Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing

antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

(2019) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Microbe-driven chemical ecology: past, present and future

(2019) Ruth Schmidt et al.   ISME Journal

Chemical language and warfare of bacterial natural products in bacteria–nematode–insect interactions

(2018) Yi-Ming Shi et al.   NATURAL PRODUCT REPORTS

Direct Pathway Cloning Combined with Sequence- and Ligation-Independent Cloning for Fast Biosynthetic Gene Cluster Refactoring and Heterologous Expression

(2018) Paul M. D’Agostino et al.   ACS Synthetic Biology

Species-specific activity of antibacterial drug combinations

(2018) Ana Rita Brochado et al.   NATURE

Activation of silent biosynthetic gene clusters using transcription factor decoys

(2018) Bin Wang et al.   Nature Chemical Biology

Biosynthesis and function of simple amides in Xenorhabdus doucetiae

(2017) Edna Bode et al.   ENVIRONMENTAL MICROBIOLOGY

PRISM 3: expanded prediction of natural product chemical structures from microbial genomes

(2017) Michael A. Skinnider et al.   NUCLEIC ACIDS RESEARCH

Bacterial Alkaloids Prevent Amoebal Predation

(2016) Martin Klapper et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photorhabdus-nematode symbiosis is dependent onhfq-mediated regulation of secondary metabolites

(2016) Nicholas J. Tobias et al.   ENVIRONMENTAL MICROBIOLOGY

Biosynthesis of the acetyl-CoA carboxylase-inhibiting antibiotic, andrimid in Serratia is regulated by Hfq and the LysR-type transcriptional regulator, AdmX

(2016) Miguel A. Matilla et al.   ENVIRONMENTAL MICROBIOLOGY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters

(2016) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Simple “On-Demand” Production of Bioactive Natural Products

(2015) Edna Bode et al.   CHEMBIOCHEM

Biosynthesis of the antifungal haterumalide, oocydin A, inSerratia, and its regulation by quorum sensing, RpoS and Hfq

(2015) Miguel A. Matilla et al.   ENVIRONMENTAL MICROBIOLOGY

Taxonomy, Physiology, and Natural Products of Actinobacteria

(2015) Essaid Ait Barka et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Fabclavines: Bioactive Peptide-Polyketide-Polyamino Hybrids fromXenorhabdus

(2014) Sebastian W. Fuchs et al.   CHEMBIOCHEM

The Chemical Arsenal of Burkholderia pseudomallei Is Essential for Pathogenicity

(2014) John B. Biggins et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetic Basis for the Biosynthesis of the Pharmaceutically Important Class of Epoxyketone Proteasome Inhibitors

(2013) Michelle Schorn et al.   ACS Chemical Biology

Specialized microbial metabolites: functions and origins

(2013) Julian Davies   JOURNAL OF ANTIBIOTICS

Merging chemical ecology with bacterial genome mining for secondary metabolite discovery

(2013) Maria I. Vizcaino et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Structure determination of the bioactive depsipeptide xenobactin from Xenorhabdus sp. PB30.3

(2013) Florian Grundmann et al.   RSC Advances

Identification and isolation of insecticidal oxazoles fromPseudomonasspp.

(2012) Florian Grundmann et al.   Beilstein Journal of Organic Chemistry

The RNA Chaperone Hfq Regulates Antibiotic Biosynthesis in the Rhizobacterium Pseudomonas aeruginosa M18

(2012) G. Wang et al.   JOURNAL OF BACTERIOLOGY

Heterologous expression of a Photorhabdus luminescens syrbactin-like gene cluster results in production of the potent proteasome inhibitor glidobactin A

(2012) Alexey Dudnik et al.   MICROBIOLOGICAL RESEARCH

One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitor

(2012) M. L. Stein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small RNAs as regulators of primary and secondary metabolism in Pseudomonas species

(2011) Elisabeth Sonnleitner et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The RNA chaperone, Hfq, controls two luxR-type regulators and plays a key role in pathogenesis and production of antibiotics in Serratia sp. ATCC 39006

(2011) Nabil M. Wilf et al.   ENVIRONMENTAL MICROBIOLOGY

Structure elucidation and biosynthesis of lysine-rich cyclic peptides in Xenorhabdus nematophila

(2011) Sebastian W. Fuchs et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Fungal secondary metabolites – Strategies to activate silent gene clusters

(2010) Axel A. Brakhage et al.   FUNGAL GENETICS AND BIOLOGY

Association of Hemolytic Activity of Pseudomonas entomophila, a Versatile Soil Bacterium, with Cyclic Lipopeptide Production

(2009) I. Vallet-Gely et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY