Biology of the cell cycle inhibitor p21CDKN1A: molecular mechanisms and relevance in chemical toxicology

Cladosporol A, a new peroxisome proliferator-activated receptor γ (PPARγ) ligand, inhibits colorectal cancer cells proliferation through β-catenin/TCF pathway inactivation

(2014) Diana Zurlo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A cell-based biosensor system HepG2CDKN1A–DsRed for rapid and simple detection of genotoxic agents

(2014) Tanja Blagus et al.   BIOSENSORS & BIOELECTRONICS

Progression of Breast Cancer Cells Was Enhanced by Endocrine-Disrupting Chemicals, Triclosan and Octylphenol, via an Estrogen Receptor-Dependent Signaling Pathway in Cellular and Mouse Xenograft Models

(2014) Hye-Rim Lee et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Methoxychlor and triclosan stimulates ovarian cancer growth by regulating cell cycle- and apoptosis-related genes via an estrogen receptor-dependent pathway

(2014) Joo-Young Kim et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Altered expression of p21, activated caspase-3, and PCNA in bronchiolar epithelium of smokers with and without chronic obstructive pulmonary disease

(2014) Giuseppina Chiappara et al.   EXPERIMENTAL LUNG RESEARCH

Induction of p21Waf1/Cip1 by Garcinol via Downregulation of p38-MAPK Signaling in p53-Independent H1299 Lung Cancer

(2014) Sheng-Yung Yu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

RhoA-Mediated Inhibition of Vascular Endothelial Cell Mobility: Positive Feedback Through Reduced Cytosolic p21 and p27

(2014) Yung-Ho Hsu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Transcriptional activation of p21WAF1/CIP1 is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts

(2014) Hyun-Seok Kim et al.   MOLECULAR BIOLOGY REPORTS

Notch inhibition allows oncogene-independent generation of iPS cells

(2014) Justin K Ichida et al.   Nature Chemical Biology

CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis

(2014) Ornella Cazzalini et al.   NUCLEIC ACIDS RESEARCH

Bidirectional Functions of Arsenic as a Carcinogen and an Anti-Cancer Agent in Human Squamous Cell Carcinoma

(2014) Nguyen Dinh Thang et al.   PLoS One

Aluminium Induced Endoplasmic Reticulum Stress Mediated Cell Death in SH-SY5Y Neuroblastoma Cell Line Is Independent of p53

(2014) Syed Husain Mustafa Rizvi et al.   PLoS One

In vivo treatment with aflatoxin B1 increases DNA oxidation, base excision repair activity and 8-oxoguanine DNA glycosylase 1 levels in mouse lung

(2014) Katherine A. Guindon-Kezis et al.   TOXICOLOGY

Zinc oxide nanoparticles induce apoptosis by enhancement of autophagy via PI3K/Akt/mTOR inhibition

(2014) Ruchi Roy et al.   TOXICOLOGY LETTERS

The Cytolethal Distending Toxin Effects on Mammalian Cells: A DNA Damage Perspective

(2014) Elisabeth Bezine et al.   Cells

Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: a critical review

(2013) Olesja Bondarenko et al.   ARCHIVES OF TOXICOLOGY

Osteoblasts survive the arsenic trioxide treatment by activation of ATM-mediated pathway

(2013) Yu-Chen Hu et al.   BIOCHEMICAL PHARMACOLOGY

The role of p21 Waf1/Cip1 in large airway epithelium in smokers with and without COPD

(2013) Giuseppina Chiappara et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Proliferation-Quiescence Decision Is Controlled by a Bifurcation in CDK2 Activity at Mitotic Exit

(2013) Sabrina L. Spencer et al.   CELL

DDB2 association with PCNA is required for its degradation after UV-induced DNA damage

(2013) Ornella Cazzalini et al.   CELL CYCLE

A role for p38 in transcriptional elongation of p21CIP1in response to Aurora B inhibition

(2013) Geeta Kumari et al.   CELL CYCLE

Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21Cip1

(2013) Marianna Trakala et al.   CELL CYCLE

STAT3 interacts with Skp2/p27/p21 pathway to regulate the motility and invasion of gastric cancer cells

(2013) Zheng Wei et al.   CELLULAR SIGNALLING

Paraquat inhibits cell viability via enhanced oxidative stress and apoptosis in human neural progenitor cells

(2013) Xiuli Chang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A Functional Role of the Cyclin-Dependent Kinase Inhibitor 1 (P21WAF1/CIP1) for Neuronal Preconditioning

(2013) Philipp Mergenthaler et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Silver-based nanoparticles induce apoptosis in human colon cancer cells mediated through p53

(2013) Shakti Ranjan Satapathy et al.   Nanomedicine

Transcriptional repression of Bmp2 by p21Waf1/Cip1 links quiescence to neural stem cell maintenance

(2013) Eva Porlan et al.   NATURE NEUROSCIENCE

p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia

(2013) C Saiz-Ladera et al.   ONCOGENE

Sterigmatocystin-Induced DNA Damage Triggers G2 Arrest via an ATM/p53-Related Pathway in Human Gastric Epithelium GES-1 Cells In Vitro

(2013) Donghui Zhang et al.   PLoS One

P21-PARP-1 Pathway Is Involved in Cigarette Smoke-Induced Lung DNA Damage and Cellular Senescence

(2013) Hongwei Yao et al.   PLoS One

Runx1 and p21 synergistically limit the extent of hair follicle stem cell quiescence in vivo

(2013) J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity

(2013) Rina Sakai et al.   TOXICOLOGY

p53 activation by Ni(II) is a HIF-1α independent response causing caspases 9/3-mediated apoptosis in human lung cells

(2013) Victor C. Wong et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

Cyclin-dependent kinase inhibitor p21Waf1: Contemporary view on its role in senescence and oncogenesis

(2012) V. S. Romanov et al.   BIOCHEMISTRY-MOSCOW

The resveratrol analog 4,4'-dihydroxy-trans-stilbene suppresses transformation in normal mouse fibroblasts and inhibits proliferation and invasion of human breast cancer cells

(2012) C. Maccario et al.   CARCINOGENESIS

p53 Counteracts reprogramming by inhibiting mesenchymal-to-epithelial transition

(2012) R Brosh et al.   CELL DEATH AND DIFFERENTIATION

Cyclin-Dependent Kinase Inhibitor p21 Controls Adult Neural Stem Cell Expansion by Regulating Sox2 Gene Expression

(2012) M. Ángeles Marqués-Torrejón et al.   Cell Stem Cell

The Cyclin-Dependent Kinase Inhibitor p21CDKN1A as a Target of Anti-Cancer Drugs

(2012) L. A. Stivala et al.   CURRENT CANCER DRUG TARGETS

p21WAF1 and tumourigenesis

(2012) Noel A. Warfel et al.   CURRENT OPINION IN ONCOLOGY

PCNA-dependent accumulation of CDKN1A into nuclear foci after ionizing irradiation

(2012) Claudia Wiese et al.   DNA REPAIR

p300/CBP acetyl transferases interact with and acetylate the nucleotide excision repair factor XPG

(2012) Micol Tillhon et al.   DNA REPAIR

Black tea polyphenols induce human leukemic cell cycle arrest by inhibiting Akt signaling

(2012) Babli Halder et al.   FEBS Journal

Manganese activates caspase-9-dependent apoptosis in human bronchial epithelial cells

(2012) L Zhang et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Nano-titanium dioxide induces genotoxicity and apoptosis in human lung cancer cell line, A549

(2012) RK Srivastava et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Inhibitory Effect and Mechanisms of an Anthocyanins- and Anthocyanidins-Rich Extract from Purple-Shoot Tea on Colorectal Carcinoma Cell Proliferation

(2012) Chih-Ping Hsu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Aluminium chloride promotes anchorage-independent growth in human mammary epithelial cells

(2012) André-Pascal Sappino et al.   JOURNAL OF APPLIED TOXICOLOGY

Reactive Oxygen Species and Mitochondrial Sensitivity to Oxidative Stress Determine Induction of Cancer Cell Death by p21

(2012) Ionica Masgras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Investigation on Mechanism of Growth Arrest Induced by Iron Oxide Nanoparticles in PC12 Cells

(2012) Jie Wu et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Dichlorvos-induced cell cycle arrest and DNA damage repair activation in primary rat microglial cells

(2012) Aditya Sunkaria et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mechanisms involved in alternariol-induced cell cycle arrest

(2012) A. Solhaug et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

p21 promotes error-free replication-coupled DNA double-strand break repair

(2012) Maurizio Mauro et al.   NUCLEIC ACIDS RESEARCH

Cadmium Induces p53-Dependent Apoptosis in Human Prostate Epithelial Cells

(2012) Pierpaolo Aimola et al.   PLoS One

Topical Application of Ochratoxin A Causes DNA Damage and Tumor Initiation in Mouse Skin

(2012) Rahul Kumar et al.   PLoS One

Ochratoxin A and Mitotic Disruption: Mode of Action Analysis of Renal Tumor Formation by Ochratoxin A

(2012) Angela Mally   TOXICOLOGICAL SCIENCES

Inherited Effects of Low-Dose Exposure to Methylmercury in Neural Stem Cells

(2012) Raj Bose et al.   TOXICOLOGICAL SCIENCES

Rhodium and iridium salts inhibit proliferation and induce DNA damage in rat fibroblasts in vitro

(2012) Ivo Iavicoli et al.   TOXICOLOGY IN VITRO

Copper ability to induce premature senescence in human fibroblasts

(2011) Liliana Matos et al.   AGE

Genotoxic effects of the cyanobacterial hepatotoxin cylindrospermopsin in the HepG2 cell line

(2011) Alja Štraser et al.   ARCHIVES OF TOXICOLOGY

Accumulation of p21 proteins at DNA damage sites independent of p53 and core NHEJ factors following irradiation

(2011) Manabu Koike et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Green tea polyphenols causes cell cycle arrest and apoptosis in prostate cancer cells by suppressing class I histone deacetylases

(2011) V. S. Thakur et al.   CARCINOGENESIS

(-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells

(2011) V. Nandakumar et al.   CARCINOGENESIS

Caspase 2 is both required for p53-mediated apoptosis and downregulated by p53 in a p21-dependent manner

(2011) Nicole Baptiste-Okoh et al.   CELL CYCLE

The p21 and PCNA partnership: A new twist for an old plot

(2011) Carol Prives et al.   CELL CYCLE

p21Cip1/WAF1mediates cyclin B1 degradation in response to DNA damage

(2011) Laura D. Gillis et al.   CELL CYCLE

Loss of p21CDKN1Aimpairs entry to quiescence and activates a DNA damage response in normal fibroblasts induced to quiescence

(2011) Paola Perucca et al.   CELL CYCLE

Caspase-2 is required for DNA damage-induced expression of the CDK inhibitor p21WAF1/CIP1

(2011) D Sohn et al.   CELL DEATH AND DIFFERENTIATION

Effects of 4-nonylphenol on proliferation of AGS gastric cells

(2011) L. Manente et al.   CELL PROLIFERATION

N-Methyl-N′-nitro-N-nitrosoguanidine (MNNG) Triggers MSH2 and Cdt2 Protein-dependent Degradation of the Cell Cycle and Mismatch Repair (MMR) Inhibitor Protein p21Waf1/Cip1

(2011) Thomas Jascur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ETS Family Transcription Factor ELK-1 Regulates Induction of the Cell Cycle-regulatory Genep21Waf1/Cip1and theBAXGene in Sodium Arsenite-exposed Human Keratinocyte HaCaT Cells

(2011) Soon Young Shin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein and its function based on a subcellular localization

(2011) Jana Ćmielová et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Aflatoxin genotoxicity is associated with a defective DNA damage response bypassing p53 activation

(2011) Ozge Gursoy-Yuzugullu et al.   LIVER INTERNATIONAL

Disrupting effects of bifenthrin on ovulatory gene expression and prostaglandin synthesis in rat ovarian granulosa cells

(2011) Jing Liu et al.   TOXICOLOGY

p21WAF1/Cip1/Sdi1 knockout mice respond to doxorubicin with reduced cardiotoxicity

(2011) Jerome Terrand et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Beryllium sulfate induces p21 CDKN1A expression and a senescence-like cell cycle arrest in susceptible cancer cell types

(2010) Priyatham Gorjala et al.   BIOMETALS

Protective mechanisms of p53-p21-pRb proteins against DNA damage-induced cell death

(2010) Elizabeth Garner et al.   CELL CYCLE

Examination of the expanding pathways for the regulation of p21 expression and activity

(2010) Yong-Sam Jung et al.   CELLULAR SIGNALLING

Occurrence of molecular abnormalities of cell cycle in L132 cells after in vitro short-term exposure to air pollution PM2.5

(2010) Imane Abbas et al.   CHEMICO-BIOLOGICAL INTERACTIONS

CRL2LRR-1 Targets a CDK Inhibitor for Cell Cycle Control in C. elegans and Actin-Based Motility Regulation in Human Cells

(2010) Natalia G. Starostina et al.   DEVELOPMENTAL CELL

p21CDKN1A participates in base excision repair by regulating the activity of poly(ADP-ribose) polymerase-1

(2010) Ornella Cazzalini et al.   DNA REPAIR

PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?

(2010) Gastón Soria et al.   DNA REPAIR

Involvement of E2F1 transcriptional activity in cadmium-induced cell-cycle arrest at G1 in human lung fibroblasts

(2010) You-Jin Choi et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Bcl-XL Is the primary mediator of p21 protection against hyperoxia-induced cell death

(2010) Yu-Chieh M. Wu et al.   EXPERIMENTAL LUNG RESEARCH

Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, are important for CRL4Cdt2-mediated proteolysis

(2010) Masato Michishita et al.   GENES TO CELLS

ERK mediates anti-apoptotic effect through phosphorylation and cytoplasmic localization of p21Waf1/Cip1/Sdi in response to DNA damage in normal human embryonic fibroblast (HEF) cells

(2010) Jee-In Heo et al.   MOLECULAR BIOLOGY REPORTS

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Multiple roles of the cell cycle inhibitor p21CDKN1A in the DNA damage response

(2010) Ornella Cazzalini et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

DNA damage and alterations in expression of DNA damage responsive genes induced by TiO2nanoparticles in human hepatoma HepG2 cells

(2010) Jana PetkoviĆ et al.   Nanotoxicology

p21 does not protect cancer cells from apoptosis induced by nongenotoxic p53 activation

(2010) M Xia et al.   ONCOGENE

Lack of p21 expression links cell cycle control and appendage regeneration in mice

(2010) K. Bedelbaeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Divergent Effect of Cobalt and Beryllium Salts on the Fate of Peripheral Blood Monocytes and T Lymphocytes

(2010) F. Paladini et al.   TOXICOLOGICAL SCIENCES

Mycotoxin Citrinin Induced Cell Cycle G2/M Arrest and Numerical Chromosomal Aberration Associated with Disruption of Microtubule Formation in Human Cells

(2010) Chia-Hao Chang et al.   TOXICOLOGICAL SCIENCES

Nucleolar Disruption Ensures Nuclear Accumulation of p21 upon DNA Damage

(2010) Neus Abella et al.   TRAFFIC

The Antioxidant Quercetin Inhibits Cellular Proliferation via HIF-1-Dependent Induction of p21WAF

(2009) Aline Bach et al.   ANTIOXIDANTS & REDOX SIGNALING

Nuclear translocation of p21WAF1/CIP1 protein prior to its cytosolic degradation by UV enhances DNA repair and survival

(2009) Ji Young Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p21 WAF1 negatively regulates DNMT1 expression in mammalian cells

(2009) Hwee Hong Tan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gambogic acid down-regulates MDM2 oncogene and induces p21Waf1/CIP1 expression independent of p53

(2009) Jing-Jing Rong et al.   CANCER LETTERS

Modulation of key regulators of mitosis linked to chromosomal instability is an early event in ochratoxin A carcinogenicity

(2009) Melanie Adler et al.   CARCINOGENESIS

Degradation of p21CDKN1A after DNA damage is independent of type of lesion, and is not required for DNA repair

(2009) Monica Savio et al.   DNA REPAIR

In vitro toxicity of silica nanoparticles in myocardial cells

(2009) Yiyi Ye et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

The CDK domain of p21 is a suppressor of IL-1β-mediated inflammation in activated macrophages

(2009) John C. Scatizzi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of macrophage activation and septic shock susceptibilityviap21(WAF1/CIP1)

(2009) Marianna Trakala et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Let-7a elevates p21WAF1levels by targeting of NIRF and suppresses the growth of A549 lung cancer cells

(2009) Xiaoyan He et al.   FEBS LETTERS

MicroRNA 125a and its regulation of the p53 tumor suppressor gene

(2009) Yingjie Zhang et al.   FEBS LETTERS

MicroRNA-125b is a novel negative regulator of p53

(2009) M. T.N. Le et al.   GENES & DEVELOPMENT

Magnolol Inhibits Human Glioblastoma Cell Proliferation through Upregulation of p21/Cip1

(2009) Li-Ching Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Toxicities induced in cultured human hepatocarcinoma cells exposed to ochratoxin A: Oxidative stress and apoptosis status

(2009) Emna El Golli Bennour et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Extracellular Signal-Regulated Kinase 2-Dependent Phosphorylation Induces Cytoplasmic Localization and Degradation of p21Cip1

(2009) C. Y. Hwang et al.   MOLECULAR AND CELLULAR BIOLOGY

p38 Mitogen-Activated Protein Kinase- and HuR-Dependent Stabilization of p21Cip1 mRNA Mediates the G1/S Checkpoint

(2009) V. Lafarga et al.   MOLECULAR AND CELLULAR BIOLOGY

DNA Damage Triggers p21WAF1-dependent Emi1 Down-Regulation That Maintains G2 Arrest

(2009) Jinho Lee et al.   MOLECULAR BIOLOGY OF THE CELL

CUL4A Abrogation Augments DNA Damage Response and Protection against Skin Carcinogenesis

(2009) Liren Liu et al.   MOLECULAR CELL

Docking of a Specialized PIP Box onto Chromatin-Bound PCNA Creates a Degron for the Ubiquitin Ligase CRL4Cdt2

(2009) Courtney G. Havens et al.   MOLECULAR CELL

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

(2009) Andrea Viale et al.   NATURE

Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer

(2009) Young-Kook Kim et al.   NUCLEIC ACIDS RESEARCH

Involvement of KLF4 in Sulforaphane- and Iberin-Mediated Induction of p21waf1/cip1

(2009) Maria Traka et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Arsenite induced poly(ADP-ribosyl)ation of tumor suppressor P53 in human skin keratinocytes as a possible mechanism for carcinogenesis associated with arsenic exposure

(2009) Elena V. Komissarova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Disruption of p21 Attenuates Lung Inflammation Induced by Cigarette Smoke, LPS, and fMLP in Mice

(2008) Hongwei Yao et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Aberrant CDKN1A transcriptional response associates with abnormal sensitivity to radiation treatment

(2008) C Badie et al.   BRITISH JOURNAL OF CANCER

E2F1-Regulated MicroRNAs Impair TGFβ-Dependent Cell-Cycle Arrest and Apoptosis in Gastric Cancer

(2008) Fabio Petrocca et al.   CANCER CELL

A dual role of p21 waf1/cip1 gene in apoptosis of HEp-2 treated with cisplatin or methotrexate

(2008) S Kraljevic Pavelic et al.   CANCER GENE THERAPY

Chromium-mediated apoptosis: Involvement of DNA-dependent protein kinase (DNA-PK) and differential induction of p53 target genes

(2008) Richard Hill et al.   DNA REPAIR

Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes

(2008) Su Jin Kang et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Effects of model organophosphorous pesticides on DNA damage and proliferation of HepG2 cells

(2008) Irena Hreljac et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

p21Cip1 protects against oxidative stress by suppressing ER-dependent activation of mitochondrial death pathways

(2008) P VITIELLO et al.   FREE RADICAL BIOLOGY AND MEDICINE

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex

(2008) T. Abbas et al.   GENES & DEVELOPMENT

CDK Inhibitor p21 Is Degraded by a Proliferating Cell Nuclear Antigen-coupled Cul4-DDB1Cdt2Pathway during S Phase and after UV Irradiation

(2008) Hideo Nishitani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation

(2008) G. Soria et al.   JOURNAL OF CELL SCIENCE

Pulse Inhibition of Histone Deacetylases Induces Complete Resistance to Oxidative Death in Cortical Neurons without Toxicity and Reveals a Role for Cytoplasmic p21waf1/cip1 in Cell Cycle-Independent Neuroprotection

(2008) B. Langley et al.   JOURNAL OF NEUROSCIENCE

MicroRNAs in the miR-106b Family Regulate p21/CDKN1A and Promote Cell Cycle Progression

(2008) I. Ivanovska et al.   MOLECULAR AND CELLULAR BIOLOGY

miR-29 miRNAs activate p53 by targeting p85α and CDC42

(2008) Seong-Yeon Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interaction of p21 CDKN1A with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repair

(2008) Ornella Cazzalini et al.   NUCLEIC ACIDS RESEARCH

Antagomir-17-5p Abolishes the Growth of Therapy-Resistant Neuroblastoma through p21 and BIM

(2008) Laura Fontana et al.   PLoS One

p21Cip1 restricts neuronal proliferation in the subgranular zone of the dentate gyrus of the hippocampus

(2008) R. N. Pechnick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arsenic trioxide phosphorylates c-Fos to transactivate p21WAF1/CIP1 expression

(2008) Zi-Miao Liu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Patulin causes DNA damage leading to cell cycle arrest and apoptosis through modulation of Bax, p53 and p21/WAF1 proteins in skin of mice

(2008) Neha Saxena et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Suppressive effect and mechanism of saxatilin, a disintegrin from Korean snake (Gloydius saxatilis), in vascular smooth muscle cells

(2008) Young-Doug Sohn et al.   TOXICON

p21 Inhibits Cdk1 in the Absence of Cdk2 to Maintain the G1/S Phase DNA Damage Checkpoint

(2007) Ande Satyanarayana et al.   MOLECULAR BIOLOGY OF THE CELL

Ribotoxic mycotoxin deoxynivalenol induces G2/M cell cycle arrest via p21Cip/WAF1 mRNA stabilization in human epithelial cells

(2007) Hyun Yang et al.   TOXICOLOGY