期刊
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
卷 61, 期 5, 页码 357-365出版社
SPRINGER BASEL AG
DOI: 10.1007/s00005-013-0234-1
关键词
Thymoproteasomes; beta 5t; Thymus; Positive selection; Thymoma; Thymic carcinoma
类别
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Ministry of Health, Labor and Welfare of Japan
The thymoproteasome is a specialized type of proteasomes expressed exclusively in the thymic cortex. It has a unique catalytic subunit beta 5t with unusual enzymatic activity. The thymoproteasome exhibits lower chymotrypsin-like activity than other forms of proteasomes such as constitutive proteasomes and immunoproteasomes. Its cleavage specificity appears uniquely suited for the production of peptides that mediate positive selection of CD8(+) T cells. Similar to major histocompatibility complex molecules and T/B-cell receptors, the thymoproteasome occurs only in jawed vertebrates, suggesting that it evolved concomitant with the cardinal elements of adaptive immunity. beta 5t can be used as a marker in the differential diagnosis of thymic tumors. It is expressed in most type B and some type AB thymomas, but not in type A thymoma, thymic carcinoma, or tumors of non-thymic epithelial origin.
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