Chronic activation of mTOR complex 1 by branched chain amino acids and organ hypertrophy

Insight into the role of mTOR and metabolism in T cells reveals new potential approaches to preventing graft rejection

(2014) Ying-Chun Lo et al.   Current Opinion in Organ Transplantation

Ligands for FKBP12 Increase Ca2+Influx and Protein Synthesis to Improve Skeletal Muscle Function

(2014) Chang Seok Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytosolic Branched Chain Aminotransferase (BCATc) Regulates mTORC1 Signaling and Glycolytic Metabolism in CD4+T Cells

(2014) Elitsa A. Ananieva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ral and Rheb GTPase Activating Proteins Integrate mTOR and GTPase Signaling in Aging, Autophagy, and Tumor Cell Invasion

(2014) Timothy D. Martin et al.   MOLECULAR CELL

Making new contacts: the mTOR network in metabolism and signalling crosstalk

(2014) Mitsugu Shimobayashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biochemical correlates of neuropsychiatric illness in maple syrup urine disease

(2013) Emilie R. Muelly et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intrinsic-mediated caspase activation is essential for cardiomyocyte hypertrophy

(2013) C. Putinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Target of Rapamycin (mTOR) Signaling Network in Skeletal Myogenesis

(2012) Yejing Ge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exercise-induced muscle damage is reduced in resistance-trained males by branched chain amino acids: a randomized, double-blind, placebo controlled study

(2012) Glyn Howatson et al.   Journal of the International Society of Sports Nutrition

Beneficial effect of branched-chain amino acid supplementation on glycemic control in chronic hepatitis C patients with insulin resistance: Implications for type 2 diabetes

(2012) Yumie Takeshita et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

mTOR Is Essential for the Proteotoxic Stress Response, HSF1 Activation and Heat Shock Protein Synthesis

(2012) Shiuh-Dih Chou et al.   PLoS One

Glucose metabolism and cardiac hypertrophy

(2011) S. C. Kolwicz et al.   CARDIOVASCULAR RESEARCH

Rapamycin Reverses Splenomegaly and Inhibits Tumor Development in a Transgenic Model of Epstein-Barr Virus-Related Burkitt's Lymphoma

(2011) O. Cen et al.   MOLECULAR CANCER THERAPEUTICS

Not all substrates are treated equally: Implications for mTOR, rapamycin-resistance, and cancer therapy

(2010) Andrew Y. Choo et al.   CELL CYCLE

Pregnancy restores the regenerative capacity of the aged liver via activation of an mTORC1-controlled hyperplasia/hypertrophy switch

(2010) Y. Gielchinsky et al.   GENES & DEVELOPMENT

Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for the Treatment of Cancer

(2010) Qingsong Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The 24-hour respiratory quotient predicts energy intake and changes in body mass

(2009) Kenneth A. Longo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Does habitual dietary intake influence myofiber hypertrophy in response to resistance training? A cluster analysis

(2009) Anna E. Thalacker-Mercer et al.   Applied Physiology Nutrition and Metabolism

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amino Acids Activate mTOR Complex 1 via Ca2+/CaM Signaling to hVps34

(2008) Pawan Gulati et al.   Cell Metabolism

A Mechanistic Insight into SMAC Peptide Interference with XIAP-Bir2 Inhibition of Executioner Caspases

(2008) Behnaz Ahangarian Abhari et al.   JOURNAL OF MOLECULAR BIOLOGY

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

(2008) A. Y. Choo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Heat Shock Transcriptional Factor 1 and Heat Shock Proteins in Cardiac Hypertrophy

(2008) Haruhiro Toko et al.   TRENDS IN CARDIOVASCULAR MEDICINE