Article
Biochemistry & Molecular Biology
Amelie I. S. Sobczak, Samantha J. Pitt, Terry K. Smith, Ramzi A. Ajjan, Alan J. Stewart
Summary: This study investigated the plasma concentrations of free fatty acid species in individuals with Type-1 diabetes mellitus (T1DM) compared to healthy controls. The results showed reduced concentrations of specific FFA species in the T1DM group, along with increased saturated/unsaturated FFA ratio and other indices related to lipid metabolism. Age and HbA1c levels were found to have correlations with certain FFA concentrations and indices in T1DM patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Oncology
Heayyean Lee, Hwanhui Lee, Sujeong Park, Myeongsun Kim, Ji Young Park, Hanyong Jin, Kyungsoo Oh, Jeehyeon Bae, Young Yang, Hyung-Kyoon Choi
Summary: This study conducted metabolomic and lipidomic profiling of lung SQCC to predict its metastatic potential and suggest potential therapeutic targets, identifying characteristic metabolites and intact lipid species associated with lung SQCC metastatic potential. The findings offer valuable insights for the inhibition of lung SQCC metastasis and may lead to the development of potential biomarkers and therapeutic strategies for NSCLC.
Article
Biotechnology & Applied Microbiology
Gaela Cauchie, Guillaume Delfau-Bonnet, Guillaume Caulier, Anne-Lise Hantson, Jean-Hugues Renault, Pascal Gerbaux
Summary: Liquid chromatography - mass spectrometry (LC-MS) experiments were used to monitor the impact of bead milling and extraction solvents on the composition of lipids extracted from Microchloropsis gaditana microalgae. It was found that milling before extraction can enhance the efficiency of lipid extraction with n-heptane as the solvent. The study also highlighted the importance of liquid chromatography tandem mass spectrometry (LC-MS/MS) experiments in optimizing lipid extraction procedures from microalgae biomass.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2021)
Article
Chemistry, Multidisciplinary
Xiangyu Guo, Wenbo Cao, Xiaomin Fan, Zhiying Guo, Donghui Zhang, Haoyue Zhang, Xiaoxiao Ma, Jiahong Dong, Yunfang Wang, Wenpeng Zhang, Zheng Ouyang
Summary: Mass spectrometry imaging (MSI) of lipids in biological tissues can provide valuable information for biological research and disease diagnosis by correlating molecular distribution with pathological results. A new multiplexed MS2 imaging method (MSI-I-2) has been developed, allowing for MS2 images of 10 or more lipid species at each sampling spot, providing spatial structural lipidomic information. Coupled with on-tissue photochemical derivatization, imaging of 20 phospholipid C=C location isomers is also possible, resulting in enhanced molecular images with high structural definition for mouse brain and human liver cancer tissue sections. Spatially mapped t-distributed stochastic neighbor embedding has been utilized to visualize the tumor margin with the assistance of structural lipidomic information.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Chenglin Zhu, Xin Pan, Guo Li, Caiwu Li, Daifu Wu, Junni Tang, Yan Huang, Likou Zou, Luca Laghi
Summary: Lipidic metabolites play essential roles in the physiological health and growth performance of giant pandas. Bamboo, as their main diet, determines the lipidome of giant pandas. This study explores the lipidomic atlas of different parts of bamboo and investigates the changes in fecal and serum lipidome during the consumption of bamboo shoots, which is typical in spring. The findings suggest the importance of a balanced diet for giant panda health, even in the case of a single food-based diet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jung Nam An, Hyoseon Kim, Eun Nim Kim, Ara Cho, Yeongeun Cho, Young Wook Choi, Jin Hyuk Kim, Seung Hee Yang, Bum Soon Choi, Chun Soo Lim, Yon Su Kim, Kwang Pyo Kim, Jung Pyo Lee
Summary: Periostin plays a crucial role in kidney aging and is involved in lipid metabolism. Aged WT mice showed worse renal function and more severe fibrosis compared to aged Postn-null mice. Significant differences in lipid composition and metabolism were found between the two groups, indicating a potential relationship between lipid expression and metabolism in kidney aging.
Review
Biochemistry & Molecular Biology
Tianci Jiang, Lingling Dai, Pengfei Li, Junwei Zhao, Xi Wang, Lin An, Meng Liu, Shujun Wu, Yu Wang, Youmei Peng, Di Sun, Caopei Zheng, Tingting Wang, Xuejun Wen, Zhe Cheng
Summary: The study characterized the plasma lipid profile of asthmatic patients and healthy controls, identifying significant changes in ten lipid species in the asthmatic patients. Some lipids were positively correlated with the severity of asthma, while others were negatively correlated. PE (38:1) was identified as a potential lipid biomarker for asthma, while PE (20:0/18:1) and TG (16:0/16:0/18:1) may be related to IgE levels in asthmatic patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Food Science & Technology
Roberto Maria Pellegrino, Federica Ianni, Francesca Blasi, Paola Angelini, Carla Emiliani, Roberto Venanzoni, Lina Cossignani
Summary: In this study, lipidomic analysis of Pleurotus ostreatus was performed for the first time using liquid chromatography quadrupole time-of-flight mass spectrometry (LC/MS Q-TOF). The results showed that free fatty acids were the predominant fraction, with C18 chain length and two double bonds as the main structural characteristics. Phosphatydilcholine, phosphatydiletanolamine, and glycer-ophosphates contained high percentages of polyunsaturated fatty acids. Principal component analysis and discriminant analysis could differentiate P. ostreatus samples based on the grown substrate.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Xiaogang Li, Xi Wang, Haolong Li, Yongzhe Li, Ye Guo
Summary: The lipidomics profile of patients with Kallmann syndrome was found to be significantly different from healthy controls, with triacylglycerols, phosphatidylcholines, and phosphatidylethanolamine being identified as the main differential lipid species. This study suggests that TAGs, PCs, and PE may serve as promising biomarkers for KS diagnosis, representing the first report to analyze lipidomics in men with Kallmann syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Chemistry, Medicinal
Prema K. Agarwala, Ritu Aneja, Shobhna Kapoor
Summary: Altered lipid metabolism in cancer cells affects cellular function through changes in membrane structure and properties. Rewiring of lipid metabolism impacts the lipidomic landscape of cancer cell membranes and influences the characteristics of cancer cells. Techniques for membrane characterization play a crucial role in cancer diagnosis and monitoring treatment response.
MEDICINAL RESEARCH REVIEWS
(2022)
Article
Endocrinology & Metabolism
Yun Huang, Mixue Tu, Yuli Qian, Junyan Ma, Lifen Chen, Yifeng Liu, Yiqing Wu, Kai Chen, Juan Liu, Yanyun Ying, Yao Chen, Yinghui Ye, Lanfeng Xing, Fang Zhang, Yanjun Hu, Runjv Zhang, Ye Chun Ruan, Dan Zhang
Summary: Female fertility declines with age, and the metabolites in follicular fluids are closely related to oocyte quality. This study analyzed the metabolomic profile of follicular fluids from women of different ages and identified metabolites associated with oocyte quality and the outcomes of assisted reproductive technology (ART). These metabolites may serve as potential biomarkers for oocyte maturation and ART outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Food Science & Technology
Anne Zartmann, Leon Voelcker, Simon Hammann
Summary: Certain polyunsaturated fatty acids with n-3 double bonds are important nutrients for the human body, and this study analyzed 33 dietary supplements from the German market to determine their lipid compositions. The results showed that triacylglycerols were the dominant lipid species in most samples, but krill oil contained phospholipids. The total lipid profiles and fatty acid analysis varied depending on the lipid source, and there were differences between the labeled and actual quantities of individual fatty acids and vitamin E derivatives in some samples.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Chemistry, Applied
Mengyu Chen, Wenjie Huang, Zhibin Yin, Wenyang Zhang, Qian Kong, Shaowen Wu, Wenyan Li, Zhao Bai, Alisdair R. Fernie, Xiaodan Huang, Shijuan Yan
Summary: The research found metabolic differences among black wolfberry fruits grown in different geographical regions, with some samples showing significantly different metabolite profiles with higher levels of beneficial components, providing a new direction for further studies on the health benefits of black wolfberry fruits.
Article
Biochemical Research Methods
Guillaume Rousseau, Juan Manuel Chao de la Barca, Clotilde Rouge-Maillart, Grzegorz Teresinski, Floris Chabrun, Xavier Dieu, Guillaume Drevin, Delphine Mirebeau-Prunier, Gilles Simard, Pascal Reynier, Cristian Palmiere
Summary: In this study, potential novel biomarkers of hypothermia fatalities were identified in the vitreous humor using a targeted metabolomics approach. The signature showed distinct separation between hypothermia and control groups, characterized by altered concentrations of specific metabolites. These results provide preliminary evidence of a metabolomics signature of hypothermia fatalities, with increased activity of methionine sulfoxide reductase.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Chemistry, Applied
Yue Ma, Jiaxu Yao, Li Zhou, Minjie Zhao, Jikai Liu, Eric Marchioni
Summary: The lipid profiles of truffles were analyzed using UHPLC-QE Orbitrap/MS/MS, while the VOCs were identified using P&T-GC-MS. A total of 37 lipid molecular species and 28 VOCs were tentatively identified. LPC, TG, and SM were found to be key lipids in heat-drying truffles, while PA was important in freeze-drying and fresh truffles. The study also revealed key lipid molecules for the formation of 2-methoxyphenol.
Review
Fisheries
Amiya Kumar Sahoo, Md Abdul Wahab, Michael Phillips, Anisur Rahman, Arun Padiyar, Velmurugu Puvanendran, Rama Bangera, Ben Belton, Dilip Kumar De, Dharmendra Kumar Meena, Bijay Kumar Behera, Anil Prakash Sharma, Utpal Bhaumik, Bimal Prasanna Mohanty, Sampurna Roy Choudhury, Chadag Vishnumurthy Mohan
REVIEWS IN AQUACULTURE
(2018)
Article
Biochemistry & Molecular Biology
Arabinda Mahanty, Gopal Krishna Purohit, Sasmita Mohanty, Bimal Prasanna Mohanty
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Soma Das Sarkar, Malay Naskar, Pranab Gogoi, Rohan Kumar Raman, Ranjan Kumar Manna, Srikanta Samanta, Bimal Prasanna Mohanty, Basanta Kumar Das
Article
Ecology
Soma Das Sarkar, Amiya Kumar Sahoo, Pranab Gogoi, Rohan Kumar Raman, Manas Hoshalli Munivenkatappa, Kavita Kumari, Bimal Prasanna Mohanty, Basanta Kumar Das
Article
Endocrinology & Metabolism
Satabdi Ganguly, Tandrima Mitra, Arabinda Mahanty, Sasmita Mohanty, Bimal P. Mohanty
Article
Environmental Sciences
Bimal Prasanna Mohanty, Arabinda Mahanty, Tandrima Mitra, Sasmita Mohanty, Ajit Kumar Naik, Subas Chandra Parija
Review
Food Science & Technology
Siddhnath, Amit Ranjan, Bimal Prasanna Mohanty, Pooja Saklani, Krushna Chandra Dora, Supratim Chowdhury
Summary: The match between dry fish supply and nutrient needs is crucial for supporting the health of the increasing human population. Dry fish provides high-quality proteins, healthy fats, and essential nutrients, making it an important factor in food and nutritional security. However, there is limited knowledge about dry fish and its contribution, highlighting the need for more comprehensive information.
FOOD REVIEWS INTERNATIONAL
(2022)
Article
Environmental Sciences
Tandrima Mitra, Arabinda Mahanty, Satabdi Ganguly, Bimal Prasanna Mohanty
ENVIRONMENTAL RESEARCH
(2020)
Article
Nutrition & Dietetics
Arabinda Mahanty, Srikanta Lenka, Prakash C. Rath
Summary: The COVID-19 pandemic has had a tremendous impact on the food industry, especially on restaurants and food vendors. To revive the processed food industry, it is essential to regain consumer confidence, which requires steps to be taken by policymakers and food business operators. Maintaining hygiene at food production facilities is crucial in the COVID-19 era, with recommendations provided for both food safety regulators and business operators.
CURRENT NUTRITION & FOOD SCIENCE
(2021)
Article
Genetics & Heredity
Ipsita Mohanty, Sudeshna Banerjee, Arabinda Mahanty, Sasmita Mohanty, Nihar Ranjan Nayak, Subas Chandra Parija, Bimal Prasanna Mohanty
Summary: This study investigated acid stress-induced vasorelaxation using a goat mesenteric artery model and identified proteins associated with vasorelaxation. The results showed that the expression of actin and ATP synthase beta increased under acidosis, which may contribute to the altered vasoreactivity observed.
Article
Microbiology
Seenichamy Rathinam Prabhukarthikeyan, Chidambaranathan Parameswaran, Shraddha Bhaskar Sawant, Ramasamy Naveenkumar, Arabinda Mahanty, Umapathy Keerthana, Manoj Kumar Yadav, Annamalai Anandan, Periyasamy Panneerselvam, Manas Kumar Bag, Prakash Chandra Rath
Summary: The proteomic analysis of high virulent and less virulent isolates of Rhizoctonia solani revealed differentially expressed proteins related to fungal development, sporulation, pathogenicity, and other functions. The study also confirmed a positive correlation between the abundances of proteins and transcripts. This research provides insights into the pathogenicity mechanism of R. solani in causing sheath blight disease in rice.
Article
Biochemistry & Molecular Biology
Debashish Pradhan, Arabinda Mahanty, Sasmita Mohanty, Kasturi Samantaray, Bimal Prasanna Mohanty
Summary: This study investigated the proteomic changes in muscle tissues of carp fed with BSY-based diet, and found that a 30% BSY-replaced feed can promote muscle growth in a highly controlled manner, leading to increased weight gain%, feed conversion efficiency, and specific growth rate%.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Bimal Prasanna Mohanty, Tandrima Mitra, Satabdi Ganguly, Soma Das Sarkar, Arabinda Mahanty
Summary: The study suggests that arsenic exposure reduces the gene expression of α and β-crystallins in the eye lens and curcumin can mitigate this effect. Furthermore, the fatty acid profile remains unchanged in the group fed with curcumin-supplemented diet and exposed to arsenic, indicating the protective effect of curcumin against arsenic toxicity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
