Article
Biochemistry & Molecular Biology
Eleonore Froehlich
Summary: This review discusses pulmonary changes and treatment options for ARDS induced by viruses, focusing on the potential role of pulmonary lymphatics in the pathology. Although hyaluronan may play a role in ARDS, promising pharmacological treatments are unlikely due to the limited role of drugs in lymphedema therapy.
Review
Medicine, Research & Experimental
Sofia Tejada, Raquel Martinez-Reviejo, Hanife N. Karakoc, Yolanda Pena-Lopez, Oriol Manuel, Jordi Rello
Summary: This study summarized the efficacy and safety of ribavirin for the treatment of respiratory syncytial virus (RSV) associated lower respiratory tract infections. The results showed that ribavirin is effective in treating RSV-LRTI in patients with hematological diseases, and oral ribavirin is associated with increased viral clearance. However, there is a lack of evidence to support its use in lung transplant recipients.
ADVANCES IN THERAPY
(2022)
Article
Multidisciplinary Sciences
Xiaoting Yang, Jing Wang, Wei Liu
Summary: In this study, molecular markers associated with type II alveolar epithelial cell injury in acute lung injury (ALI) were identified using bioinformatics methods. The results provide new insights for the diagnosis and treatment of ALI/ARDS.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Kieran Dee, Verena Schultz, Joanne Haney, Laura A. Bissett, Callum Magill, Pablo R. Murcia
Summary: Virus-virus interactions can impact the infection dynamics of respiratory viruses. In this study, 3-dimensional cultures of airway epithelium were used to show that SARS-CoV-2 replication is impaired in coinfections with influenza A or respiratory syncytial virus.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Immunology
Ting Shi, Sophie Vennard, Francis Jasiewicz, Rory Brogden, Harish Nair
Summary: RSV-ARI in adults with comorbidities is a significant burden, with limited data available. This study estimated the incidence, hospitalization rate, and in-hospital case fatality ratio of RSV-ARI in this population, and found an association between the disease and any comorbidity.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Katherine M. Begley, Arnold S. Monto, Lois E. Lamerato, Anurag N. Malani, Adam S. Lauring, H. Keipp Talbot, Manjusha Gaglani, Tresa McNeal, Fernanda P. Silveira, Richard K. Zimmerman, Donald B. Middleton, Shekhar Ghamande, Kempapura Murthy, Lindsay Kim, Jill M. Ferdinands, Manish M. Patel, Emily T. Martin
Summary: In this study, adults hospitalized with respiratory syncytial virus (RSV) were found to have worse outcomes compared with influenza. They were more likely to have cardiopulmonary comorbidities, experience a longer stay, and require mechanical ventilation. This study highlights the importance of RSV surveillance and informs future vaccination strategies.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Geriatrics & Gerontology
Melissa R. Riester, Elliott Bosco, Rishik Manthana, Melissa Eliot, Barbara H. Bardenheier, Joe B. B. Silva, Robertus van Aalst, Ayman Chit, Matthew M. Loiacono, Stefan Gravenstein, Andrew R. Zullo
Summary: This study aimed to quantify the relationship between increasing influenza and RSV community viral activity and cardiorespiratory rehospitalizations among older adults discharged to skilled nursing facilities (SNFs). The results showed that cardiorespiratory rehospitalization rates increased by approximately 1% for every 5% increase in circulating influenza A(H3N2), influenza B, and RSV, but decreased by 1% for every 5% increase in circulating influenza A(H1N1pdm09). During the respiratory virus season, cardiorespiratory rehospitalization rates increased by approximately 6% for influenza A(H3N2), 3% for influenza B, and 5% for RSV, but decreased by 6% for influenza A(H1N1pdm09).
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Plant Sciences
JunMei Wang, Chunxiu Ren, WenHui Bi, Wuliji Batu
Summary: Glycyrrhiza glabra L. is a widely used traditional Chinese medicine with various therapeutic effects. This study found that its active ingredient, glycyrrhizin, has anti-inflammatory effects and can alleviate acute lung injury (ALI) by interfering with the NF-κB/NLRP3 signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Shimon Amar, Yonat Shemer Avni, Norm O'Rourke, Tal Michael
Summary: The study examines the incidence rates of infectious diseases after a successful COVID-19 vaccination campaign and the lifting of social restrictions in Israel. The results suggest that the rates of respiratory and gastrointestinal infections have increased, indicating that similar trends could occur in other countries.
Article
Virology
Hortense Petat, Vincent Gajdos, Francois Angoulvant, Pierre-Olivier Vidalain, Sandrine Corbet, Christophe Marguet, Jacques Brouard, Astrid Vabret, Meriadeg Ar Gouilh
Summary: The study found that in infants with acute bronchiolitis, 90% tested positive for respiratory syncytial virus and 34% for human rhinovirus, with a higher risk of HRV infection in the absence of RSV. This suggests the presence of interference or exclusion mechanisms between HRV and RSV.
Article
Immunology
Zaid Haddadin, Stockton Beveridge, Kailee Fernandez, Danielle A. Rankin, Varvara Probst, Andrew J. Spieker, Tiffanie M. Markus, Laura S. Stewart, William Schaffner, Mary Lou Lindegren, Natasha Halasa
Summary: Respiratory syncytial virus (RSV) is the leading cause of acute respiratory infections (ARIs) in hospitalized children. RSV-positive children were more likely to be hospitalized, require intensive care unit admission, and receive oxygen compared with children positive for other viruses. Higher viral load, White race, younger age, and higher severity score were independently associated with hospitalization in RSV-positive children.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Thomas S. Metkus, Lori J. Sokoll, Andreas S. Barth, Matthew J. Czarny, Allison G. Hays, Charles J. Lowenstein, Erin D. Michos, Eric P. Nolley, Wendy S. Post, Jon R. Resar, David R. Thiemann, Jeffrey C. Trost, Rani K. Hasan
Summary: The study found that over 50% of intubated patients with severe COVID-19 had myocardial injury, which was associated with a higher mortality rate. Myocardial injury in COVID-19 was closely related to baseline comorbidities, age, and multisystem organ dysfunction. Compared with ARDS patients without COVID-19, COVID-19 patients were older and had poorer cardiac function, but had a lower incidence of myocardial injury.
Article
Virology
Chantal J. Snoeck, Konstantin Evdokimov, Kinnaly Xaydalasouk, Sodaly Mongkhoune, Aurelie Sausy, Keoudomphone Vilivong, Maude Pauly, Judith M. Hubschen, Somxay Billamay, Claude P. Muller, Antony P. Black
Summary: Respiratory infections are a common reason for medical consultations in children, with human rhinoviruses being the most frequently detected pathogen in Lao children. Influenza A and B viruses combined infection is also common. The study provides recommendations for vaccination and further research.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Medicine, Research & Experimental
Camilla Margaroli, Timothy Fram, Nirmal S. Sharma, Siddharth B. Patel, Jennifer Tipper, Sarah W. Robison, Derek W. Russell, Seth D. Fortmann, Mudassir M. Banday, Yixel Soto-Vazquez, Tarek Abdalla, Sawanan Saitornuang, Matthew C. Madison, Sixto M. Leal Jr, Kevin S. Harrod, Nathaniel B. Erdmann, Amit Gaggar
Summary: Neutrophilic inflammation is observed in respiratory viral infections, including COVID-19-related acute respiratory distress syndrome, but its role in disease pathogenesis is unclear. This study phenotyped immune cells in the blood and airway of 52 severe COVID-19 patients and identified two subpopulations of neutrophils. The loss of one neutrophil subset correlated with increased viral burden and decreased survival. Further experiments showed that this subset exhibited an antiviral response, which was dependent on type I interferon signaling. Understanding this neutrophil phenotype could lead to new therapeutic approaches for viral illnesses.
Article
Medicine, General & Internal
Luofei Zhang, Shenghui Mei, Bin Zhu, Zhigang Zhao
Summary: This study comprehensively reviews the cooperation and influence of countries, institutions, authors and co-cited journals/authors/references and keywords in the field of ALI/ARDS associated with viral pneumonia. The clustering evolution of knowledge structure was evaluated, and hot trends and emerging topics were identified.
FRONTIERS IN MEDICINE
(2023)
