4.4 Article

Histocompatibility as Adaptive Response to Discriminatory Within-Organism Conflict: A Historical Model

期刊

AMERICAN NATURALIST
卷 185, 期 2, 页码 228-242

出版社

UNIV CHICAGO PRESS
DOI: 10.1086/679442

关键词

conflict; cooperation; chimera; kin recognition; game theory

资金

  1. Kavli Institute for Theoretical Physics at the University of California, Santa Barbara
  2. National Science Foundation [DEB 0816690, NSF PHY11-25915]
  3. Wray-Todd graduate fellowship

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Multicellular tissue compatibility, or histocompatibility, restricts fusion to close kin. Histocompatibility depends on hypervariable cue genes, which often have more than 100 alleles in a population. To explain the evolution of histocompatibility, I here take a historical approach. I focus on the specific example of marine invertebrate histocompatibility. I use simple game-theoretical models to show that histocompatibility can evolve through five steps. These steps include the evolution of indiscriminate fusion, the evolution of discriminatory within-organism conflict, the evolution of minor histocompatibility, the evolution of major histocompatibility, and the evolution of major histocompatibility cue polymorphism. Allowing for gradual evolution reveals discriminatory within-organism conflict as a selective pressure for histocompatibility and associated cue polymorphism. Existing data from marine invertebrates and other organisms are consistent with this hypothesis.

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