Article
Clinical Neurology
Masakazu Minetama, Mamoru Kawakami, Masatoshi Teraguchi, Yoshio Enyo, Masafumi Nakagawa, Yoshio Yamamoto, Nana Sakon, Sachika Matsuo, Tomohiro Nakatani, Ryota Nakagawa, Wakana Nagata, Yukihiro Nakagawa
Summary: A randomized controlled trial found that supplementation with branched-chain amino acids (BCAA) and vitamin D did not improve postoperative recovery in patients with lumbar spinal stenosis (LSS).
Article
Nutrition & Dietetics
Minqi Liao, Yingjun Mu, Xin Su, Lu Zheng, Shiwen Zhang, Hongen Chen, Shan Xu, Junrong Ma, Ruiqing Ouyang, Wanlin Li, Chen Cheng, Jun Cai, Yuming Chen, Changyi Wang, Fangfang Zeng
Summary: This study examines the potential associations between dietary branched-chain amino acids (BCAAs) and physical function in the elderly Chinese population. The results show that a higher intake of BCAAs is positively associated with increased handgrip strength, shorter times for 4-m fast walking, and repeated chair rises. Individuals with higher BCAA intake also have a reduced risk of developing low muscle strength and low physical performance.
Review
Cell Biology
Michaela E. Trautman, Nicole E. Richardson, Dudley W. Lamming
Summary: The proportion of people suffering from age-related diseases is increasing worldwide. Recent research has shown that low protein diets, particularly those low in branched-chain amino acids (BCAAs), can reduce mortality and promote metabolic health and extended lifespan in both humans and rodents. This article discusses the emerging evidence that BCAAs play a crucial role in healthy metabolism and longevity, and explores the physiological and molecular mechanisms behind the benefits of restricting dietary BCAAs. The findings suggest that the quality of protein, specifically the composition of dietary protein, may be a previously overlooked factor in metabolic dysfunction and reducing dietary BCAAs could be a promising new approach to delaying and preventing age-related diseases.
Article
Clinical Neurology
Min Kyu Park, Sook Joung Lee, Eunseok Choi, Sangjee Lee, JungSoo Lee
Summary: Stroke-related sarcopenia is influenced by factors such as brain damage and malnutrition. The study found that BCAA supplementation combined with intensive rehabilitation therapy can significantly improve skeletal muscle index and functional status in stroke patients. Nutritional support also plays a role in improving functional outcomes during neurological recovery.
FRONTIERS IN NEUROLOGY
(2022)
Article
Physiology
Yunfeng Dong, Xuejiao Zhang, Rui Miao, Wei Cao, Hao Wei, Wei Jiang, Ruirui Gao, Yanhui Yang, Haipeng Sun, Junqiang Qiu
Summary: This study found that branched-chain amino acids (BCAAs) promote the repair of exercise-induced muscle damage (EIMD) by regulating the polarization state of macrophages. BCAAs enhance M1 polarization through the mTORC1-HIF1 alpha-glycolysis pathway and promote M2 polarization independently of mTORC1. Furthermore, BCAAs stimulate the proliferation of M1 macrophages and the differentiation of M2 macrophages.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Physiology
Gagandeep Mann, Stephen Mora, Glory Madu, Olasunkanmi A. J. Adegoke
Summary: BCAAs are crucial for skeletal muscle and whole-body anabolism and energy balance, but elevated levels and impaired metabolism may lead to chronic diseases like insulin resistance. Research is focusing on mechanisms regulating BCAA metabolism and its impact on muscle and whole-body metabolism.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Rheumatology
Naoki Kimura, Takuya Kawahara, Yukari Uemura, Tatsuya Atsumi, Takayuki Sumida, Toshihide Mimura, Yasushi Kawaguchi, Hirofumi Amano, Yukiko Iwasaki, Yuko Kaneko, Toshihiro Matsui, Yoshinao Muro, Yoshitaka Imura, Takashi Kanda, Yoshiya Tanaka, Atsushi Kawakami, Masatoshi Jinnin, Tomonori Ishii, Keiju Hiromura, Yusuke Miwa, Hiroshi Nakajima, Masataka Kuwana, Yasuhiko Nishioka, Akio Morinobu, Hideto Kameda, Hitoshi Kohsaka
Summary: BCAAs showed no significant effect on improving MMT scores and clinical response, but were partially effective in improving dynamic repetitive muscle functions.
Article
Nutrition & Dietetics
Katarzyna Paczkowska, Dominik Rachon, Andrzej Berg, Jacek Rybka, Katarzyna Kapczynska, Marek Bolanowski, Jacek Daroszewski
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that predisposes women to metabolic disturbances. Recent research suggests that alterations in amino acid profiles may be indicative of metabolic disorders. This study found elevated levels of aromatic amino acids in PCOS women, and significant differences in amino acid concentrations between metabolically healthy and unhealthy obesity subgroups of PCOS women.
Article
Pharmacology & Pharmacy
Tiangang Wu, Mengling Wang, Fengling Ning, Shilin Zhou, Xuetao Hu, Hong Xin, Svetlana Reilly, Xuemei Zhang
Summary: Fibrosis, characterized by excessive production of extracellular matrix, is a common pathological feature of organ diseases. Metabolic alterations, especially in the regulation of branched-chain amino acids (BCAAs), have been found to play significant roles in fibrogenesis. Dysregulation of BCAAs metabolism has been implicated in various diseases. This review summarizes the metabolic regulation of fibrosis, changes in BCAAs metabolism associated with fibrosis, and the effects and mechanisms of BCAAs intervention in hepatic, renal, and cardiac fibrosis, with a focus on liver fibrosis and associated hepatocellular carcinoma.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Despoina D. Aspragkathou, Martha G. Spilioti, Anastasia Gkampeta, Efterpi Dalpa, Vasiliki Holeva, Maria T. Papadopoulou, Aspasia Serdari, Vaios Dafoulis, Dimitrios I. Zafeiriou, Athanasios E. Evangeliou
Summary: The branched-chain amino acid (BCAA) is essential for maintaining energy balance and neurotransmitter systems in the human body. Low levels of BCAA have been found in autism patients, and a study was conducted to investigate the use of BCAA in children with autistic behavior. After administering BCAA for more than 10 weeks, improvements in social behavior, speech, cooperation, stereotypy, and hyperactivity were observed in 26 out of 55 children. These preliminary results suggest that BCAA may be used as an adjunctive treatment for autism.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Physiology
Hannah Crossland, Kenneth Smith, Iskandar Idris, Bethan E. Phillips, Philip J. Atherton, Daniel J. Wilkinson
Summary: The compound sodium phenylbutyrate (PB) accelerates BCAA catabolism, leading to adverse effects on mTOR signaling and muscle protein metabolism, which may limit its application in settings where muscle wasting is a risk.
EXPERIMENTAL PHYSIOLOGY
(2021)
Review
Nutrition & Dietetics
Joshua L. Hudson, Jamie I. Baum, Eva C. Diaz, Elisabet Borsheim
Summary: Current estimates of protein requirements in children are largely based on the nitrogen balance technique, which may underestimate protein needs. Recent advances in stable isotope techniques suggest protein requirements may be up to 60% higher, especially in children engaging in higher levels of physical activity.
Article
Fisheries
Xin Zhu, Jiangli Hu, Jianshe Zhang, Jingjie Liu, Lingsheng Bao, Yaxiong Pan, Jia Cheng, Wuying Chu
Summary: The study revealed that the catabolism of BCAAs in the skeletal muscle of Chinese perch was enhanced to maintain physiological homeostasis during food deprivation and glucocorticoid stress. KLF15 plays a crucial role in the adaptive regulation of BCAAs metabolism in Chinese perch skeletal muscle.
AQUACULTURE REPORTS
(2021)
Review
Genetics & Heredity
Can Chen, Hassan Naveed, Keping Chen
Summary: This article introduces the important role of branched-chain amino acid aminotransferases in cellular metabolism, summarizes the related research in animals, plants, microorganisms, and humans, and analyzes the molecular mechanism. It has been found that disorders in branched-chain amino acid metabolism are closely related to various diseases, especially tumor development.
FRONTIERS IN GENETICS
(2023)
Article
Nutrition & Dietetics
Qiu-Ming Shen, Jing Wang, Zhuo-Ying Li, Jia-Yi Tuo, Yu-Ting Tan, Hong-Lan Li, Yong-Bing Xiang
Summary: This study found no significant correlations between dietary intakes and plasma concentrations of branched-chain amino acids (BCAA) in Chinese male and female adults.
JOURNAL OF NUTRITION
(2023)
Review
Sport Sciences
Kevin D. Tipton
Letter
Nutrition & Dietetics
Stuart M. Phillips, Kevin D. Tipton, Luc J. C. van Loon, Lex B. Verdijk, Douglas Paddon-Jones, Graeme L. Close
BRITISH JOURNAL OF NUTRITION
(2016)
Review
Nutrition & Dietetics
Oliver C. Witard, Sophie L. Wardle, Lindsay S. Macnaughton, Adrian B. Hodgson, Kevin D. Tipton
Article
Nutrition & Dietetics
Oliver C. Witard, Sarah R. Jackman, Leigh Breen, Kenneth Smith, Anna Selby, Kevin D. Tipton
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2014)
Article
Nutrition & Dietetics
Oliver C. Witard, Tara L. Cocke, Arny A. Ferrando, Robert R. Wolfe, Kevin D. Tipton
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2014)
Article
Immunology
Oliver C. Witard, James E. Turner, Sarah R. Jackman, Arie K. Kies, Asker E. Jeukendrup, Jos A. Bosch, Kevin D. Tipton
BRAIN BEHAVIOR AND IMMUNITY
(2014)
Article
Nutrition & Dietetics
Nicolaas E. P. Deutz, Juergen M. Bauer, Rocco Barazzoni, Gianni Biolo, Yves Boirie, Anja Bosy-Westphal, Tommy Cederholm, Alfonso Cruz-Jentoft, Zeljko Krznaric, K. Sreekumaran Nair, Pierre Singer, Daniel Teta, Kevin Tipton, Philip C. Calder
CLINICAL NUTRITION
(2014)
Article
Physiology
S. O. Shepherd, M. Cocks, K. D. Tipton, O. C. Witard, A. M. Ranasinghe, T. A. Barker, A. J. M. Wagenmakers, C. S. Shaw
EXPERIMENTAL PHYSIOLOGY
(2014)
Article
Geriatrics & Gerontology
Daniel R. Moore, Tyler A. Churchward-Venne, Oliver Witard, Leigh Breen, Nicholas A. Burd, Kevin D. Tipton, Stuart M. Phillips
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2015)
Article
Hematology
Matthew Cocks, Christopher S. Shaw, Sam O. Shepherd, James P. Fisher, Aaron M. Ranasinghe, Thomas A. Barker, Kevin D. Tipton, Anton J. M. Wagenmakers
Article
Biochemistry & Molecular Biology
Chris McGlory, Stuart D. R. Galloway, D. Lee Hamilton, Craig McClintock, Leigh Breen, James R. Dick, John G. Bell, Kevin D. Tipton
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2014)
Article
Nutrition & Dietetics
Robert M. Edinburgh, Aaron Hengist, Harry A. Smith, Rebecca L. Travers, James A. Betts, Dylan Thompson, Jean-Philippe Walhin, Gareth A. Wallis, D. Lee Hamilton, Emma J. Stevenson, Kevin D. Tipton, Javier T. Gonzalez
JOURNAL OF NUTRITION
(2019)
Article
Physiology
Lindsay S. Macnaughton, Sophie L. Wardle, Oliver C. Witard, Chris McGlory, D. Lee Hamilton, Stewart Jeromson, Clare E. Lawrence, Gareth A. Wallis, Kevin D. Tipton
PHYSIOLOGICAL REPORTS
(2016)
Article
Physiology
Chris McGlory, Sophie L. Wardle, Lindsay S. Macnaughton, Oliver C. Witard, Fraser Scott, James Dick, J. Gordon Bell, Stuart M. Phillips, Stuart D. R. Galloway, D. Lee Hamilton, Kevin D. Tipton
PHYSIOLOGICAL REPORTS
(2016)
Letter
Physiology
Lindsay S. Macnaughton, Sophie L. Wardle, Kevin D. Tipton
JOURNAL OF APPLIED PHYSIOLOGY
(2015)