The fluid shear stress sensor TRPM7 regulates tumor cell intravasation

The nuclear piston activates mechanosensitive ion channels to generate cell migration paths in confining microenvironments

(2021) Hong-pyo Lee et al.   Science Advances

Hydraulic resistance induces cell phenotypic transition in confinement

(2021) Runchen Zhao et al.   Science Advances

The scaffold protein IQGAP1 is crucial for extravasation and metastasis

(2020) Jess D. Hebert et al.   Scientific Reports

Dorsoventral polarity directs cell responses to migration track geometries

(2020) Emily O. Wisniewski et al.   Science Advances

A microfluidic cell-migration assay for the prediction of progression-free survival and recurrence time of patients with glioblastoma

(2020) Bin Sheng Wong et al.   Nature Biomedical Engineering

A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens

(2019) Christopher L. Yankaskas et al.   Nature Biomedical Engineering

Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area

(2019) Runchen Zhao et al.   Science Advances

Confinement hinders motility by inducing RhoA-mediated nuclear influx, volume expansion, and blebbing

(2019) Panagiotis Mistriotis et al.   JOURNAL OF CELL BIOLOGY

Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses

(2018) Carlos Pardo-Pastor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity

(2018) P. Doñate-Macián et al.   Nature Communications

Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis

(2018) Konstantin Stoletov et al.   Nature Communications

Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets

(2018) Ádám Nagy et al.   Scientific Reports

Optogenetic dissection of Rac1 and Cdc42 gradient shaping

(2018) S. de Beco et al.   Nature Communications

Cells lay their own tracks – optogenetic Cdc42 activation stimulates fibronectin deposition supporting directed migration

(2017) Seth P. Zimmerman et al.   JOURNAL OF CELL SCIENCE

Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4

(2017) Mui Cheung et al.   ACS Medicinal Chemistry Letters

Alterations in IQGAP1 expression and localization in colorectal carcinoma and liver metastases following oxaliplatin-based chemotherapy

(2017) Deborah Rotoli et al.   Oncology Letters

Optogenetic control of cellular forces and mechanotransduction

(2017) Léo Valon et al.   Nature Communications

Tumor cell intravasation

(2016) Serena P. H. Chiang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Multiple mechanisms of 3D migration: the origins of plasticity

(2016) Ryan J Petrie et al.   CURRENT OPINION IN CELL BIOLOGY

Subcellular optogenetic activation of Cdc42 controls local and distal signaling to drive immune cell migration

(2016) Patrick R. O’Neill et al.   MOLECULAR BIOLOGY OF THE CELL

Ion Channels in Endothelial Responses to Fluid Shear Stress

(2016) Kristin A. Gerhold et al.   PHYSIOLOGY

Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways

(2016) Wei-Chien Hung et al.   Cell Reports

Identification of Cancer-Associated Fibroblasts in Circulating Blood from Patients with Metastatic Breast Cancer

(2015) Z. Ao et al.   CANCER RESEARCH

Rho GTPase signalling in cell migration

(2015) Anne J Ridley   CURRENT OPINION IN CELL BIOLOGY

The biology of IQGAP proteins: beyond the cytoskeleton

(2015) A. C. Hedman et al.   EMBO REPORTS

A novel role for IQGAP1 protein in cell motility through cell retraction

(2014) Sahar Foroutannejad et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A three-dimensional in vitro model of tumor cell intravasation

(2014) Seema M. Ehsan et al.   Integrative Biology

Piezo1 integration of vascular architecture with physiological force

(2014) Jing Li et al.   NATURE

Activation of TRPM7 channels by small molecules under physiological conditions

(2014) T. Hofmann et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Invadopodia Are Required for Cancer Cell Extravasation and Are a Therapeutic Target for Metastasis

(2014) Hon S. Leong et al.   Cell Reports

Distinct signaling mechanisms regulate migration in unconfined versus confined spaces

(2013) Wei-Chien Hung et al.   JOURNAL OF CELL BIOLOGY

From Mechanical Force to RhoA Activation

(2012) Elizabeth C. Lessey et al.   BIOCHEMISTRY

TRPM7 Is Required for Breast Tumor Cell Metastasis

(2012) Jeroen Middelbeek et al.   CANCER RESEARCH

Physical confinement alters tumor cell adhesion and migration phenotypes

(2012) Eric M. Balzer et al.   FASEB JOURNAL

Selectin-mediated adhesion in shear flow using micropatterned substrates: multiple-bond interactions govern the critical length for cell binding

(2012) ZiQiu Tong et al.   Integrative Biology

N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors

(2012) B. Gligorijevic et al.   JOURNAL OF CELL SCIENCE

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating fibroblast-like cells in men with metastatic prostate cancer

(2012) Michelle L. Jones et al.   PROSTATE

Fluid Flow Mechanotransduction in Vascular Smooth Muscle Cells and Fibroblasts

(2011) Zhong-Dong Shi et al.   ANNALS OF BIOMEDICAL ENGINEERING

Control of Local Rho GTPase Crosstalk by Abr

(2011) Emily M. Vaughan et al.   CURRENT BIOLOGY

Calcium gradients underlying cell migration

(2011) Chaoliang Wei et al.   CURRENT OPINION IN CELL BIOLOGY

Rho protein crosstalk: another social network?

(2011) Christophe Guilluy et al.   TRENDS IN CELL BIOLOGY

The Distribution of Fluid Shear Stresses in Capillary Sprouts

(2011) Peter C. Stapor et al.   Cardiovascular Engineering and Technology

Macro- and microscale fluid flow systems for endothelial cell biology

(2009) Edmond W. K. Young et al.   LAB ON A CHIP

Calcium flickers steer cell migration

(2009) Chaoliang Wei et al.   NATURE

Collagen-based cell migration models in vitro and in vivo

(2009) Katarina Wolf et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY