A Novel High-Throughput Cell-Based Assay Aimed at Identifying Inhibitors of DNA Metabolism in Bacteria

Discovery of Inhibitors of 4′-Phosphopantetheine Adenylyltransferase (PPAT) To Validate PPAT as a Target for Antibacterial Therapy

(2013) Boudewijn L. M. de Jonge et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel topoisomerase inhibitors: microbiological characterisation and in vivo efficacy of pyrimidines

(2013) Maria Uria-Nickelsen et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Fragment-to-Hit-to-Lead Discovery of a Novel Pyridylurea Scaffold of ATP Competitive Dual Targeting Type II Topoisomerase Inhibiting Antibacterial Agents

(2013) Gregory S. Basarab et al.   JOURNAL OF MEDICINAL CHEMISTRY

A comprehensive regulatory framework to address the unmet need for new antibacterial treatments

(2013) John H Rex et al.   LANCET INFECTIOUS DISEASES

In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound

(2012) Thomas A. Keating et al.   ACS Chemical Biology

Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV

(2012) John I. Manchester et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sulfonylpiperidines as novel, antibacterial inhibitors of Gram-positive thymidylate kinase (TMK)

(2012) Gabriel Martínez-Botella et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bacterial DNA replication enzymes as targets for antibacterial drug discovery

(2012) Gautam Sanyal et al.   Expert Opinion on Drug Discovery

Discovery of Selective and Potent Inhibitors of Gram-Positive Bacterial Thymidylate Kinase (TMK)

(2012) Gabriel Martínez-Botella et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II with Reduced pKa: Antibacterial Agents with an Improved Safety Profile

(2012) Folkert Reck et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyrrolamide DNA Gyrase Inhibitors: Fragment-Based Nuclear Magnetic Resonance Screening To Identify Antibacterial Agents

(2011) Ann E. Eakin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery of bacterial NAD+-dependent DNA ligase inhibitors: Optimization of antibacterial activity

(2011) Suzanne S. Stokes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacy

(2011) Brian A. Sherer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of bacterial NAD+-dependent DNA ligase inhibitors: Improvements in clearance of adenosine series

(2011) Suzanne S. Stokes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Challenges of Antibacterial Discovery

(2011) L. L. Silver   CLINICAL MICROBIOLOGY REVIEWS

Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics

(2011) S. Alt et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Novel Bacterial NAD+-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial EfficacyIn Vivo

(2010) Scott D. Mills et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors

(2008) A. A. Miller et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanism of Action of the Antibiotic NXL101, a Novel Nonfluoroquinolone Inhibitor of Bacterial Type II Topoisomerases

(2008) M. T. Black et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Low selection of topoisomerase mutants from strains of Escherichia coli harbouring plasmid-borne qnr genes

(2008) A. Cesaro et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE

(2008) Louis B. Rice   JOURNAL OF INFECTIOUS DISEASES

DEG 5.0, a database of essential genes in both prokaryotes and eukaryotes

(2008) R. Zhang et al.   NUCLEIC ACIDS RESEARCH

The Epidemic of Antibiotic-Resistant Infections: A Call to Action for the Medical Community from the Infectious Diseases Society of America

(2007) B. Spellberg et al.   CLINICAL INFECTIOUS DISEASES