Article
Chemistry, Physical
Liping Fang, Shan He, Peng Yin, Ning Wang, Bin Zhang, Haixiao Jin
Summary: This study presents the design, synthesis, and evaluation of a series of novel tryptamine derivatives with 5-HT 1B R activation. Several compounds were identified as more potent 5-HT 1B R activators compared to the FDA-approved drug sumatriptan. The molecular docking results provided insights into the binding mode and interactions between the compounds and 5-HT 1B R.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Fateme Zohairi, Himanshu Khandelia, Ali Asghar Hakami Zanjani
Summary: Naturally occurring psychedelics have been used for various purposes, including remedies, religious ceremonies, and recreational activities. Recent studies have demonstrated the therapeutic potential of certain psychedelic compounds in treating anxiety, depression, migraine, and addiction. This research focuses on the impact of different tryptamine class compounds on a model bilayer lipid membrane and reveals how their chemical structure affects partitioning and passage across the membrane.
CHEMISTRY AND PHYSICS OF LIPIDS
(2023)
Article
Biotechnology & Applied Microbiology
Jie Ren, Wenzhu Tang, Caleb Don Barton, Owen M. Price, Mark Wayne Mortensen, Alexandra Phillips, Banner Wald, Simon Elgin Hulme, Logan Powell Stanley, Joan Hevel, Jixun Zhan
Summary: The study discovered a novel glycosyltransferase gene and demonstrated its ability to glycosylate various substrates through in vitro enzymatic reactions. The enzyme showed flexibility in different hosts and efficiently produced valuable glycosides, providing a promising method for biocatalysis and production of natural products.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Plant Sciences
Ponnuvel Deepa, Minji Hong, Kandhasamy Sowndhararajan, Songmun Kim
Summary: Obesity is a major health issue worldwide and is associated with various chronic diseases. Cyanidin-3-O-beta-glucoside (C3G), an anthocyanin compound, has shown potential health benefits in reducing obesity-related complications.
Article
Agriculture, Multidisciplinary
Wen Zhang, Manman Shi, Fang Zhang, Fuliang Cao, Erzheng Su
Summary: In this study, inhibitors for endogenous enzymes in Ginkgo biloba seeds were screened, and it was found that silver fluoride could effectively inhibit enzymes such as glucosidase and phosphatase. A new sample preparation method based on water extraction with the addition of 25 mmol/L silver fluoride was developed. This method allowed for accurate quantification of the natural contents of MPN and MPNG in Ginkgo biloba seeds.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Yu-Hsuan Wen, Hui-Yi Lin, Jia-Ni Lin, Guo-Fang Tseng, Chung-Feng Hwang, Chung-Ching Lin, Chuan-Jen Hsu, Hung-Pin Wu
Summary: This study investigated the otoprotective mechanism of 2,3,4',5-tetrahydroxystilbene-2-O-beta-D-glucoside (THSG) in attenuating gentamicin ototoxicity. THSG was found to decrease gentamicin-induced ototoxicity in UB/OC-2 cochlear cells via regulating the autophagic signaling involving Sesn2/AMPK/mTOR pathway.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Chemistry, Medicinal
Dilip K. Tosh, Maggie M. Calkins, Marko S. Ivancich, Hailey A. Bock, Ryan G. Campbell, Sarah A. Lewicki, Eric Chen, Zhan-Guo Gao, John D. Mccorvy, Kenneth A. Jacobson
Summary: Derivatives of (N)-Methanocarba adenosine were modified to target 5-HT2B serotonin receptors as antagonists, showing affinity enhancement with the bicyclic ring system. Compound 43 (MRS7925) exhibited potential for anti-fibrotic therapy due to its affinity and moderate 5-HT2BR binding selectivity. The compounds also demonstrated dual action as 5-HT2B antagonists and A(1)AR agonists.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Wan Xu, Feiye Zhou, Qin Zhu, Mengyao Bai, Tiancheng Luo, Libin Zhou, Ruyuan Deng
Summary: The study found that CG can attenuate palmitate-induced lipid accumulation in hepatocytes by activating AMPK, suggesting it may be a promising therapeutic medicine for hepatic steatosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Applied
Xuejiao Qie, Wenpu Chen, Yaru Wu, Tian Yang, Zhaojun Wang, Maomao Zeng, Jie Chen, H. Douglas Goff, Zhiyong He
Summary: The study investigates the thermal-induced interaction between beta-conglycinin (7S) and cyanidin-3-O-glucoside (C3G) and its effects on the bioaccessibility and antioxidant capacity of C3G. High ratio of 7S to C3G resulted in a more ordered secondary structure of 7S. Thermal treatment enhanced the formation of 7S-C3G complexes, but not covalent products. The increased binding affinity of C3G to 7S limited its bioaccessibility and promoted the antagonism of antioxidant capacity between 7S and C3G.
Article
Biochemistry & Molecular Biology
Agata Hogendorf, Adam S. Hogendorf, Rafal Kurczab, Grzegorz Satala, Bernadeta Szewczyk, Paulina Cieslik, Gniewomir Latacz, Jadwiga Handzlik, Tomasz Lenda, Katarzyna Kaczorowska, Jakub Staron, Ryszard Bugno, Beata Duszynska, Andrzej J. Bojarski
Summary: A series of N-skateletryptamines were synthesized and evaluated for their affinities for serotonin and dopamine receptors. Some compounds exhibited antipsychotic and procognitive activities, while others had unique receptor combinations that had not been studied before. Through screening and modeling, the compounds with specific receptor antagonist and agonist properties were identified.
Article
Plant Sciences
Xu Wang, Guode Zhao, Chengguo Ju, Lingwen Dong, Yuyang Liu, Zifang Ding, Weiwei Li, Ying Peng, Jiang Zheng
Summary: This study aimed to elucidate the mechanism underlying the reduced hepatotoxicity of Polygoni Multiflori Radix (PMR) after processing. It was found that processed PMR contained lower levels of emodin-8-O-beta-D-glucoside (EG). Processed PMR showed fewer adverse effects and less hepatic protein adduction compared to raw PMR. Effective hydrolysis of EG to emodin (EMD) occurred in the intestinal epithelial cells during absorption. Cytosolic broad-specificity beta-glucosidase, lactase phlorizin hydrolase, and intestinal flora participated in the hydrolysis of EG. Circulating EMD resulting from the deglycosylation of EG exerted hepatotoxic effects. The reduction of EG content due to processing is a key factor in the detoxification of PMR.
Article
Medicine, Research & Experimental
Liyuan Mao, Fang Xin, Jie Ren, Shuai Xu, Haixia Huang, Xu Zha, Xinxin Wen, Guoqing Gu, Guang Yang, Yuan Cheng, Chen Zhang, Wei Wang, Xicheng Liu
Summary: This study demonstrates the dual functions of 5-HT/5-HT2B/TGF-beta signaling in the initiation and progression of colitis-associated cancer (CAC), with a critical role in tumor suppression but a promotion of cancer progression in the late-stage of CAC.
Article
Biochemistry & Molecular Biology
Dorota Lazewska, Malgorzata Wiecek, Grzegorz Satala, Paulina Chalupnik, Ewa Zeslawska, Ewelina Honkisz-Orzechowska, Monika Tarasek, Gniewomir Latacz, Wojciech Nitek, Ewa Szymanska, Jadwiga Handzlik
Summary: With the increasing number of Alzheimer's disease patients, there is an urgent need for new and effective drugs to slow down or prevent the progression of the disease. 1,3,5-Triazine derivatives have shown potential as potent ligands for the serotonin 5-HT6 receptor (5-HT6R), which is a promising therapeutic target for AD. A new derivative of MST4 compound was designed and tested for its affinity towards 5-HT6R and other receptors. Compound 3 showed promising results as a potent and selective 5-HT6R ligand, making it a potential candidate for further pharmacological studies.
Article
Biochemistry & Molecular Biology
K. Elaine Ritter, Dennis P. Buehler, Stephanie B. Asher, Karen K. Deal, Shilin Zhao, Yan Guo, E. Michelle Southard-Smith
Summary: The study highlights the crucial role of the serotonin receptor 5-HT3 in the development of bladder neurons from sacral NC cells. In vitro experiments showed that disrupting 5-HT3 signaling altered the differentiation outcomes of NC cells, while stimulating 5-HT3 in explanted fetal ganglia hindered neurite outgrowth. These findings suggest that perturbations in 5-HT3 signaling during gestation may impact bladder function later in life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Ching-Feng Wu, Ching-Yang Wu, Chuen-Fu Lin, Yi-Wen Liu, Tzu-Chun Lin, Huei-Jyuan Liao, Geng-Ruei Chang
Summary: This study found that cyanidin-3-O-glucoside (C3G) can inhibit the growth of lung large-cell carcinoma (LCC), and its inhibitory effects can be enhanced when used in combination with 5-fluorouracil (5-FU). C3G can induce tumor cell apoptosis, reduce inflammation, and affect the expression of tumor microenvironment-related factors.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Food Science & Technology
Giuseppe Squitieri, Giuseppe Pirone, Liliana La Pietra, Mariarosaria Cannavacciuolo, Aldo Pezzani, Giovanna Ferrari, Domenico Castaldo, Maria Luisa Balestrieri, Domenico Cautela
Summary: This review presents the current laboratory criteria for detecting and evaluating the potential causes of changes in non-concentrated industrial tomato derivatives packaged in coated or uncoated tinplate cans. Gas composition analysis and microbiological and chemical analyses can be used to diagnose the causes of alterations in tomatoes, indicated by container swelling.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2023)
Article
Biotechnology & Applied Microbiology
Jules Harrouard, Etienne Pilard, Cecile Miot-Sertier, Lena Pouget, Philippe Marullo, Giovanna Ferrari, Gianpiero Pataro, Warren Albertin
Summary: This study investigates the efficiency of pulsed light (PL) treatment for managing microorganisms in wine, particularly focusing on the sensitivity of Brettanomyces bruxellensis strains. The results show that PL treatment can effectively reduce the number of different B. bruxellensis strains in wine, highlighting its potential for wine microbial stabilization.
Article
Chemistry, Analytical
Francesco Siano, Gianluca Picariello, Domenico Castaldo, Domenico Cautela, Tonino Caruso, Ermanno Vasca
Summary: A recently optimized coulometric method was used to determine the antioxidant capacity of bergamot by-products. The results showed that bergamot FPJ and SPJ had high antioxidant capacity. The concentration of flavonoids in bergamot SPJ and peel was higher, indicating their potential for pharmaceutical, nutraceutical, and food applications.
Review
Food Science & Technology
Elham Eslami, Serena Carpentieri, Gianpiero Pataro, Giovanna Ferrari
Summary: The tomato processing industry generates a significant amount of residue, causing disposal issues and environmental burdens. Previous studies have shown that tomato by-products contain valuable compounds that can be utilized in various industries. Conventional solvent extraction, although widely used, has drawbacks such as solvent usage and biomass utilization. Recent advances in extraction techniques, including the use of green technologies, have greatly improved the recovery of these compounds.
Article
Agriculture, Dairy & Animal Science
Gianluca Neglia, Serena Calabro, Alessio Cotticelli, Angela Salzano, Roberta Matera, Alessandro Vastolo, Nunzia D'Onofrio, Andrea Giorgino, Elisa Martino, Maria L. Balestrieri, Giuseppe Campanile
Summary: The inclusion of former food products in the diet of buffaloes as an alternative to green forage did not significantly affect fermentation characteristics, milk yield and quality, and the content of certain biomolecules and total antioxidant activity. Therefore, biscuit meal can be used as a substitute for green fodder to ensure environmental sustainability and optimize costs without compromising milk quality.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Elisa Martino, Amalia Luce, Anna Balestrieri, Luigi Mele, Camilla Anastasio, Nunzia D'Onofrio, Maria Luisa Balestrieri, Giuseppe Campanile
Summary: Endothelial dysfunction plays a critical role in the progression of type 2 diabetes mellitus (T2DM), leading to cardiovascular complications. Whey (WH), a dairy by-product with a considerable content of bioactive compounds, showed protective effects on human endothelial cell function under diabetic conditions mimicked in vitro.
Article
Nutrition & Dietetics
Serena Carpentieri, Giovanna Ferrari, Gianpiero Pataro
Summary: This study optimized the pulsed electric fields (PEF)-assisted extraction process to enhance the extraction yields of bioactive compounds from red grape pomace. Results showed that under the optimal processing conditions (electric field strength of 4.6 kV/cm, energy input of 20 kJ/kg), PEF significantly improved the permeability of grape pomace cell membrane, resulting in increased extraction yields of total phenolic content, flavonoid content, total anthocyanin content, tannin content, and antioxidant activity.
FRONTIERS IN NUTRITION
(2023)
Article
Medicine, General & Internal
Celestino Sardu, Gianluca Gatta, Gorizio Pieretti, Nunzia D' Onofrio, Maria Luisa Balestrieri, Lucia Scisciola, Salvatore Cappabianca, Giuseppe Ferraro, Giovanni Francesco Nicoletti, Giuseppe Signoriello, Liberata Sportiello, Gianluigi Savarese, Mario Melchionna, Feliciano Ciccarelli, Daniele La Forgia, Giuseppe Paolisso, Raffaele Marfella
Summary: This study evaluated the expression of SGLT2, inflammatory cytokines, and sirtuins in breast fat tissue and serum cytokines of pre-menopausal women. The results showed that women with fatty breasts over-expressed SGLT2 and inflammatory cytokines, while downregulating breast sirtuins. The study also found correlations between the expression of SGLT2/cytokines/sirtuins and clinical variables related to cardiovascular health.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Oncology
Elisa Martino, Anna Balestrieri, Francesca Aragona, Giovanna Bifulco, Luigi Mele, Giuseppe Campanile, Maria Luisa Balestrieri, Nunzia D'Onofrio
Summary: This study reports the antineoplastic effect of miR-148a-3p overexpression in a colorectal cancer (CRC) model, which occurs through apoptosis, mitochondrial impairment, lipid peroxidation, and ferroptosis sustained by the ACSL4/TFRC/Ferritin axis. The downregulation of SLC7A11 by miR-148a-3p may contribute to the cytotoxicity. These findings highlight the oncosuppressor role of miR-148a-3p and its potential as a diagnostic and therapeutic biomarker in CRC.
Article
Food Science & Technology
Filomena Monica Vella, Roberto Calandrelli, Domenico Cautela, Bruna Laratta
Summary: Agricultural and food waste recycling contributes to the development of green markets. In this study, the peels of Italian cantaloupe cultivars were characterized for their potential use as biomasses. The research showed promising results in terms of cell wall-modifying enzymes, polyphenols, and antioxidant properties. Further investigation demonstrated that the enriched sea water containing cantaloupe peel extracts had significant antioxidant activity, indicating the potential for utilizing melon by-products for food fortification.
Article
Engineering, Environmental
Michele Miccio, Michela Fraganza, Aisylu Zainutdinova, Blandine Tauleigne, Paola Brachi, Marcello Casa, Giovanna Ferrari, Natalia Kostryukova
Summary: This study investigates the valorization of roasted hazelnut cuticles through chemical (solvent extraction) and thermochemical treatment (torrefaction) routes. The potential of using water as a green solvent for the extraction of bioactive compounds in hazelnut residues has been explored using the conventional laboratory Soxhlet extraction procedure. The spent post-extraction residues can be converted into renewable solid fuels through torrefaction. The results include the theoretical yields of bioactive compounds and the performance indexes of torrefaction.
Article
Polymer Science
Oscar Pulgarin, Dominique Larrea-Wachtendorff, Giovanna Ferrari
Summary: This study examines the effects of amylose/amylopectin content on the gelation of starch and the physical properties of hydrogels produced by HPP. The study also evaluates the impact of storage temperature and packaging type on the stability of hydrogels during a 30-day storage period. The results show that amylose has an antagonistic role in water absorption and gel formation, as well as the physical stability of hydrogels. A minimum amylose concentration of 20% is needed to form stable corn starch HPP hydrogels. Storage at a temperature of 20 degrees C and the use of polymeric bags are recommended for long-term storage of corn starch hydrogels.