Article
Environmental Sciences
Liru Xue, Xiang Li, Xiaoran Zhu, Jinjin Zhang, Su Zhou, Weicheng Tang, Dan Chen, Yingying Chen, Jun Dai, Meng Wu, Mingfu Wu, Shixuan Wang
Summary: In this study, it was found that exposure to carbon tetrachloride (CCL4) can cause damage to the ovaries by inducing oxidative stress, inflammatory cytokine production, and ovarian fibrosis. This leads to decreased ovarian function, disturbed estrus cycle, and reduced number of healthy follicles.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Jinxin Wang, Xuzhu Gao, Feixue Liu, Fang Wang, Jingquan Dong, Panpan Zhao
Summary: This study revealed that the widespread use of difenoconazole in fish culture in paddy fields can cause cardiotoxicity in common carp. The cardiotoxicity is regulated by multiple mechanisms including oxidative stress, inflammation, apoptosis, and autophagy.
Article
Environmental Sciences
Jia Zhao, Hongxia Zhao, Zhihui Zhong, Tadiyose Girma Bekele, Huihui Wan, Yuming Sun, Xintong Li, Xiaonuo Zhang, Zhansheng Li
Summary: Tetrabromobisphenol A bis (allyl ether) (TBBPA-BAE) is a widely used brominated flame retardant with neurotoxic and endocrine disruption effects on aquatic organisms. This study investigated the bioconcentration, elimination kinetics, and biotransformation of TBBPA-BAE in common carp. The results showed rapid accumulation of TBBPA-BAE in the fish, with the highest concentrations found in the liver and the longest residence time in the kidney. Biotransformation of TBBPA-BAE was observed, with 14 different metabolites identified in the liver. These findings highlight the importance of considering the biotransformation products of TBBPA-BAE in risk assessment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Fisheries
Haoran Zhang, Fuqing Zhao, Xiaoxue Gai, Jingzeng Cai, Xintong Zhang, Xiaoming Chen, Yue Zhu, Ziwei Zhang
Summary: Cadmium is a common environmental pollutant that has toxic effects on fish head kidney lymphocytes. This study utilized an in vitro Cd exposure model and antioxidant treatment to demonstrate that Cd induced lymphocyte apoptosis, which could be alleviated by antioxidants.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Zhou Jiang, Xuejun Li, Chuanju Dong
Summary: The study reveals that Nrf genes in common carp are highly conserved and play a key role in oxidative stress. Bacillus coagulans at a certain concentration is identified as the optimum for activating Nrf gene expression.
Article
Biochemistry & Molecular Biology
Qiujie Wang, Dongjie Wang, Zhiheng Zuo, Bin Ye, Zaijie Dong, Jixing Zou
Summary: Gelsemium elegans Benth. (GEB) is a traditional medicinal plant in China, and its alkaloid compound koumine (KM) has been found to promote growth and modulate immunity in aquatic animals. This study investigated the growth-promoting effects of KM in Cyprinus carpio and found that KM influenced the intestinal microbial populations and intestinal morphology through specific signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
Dongjie Wang, Qiujie Wang, Zhiheng Zuo, Zaijie Dong, Jiayang He, Xiangchen Ye, Huijuan Tang, Jixing Zou
Summary: This study discovered that koumine can be used as an immunostimulant in aquaculture and investigated its molecular mechanism. The results showed that increasing koumine concentration led to an increase in apoptotic cells in the liver and elevated levels of various biochemical parameters. Transcriptome data analysis revealed that koumine affected multiple signaling pathways, with JAK-STAT and p53 pathways being the important targets. These findings contribute to a better understanding of the potential mechanism by which koumine regulates hepatic immunity.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Hongxia Li, Lei Zhang, Jianlin Li, Fan Yu, Meiyao Wang, Qin Wang, Yunsheng Wu, Qiyuan Zhang, Yongkai Tang, Juhua Yu
Summary: The study identified two interleukin (IL)-17 N genes in the common carp genome, showing high identity and similarity between the two genes. IL-17 N was found to be highly expressed in the brain of healthy individuals and upregulated in various tissues post-infection, promoting inflammation. The evolutionary analysis indicates that IL-17 N is an ancient and conserved gene that plays a role in the immune response.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Fisheries
Chi Cheng, Se Chang Park, Sib Sankar Giri
Summary: The study investigated the effects of Pandanus tectorius extract on the growth, antioxidant capacity, immune response, and disease resistance of Cyprinus carpio. The results showed that a dosage of 20g kg-1 had significant positive impacts on weight gain, serum antioxidant parameters, immunity, and disease resistance of the fish.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Environmental Sciences
Yu Wang, Hongjing Zhao, Mengyao Mu, Menghao Guo, Mingwei Xing
Summary: Arsenic accumulation in the spleen due to environmental exposure can cause severe injuries, while zinc treatment may offer protection against arsenic-induced splenic toxicity in common carp.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Immunology
Rongrong Liu, Xiaoye Liu, Meijiao Song, Yue Qi, Hua Li, Guiwen Yang, Shijuan Shan
Summary: In this study, TRIF from common carp was cloned and characterized, showing a role in the immune response against bacterial and viral infection. TRIF was found to be constitutively expressed in various tissues, with the highest expression in the spleen and lowest in the head kidney. Stimulation with different factors led to upregulation of TRIF, while its downstream signaling involved interactions with TBK1 and activation of interferon-stimulated genes, inflammatory cytokines, and caspase-8-mediated apoptosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Marine & Freshwater Biology
Menghao Guo, Yu Wang, Hongjing Zhao, Dongxu Wang, Kai Yin, Yachen Liu, Baoying Li, Mingwei Xing
Summary: This study found that natural antioxidant zinc has a mitigating effect on arsenic toxicity in the foregut and midgut of common carp, by reversing the burst of reactive oxygen species and breakdown of the antioxidant system, as well as inhibiting the activation of related signal cascades.
AQUATIC TOXICOLOGY
(2021)
Article
Fisheries
Shuqun Xue, Jiawen Lin, Qun Zhou, Haitao Wang, Ying Han
Summary: The study investigated the gene expression profiles in common carp hepatopancreas under ammonia stress, identifying differentially expressed genes involved in metabolic pathways such as protein processing in the endoplasmic reticulum. Ammonia stress induced apoptosis in hepatopancreatic cells, mediated by the endoplasmic reticulum stress and unfolded protein response signaling pathways.
AQUACULTURE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Khalid Saad Alharbi, Neeraj Kumar Fuloria, Shivkanya Fuloria, Sk Batin Rahman, Waleed Hassan Al-Malki, Mohammad Arshad Javed Shaikh, Lakshmi Thangavelu, Sachin K. Singh, Venkata Sita Rama Raju Allam, Niraj Kumar Jha, Dinesh Kumar Chellappan, Kamal Dua, Gaurav Gupta
Summary: NF-xB is a crucial transcription factor involved in inflammation, immune response, and various physiological processes, playing a key role in many respiratory disorders.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Baohua Li, Pengju Qi, Ying Qu, Beibei Wang, Jianjun Chen, Zhongjie Chang
Summary: The levels of the chlorinated organic compound Dechlorane Plus (DP) are increasing in aquatic ecosystems. Research shows that DP exposure causes severe damage to the liver and brain of common carp, disrupts fish metabolism, inhibits antioxidant enzyme activity, increases lipid peroxidation, promotes inflammation, and induces cell apoptosis. This information is important for future ecological risk assessments.
DRUG AND CHEMICAL TOXICOLOGY
(2022)