Review
Immunology
Ping-Heng Tan, Jasmine Ji, Chun-Chang Yeh, Ru-Rong Ji
Summary: IFNs exert antiviral, antiproliferative, and immunomodulatory actions, with type-I IFNs like IFN-alpha and IFN-beta used in treating diseases such as hepatitis and multiple sclerosis. Emerging evidence indicates non-genomic regulation by IFN-alpha and IFN-beta in addition to canonical transcriptional regulations, leading to rapid suppression of neuronal activity and synaptic transmission. Type-I and type-II IFNs modulate pain and infection via neuro-immune interactions, with IFN-gamma inducing central sensitization and microglia activation in persistent pain. Insights into IFN signaling in nociceptors and their roles in distinct physiological vs. pathological conditions will enhance pain treatments after surgeries, traumas, and infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Debpali Sur, Katerina Leonova, Bar Levi, Shany Ivon Markowitz, Raichel Cohen-Harazi, Ilya Gitlin, Katerina Gurova, Andrei Gudkov, Albert Pinhasov, Igor Koman, Elimelech Nesher
Summary: Interferon signaling in inflammation releases cytokines and chemokines to combat viral, bacterial, and cancerous invasions. However, prolonged exposure to interferons leads to immune exhaustion, enhancing inflammation and disease promotion. A peptide called ALOS4 has shown anti-inflammatory properties by upregulating interferon-response genes, supporting antiviral response without inhibiting interferon signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Elisa Petruccioli, Linda Petrone, Teresa Chiacchio, Chiara Farroni, Gilda Cuzzi, Assunta Navarra, Valentina Vanini, Umberto Massafra, Marianna Lo Pizzo, Giuliana Guggino, Nadia Caccamo, Fabrizio Cantini, Fabrizio Palmieri, Delia Goletti
Summary: Patients with immune-mediated inflammatory diseases (IMID), such as rheumatoid arthritis (RA), have a higher risk of developing active tuberculosis (TB) compared to the general population. Studying the M. tuberculosis (Mtb) specific T-cell response may help identify immune biomarkers of Mtb burden or clearance in different TB statuses and risk groups.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Zhijie Jian, Rui Ma, Ling Zhu, Huidan Deng, Fengqin Li, Jun Zhao, Lishuang Deng, Siyuan Lai, Xiangang Sun, Huaqiao Tang, Zhiwen Xu
Summary: This article reviews the strategies used by Arteriviruses to antagonize IFN production and thwart IFN-activated antiviral signaling, emphasizing the significance of this research in understanding the pathogenesis of arthritis virus and developing vaccines.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Charu Aggarwal, Viswanathan Ramasamy, Amit Garg, Rahul Shukla, Navin Khanna
Summary: Vaccines should stimulate both B-cell mediated humoral immunity and T-cell mediated cellular immunity. The pre-clinical tetravalent dengue subunit vaccine candidate, DSV4, can induce type-specific neutralizing antibody responses and dengue-specific T-cell responses in mice. These findings demonstrate that DSV4 can mediate both arms of adaptive immunity in mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Paolo Cortese, Felice Amato, Antonio Davino, Raffaella De Franchis, Speranza Esposito, Immacolata Zollo, Marina Di Domenico, Egle Solito, Federica Zarrilli, Laura Gentile, Gustavo Cernera, Giuseppe Castaldo
Summary: A vaccination plan against COVID in Italy has been implemented, and the immune response of pediatricians to the BNT162b2-mRNA vaccine has been studied. The study found that the vaccine induced an increase in specific antibodies after the third dose, but the antibody titer was not predictive of the risk of infection. However, an increase in CD8(+) IFN-?(+) level after the third dose was found to predict the risk of infection in the following six months.
Article
Cell Biology
Huisi He, Shuzhen Chen, Zhecai Fan, Yaping Dong, Ying Wang, Shiyao Li, Xiaojuan Sun, Yuting Song, Jinxian Yang, Qiqi Cao, Jie Jiang, Xianming Wang, Wen Wen, Hongyang Wang
Summary: This study aimed to identify the characteristics and potential treatment targets of AFP-negative HCC (ANHC) and AFP-positive HCC (APHC). Single-cell RNA sequencing was used to analyze tumor cells from ANHC, APHC, and adjacent normal tissues. The study found that APHC was associated with immune distortion and the accumulation of tumor-associated macrophages (TAMs) enriched with TAM-SPP1(+). Targeting the Spp1-Cd44 axis improved T cell function and reduced tumor burden in APHC treatment.
Article
Immunology
Rebeca Viurcos-Sanabria, Aaron N. Manjarrez-Reyna, Helena Solleiro-Villavicencio, Salma A. Rizo-Tellez, Lucia A. Mendez-Garcia, Victoria Viurcos-Sanabria, Jacquelina Gonzalez-Sanabria, America Arroyo-Valerio, Jose D. Carrillo-Ruiz, Antonio Gonzalez-Chavez, Jose I. Leon-Pedroza, Raul Flores-Mejia, Octavio Rodriguez-Cortes, Galileo Escobedo
Summary: In this study, a prospective cohort study was conducted to investigate the contribution of cellular immune response to the severity of COVID-19. The results showed that a specific immune response pattern in T cells and monocytes was associated with a predisposition to developing severe COVID-19. High expression of PD-1 and low production of IL-2 and IFN-gamma in CD4+ and CD8+ T cells, as well as poor expression of IFN-alpha in classical and non-classical monocytes, were observed in participants who later developed severe COVID-19. These findings suggest that cellular immunity may play a more crucial role than humoral immunity in preventing COVID-19 progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Antoni Ribas, W. Nicholas Haining, Ton N. M. Schumacher
Summary: Tumor-specific cytotoxic T cells need to change the tumor microenvironment to enhance their antitumor effects. IFN-γ plays a critical role by altering the gene expression of cancer cells and immune cells, turning them into enablers of the antitumor immune response.
Article
Biology
Taimoor Khan, Muhammad Suleman, Syed Shujait Ali, Muhammad Farhan Sarwar, Imtiaz Ali, Liaqat Ali, Abbas Khan, Bakht Rokhan, Yanjing Wang, Ruili Zhao, Dong-Qing Wei
Summary: This study uses subtractive proteomics and immune-informatics approaches to design multi-epitope vaccine candidates against Candida auris. The designed vaccines demonstrate strong antigenic features and non-allergenic properties, and show efficacy in immune response. This is of significant importance for designing strategies to counter Candida auris infections.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Fisheries
Yuanmei Li, Xue Qiao, Zhaoqun Liu, Lingling Wang, Linsheng Song
Summary: The research identified an Mx homologue named CgMx1 in the oyster Crassostrea gigas, which encodes a 562-amino acid peptide. CgMx1 showed abundant expression in tissues and exhibited significant responses to poly (I:C) and recombinant IFN-like protein stimulation. CgMx1 was involved in the immune response of C. gigas through a signal pathway mediated by CgIFNLP and CgSTAT.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Immunology
Julius Beer, Stefania Crotta, Angele Breithaupt, Annette Ohnemus, Jan Becker, Benedikt Sachs, Lisa Kern, Miriam Llorian, Nadine Ebert, Fabien Labroussaa, Tran Thi Nhu Thao, Bettina Salome Trueeb, Joerg Jores, Volker Thiel, Martin Beer, Jonas Fuchs, Georg Kochs, Andreas Wack, Martin Schwemmle, Daniel Schnepf
Summary: The study reveals that advanced age is correlated with severe COVID-19 due to impaired immune response, specifically the diminished IFN-gamma response and excessive virus replication. It suggests that immunotherapy combining IFN-gamma and IFN-lambda could benefit highly vulnerable individuals.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Xinhuai Dong, Can Lin, Xu Lin, Chong Zeng, Liming Zeng, Zibo Wei, Xiaokang Zeng, Jie Yao
Summary: Lactate reduces the protein level and activation of STAT1 in ovarian cancer cells, weakens the antitumor effect of IFN alpha, and hinders the recruitment of NKT and CD8(+)T cells. Lactate triggers the degradation of STAT1 through the proteasomal pathway by promoting the expression of Fbxo40, which acts as an E3 ubiquitin ligase, resulting in the induction of STAT1 polyubiquitination and degradation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Dandan Lin, Yu Mei, Lei Lei, Zuhairah Binte Hanafi, Ziqi Jin, Yonghao Liu, Yuan Song, Yinsheng Zhang, Bo Hu, Chunliang Liu, Jinhua Lu, Haiyan Liu
Summary: Tumoral-released IL-1α promotes tumor development by inhibiting T cell activation and recruiting MDSCs, while systemic IL-1α protein inhibits tumor development and activates T cell responses. Additionally, calpain 1 is identified as a major intracellular protease mediating tumoral IL-1α secretion.
Article
Immunology
Chaohu Pan, Qiaomei Cai, Xiaorong Li, Lili Li, Liping Yang, Yu Chen, Junxiao Liu, Wancheng Liu, Meiling Gao, Tianqi Sui, Xiaoyang Wang, Huiming Fan, Jiayin Ruan, Yueyue Shi, Saihua Chen, Lucy S. Cheng, Jiayong Liu, Heng Yang, Genhong Cheng
Summary: This study uncovered a novel antiviral activity of BACH1 and provided a new strategy for improving the clinical efficiency of the oncolytic virus HSV-1.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Cheng Xu, Oystein Evensen, Hetron Mweemba Munang'andu
Article
Fisheries
A. A. A. Gamil, T. -C. Guo, M. Koenig, O. Evensen
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2015)
Article
Fisheries
E. Thoen, T. Vralstad, E. Rolen, R. Kristensen, O. Evensen, I. Skaar
DISEASES OF AQUATIC ORGANISMS
(2015)
Article
Fisheries
Helle Holm, Nina Santi, Sissel Kjoglum, Nebojsa Perisic, Stanko Skugor, Oystein Evensen
FISH & SHELLFISH IMMUNOLOGY
(2015)
Article
Biotechnology & Applied Microbiology
Elin Patterson, Tz-Chun Guo, Oystein Evensen, Oyvind Haugland, Aase B. Mikalsen
JOURNAL OF GENERAL VIROLOGY
(2015)
Article
Virology
Sung-Hyun Kim, Tz-Chun Guo, Vikram N. Vakharia, Oystein Evensen
Article
Virology
Sung-Hyun Kim, Shamila Yusuff, Vikram N. Vakharia, Oystein Evensen
Article
Virology
Lihan Chen, Oystein Evensen, Stephen Mutoloki
Review
Immunology
Hetron Mweemba Munang'andu, Oystein Evensen
JOURNAL OF IMMUNOLOGY RESEARCH
(2015)
Review
Immunology
Hetron Mweemba Munang'andu, Stephen Mutoloki, Oystein Evensen
FRONTIERS IN IMMUNOLOGY
(2015)
Review
Immunology
Hetron Mweemba Munang'andu, Stephen Mutoloki, Oystein Evensen
FRONTIERS IN IMMUNOLOGY
(2015)
Review
Immunology
Stephen Mutoloki, Hetron Mweemba Munang'andu, Oystein Evensen
FRONTIERS IN IMMUNOLOGY
(2015)
Article
Biotechnology & Applied Microbiology
Tz-Chun Guo, Daniel X. Johansson, Peter Liljestrom, Oystein Evensen, Oyvind Haugland
JOURNAL OF GENERAL VIROLOGY
(2015)
Article
Multidisciplinary Sciences
Tz Chun Guo, Amr Ahmed Abdelrahim Gamil, Melanie Koenig, Oystein Evensen
Article
Multidisciplinary Sciences
Amr A. A. Gamil, Oystein Evensen, Stephen Mutoloki
Article
Fisheries
Hunter S. Bailey, Ashley N. Fincannon, Lee A. Fuiman
Summary: This study investigated the transfer of fatty acids from broodstock diets to eggs and the time needed for the eggs to equilibrate to the diet in Southern flounder. The findings indicate that different diet treatments significantly affect the fatty acid composition of eggs, and it takes 8-16 weeks for the eggs to adapt to changes in the adult diet. These results are important for improving broodstock diets and feeding protocols in stock-enhancement programs.
Article
Fisheries
Yu Liu, Mingtao Lei, Hector Victor, Yan Wang
Summary: This study confirms the feasibility of replacing raw fish diet with a formulated diet in commercial farming of large yellow croaker, which can increase fish survival and yield, and reduce feed cost and body lipid deposition.
Article
Fisheries
Xiaoyan Zhang, Lize San, Yucong Yang, Yuehong Tao, Jiangong Ren, Yufeng Liu, Zhongwei He, Jiashuo Di, Ziteng Pei, Guixing Wang, Jilun Hou
Summary: Gynogenesis is an effective technique for establishing homogeneous lines and confirming potential chromosomal mechanisms of sex determination in fish. This study successfully induced gynogenetic families in Thamnaconus modestus and established a complete method for gynogenesis induction.
Article
Fisheries
Julieta C. Martinelli, Megan Considine, Helen R. Casendino, Carolyn M. Tarpey, Isadora Jimenez-Hidalgo, Jacqueline L. Padilla-Gamino, Teri L. King, Lorenz Hauser, Steven Rumrill, Chelsea L. Wood
Summary: Shell-boring polychaetes have caused significant damage to mariculture operations worldwide, particularly in the US Pacific region. This study provides a comprehensive dataset on the prevalence, species distribution, and environmental associations of these parasites, highlighting the impact of season, culturing methods, and environmental factors on infestation.
Article
Fisheries
Juan Gao, Xueshan Li, Kangle Lu, Kai Song, Jian Zhang, Ling Wang, Chunxiao Zhang
Summary: This study investigated the effects of dietary protein levels on growth performance, antioxidant capacity, digestive enzyme activity, and metamorphosis rate of bullfrog tadpoles. The optimal dietary protein level for bullfrog tadpoles was estimated to be 42.49%-46.50% of the diet.
Article
Fisheries
Qiang Li, Lijun Duan, Dongsheng Jin, Yuxin Chen, Yirong Lou, Qianjin Zhou, Zhongjie Xu, Fangjie Chen, Hongxian Chen, Guizong Xu, Maocang Yan, Guanjun Yang, Jianfei Lu, Yanjun Zhang, Jiong Chen
Summary: This study developed a centrifugal microfluidic chip with on-chip RPA to detect five pathogenic microorganisms. The chip enabled the parallel analysis of six genetic markers from a single sample and allowed for the highly automated detection of multiple samples. Compared with PCR and DNA sequencing, the on-chip RPA assay showed high sensitivity and specificity for detecting multiple pathogens in shrimp aquaculture.
Article
Fisheries
Xingchen Huo, Pengxu Wang, Fengxia Zhao, Qian Liu, Qingqing Tian, Lingjie Tang, Maolin Lv, Zhaohui Wei, Chunrong Yang, Jianguo Su
Summary: Bacterial diseases in aquaculture ponds have negative effects on sustainable development. The use of composite I20 biotherapy has been shown to effectively treat bacterial diseases in bullfrog ponds, providing a new strategy for controlling bacterial diseases in aquaculture.
Article
Fisheries
Peng Yin, Takaya Saito, Per Gunnar Fjelldal, Bjorn Tharandur Bjornsson, Sofie Charlotte Remo, Sandeep Sharma, Rolf Erik Olsen, Kristin Hamre
Summary: This study aims to investigate the effect of seasonal changes in temperature and photoperiod on the redox metabolism of Atlantic salmon at the molecular level. The research findings suggest that the changing photoperiod and temperature influenced the redox metabolism of Atlantic salmon, highlighting the importance of oxidative status in the ecological implications.
Article
Fisheries
Nicholas Oppong Mensah, Jeffery Kofi Asare, Emmanuel Tetteh-Doku Mensah, Ernest Christlieb Amrago, Frank Osei Tutu, Anthony Donkor
Summary: This study investigates aquaculture farmers' preference for climate-smart aquaculture insurance products, the challenges they face, and their preferred insurance coverage. The results show that farmers prefer Climate-Induced Aquaculture Stock Mortality Insurance and the most significant constraint is the delay in claim settlement.
Article
Fisheries
Qiu-Ping Chai, Pei Wu, Wei-Dan Jiang, Yang Liu, Hong-Mei Ren, Xiao-Wan Jin, Lin Feng, Xiao-Qiu Zhou
Summary: The study found that appropriate levels of potassium diformate (KDF) can enhance the immune defense and mediate the inflammatory process in fish, possibly through the regulation of T cell differentiation via JAK-STAT and NF-kappa B signaling pathways.
Article
Fisheries
Tian Zhu, Haomin Jia, Haopeng Zhang, Yujing Xiao, Cui Han, Jiaxin Yang
Summary: Chicken manure has significant effects on the cultivation of Chlorella and rotifers. The optimal amount of chicken manure extract for continuous cultivation is 10 mLL-1. Chicken manure can promote the growth of Chlorella and improve the fatty acid composition, indirectly enhancing the growth condition and fatty acid content of rotifers.
Article
Fisheries
Zheng Luo, Yang Yu, Zhenning Bao, Fuhua Li
Summary: This study analyzed the heritability and genetic correlation of two growth traits in Pacific white shrimp and evaluated the genomic prediction using different genomic selection models. The results showed that the NeuralNet model had the highest prediction accuracy and better prospects for predicting shrimp growth traits.
Article
Fisheries
Alberto Ruiz, Ignasi Sanahuja, Karl B. Andree, Dolors Furones, Paul G. Holhorea, Josep A. Calduch-Giner, Jose J. Pastor, Marc Vinas, Jaume Perez-Sanchez, Sofia Morais, Enric Gisbert
Summary: Supplementing diets with a combination of spice oleoresins can reduce lipid accumulation and inflammation in farmed fish. The combination of spice oleoresins also has an immunomodulatory effect on the fish's intestinal immune system, potentially offering anti-inflammatory benefits.
Article
Fisheries
Beibei Zhao, Renhui Mei, Le Li, Di Hu, Lei Li
Summary: This study reveals that JfCXCL8_L1a and JfCXCL8_L1b have different immune pathways, and JfCXCL8_L1b plays a significant role in enhancing the adaptive immunity of T cell-dependent antigen.
Article
Fisheries
Yuhang Liu, Danying Cao, Nan Wu, Xuyang Zhao, Qingsong Zhu, Lian Su, Fatima Altaf, Qianqian Zhang, Haokun Liu, Yongming Li, Bruno Hamish Unger, Yingyin Cheng, Wanting Zhang, Aihua Li, Yaping Wang, Xiao-Qin Xia
Summary: Based on previous research, sinomenine has been found to protect mucosal immunity in farmed fish species by preventing intestinal pathological changes and regulating gene expression related to inflammation. It also enhances immune homeostasis and controls the growth of pathogenic bacteria.