期刊
ARCHIVES OF TOXICOLOGY
卷 88, 期 6, 页码 1249-1256出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00204-014-1239-1
关键词
Cisplatin; Nephrotoxicity; Mitochondria; Apoptosis; Reactive oxygen species
类别
资金
- National Natural Science Foundation of China [81370791]
- Hunan Province Natural Science Foundation, China [2009TP-1066-2]
- National Institutes of Health
- Department of Veterans Administration of USA
Nephrotoxicity is a major side effect of cisplatin in chemotherapy. Pathologically, cisplatin nephrotoxicity is characterized by cell injury and death in renal tubules. The research in the past decade has gained significant understanding of the cellular and molecular mechanisms of tubular cell death, revealing a central role of mitochondrial dysregulation. The pathological changes in mitochondria in cisplatin nephrotoxicity are mainly triggered by DNA damage response, pro-apoptotic protein attack, disruption of mitochondrial dynamics, and oxidative stress. As such, inhibitory strategies targeting these cytotoxic events may provide renal protection. Nonetheless, ideal approaches for renoprotection should not only protect kidneys but also enhance the anticancer efficacy of cisplatin in chemotherapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据