Omne Vivum Ex Vivo … Omne? How to Feed an Inanimate Evolvable Chemical System so as to Let it Self-evolve into Increased Complexity and Life-like Behaviour

Self-Assembly of Phosphate Amphiphiles in Mixtures of Prebiotically Plausible Surfactants

(2014) A.N. Albertsen et al.   ASTROBIOLOGY

Systems chemistry: a web themed issue

(2014) Bartosz Grzybowski et al.   CHEMICAL COMMUNICATIONS

Transmission of photo-catalytic function in a self-replicating chemical system: in situ amphiphile production over two protocell generations

(2014) A. N. Albertsen et al.   CHEMICAL COMMUNICATIONS

Emergent properties arising from the assembly of amphiphiles. Artificial vesicle membranes as reaction promoters and regulators

(2014) Peter Walde et al.   CHEMICAL COMMUNICATIONS

Evolution of the first genetic cells and the universal genetic code: A hypothesis based on macromolecular coevolution of RNA and proteins

(2014) Duncan A. Rouch   JOURNAL OF THEORETICAL BIOLOGY

A hydrophobic disordered peptide spontaneously anchors a covalently bound RNA hairpin to giant lipidic vesicles

(2014) Alexandra Le Chevalier Isaad et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Evolution of the ribosome at atomic resolution

(2014) A. S. Petrov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of Aldehydic Ribonucleotide and Amino Acid Precursors by Photoredox Chemistry

(2013) Dougal J. Ritson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cover Picture: Recoding the Genetic Code with Selenocysteine (Angew. Chem. Int. Ed. 1/2014)

(2013) Markus J. Bröcker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Prebiotic Systems Chemistry: New Perspectives for the Origins of Life

(2013) Kepa Ruiz-Mirazo et al.   CHEMICAL REVIEWS

New insights into prebiotic chemistry from Stanley Miller's spark discharge experiments

(2013) Jeffrey L. Bada   CHEMICAL SOCIETY REVIEWS

The Origin of RNA and “My Grandfather’s Axe”

(2013) Nicholas V. Hud et al.   CHEMISTRY & BIOLOGY

Evolution of the Genetic Code by Incorporation of Amino Acids that Improved or Changed Protein Function

(2013) Brian R. Francis   JOURNAL OF MOLECULAR EVOLUTION

Competition between model protocells driven by an encapsulated catalyst

(2013) Katarzyna Adamala et al.   Nature Chemistry

Enzyme-free translation of DNA into sequence-defined synthetic polymers structurally unrelated to nucleic acids

(2013) Jia Niu et al.   Nature Chemistry

A ribonucleotide Origin for Life – Fluctuation and Near-ideal Reactions

(2013) Michael Yarus   ORIGINS OF LIFE AND EVOLUTION OF BIOSPHERES

Nucleobases bind to and stabilize aggregates of a prebiotic amphiphile, providing a viable mechanism for the emergence of protocells

(2013) R. A. Black et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonenzymatic Template-Directed RNA Synthesis Inside Model Protocells

(2013) K. Adamala et al.   SCIENCE

Towards an evolutionary theory of the origin of life based on kinetics and thermodynamics

(2013) R. Pascal et al.   Open Biology

Abiotic Self-Replication

(2012) Adam J. Meyer et al.   ACCOUNTS OF CHEMICAL RESEARCH

Origins of Chemical Evolution

(2012) David Lynn et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Use of Solid Supports to Generate Nucleic Acid Carriers

(2012) Asier Unciti-Broceta et al.   ACCOUNTS OF CHEMICAL RESEARCH

Lipid-like Self-Assembling Peptides

(2012) Shuguang Zhang   ACCOUNTS OF CHEMICAL RESEARCH

Asphalt, Water, and the Prebiotic Synthesis of Ribose, Ribonucleosides, and RNA

(2012) Steven A. Benner et al.   ACCOUNTS OF CHEMICAL RESEARCH

Digital and Analog Chemical Evolution

(2012) Jay T. Goodwin et al.   ACCOUNTS OF CHEMICAL RESEARCH

5(4H)-Oxazolones as Intermediates in the Carbodiimide- and Cyanamide-Promoted Peptide Activations in Aqueous Solution

(2012) Grégoire Danger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Darwinian Behavior in a Cold, Sporadically Fed Pool of Ribonucleotides

(2012) Michael Yarus   ASTROBIOLOGY

Three-Dimensional Structure of Glycolipids in Biological Membranes

(2012) Mari L. DeMarco   BIOCHEMISTRY

Lipid Conjugated Oligonucleotides: A Useful Strategy for Delivery

(2012) Mouna Raouane et al.   BIOCONJUGATE CHEMISTRY

How did bacterial ancestors reproduce? Lessons from L-form cells and giant lipid vesicles

(2012) Yves Briers et al.   BIOESSAYS

Early evolution of efficient enzymes and genome organization

(2012) András Szilágyi et al.   Biology Direct

Evolution before genes

(2012) Vera Vasas et al.   Biology Direct

Formation of RNA Phosphodiester Bond by Histidine-Containing Dipeptides

(2012) Rafał Wieczorek et al.   CHEMBIOCHEM

Liquid crystalline nanostructures: organizing matrices for non-enzymatic nucleic acid polymerization

(2012) David Deamer   CHEMICAL SOCIETY REVIEWS

The Plausibility of RNA-Templated Peptides: Simultaneous RNA Affinity for Adjacent Peptide Side Chains

(2012) Rebecca M. Turk-MacLeod et al.   JOURNAL OF MOLECULAR EVOLUTION

Multicomponent Assembly of Proposed DNA Precursors in Water

(2012) Matthew W. Powner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantum-Mechanical Study on the Mechanism of Peptide Bond Formation in the Ribosome

(2012) Carles Acosta-Silva et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure and function of a unique pore-forming protein from a pathogenic acanthamoeba

(2012) Matthias Michalek et al.   Nature Chemical Biology

Prebiotic synthesis of simple sugars by photoredox systems chemistry

(2012) Dougal Ritson et al.   Nature Chemistry

Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor

(2012) Hanyang Yu et al.   Nature Chemistry

Glycans pattern the phase behaviour of lipid membranes

(2012) Anand Bala Subramaniam et al.   NATURE MATERIALS

Photochemically driven redox chemistry induces protocell membrane pearling and division

(2012) T. F. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small aminoacyl transfer centers at GU within a larger RNA

(2012) Mali Illangasekare et al.   RNA Biology

Human tRNASec associates with HeLa membranes, cell lipid liposomes, and synthetic lipid bilayers

(2012) T. Janas et al.   RNA

Peptide-mediated Cell and In Vivo Delivery of Antisense Oligonucleotides and siRNA

(2012) Peter Järver et al.   Molecular Therapy-Nucleic Acids

Etiology of Potentially Primordial Biomolecular Structures: From Vitamin B12 to the Nucleic Acids and an Inquiry into the Chemistry of Life’s Origin: A Retrospective

(2011) Albert Eschenmoser   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

On origin of genetic code and tRNA before translation

(2011) Andrei S Rodin et al.   Biology Direct

Crystalline Architectures as Templates of Relevance to the Origins of Homochirality

(2011) Isabelle Weissbuch et al.   CHEMICAL REVIEWS

Catalyzed and Spontaneous Reactions on Ribozyme Ribose

(2011) Rebecca M. Turk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A de novo peptide hexamer with a mutable channel

(2011) Nathan R Zaccai et al.   Nature Chemical Biology

Efficient enzyme-free copying of all four nucleobases templated by immobilized RNA

(2011) Christopher Deck et al.   Nature Chemistry

A vestige of a prebiotic bonding machine is functioning within the contemporary ribosome

(2011) M. Krupkin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Prebiotic chemistry: a new modus operandi

(2011) M. W. Powner et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Physical effects underlying the transition from primitive to modern cell membranes

(2011) I. Budin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Origins of Nucleotides

(2011) Matthew Powner et al.   SYNLETT

On the Origin of Primitive Cells: From Nutrient Intake to Elongation of Encapsulated Nucleotides

(2010) Uwe J. Meierhenrich et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Non-enzymatic transfer of sequence information under plausible prebiotic conditions

(2010) Felix Olasagasti et al.   BIOCHIMIE

The scenario on the origin of translation in the RNA world: in principle of replication parsimony

(2010) Wentao Ma   Biology Direct

The transition from noncoded to coded protein synthesis: did coding mRNAs arise from stability-enhancing binding partners to tRNA?

(2010) Harold Bernhardt et al.   Biology Direct

Achievements and open questions in the self-reproduction of vesicles and synthetic minimal cells

(2010) Pasquale Stano et al.   CHEMICAL COMMUNICATIONS

The Proto-Ribosome: An Ancient Nano-machine for Peptide Bond Formation

(2010) Chen Davidovich et al.   ISRAEL JOURNAL OF CHEMISTRY

Proteome Evolution and the Metabolic Origins of Translation and Cellular Life

(2010) Derek Caetano-Anollés et al.   JOURNAL OF MOLECULAR EVOLUTION

Selfishness versus functional cooperation in a stochastic protocell model

(2010) Elias Zintzaras et al.   JOURNAL OF THEORETICAL BIOLOGY

A formal test of the theory of universal common ancestry

(2010) Douglas L. Theobald   NATURE

A colorful origin for the genetic code: Information theory, statistical mechanics and the emergence of molecular codes

(2010) Tsvi Tlusty   Physics of Life Reviews

Multiple translational products from a five-nucleotide ribozyme

(2010) R. M. Turk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Racemic β-Sheets as Templates of Relevance to the Origin of Homochirality of Peptides: Lessons from Crystal Chemistry

(2009) Isabelle Weissbuch et al.   ACCOUNTS OF CHEMICAL RESEARCH

A Thermodynamic Basis for Prebiotic Amino Acid Synthesis and the Nature of the First Genetic Code

(2009) Paul G. Higgs et al.   ASTROBIOLOGY

Chemical Evolution of Amphiphiles: Glycerol Monoacyl Derivatives Stabilize Plausible Prebiotic Membranes

(2009) S.E. Maurer et al.   ASTROBIOLOGY

Solid-Phase Synthesis of Oligonucleotide Conjugates Useful for Delivery and Targeting of Potential Nucleic Acid Therapeutics

(2009) Harri Lönnberg   BIOCONJUGATE CHEMISTRY

Chemical Strategies for the Synthesis of Peptide−Oligonucleotide Conjugates

(2009) Kui Lu et al.   BIOCONJUGATE CHEMISTRY

A four-column theory for the origin of the genetic code: tracing the evolutionary pathways that gave rise to an optimized code

(2009) Paul G Higgs   Biology Direct

One ancestor for two codes viewed from the perspective of two complementary modes of tRNA aminoacylation

(2009) Andrei S Rodin et al.   Biology Direct

Growth and shape transformations of giant phospholipid vesicles upon interaction with an aqueous oleic acid suspension

(2009) Primož Peterlin et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Adding to Hans Kuhn's thesis on the emergence of the genetic apparatus: Of the Darwinian advantage to be neither too soluble, nor too insoluble, neither too solid, nor completely liquid

(2009) Peter Strazewski   COLLOIDS AND SURFACES B-BIOINTERFACES

Coupled Growth and Division of Model Protocell Membranes

(2009) Ting F. Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Vesicle Budding Induced by a Pore-Forming Peptide

(2009) Yan Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peeling the Onion: Ribosomes Are Ancient Molecular Fossils

(2009) C. Hsiao et al.   MOLECULAR BIOLOGY AND EVOLUTION

Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions

(2009) Matthew W. Powner et al.   NATURE

A hierarchical model for evolution of 23S ribosomal RNA

(2009) Konstantin Bokov et al.   NATURE

Dual Role of Hydrophobic Racemic Thioesters of α-Amino Acids in the Generation of Isotactic Peptides and Co-peptides in Water; Implications for the Origin of Homochirality

(2009) Roni A. Illos et al.   ORIGINS OF LIFE AND EVOLUTION OF BIOSPHERES

siRNA Conjugate Delivery Systems

(2008) Ji Hoon Jeong et al.   BIOCONJUGATE CHEMISTRY

Glutamate–Glycine and Histidine–Glycine Co-oligopeptides: Batch Co-oligomerization versus Pulsed Addition ofN-Carboxyanhydrides

(2008) Carole Lamy et al.   CHEMBIOCHEM

On the origin of the genetic code: signatures of its primordial complementarity in tRNAs and aminoacyl-tRNA synthetases

(2008) S N Rodin et al.   HEREDITY

Template-directed synthesis of a genetic polymer in a model protocell

(2008) Sheref S. Mansy et al.   NATURE

The Homeodomain Derived Peptide Penetratin Induces Curvature of Fluid Membrane Domains

(2008) Antonin Lamazière et al.   PLoS One