Article
Immunology
Lily Chan, Yeganeh Mehrani, Jessica A. Minott, Byram W. Bridle, Khalil Karimi
Summary: This research examined the effects of DC vaccination on ILC2 populations and their cytokine production. The results showed an increase in the number of ILC2s in certain areas in the absence of tumors, indicating a complex interplay between DC vaccines and ILC2s.
Article
Gastroenterology & Hepatology
Shuai Wang, Qinchuan Wu, Tianchi Chen, Rong Su, Caixu Pan, Junjie Qian, Hechen Huang, Shengyong Yin, Haiyang Xie, Lin Zhou, Shusen Zheng
Summary: In addition to the classical DC-T cell axis, CD47 blockade significantly enhances the ability of CD103(+) DCs to take up tumor DNA, resulting in the stimulation of the cGAS-STING pathway and the promotion of NK cell infiltration and activation in liver cancer.
JOURNAL OF HEPATOLOGY
(2022)
Article
Chemistry, Physical
Hailong Tian, Sai Zhao, Edouard C. Nice, Canhua Huang, Weifeng He, Bingwen Zou, Jie Lin
Summary: A novel cascaded copper-based metal-organic framework therapeutic nanocatalyst was reported for amplified hepatocellular carcinoma therapy by integrating a COX-2 inhibitor and a chemotherapeutic agent to trigger ferroptosis-mediated therapy.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Plant Sciences
Faten M. Ibrahim, Abeer Y. Ibrahim, Samah A. El-Newary, Saber F. Hendawy, Mohamad F. Mahomoodally
Summary: The aqueous-alcoholic crude extract and fractions of Vitex agnus-castus showed significant antioxidant and anti-inflammatory properties in vitro, with potential anti-tumor effects.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Immunology
Nitin Kamble, Angila Gurung, Benedikt B. Kaufer, Ansar Ahmed Pathan, Shahriar Behboudi
Summary: MDV infection induces activation of COX-2 and production of PGE2, leading to inhibition of T cell proliferation via EP2 and EP4 receptors on day 21 post infection. Oral administration of the COX-2 inhibitor meloxicam during MDV infection suppresses COX-2 activation and rescues T cell proliferation on day 21 post infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medical Laboratory Technology
Wanjun Li, Zhiwei Zhang, Baiyun Wang, Na Liang, Qier Zhou, Songkai Long
Summary: Breast cancer is among the most common cancers in women worldwide, and miRNAs and COX-2 are new diagnostic and therapeutic biomarkers for monitoring BC. COX-2 is associated with tumor growth and metastasis, while MiRs show differential expression in breast tumor tissue. Understanding the pathway between miRNAs and COX-2 can lead to the development of new therapeutic approaches for BC.
CLINICA CHIMICA ACTA
(2021)
Article
Medicine, General & Internal
Onur Ceylan, Ozgur Caglar
Summary: In our study, no significant relationship was found between significant prognostic parameters and COX-2 expression. Since COX-2 expression was observed in almost all patients, we consider that the COX-2 pathway is effective during the development phase of WT.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Immunology
Seyed Mohammad Lellahi, Waqas Azeem, Yaping Hua, Benjamin Gabriel, Kristin Paulsen Rye, Hakon Reikvam, Karl-Henning Kalland
Summary: Conventional type 1 dendritic cells (cDC1) and conventional type 2 dendritic cells (cDC2) are being considered as alternative options to monocyte-derived dendritic cells (moDCs) in cancer immunotherapy. However, the low numbers of cDCs in peripheral blood and their extensive spontaneous apoptosis and death in culture within 24hrs pose challenges. The study found that GM-CSF improved the viability of both cDC1 and cDC2, while Flt3-L and IL-4 specifically increased the viability of cDC1 and cDC2, respectively. Combinations of these three cytokines further improved the viability of both cDCs at different time points.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Yashavanth Shaan Lakshmanappa, Sonny R. Elizaldi, Jamin W. Roh, Brian A. Schmidt, Timothy D. Carroll, Kourtney D. Weaver, Justin C. Smith, Anil Verma, Jesse D. Deere, Joseph Dutra, Mars Stone, Sergej Franz, Rebecca Lee Sammak, Katherine J. Olstad, J. Rachel Reader, Zhong-Min Ma, Nancy K. Nguyen, Jennifer Watanabe, Jodie Usachenko, Ramya Immareddy, JoAnn L. Yee, Daniela Weiskopf, Alessandro Sette, Dennis Hartigan-O'Connor, Stephen J. McSorley, John H. Morrison, Nam K. Tran, Graham Simmons, Michael P. Busch, Pamela A. Kozlowski, Koen K. A. Van Rompay, Christopher J. Miller, Smita S. Iyer
Summary: Induction of CD4 T follicular helper (Tfh) cells is crucial for antibody responses to viral infections, as shown in a rhesus macaque model of mild COVID-19 where SARS-CoV-2 infection resulted in transient accumulation of proliferating Tfh cells with a Th1 profile in peripheral blood and the generation of germinal center Tfh cells specific for viral proteins.
NATURE COMMUNICATIONS
(2021)
Review
Medicine, General & Internal
Xueting Liu, Litao Huang, Menghan Liu, Zhu Wang
Summary: This study used meta-analysis and systematic review to clarify the molecular associations of signet ring cell carcinoma (SC) in colorectal cancer (CRC) patients. The results showed that SC was positively associated with microsatellite instability (MSI) and BRAF mutation, and negatively associated with KRAS mutation.
MEDICINA-LITHUANIA
(2022)
Article
Cell Biology
Yumeng Zhang, Premsai Kumar, Jacob J. Adashek, William P. Skelton, Jiannong Li, Aram Vosoughi, Jad Chahoud, Brandon J. Manley, Philippe E. Spiess
Summary: Modulating the COX-2 pathway has not shown improved outcomes in metastatic renal cell carcinoma patients undergoing immune checkpoint inhibitor therapies. However, concurrent use of NSAIDs was associated with worse progression and survival outcomes.
Article
Oncology
Hiroto Matsui Matsui, Shoichi Hazama, Masao Nakajima, Ming Xu, Satoshi Matsukuma, Yukio Tokumitsu, Yoshitaro Shindo, Shinobu Tomochika, Shin Yoshida, Michihisa Iida, Nobuaki Suzuki, Shigeru Takeda, Shigefumi Yoshino, Tomio Ueno, Masaaki Oka, Hiroaki Nagano
Summary: Researchers developed an HSP70 mRNA-transfected DC therapy for treating HCC and found it to be safe and effective in clinical trials. Particularly, the therapy showed better prognosis in cases with HSP70-expressing HCC.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Immunology
Alberto Perez-Gomez, Joana Vitalle, Carmen Gasca-Capote, Alicia Gutierrez-Valencia, Maria Trujillo-Rodriguez, Ana Serna-Gallego, Esperanza Munoz-Muela, Maria de los Reyes Jimenez-Leon, Mohamed Rafii-El-Idrissi Benhnia, Inmaculada Rivas-Jeremias, Cesar Sotomayor, Cristina Roca-Oporto, Nuria Espinosa, Carmen Infante-Dominguez, Juan Carlos Crespo-Rivas, Alberto Fernandez-Villar, Alexandre Perez-Gonzalez, Luis Fernando Lopez-Cortes, Eva Poveda, Ezequiel Ruiz-Mateos
Summary: SARS-CoV-2 infection causes abnormal immune response, affecting the quantity and function of dendritic cells, with some markers remaining altered during acute phase and follow-up.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
N. Carrossini, N. Meireles Da Costa, E. Andrade-Barreto, V. P. L. Sousa, P. Nicolau-Neto, P. T. Souza-Santos, G. R. Mansur, L. Wernersbach, P. T. Bozza, J. P. B. Viola, Luis Felipe Ribeiro Pinto
Summary: Esophageal cancer presents two main histological subtypes, with ESCC mainly associated with tobacco and alcohol abuse, and EAC and BE linked to obesity and chronic GERD. Obesity triggers LD accumulation in non-adipose tissues, which may contribute to the production and action of inflammatory mediators, thus promoting the genesis and progression of BE and EAC.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Zhi Zhang, Peng-Fei Yu, Guo-Li Gu, Yu-Hui Zhang, Yu-Ming Wang, Zhi-Wei Dong, Hai-Rui Yang
Summary: Diffuse invasive signet ring cell carcinoma of the colorectum is an extremely rare type of colorectal cancer, with different pathological characteristics and poor prognosis compared to ordinary colorectal cancer.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Gastroenterology & Hepatology
Joseph Diab, Rania Al-Mahdi, Sandra Gouveia-Figueira, Terkel Hansen, Einar Jensen, Rasmus Goll, Thomas Moritz, Jon Florholmen, Guro Forsdahl
INFLAMMATORY BOWEL DISEASES
(2019)
Article
Infectious Diseases
H. Kileng, T. Gutteberg, R. Goll, E. J. Paulssen
BMC INFECTIOUS DISEASES
(2019)
Article
Biochemical Research Methods
Armin Schniers, Rasmus Goll, Yvonne Pasing, Sveinung Wergeland Sorbye, Jon Florholmen, Terkel Hansen
CLINICAL PROTEOMICS
(2019)
Article
Gastroenterology & Hepatology
Joseph Diab, Terkel Hansen, Rasmus Goll, Hans Stenlund, Maria Ahnlund, Einar Jensen, Thomas Moritz, Jon Florholmen, Guro Forsdahl
INFLAMMATORY BOWEL DISEASES
(2019)
Article
Gastroenterology & Hepatology
Mona Dixon Gundersen, Rasmus Goll, Christopher Graham Fenton, Endre Anderssen, Sveinung Wergeland Sorbye, Jon Ragnar Florholmen, Ruth Hracky Paulssen
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2019)
Article
Biochemistry & Molecular Biology
Joseph Diab, Terkel Hansen, Rasmus Goll, Hans Stenlund, Einar Jensen, Thomas Moritz, Jon Florholmen, Guro Forsdahl
Article
Multidisciplinary Sciences
Rasmus Goll, Richard Heitmann, Oystein Kittel Moe, Katrine Carlsen, Jon Florholmen
Article
Gastroenterology & Hepatology
Christian Borde Arkteg, Rasmus Goll, Mona Dixon Gundersen, Endre Anderssen, Christopher Fenton, Jon Florholmen
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Medicine, General & Internal
Peter Holger Johnsen, Frank Hilpusch, Per Christian Valle, Rasmus Goll
Article
Gastroenterology & Hepatology
Leif Kyrre Berg, Rasmus Goll, Erik Fagerli, Judith Krey Ludviksen, Hilde Fure, Odd Sverre Moen, Sveinung W. Sorbye, Tom Eirik Mollnes, Jon Florholmen
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Multidisciplinary Sciences
Guanglin Cui, Aping Yuan, Zhenfeng Li, Rasmus Goll, Jon Florholmen
SCIENTIFIC REPORTS
(2020)
Article
Gastroenterology & Hepatology
Rasmus Goll, Peter Holger Johnsen, Erik Hjerde, Joseph Diab, Per Christian Valle, Frank Hilpusch, Jorunn Pauline Cavanagh
Article
Multidisciplinary Sciences
Christian Borde Arkteg, Sveinung Wergeland Sorbye, Lene Buhl Riis, Stig Manfred Dalen, Jon Florholmen, Rasmus Goll
Summary: Despite being in clinical and endoscopic remission, 7-35% of UC patients show histological inflammation on a level classified as active disease, depending on the index and cut-off used for evaluation. The ability to accurately and consistently classify these patients could be improved.
Article
Multidisciplinary Sciences
Oddmund Nestegard, Behrouz Moayeri, Fred-Arne Halvorsen, Tor Tonnesen, Sveinung Wergeland Sorbye, Eyvind Paulssen, Kay-Martin Johnsen, Rasmus Goll, Jon Ragnar Florholmen, Kjetil K. Melby
Summary: This study characterized the antimicrobial resistance pattern of H. pylori before and after treatment, and found that clarithromycin resistance was more frequent in the treatment-resistant group. No resistance was observed for amoxicillin and levofloxacin.
Article
Endocrinology & Metabolism
M. A. Larsen, V. T. Isaksen, E. J. Paulssen, R. Goll, J. R. Florholmen