Editorial Material
Nanoscience & Nanotechnology
Peter C. Searson
Summary: Reducing cancer-related deaths requires a better understanding of cancer biology and the development of improved therapeutics and delivery mechanisms. The accuracy of the models used in cancer research and their appropriate validation and benchmarking are crucial for achieving this goal. This article discusses the need for such considerations in line with the Cancer Moonshot initiative.
NATURE NANOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Christopher L. Yankaskas, Kaustav Bera, Konstantin Stoletov, Selma A. Serra, Julia Carrillo-Garcia, Soontorn Tuntithavornwat, Panagiotis Mistriotis, John D. Lewis, Miguel A. Valverde, Konstantinos Konstantopoulos
Summary: The study reveals a molecular mechanism by which cells avoid high shear during intravasation by activating TRPM7 channel to promote extracellular calcium influx, which then activates different pathways to coordinate the reversal of migration direction and avoid shear stress. Cells with higher TRPM7 activity levels intravasate less efficiently and establish less invasive metastatic lesions. This study provides a mechanistic interpretation for the role of shear stress and its sensor, TRPM7, in tumor cell intravasation.
Article
Medicine, General & Internal
Lucia Borriello, John Condeelis, David Entenberg, Maja H. Oktay
Summary: The research found that breast cancer cells can disseminate not only from primary tumors and metastatic nodules in the lymph nodes to distant organs, but also from lung metastases. Re-dissemination of cancer cells could be a crucial mechanism leading to overt metastases and patient demise.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Magdalena K. Sznurkowska, Nicola Aceto
Summary: Metastasis is a major cause of cancer-related deaths, involving tumor expansion, intravasation of cancer cells into the circulation, survival in the bloodstream, extravasation at distant sites, and organ colonization. The process of intravasation, where cancer cells leave the primary tumor site, plays a crucial role in initiating the metastatic cascade. Various factors, such as intrinsic properties of cancer cells, tumor microenvironment, and mechanical cues, are involved in this process.
Review
Biochemistry & Molecular Biology
Ghassan Bkaily, Danielle Jacques
Summary: The vascular endothelium is crucial in embryogenesis and aging, and it lines the blood vessels as a cell monolayer. It is recognized by the immune system as part of the body, so any abnormality in the endothelium exposes tissues to the immune system, leading to inflammation and vascular diseases like atherosclerosis. The endothelium's secretory role allows it to release vasoconstrictors, vasorelaxants, and cardio-modulatory factors that maintain proper circulatory system functioning. Adhesion molecules play a significant role in cardiovascular physiology and pathology by providing a seal for the monolayer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Sreelakshmi N. Menon, Farzana Zerin, Emmanuella Ezewudo, Nimi P. Simon, Sreeranjini N. Menon, Morgan L. Daniel, Andrea J. Green, Ajay Pandey, Charles E. Mackay, Sherif Hafez, Nader H. Moniri, Raquibul Hasan
Summary: Neflamapimod effectively inhibits endothelial cell activation, adhesion molecule expression, and leukocyte attachment, thereby reducing vascular inflammation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Shozo Yokoyama, Takashi Watanabe, Yoichi Fujita, Shuichi Matsumura, Katsuya Ueda, Shotaro Nagano, Ikuharu Kinoshita, Daisuke Murakami, Hirotaka Tabata, Toshiaki Tsuji, Satoru Ozawa, Takuya Tamaki, Yoshihiro Nakatani, Masami Oka
Summary: This study investigated the histologies of lymph node metastasis (LNM) in 119 patients with colorectal cancer (CRC) and found that the LNM histologies showed heterogeneity. The study also found that the histology in LNM was associated with the differentiation of the primary tumor and prognosis in CRC patients.
Article
Pharmacology & Pharmacy
Xiaozhi Li, Longyu Jin, Yuchao Ma, Zhibin Jiang, Hao Tang, Xiyuan Tong
Summary: Xanthohumol exhibits anti-tumor activity in non-small cell lung cancer cells by activating mitochondrial apoptosis pathway.
Article
Oncology
Alice Turdo, Antonino Glaviano, Giacomo Pepe, Federica Calapa, Stefania Raimondo, Micol Eleonora Fiori, Daniela Carbone, Manuela Giovanna Basilicata, Veronica Di Sarno, Carmine Ostacolo, Barbara Parrino, Stella Cascioferro, Camilla Pecoraro, Simone Di Franco, Diana Bellavia, Miriam Gaggianesi, Veronica Veschi, Melania Lo Iacono, Gloria Ganduscio, Vincenzo Davide Pantina, Laura Rosa Mangiapane, Maria Rita Bongiorno, Riccardo Alessandro, Matilde Todaro, Ruggero De Maria, Patrizia Diana, Pietro Campiglia, Giorgio Stassi
Summary: Colorectal cancer stem cells (CR-CSCs) play a crucial role in therapy resistance and relapse. New treatment approaches involving polymethoxyflavones and prenylflavonoids show efficacy in targeting CR-CSCs, reducing stemness properties, and synergizing with chemotherapy. These natural compounds hold promise as adjuvants in oncological therapies to improve patient outcomes.
Article
Plant Sciences
Shu-Ling Hsieh, Jinn-Chyi Wang, Yun-Shan Huang, Chih-Chung Wu
Summary: GBEE has antioxidant effects in vitro and in vivo, as well as the ability to regulate the expression of adhesion molecules in vascular endothelium, which may contribute to the prevention of atherosclerosis.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Oncology
Kartikey Kumar Gupta, Kamal Kant Sharma, Harish Chandra, Himalaya Panwar, Nitin Bhardwaj, Najla A. Altwaijry, Aisha A. Alsfouk, Zodwa Dlamini, Obaid Afzal, Abdulmalik S. A. Altamimi, Shahanavaj Khan, Abhay Prakash Mishra
Summary: Xanthohumol has demonstrated significant binding affinity to multiple targets within breast cancer-related signaling pathways in in silico analysis, offering new research possibilities for breast cancer treatment.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sosmitha Girisa, Queen Saikia, Devivasha Bordoloi, Kishore Banik, Javadi Monisha, Uzini Devi Daimary, Elika Verma, Kwang Seok Ahn, Ajaikumar B. Kunnumakkara
Summary: Xanthohumol (XN), a prenylated chalcone present in Hop, has been found to possess significant anti-cancer activities by modulating multiple molecular targets and pathways, making it a potential multi-targeted anti-cancer agent.
Article
Oncology
Margherita Pergolizzi, Laura Bizzozero, Federica Maione, Elena Maldi, Claudio Isella, Marco Macagno, Elisa Mariella, Alberto Bardelli, Enzo Medico, Caterina Marchio, Guido Serini, Federica Di Nicolantonio, Federico Bussolino, Marco Arese
Summary: This study revealed that NLGN1 is expressed in human colorectal tumors and promotes CRC cell migration and metastasis. Mechanistically, NLGN1 promotes the localization of APC to the cell membrane, stimulates beta-catenin translocation to the nucleus, and induces an EMT phenotype in CRC cell lines. This novel finding suggests NLGN1 as a potential therapeutic target for CRC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Food Science & Technology
Margalida Torrens-Mas, Marina Alorda-Clara, Maria Martinez-Vigara, Pilar Roca, Jorge Sastre-Serra, Jordi Oliver, Daniel Gabriel Pons
Summary: The study found that low doses of XN treatment did not significantly affect cell viability, but led to a general decrease in pro-inflammatory, antioxidant and mitochondrial biogenesis gene expression. Additionally, glucose and oxidative metabolism enzymes were also reduced.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2022)
Article
Veterinary Sciences
L. Etchevers, M. S. Renna, E. M. Belotti, P. U. Diaz, N. R. Salvetti, H. H. Ortega, A. N. Amweg
Summary: ACTH treatment decreases the expression of adhesion molecules in PBMCs and endothelial cells, reducing the infiltration of PBMCs and alleviating the inflammatory response during ovulation in cows.
RESEARCH IN VETERINARY SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Bhupinder Kapoor, Monica Gulati, Pooja Rani, Rajpal Singh Kochhar, Atanas G. Atanasov, Reena Gupta, Deepika Sharma, Deepak Kapoor
Summary: This article reviews the neuroprotective effects of lycopene in the treatment of Alzheimer's disease (AD) and discusses the evidence from various studies and investigations on its protective effects. The mechanisms through which lycopene exerts its remissive effects in AD and the development of novel delivery systems for lycopene are also discussed briefly.
Article
Oncology
Alexander Ries, Daniela Flehberger, Astrid Slany, Christine Pirker, Johanna C. C. Mader, Thomas Mohr, Karin Schelch, Katharina Sinn, Berta Mosleh, Mir Alireza Hoda, Balazs Dome, Helmut Dolznig, Georg Krupitza, Leonhard Muellauer, Christopher Gerner, Walter Berger, Michael Grusch
Summary: This study characterizes patient-derived Meso-CAFs for the first time and demonstrates the significant impact of Meso-CAFs on PM cell growth and migration, two key characteristics of PM aggressiveness, indicating a major role of Meso-CAFs in driving PM progression. Moreover, signaling pathways required for Meso-CAF-mediated growth stimulation are identified, which could be relevant for novel therapeutic strategies against PM.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Karin Schelch, Sebastian Eder, Benjamin Zitta, Monica Phimmachanh, Thomas G. Johnson, Dominik Emminger, Andrea Wenninger-Weinzierl, Caterina Sturtzel, Hugo Poplimont, Alexander Ries, Konrad Hoetzenecker, Mir A. Hoda, Walter Berger, Martin Distel, Balazs Dome, Glen Reid, Michael Grusch
Summary: Pleural mesothelioma (PM) is a highly aggressive cancer with limited treatment options. The oncoprotein Y-box-binding protein-1 (YB-1) is overexpressed in cancer and has been shown to promote cancer cell migration. This study investigates the role of YB-1 in PM cell behavior and identifies snail as a critical regulator of YB-1-mediated cell motility. The findings provide insights into the mechanism underlying PM's aggressive nature and highlight the importance of YB-1 in this cancer.
MOLECULAR ONCOLOGY
(2023)
Article
Chemistry, Analytical
Xiaomu Zhu, Ting Zhou, Shu Wang, Bengui Ye, Rajeev K. Singla, Devesh Tewari, Atanas G. Atanasov, Dongdong Wang, Simei Liu
Summary: In this study, an UPLC-ESI-MS/MS method was developed for the simultaneous quantification of nine steroidal alkaloids in Fritillariae cirrhosae bulbus (FCB) and its substitutes. Multivariate chemometric analyses were applied to distinguish FCB from its substitutes, and four compounds were discovered as potential markers for identification.
Article
Oncology
Zsuzsanna Valko, Zsolt Megyesfalvi, Anna Schwendenwein, Christian Lang, Sandor Paku, Nandor Barany, Bence Ferencz, Anita Horvath-Rozsas, Ildiko Kovacs, Erzsebet Schlegl, Veronika Pozonec, Kristiina Boettiger, Melinda Rezeli, Gyorgy Marko-Varga, Ferenc Renyi-Vamos, Mir Alireza Hoda, Thomas Klikovits, Konrad Hoetzenecker, Michael Grusch, Viktoria Laszlo, Balazs Dome, Karin Schelch
Summary: This study demonstrates the subtype specificity of BCL-2 expression and reveals the mechanism of venetoclax resistance in SCLC. Moreover, it provides preclinical evidence that combined BCL-2 and MCL-1 targeting is an effective approach to overcome venetoclax resistance in high BCL-2-expressing SCLCs with intact BAX.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Coralie Dorard, Claire Madry, Olivier Buhard, Stefanie Toifl, Sebastian Didusch, Toky Ratovomanana, Quentin Letourneur, Helmut Dolznig, Mathew J. Garnett, Alex Duval, Manuela Baccarini
Summary: This study shows that RAF1 plays a crucial role in the proliferation of colorectal cancer and is independent of KRAS mutation status. RAF1 ablation decreases proliferation and STAT3 phosphorylation, indicating that RAF1 could be a therapeutic target for colorectal cancer.
Article
Oncology
Berta Mosleh, Karin Schelch, Thomas Mohr, Thomas Klikovits, Christina Wagner, Lukas Ratzinger, Yawen Dong, Katharina Sinn, Alexander Ries, Walter Berger, Bettina Grasl-Kraupp, Konrad Hoetzenecker, Viktoria Laszlo, Balazs Dome, Balazs Hegedus, Marko Jakopovic, Mir Alireza Hoda, Michael Grusch
Summary: This study found that FGF18 expression is elevated in pleural mesothelioma (PM) tissue compared to normal mesothelium. However, despite high mRNA levels in PM cells, circulating FGF18 protein is significantly lower in PM patients and patients with pleural fibrosis than in healthy controls. The results suggest that FGF18 is not a prognostic biomarker in PM, and further investigation is needed to understand its role in tumor biology and the clinical significance of decreased plasma FGF18 in PM patients.
Article
Plant Sciences
Jaroslav Nisler, Zuzana Kucerova, Radoslav Koprna, Roman Sobotka, Jana Slivkova, Stephen Rossall, Martina Spundova, Alexandra Husickova, Jan Pilny, Danuse Tarkowska, Ondrej Novak, Maria Skrabisova, Miroslav Strnad
Summary: Increasing crop productivity and mitigating yield losses under stressful conditions are major challenges in agriculture. A recently discovered compound, MTU, delays senescence and enhances the growth of wheat plants. Multiyear field trials demonstrate that treatment with MTU increases average grain yields of wheat and barley by 5-8%. This compound acts independently of cytokinins or other phytohormones and appears to be the only chemical known to affect the stability and activity of PSI.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Chemistry, Medicinal
Urte Sachleviciute, Gabriel Gonzalez, Marie Kvasnicova, Sarka Stepankova, Neringa Kleiziene, Aurimas Bieliauskas, Marek Zatloukal, Miroslav Strnad, Frank A. Slok, Miroslav Kvasnica, Algirdas Sackus, Asta Zukauskaite
Summary: A library of 3-aryl-3-azetidinyl acetic acid methyl ester derivatives was synthesized and evaluated for neuroprotective activity in salsolinol- and glutamate-induced neurodegeneration models. Compound 28 showed the highest neuroprotective effect, which may be driven by reductions in oxidative stress and caspase-3/7 activity.
ARCHIV DER PHARMAZIE
(2023)
Article
Plant Sciences
Mirta Resetar, Borris R. Tietcheu R. Galani, Armelle T. T. Tsamo, Ya Chen, Daniel Schachner, Stefanie Stolzlechner, Julio I. I. Mawouma Pagna, Mehdi A. A. Beniddir, Johannes Kirchmair, Verena M. M. Dirsch
Summary: This study assessed the ability of six limonoids from Trichilia prieuriana to activate the liver X receptor. One of these, flindissone, was shown to activate LXR by reporter-gene assays. Flindissone is a ring-intact limonoid, structurally similar to sterol-like LXR ligands.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Genetics & Heredity
Miroslav Misik, Michael Kundi, Nadine Worel, Franziska Ferk, Hans-Peter Hutter, Michael Grusch, Armen Nersesyan, Denise Herrera Morales, Siegfried Knasmueller
Summary: The aim of this study was to investigate the impact of age and body mass on the DNA-damaging properties of high-frequency mobile phone-specific electromagnetic fields (HF-EMF) and its effects on genotoxicity. The results showed a significant increase in DNA damage in cells from older participants after exposure to HF-EMF, but no impact on chemically induced DNA damage. In conclusion, HF-EMF can cause DNA damage in older individuals, but does not increase the genotoxic effects of occupational exposures.
Article
Biochemistry & Molecular Biology
Vaclav Mik, Tomas Pospisil, Federica Brunoni, Jiri Gruz, Vladimfra Nozkova, Claus Wasternack, Otto Miersch, Miroslav Strnad, Kristyna Flokova, Ondrej Novak, Jitka Siroka
Summary: This research presents a highly sensitive method for the reliable determination of seven OPDA-aa compounds in plants. The method was optimized for extraction, sample clean-up, and final analysis. Five endogenous (+)-OPDA-aa were identified and their levels were estimated in mechanically wounded Arabidopsis thaliana leaves, with a peak observed 60 minutes after the wounding. The synthetic and analytical methodologies developed in this study will contribute to the understanding of the biological significance of these metabolites in plants.
Article
Plant Sciences
Gabriel Gomez-Ocampo, Carlos D. Crocco, Jimena Cascales, Jana Oklestkova, Danuse Tarkowska, Miroslav Strnad, Santiago Mora-Garcia, Jose L. Pruneda-Paz, Miguel A. Blazquez, Javier F. Botto
Summary: B-Box-containing zinc finger transcription factor BBX21 inhibits hypocotyl elongation in Arabidopsis through the brassinosteroid pathway. It reduces sensitivity to synthetic active brassinosteroid 24-epiBL at low concentrations in simulated shade and represses the biosynthesis and signaling genes of brassinosteroids. BBX21 integrates brassinosteroid homeostasis and shade-light signaling to fine-tune hypocotyl elongation in Arabidopsis.
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Plant Sciences
Vladimir Skalicky, Ioanna Antoniadi, Ales Pencik, Ivo Chamrad, Rene Lenobel, Martin F. Kubes, Marek Zatloukal, Asta Zukauskaite, Miroslav Strnad, Karin Ljung, Ondrej Novak
Summary: Auxin and cytokinin show subcellular distribution in Arabidopsis cells, forming hormone gradients. This finding provides important insights into the mechanisms of plant growth and development.
Article
Health Care Sciences & Services
Olena Litvinova, Fabian Peter Hammerle, Jivko Stoyanov, Natalia Ksepka, Maima Matin, Michal Lawinski, Atanas G. Atanasov, Harald Willschke
Summary: This study conducted a comprehensive patent and bibliometric analysis to explore the development and application of pulse oximeters in the field of digital medicine. The findings highlight the increasing importance of pulse oximeters in digitally-enabled medical practice and identify six primary research clusters related to these devices. The study suggests the potential of leveraging digital technologies in pulse oximetry for advancing the understanding, diagnosis, prevention, and treatment of cardio-respiratory pathologies.
