Article
Immunology
An-Liang Guo, Jin-Fang Zhao, Lin Gao, Hui-Huang Huang, Ji-Yuan Zhang, Chao Zhang, Jin-Wen Song, Ruo-Nan Xu, Xing Fan, Ming Shi, Yan-Mei Jiao, Fu-Sheng Wang
Summary: The study found that CD11c(+) CD8(+) T cells can effectively control viral replication during HIV-1 infection and have the potential to be used as an immunotherapeutic approach.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Plant Sciences
Ke Yang, Jing Qiu, Zecheng Huang, Ziwei Yu, Wenjun Wang, Huiling Hu, Yu You
Summary: Schisandra chinensis and Schisandra sphenanthera, known as bei-wuweizi and nan-wuweizi in Chinese respectively, are highly similar plants with traditional uses in Chinese medicine for treating various conditions. They have similar chemical compositions and pharmacological activities, with potential drug interactions due to their inhibitory effects on CYP3A and P-gp. Further research is needed to explore their traditional uses and differences for clinical applications.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Shiqi Huang, Dongdong Zhang, Yuze Li, Hao Fan, Yuanyuan Liu, Wenli Huang, Chong Deng, Wei Wang, Xiaomei Song
Summary: Schisandra sphenanthera is a medicinal herb with a wide range of bioactivities, including antitumor, anti-oxidant, anti-inflammatory, osteoblastic, immune regulation, neuroprotective, kidney protection, hepatoprotective, and antiviral activities. There is still a need for further studies on resource availability, quality control measures, in-depth in vivo pharmacological study, and clinical application.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Microbiology
Chuan You, Dan Qin, Yumeng Wang, Wenyi Lan, Yehong Li, Baohong Yu, Yajun Peng, Jieru Xu, Jinyan Dong
Summary: Beneficial interactions between endophytes and plants are crucial for plant growth and metabolite accumulation. Plant-derived triterpenoids were found to promote the growth of endophytic bacteria and fungi, which in turn enhanced host plant growth and secondary metabolite productions. This study suggests a strategy for constructing synthetic communities (SynComs) based on the screening of secondary metabolites, where bacteria and fungi work together to promote plant health.
Article
Agricultural Engineering
Xiaorui Wang, Min Yan, Xinxin Wang, Zhiting Wu, Jia Zhou, Chan Wang, Ruidun Chen, Xiaolu Qin, Heyu Yang, Haiyan Wei, Wei Gu
Summary: This study evaluated the phenotypic diversity of Schisandra sphenanthera fruits on a large scale and investigated the relationship between environmental factors and fruit phenotypes. Significant correlations were found between phenotype and environmental factors, with some factors having direct effects on phenotype and others having indirect effects. The study also proposed a machine learning method to predict the phenotype of S. sphenanthera in different environments with high accuracy.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Chemistry, Medicinal
Reon Takeuchi, Kasumi Ogihara, Junko Fujimoto, Kohei Sato, Nobuyuki Mase, Kazuhisa Yoshimura, Shigeyoshi Harada, Tetsuo Narumi
Summary: In this study, a novel HIV-1 entry inhibitor oleanolic acid derivative was discovered and it was found that modifying the structure of the compound significantly increased its anti-HIV activity and reduced cytotoxicity.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Applied
Nguyen Thi Mai, Vu Van Doan, Hoang Thi Tuyet Lan, Bui Thi Mai Anh, Nguyen Huy Hoang, Bui Huu Tai, Nguyen Xuan Nhiem, Pham Hai Yen, Seon Ju Park, Yohan Seo, Wan Namkung, Seung Hyun Kim, Phan Van Kiem
Summary: Phytochemical investigation of Schisandra sphenanthera leaves led to the isolation of new compounds, with schirubrisin B showing strong cytotoxic effects on prostate and breast cancer cells.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Boshi Sun, Peng Wang, Meng Guan, Entong Jia, Qian Li, Jun Li, Ziyun Zhou, Pengda Ma
Summary: This study investigated the gene expression and metabolite content in different tissues of Schisandra sphenanthera through transcriptome and metabolome analyses. It was found that the root and fruit had high levels of lignan accumulation, while the leaves had lower levels. Transcription factor analysis revealed the importance of MYB, bHLH, and ERF transcription factors in secondary metabolism regulation. Additionally, a weighted gene co-expression network analysis identified genes related to lignan accumulation.
Article
Plant Sciences
Shiqi Huang, Yuanyuan Liu, Yuze Li, Hao Fan, Wenli Huang, Chong Deng, Xiaomei Song, Dongdong Zhang, Wei Wang
Summary: Two new dibenzocyclooctadiene lignans, schisphenlignan M and N, along with nine known analogues, were isolated from the root bark of Schisandra sphenanthera. These lignans showed cytotoxic activities against human lung and colon cancer cell lines, indicating potential anti-cancer properties.
PHYTOCHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Mei-Chia Chou, Yuan-Jia Lee, Yao-Ting Wang, Shi-Yie Cheng, Hsueh-Ling Cheng
Summary: Momordica charantia L. has anti-inflammatory effects, but its safety profile needs to be further studied. Momordicine I showed cytotoxicity while other compounds had no obvious adverse effects. TCD exhibited anti-inflammatory activity by inhibiting a specific pathway and enhancing the expression of related factors. Caution should be taken when using the vines and leaves of M. charantia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Organic
Lu Guo, Pingping Tang
Summary: Schisandraceae, a traditional Chinese herb known for its anti-hepatitis bioactivity, has diverse and unique structures that have caught the interest of synthetic chemists. Recent efforts towards the total synthesis of schisandra triterpenoid have been summarized.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jiao-Jiao Cui, Ying-Shan Han, Bin Zhou, Jian-Min Yue
Summary: Investigations on Antirhea chinensis led to the discovery of two new pentacyclic triterpenoids and nine known analogs. One of the new compounds showed potent anti-HIV activity and high selectivity.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Biochemistry & Molecular Biology
Ermias Mergia Terefe, Faith Apolot Okalebo, Solomon Derese, Moses K. Langat, Eduard Mas-Claret, Kamal Ahmad Qureshi, Mariusz Jaremko, Joseph Muriuki
Summary: This study reported three new anti-HIV eudesmane-type sesquiterpenes isolated from the bark of Croton megalocarpus, one of which demonstrated the highest antiviral activity by inhibiting 93% of viral replication.
Article
Biochemistry & Molecular Biology
Takuya Kobayakawa, Masaru Yokoyama, Kohei Tsuji, Masayuki Fujino, Masaki Kurakami, Sayaka Boku, Miyuki Nakayama, Moemi Kaneko, Nami Ohashi, Osamu Kotani, Tsutomu Murakami, Hironori Sato, Hirokazu Tamamura
Summary: A small molecule designed to mimic hydrophobic interactions between HIV-1 capsid proteins has shown significant anti-HIV-1 activity. Structure activity relationship (SAR) studies of its derivatives provide valuable information for the design and development of novel anti-HIV agents targeting the capsid protein. This new drug has the potential to be an effective treatment for HIV in the future.
Review
Nutrition & Dietetics
Mengzhen Jia, Li Zhou, Yuanyuan Lou, Xiaoqing Yang, Hangyu Zhao, Xinshou Ouyang, Yanjie Huang
Summary: Objective: This review aims to summarize the nutritional components and medicinal properties of Schisandra chinensis, as well as the advancements in quality control studies. Through literature review and analysis, the main nutritional components of S. chinensis and their benefits to human health are identified, and future research directions are suggested.
FRONTIERS IN NUTRITION
(2023)
Article
Chemistry, Multidisciplinary
Gina L. C. Grammbitter, Maximilian Schmalhofer, Kudratullah Karimi, Yi-Ming Shi, Tim A. Schoener, Nicholas J. Tobias, Nina Morgner, Michael Groll, Helge B. Bode
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Biochemistry & Molecular Biology
Yi-Ming Shi, Alexander O. Brachmann, Margaretha A. Westphalen, Nick Neubacher, Nicholas J. Tobias, Helge B. Bode
NATURE CHEMICAL BIOLOGY
(2019)
Article
Microbiology
Nicholas J. Tobias, Cesar Parra-Rojas, Yan-Ni Shi, Yi-Ming Shi, Svenja Simonyi, Aunchalee Thanwisai, Apichat Vitta, Narisara Chantratita, Esteban A. Hernandez-Vargas, Helge B. Bode
ENVIRONMENTAL MICROBIOLOGY
(2019)
Article
Biochemical Research Methods
Laura Drummond, Max J. Kschowak, Juergen Breitenbach, Hendrik Wolff, Yi-Ming Shi, Jens Schrader, Helge B. Bode, Gerhard Sandmann, Markus Buchhaupt
ACS SYNTHETIC BIOLOGY
(2019)
Article
Chemistry, Organic
Yan-Ni Shi, Stefan Pusch, Yi-Ming Shi, Christian Richter, Jose G. Macia-Vicente, Harald Schwalbe, Marcel Kaiser, Till Opatz, Helge B. Bode
JOURNAL OF ORGANIC CHEMISTRY
(2019)
Article
Microbiology
Gaoyan Wang, Zhiying Zhao, Jing Ke, Yvonne Engel, Yi-Ming Shi, David Robinson, Kerem Bingol, Zheyun Zhang, Benjamin Bowen, Katherine Louie, Bing Wang, Robert Evans, Yu Miyamoto, Kelly Cheng, Suzanne Kosina, Markus De Raad, Leslie Silva, Alicia Luhrs, Andrea Lubbe, David W. Hoyt, Charles Francavilla, Hiroshi Otani, Samuel Deutsch, Nancy M. Washton, Edward M. Rubin, Nigel J. Mouncey, Axel Visel, Trent Northen, Jan-Fang Cheng, Helge B. Bode, Yasuo Yoshikuni
NATURE MICROBIOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Edna Bode, Antje K. Heinrich, Merle Hirschmann, Desalegne Abebew, Yan-Ni Shi, Tien Duy Vo, Frank Wesche, Yi-Ming Shi, Peter Gruen, Svenja Simonyi, Nadine Keller, Yvonne Engel, Sebastian Wenski, Reuel Bennet, Sophie Beyer, Iris Bischoff, Anthony Buaya, Sophie Brandt, Ibrahim Cakmak, Harun Cimen, Simone Eckstein, Denia Frank, Robert Fuerst, Martin Gand, Gerd Geisslinger, Selcuk Hazir, Marina Henke, Ralf Heermann, Virginie Lecaudey, Wilhelm Schaefer, Susanne Schiffmann, Anja Schueffler, Rebecca Schwenk, Marisa Skaljac, Eckhard Thines, Marco Thines, Thomas Ulshoefer, Andreas Vilcinskas, Thomas A. Wichelhaus, Helge B. Bode
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Biotechnology & Applied Microbiology
Ricardo A. R. Machado, Lisa Thonen, Carla C. M. Arce, Vanitha Theepan, Fausto Prada, Daniel Wuthrich, Christelle A. M. Robert, Evangelia Vogiatzaki, Yi-Ming Shi, Olivier P. Schaeren, Matheus Notter, Remy Bruggmann, Siegfried Hapfelmeier, Helge B. Bode, Matthias Erb
NATURE BIOTECHNOLOGY
(2020)
Correction
Biotechnology & Applied Microbiology
Ricardo A. R. Machado, Lisa Thoenen, Carla C. M. Arce, Vanitha Theepan, Fausto Prada, Daniel Wuethrich, Christelle A. M. Robert, Evangelia Vogiatzaki, Yi-Ming Shi, Olivier P. Schaeren, Matheus Notter, Remy Bruggmann, Siegfried Hapfelmeier, Helge B. Bode, Matthias Erb
NATURE BIOTECHNOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Esmeralda Z. Reyes-Fernandez, Yi-Ming Shi, Peter Gruen, Helge B. Bode, Michael Boelker
Summary: The fungus Ustilago maydis synthesizes a novel type of melanin based on coumarin and pyran-2-one intermediates, requiring multiple enzymes for producing melanin precursors. This study not only helps reveal the metabolic pathways of this fungus, but also provides insights into the mechanisms of polyketide synthases in this filamentous fungus.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yi-Ming Shi, Merle Hirschmann, Yan-Ni Shi, Shabbir Ahmed, Desalegne Abebew, Nicholas J. Tobias, Peter Grun, Jan J. Crames, Laura Poeschel, Wolfgang Kuttenlochner, Christian Richter, Jennifer Herrmann, Rolf Mueller, Aunchalee Thanwisai, Sacha J. Pidot, Timothy P. Stinear, Michael Groll, Yonggyun Kim, Helge B. Bode
Summary: This study analyzed the biosynthetic gene clusters (BGCs) of Xenorhabdus and Photorhabdus (XP) strains and identified the functional basis of bacterial natural products in the tripartite relationship between bacteria, nematodes, and insects. The prevalent compounds produced by these strains include eukaryotic proteasome inhibitors, virulence factors against insects, metallophores, and insect immunosuppressants.
Article
Biochemistry & Molecular Biology
Yi-Ming Shi, Merle Hirschmann, Yan-Ni Shi, Helge B. Bode
Summary: This study characterizes the biosynthetic logic of Piscibactins and photoxenobactins, metallophores and virulence factors. It shows that the biosynthesis involves heterocyclization domains with different catalytic efficiencies and putative bond cleavage off-loading manners. Spontaneous conversions of the biosynthetic end product also contribute to the production of other products.
ACS CHEMICAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yi-Ming Shi, Jan J. Crames, Laura Czech, Kenan A. J. Bozhuyuk, Yan-Ni Shi, Merle Hirschmann, Stefanie Lamberth, Peter Claus, Nicole Paczia, Christian Ruckert, Jorn Kalinowski, Gert Bange, Helge B. Bode
Summary: This study reveals the biosynthetic potential of a widespread benzobactin gene cluster and identifies the acyl AMP-ligase responsible for the last cyclization step. Genome mining of Pseudomonas chlororaphis uncovered the presence of the gene cluster in different bacterial species, highlighting the regulatory mechanisms and structural diversity of benzobactin biosynthesis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Plant Sciences
Shu-Xi Jing, Ran Fu, Chun-Huan Li, Cedric L. Hugelshofer, Yi-Ming Shi, Shi-Hong Luo, Yan-Chun Liu, Yan Liu, Sheng-Hong Li
Summary: Three unusual sesterterpenoids with novel rearranged colquhounane and tetranorcolquhounane frameworks were isolated from Colquhounia coccinea var. mollis, a medicinal plant from the Lamiaceae family. The structures of these compounds were determined through spectroscopic analysis and quantum chemical calculations. A biomimetic regioselective cyclopropane cleavage reaction was successfully achieved under acidic conditions. Additionally, the immunosuppressive activities of these new sesterterpenoids were evaluated.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Jungho Lee, Yi-Ming Shi, Peter Grun, Matthias Gube, Michael Feldbrugge, Helge Bode, Florian Hennicke