenuated an increase in protein synthesis in AngII-stimulated vascular smooth muscle cells.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Biographical-Item
Peripheral Vascular Disease
Satoru Eguchi, Masaaki Tamura, Teruyoshi Matoba
Article
Peripheral Vascular Disease
Keisuke Okuno, Keiichi Torimoto, Ryohei Kuroda, Stephanie M. M. Cicalese, Yoshiharu Okuno, Ryohei Kono, Shinsuke Marumoto, Hirotoshi Utsunomiya, Satoru Eguchi
Summary: Fruit from the Prunus mume tree, especially the infused juice concentrate known as bainiku-ekisu, has been found to have potential health benefits in preventing hypertension and inflammatory vascular remodeling induced by Angiotensin II. This was observed in a mouse model of hypertension, where bainiku-ekisu attenuated aortic hypertrophy, infiltration of collagen producing cells and immune cells, and prevented the development of hypertension and cardiac hypertrophy. Further studies should be conducted to explore the cardiovascular health benefits of taking bainiku-ekisu.
HYPERTENSION RESEARCH
(2023)
