Article
Psychology, Multidisciplinary
David J. Libon, Emily Frances Matusz, Stephanie Cosentino, Catherine C. Price, Rod Swenson, Meagan Vermeulen, Terrie Beth Ginsberg, Adaora Obiageli Okoli-Umeweni, Leonard Powell, Robert Nagele, Sean Tobyne, Joyce Rios Gomes-Osman, Alvaro Pascual-Leone
Summary: The Core Cognitive Evaluation (CCE), administered and scored using an iPad, is a powerful neurocognitive assessment tool for screening patients' neurocognitive impairment and psychological distress in ambulatory medical care settings. It is linked with patients' self-reported concerns about memory and cardiovascular risks.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Neurosciences
Anni Richter, Joram Soch, Jasmin M. Kizilirmak, Larissa Fischer, Hartmut Schutze, Anne Assmann, Gusalija Behnisch, Hannah Feldhoff, Lea Knopf, Matthias Raschick, Annika Schult, Constanze I. Seidenbecher, Renat Yakupov, Emrah Duezel, Bjorn H. Schott
Summary: In this study, we investigated the associations between two single-value scores and brain function and cognitive changes in middle-aged and older adults. The results showed that these scores were related to memory recall performance and one of the scores also correlated with brain gray matter and other neuropsychological measures. This suggests that single-value scores of memory-related fMRI provide valuable information about network dysfunction in individuals and age-related cognitive decline.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Arthur Cassa Macedo, Paulo Caramelli, Elisa de Paula Franca Resende, Luciano Inacio Mariano, Vitor Tumas, Antonio Lucio Teixeira, Sarah Teixeira Camargos, Francisco Eduardo Costa Cardoso, Leonardo Cruz de Souza
Summary: The study found that episodic memory impairment in PSP may be related to the damage of medial temporal structures, rather than solely due to executive dysfunction.
NEUROLOGICAL SCIENCES
(2022)
Article
Behavioral Sciences
Davide Quaranta, Naike Caraglia, Federica L'Abbate, Guido Maria Giuffre, Valeria Guglielmi, Giovanna Masone Iacobucci, Paolo Maria Rossini, Paolo Calabresi, Camillo Marra
Summary: Early impairment of semantic memory could predict the progression to Alzheimer's disease before the onset of memory disorders, and the discrepancy between phonological and semantic verbal fluency tests could be able to detect this impairment in advance.
BRAIN AND BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Cameron T. Ellis, Lena J. Skalaban, Tristan S. Yates, Vikranth R. Bejjanki, Natalia Cordova, Nicholas B. Turk-Browne
Summary: The hippocampus is essential for human memory and supports statistical learning. Infants' hippocampal function is recruited for statistical learning around 3 months, regardless of age. In addition, statistical learning is clearer in the anterior hippocampus than the posterior hippocampus.
Article
Neurosciences
Ueli Rutishauser, Leila Reddy, Florian Mormann, Johannes Sarnthein
Summary: Recordings from neurons in humans implanted with electrodes reveal the existence of different types of cells related to memory, including those encoding selective and invariant representations of abstract concepts, and memory-selective cells associated with familiarity and episodic retrieval. Insights derived from observing these cells include the activation of semantic representations before episodic representations, the segregation of memory content and memory strength, and the relationship between cell activity and subjective awareness in declarative memory.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Matthias Fastenrath, Klara Spalek, David Coynel, Eva Loos, Annette Milnik, Tobias Egli, Nathalie Schicktanz, Leonie Geissmann, Benno Roozendaal, Andreas Papassotiropoulos, Dominique J-F de Quervain
Summary: Emotional information is more easily remembered than neutral information. The amygdala plays a key role in the memory-enhancing effect of emotional arousal, while the role of the cerebellum in emotional enhancement of episodic memory is less clear. This study found that the cerebellum is an integral part of a network involved in emotional enhancement of episodic memory.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Zhisen J. Urgolites, John T. Wixted, Stephen D. Goldinger, Megan H. Papesh, David M. Treiman, Larry R. Squire, Peter N. Steinmetz
Summary: Previous studies have identified generic and item-specific memory signals in the human hippocampus, and this study finds that both types of signals can be detected in hippocampal neurons in the same experiment. The generic signal is found in multiple brain regions, while the item-specific signal is exclusive to the hippocampus and exhibits sparse coding.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Psychology
Qi Wang
Summary: Human memory is inherently private and personal, yet it is also deeply collective and cultural. Cultural elements shape the processes and consequences of remembering, laying the foundation for human memory.
ANNUAL REVIEW OF PSYCHOLOGY, VOL 72
(2021)
Article
Neurosciences
Michael Freedberg, Jack A. Reeves, Cynthia M. Fioriti, Jorge Murillo, Joel L. Voss, Eric M. Wassermann
Summary: This study provides experimental evidence of competition between episodic and procedural memory networks, and suggests that increased connectivity within the hippocampal network can enhance episodic memory while reducing procedural memory.
Article
Psychology, Multidisciplinary
Ramon Lopez-Higes, Susana Rubio-Valdehita, Maria Luisa Delgado-Losada, David Lopez-Sanz
Summary: The study aimed to explore the relationships between cognitive reserve and different cognitive domains in older adults with subjective cognitive decline and mild cognitive impairment. The results showed that cognitive reserve strongly influences working memory, moderately influences sentence comprehension, but has little effect on episodic memory. In the patients' group, there is an inverse association between cognitive reserve and episodic memory.
CURRENT PSYCHOLOGY
(2023)
Review
Clinical Neurology
Sanya Rastogi, Kimford J. Meador, William B. Barr, Orrin Devinsky, Beth A. Leeman-Markowski
Summary: Studies of epilepsy patients provide insights into the neuroscience of human memory. The impairment of remote memory in patients may result from the interaction of multiple factors, including hippocampal dysfunction. The lateralization of remote memory has been the focus of research, with left temporal lobe epilepsy patients experiencing more severe deficits than others.
FRONTIERS IN NEUROLOGY
(2022)
Review
Nanoscience & Nanotechnology
Oluwafemi Obisesan, Lebogang Katata-Seru, Steven Mufamadi, Hazel Mufhandu
Summary: Nanoparticles encapsulating drugs show better treatment outcomes in HSV and HIV infections, providing sustained drug release to improve therapeutic effect and mitigate the low drug compliance associated with standalone drugs.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2021)
Article
Clinical Neurology
Panagiotis Kourtesis, Simona Collina, Leonidas A. A. Doumas, Sarah E. MacPherson
Summary: The study validated the VR-EAL as an effective neuropsychological tool for assessing everyday cognitive functions, showing good construct and convergent validity compared to paper-and-pencil tests. Participants found VR-EAL tasks to be more ecologically valid and pleasant, with the added benefit of shorter administration time.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2021)
Article
Behavioral Sciences
Matilde Conti, Alice Teghil, Antonella Di Vita, Maddalena Boccia
Summary: This article describes the case of a 53-year-old woman, DR, who complains of a specific and lifelong deficit in recalling autobiographical episodes. Through neuropsychological assessment and MRI examination, it was found that she has a deficit in episodic re-experiencing of personal life events and shows structural and functional abnormalities in certain brain regions. The study provides further evidence of a severely deficient autobiographical memory condition and offers important insights into the underlying neurocognitive mechanisms.
Article
Neurosciences
Chang-Ki Oh, Nima Dolatabadi, Piotr Cieplak, Maria T. Diaz-Meco, Jorge Moscat, John P. Nolan, Tomohiro Nakamura, Stuart A. Lipton
Summary: This article investigates the mechanism by which dysregulation of autophagic pathways leads to the accumulation of abnormal proteins and damaged organdies in neurodegenerative disorders. The authors found that pathologic protein S-nitrosylation of p62 is a critical factor for autophagic inhibition and cell-to-cell spread.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Jennifer L. Thompson, Steven Paul Woods, Luis D. Medina, Troy A. Webber
Summary: Older age and HIV disease are independent risk factors for problems in everyday functioning. This study examined the combined effects of age and HIV serostatus on changes in everyday functioning and its associations with changes in neurocognition over a 1-year period. The results showed that older individuals with HIV reported the poorest everyday functioning, which remained stable over time, while younger individuals with HIV showed mild improvements. The study also found that problems with everyday functioning may precede declines in neurocognition. Further research is needed to understand the long-term trajectory of neurocognitive and functional changes in older individuals with HIV.
JOURNAL OF NEUROVIROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Takumi Satoh, Dorit Trudler, Chang-Ki Oh, Stuart A. Lipton
Summary: This article reviews the potential applications of carnosic acid (CA) and carnosol (CS) in rosemary for conditions such as Alzheimer's disease, Parkinson's disease, and COVID-19. It highlights the antioxidant, anti-inflammatory, and neuroprotective effects of CA, as well as its potential to inhibit the NLRP3 inflammasome. The article suggests that CA-related compounds could serve as therapeutics for acute and chronic neurological effects caused by SARS-CoV-2 infection and other neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Ki-Ryeong Kim, Eun-Jung Cho, Jae-Won Eom, Sang-Seok Oh, Tomohiro Nakamura, Chang-ki Oh, Stuart A. Lipton, Yang-Hee Kim
Summary: This study reveals that S-nitrosylation of lysosomal protease cathepsin B (CTSB) inhibits its activity, blocks autophagic flux, and contributes to the pathogenesis of Alzheimer's disease (AD).
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Psychology, Clinical
Kelli L. Sullivan, Matthew W. Gallagher, Romola S. Bucks, Michael Weinborn, Steven Paul Woods
Summary: MIsT has a robust factor structure across older adults and people with HIV disease. Total score of MIsT provides the most parsimonious solution, although subscales may also be used.
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2022)
Article
Neurosciences
Steven Paul Woods, Anastasia Matchanova, Christina Alex, Samina Rahman, Michelle A. Babicz, Kelli L. Sullivan, Gunes Avci, Rodrigo Hasbun, Pariya L. Fazeli, Thomas P. Giordano
Summary: Creativity can help HIV patients overcome challenges in daily life. This pilot study found a positive correlation between neuropsychological functioning and creativity in HIV patients, regardless of different domains of creativity and premorbid IQ. However, creativity scores were not related to everyday functioning.
JOURNAL OF NEUROVIROLOGY
(2022)
Article
Psychiatry
Ilex Beltran-Najera, Andrea Mustafa, Desmond Warren, Zach Salling, Maria Misiura, Steven Paul Woods, Vonetta M. Dotson
Summary: This study aimed to determine the frequency and everyday functioning implications of vascular depression among people living with HIV. The results showed that HIV infection was associated with a three-fold increased risk of vascular depression, and PLWH with vascular depression had significantly greater odds of dependence in everyday functioning. This study highlights the clinical importance of understanding vascular depression in the context of HIV disease.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Steven Paul Woods, Andrea Mustafa, Ilex Beltran-Najera, Anastasia Matchanova, Jennifer L. Thompson, Natalie C. Ridgely
Summary: This study examines the frequency and extent of effect size reporting in neuropsychology journal articles. The findings show increases in effect size reporting in the Methods and Results sections, but no significant changes in the Abstract, Introduction, and Discussion sections. Authors in neuropsychology journals have improved effect size reporting in the core sections, but still need to consider these metrics in motivating study hypotheses and interpreting their findings.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Article
Clinical Neurology
Andrea I. Mustafa, Steven Paul Woods, Shayne Loft, Erin E. Morgan
Summary: This study found that cognitive intraindividual variability is associated with prospective memory performance and symptoms among people living with HIV. The findings suggest that variability in cognitive test results is related to laboratory-based prospective memory accuracy, but has a weak relationship with self-reported prospective memory symptoms.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Article
Substance Abuse
Tanya Smit, Nubia A. A. Mayorga, Andrew H. H. Rogers, Steven P. P. Woods, Luke F. F. Heggeness, Brooke Y. Y. Kauffman, Lorra Garey, Michael J. J. Zvolensky
Summary: Past research has established a link between negative mood and opioid misuse/dependence, but the underlying mechanisms have not been scientifically investigated. This study highlights the importance of anxiety sensitivity in understanding the relationship between negative mood and opioid use among adults with chronic pain.
SUBSTANCE USE & MISUSE
(2023)
Article
Geriatrics & Gerontology
Steven Paul Woods, Antonio L. Teixeira, Lais B. Martins, Gabriel R. Fries, Gabriela D. Colpo, Natalia P. Rocha
Summary: The number of older persons with HIV (PWH) disease has significantly increased in the past 20 years, but our understanding of the biological factors and clinical correlates in this population remains limited. A study was conducted involving 149 individuals aged 50 and older, including 107 PWH and 42 seronegatives. Results showed that PWH had higher levels of epigenetic aging acceleration compared to seronegatives on four indicators. Furthermore, higher levels of epigenetic aging acceleration were associated with lower CD4 count, AIDS diagnoses, higher scores on the Veterans Aging Cohort Study Index, lower telomere values, and lower health literacy among PWH. It was concluded that PWH experience accelerated aging, which may be linked to immune compromise and all-cause mortality risk. Improving health literacy could help mitigate the risk of accelerated aging among older PWH.
Article
Psychology, Multidisciplinary
Anastasia Matchanova, Steven Paul Woods, Clayton Neighbors, Luis D. D. Medina, Kenneth Podell, Ilex Beltran-Najera, Christina Alex, Michelle A. A. Babicz, Jennifer L. L. Thompson
Summary: The online spread of COVID-19 misinformation has had negative effects on public health and society. This study examined the differences in discernment and sharing of COVID-19 misinformation between older and younger adults, as well as the role of cognitive abilities and health literacy. The findings suggest that headline accuracy judgment, numeracy, and verbal IQ are significant factors in the sharing of COVID-19 misinformation.
CURRENT PSYCHOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Elliott Michael Gomez, Steven Paul Woods, Ilex Beltran-Najera
Summary: This study examines the association between health literacy and successful aging among people with HIV (PWH). Results suggest that higher health literacy is associated with a higher frequency of successful aging among older PWH. Older PWH are less likely to experience successful aging compared to older adults without HIV. Future studies may explore whether improving health literacy among younger PWH increases the likelihood of successful aging.
Article
Psychology, Experimental
Yenifer L. Morales Mejia, Jennifer L. Thompson, Steven Paul Woods
Summary: Deficits in episodic verbal memory are commonly observed in persons with HIV disease, which impact everyday functioning. This study investigated deficits in episodic visual memory in HIV patients and found that encoding deficits were the primary issue. Factors related to other cognitive impairments in HIV patients include motor coordination and executive functions.
PERCEPTUAL AND MOTOR SKILLS
(2023)
Article
Psychology, Developmental
Kelli L. Sullivan, Clayton Neighbors, Romola S. Bucks, Michael Weinborn, Brandon E. Gavett, Steven Paul Woods
Summary: Age-related decline in prospective memory (PM) is more pronounced in event-based PM than in time-based PM among older adults. This decline is not associated with age, retrospective memory, executive functions, or everyday functioning.
AGING NEUROPSYCHOLOGY AND COGNITION
(2022)